HDC (histidine decarboxylase) - Rat Genome Database

Name: HDC
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: HDC (histidine decarboxylase) Pan paniscus

Analyze

Symbol:

HDC

Name:

histidine decarboxylase

RGD ID:

11999973

Description:

ENCODES a protein that exhibits amino acid binding (ortholog); histidine decarboxylase activity (ortholog); identical protein binding (ortholog); INVOLVED IN histamine biosynthetic process (ortholog); histamine metabolic process (ortholog); histidine catabolic process (ortholog); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH asthma (ortholog); Chlamydophila Infections (ortholog); Gilles de la Tourette syndrome (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HDC (histidine decarboxylase)	NCBI	Ortholog
Mus musculus (house mouse):	Hdc (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Hdc (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hdc (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HDC (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hdc (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HDC (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	HDC (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hdc (histidine decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	47,510,629 - 47,534,577 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	47,510,629 - 47,534,577 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	29,188,296 - 29,212,327 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

Chlamydophila Infections (ISO)

Gilles de la Tourette syndrome (ISO)

Hepatomegaly (ISO)

Mycoplasma pneumoniae pneumonia (ISO)

pneumonia (ISO)

rhinitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

histamine biosynthetic process (ISO)

histamine metabolic process (ISO)

histidine catabolic process (ISO)

histidine metabolic process (ISO)

Cellular Component

cytosol (ISO)

dendrite (ISO)

neuronal cell body (ISO)

Molecular Function

amino acid binding (ISO)

histidine decarboxylase activity (ISO)

identical protein binding (ISO)

protein binding (ISO)

pyridoxal phosphate binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histidine metabolic pathway (ISO)

histidinemia pathway (ISO)

References

Genomics

Comparative Map Data

HDC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	47,510,629 - 47,534,577 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	47,510,629 - 47,534,577 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	29,188,296 - 29,212,327 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

HDC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	50,241,947 - 50,265,965 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	50,241,945 - 50,266,049 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	50,534,144 - 50,558,162 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	48,321,436 - 48,345,218 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	15	48,321,442 - 48,345,214	NCBI
Celera	15	27,426,734 - 27,450,752 (-)	NCBI
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	27,365,086 - 27,389,097 (-)	NCBI		HuRef
CHM1_1	15	50,652,084 - 50,676,103 (-)	NCBI		CHM1_1

Hdc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	126,435,579 - 126,465,942 (-)	NCBI	GRCm39		mm39
GRCm38	2	126,593,659 - 126,624,025 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	126,593,667 - 126,619,299 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	126,419,404 - 126,444,401 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	126,285,109 - 126,310,106 (-)	NCBI			mm8
Celera	2	127,832,271 - 127,857,347 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.76	NCBI

Hdc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	119,057,524 - 119,075,599 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,057,517 - 119,075,619 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	125,585,190 - 125,603,276 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	114,119,316 - 114,138,107 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	114,024,891 - 114,043,687 (-)	NCBI
Celera	3	112,689,823 - 112,707,916 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Hdc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	4,051,271 - 4,072,642 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	4,051,574 - 4,072,641 (+)	NCBI	ChiLan1.0	ChiLan1.0

HDC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	30	16,201,589 - 16,223,662 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	30	16,201,222 - 16,223,452 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Hdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936471	12,303,802 - 12,324,613 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HDC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	121,505,742 - 121,525,255 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	121,505,677 - 121,525,416 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	135,147,966 - 135,167,683 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HDC
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	33,051,048 - 33,074,872 (+)	NCBI
ChlSab1.1 Ensembl	26	33,051,966 - 33,074,563 (+)	Ensembl

Hdc
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624731	9,835,585 - 9,856,743 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003831505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000053023 ⟹ ENSPPAP00000030165

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	47,510,629 - 47,534,577 (-)	Ensembl

RefSeq Acc Id:

XM_003831505 ⟹ XP_003831553

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	15	47,510,629 - 47,534,577 (-)	NCBI
Mhudiblu_PPA_v0	15	29,188,315 - 29,212,082 (-)	NCBI

Sequence:

show sequence

TCTTTTACGGCATCCACCTGGAGGCTGCCTGCAGGCTTGGGTTGCTAAGTGCACTGCTTAATTT
AGAAGCGCCTTTTATCCTGGCTCTCTTGACCAGTCAAAGTTGTGGTCGCTGTTTTCTACAAGGA
CTGGGGAAAGAAAGGGTGGAATTAATTAAACCTGGAGGAAGGGACTTTGAAGGGCGGAGCTAAG
GTCAAAGAAAGAACCCTTTAAATAAAGGGCCCACACTGGCTGCCAGGGAGTGCGCAGGACTGGC
AAGAGGGAAGCCGGGCTGCTCCACGCCTTTCACGCCTTCCACCTCCTGCGTGTCCATCTGTGAG
AAGGAGCCAGAGCCCAAGGGAGATGATGGAGCCTGAGGAGTACAGAGAGAGAGGGAGAGAGATG
GTGGATTACATCTGCCAGTACCTGAGCACTCTGCGGGAGAGACGTGTGACACCAGACGTGCAGC
CTGGCTACCTGCGAGCCCAGCTGCCTGAGAGTGCTCCTGAGGACCCCGACAGCTGGGACAGCAT
CTTTGGGGACATTGAACGAATCATCATGCCTGGGGTGGTACATTGGCAGAGCCCCCATATGCAC
GCCTACTACCCAGCCCTCACCTCTTGGCCCTCCCTGCTAGGAGACATGCTGGCTGATGCCATCA
ACTGCTTGGGATTCACCTGGGCATCCAGCCCTGCGTGTACAGAGCTGGAGATGAACGTCATGGA
CTGGTTGGCAAAAATGCTGGGACTTCCAGAGCACTTCTTGCACCACCACCCCAGCAGCCAGGGC
GGAGGCGTCCTGCAGAGCACGGTCAGTGAATCCACTTTGATTGCCCTGCTGGCAGCAAGGAAGA
ACAAAATCCTGGAAATGAAAACATCTGAGCCCGATGCTGATGAGTCCTGCCTAAATGCCCGACT
CGTGGCCTATGCCTCTGACCAGGCTCACTCCTCTGTGGAAAAGGCTGGTTTGATTTCCCTTGTG
AAGATGAAATTTCTGCCTGTGGATGACAACTTCTCACTCCGAGGGGAAGCTCTTCAGAAGGCCA
TCGAGGAAGACAAGCAGCGGGGCTTGGTGCCCGTCTTTGTCTGTGCAACACTAGGGACCACTGG
GGTCTGTGCATTTGACTGCCTGTCAGAGCTGGGCCCCATCTGTGCCCGTGAGGGGCTGTGGCTC
CACATCGATGCTGCTTATGCAGGCACTGCCTTCCTGTGCCCCGAGTTCCGGGGGTTTCTGAAGG
GGATTGAGTATGCCGACTCCTTCACCTTTAATCCTTCCAAGTGGATGATGGTGCATTTTGACTG
TACTGGGTTCTGGGTCAAGGACAAGTACAAGCTGCAGCAGACCTTCAGTGTGAATCCCATCTAC
CTCAGGCATGCCAACTCAGGCGTGGCCACCGACTTCATGCACTGGCAGATCCCCCTGAGCCGAC
GGTTTCGCTCTATTAAACTCTGGTTCGTGATTCGGTCCTTCGGGGTGAAGAATCTTCAAGCACA
TGTCAGACATGGTACTGAAATGGCTAAATATTTTGAATCTCTGGTCAGAAACGACCCTTCCTTT
GAAATTCCTGCCAAGAGGCACCTTGGCCTGGTGGTTTTTCGTCTAAAGGGTCCTAATTGTCTCA
CAGAAAATGTGTTAAAGGAAATAGCTAAAGCTGGCCGTCTCTTCCTCATCCCGGCCACTATCCA
GGACAAGTTAATCATCCGTTTCACTGTGACATCCCAGTTTACCACTAGGGATGACATCCTGAGA
GACTGGAATCTCATTCGAGATGCTGCCACTCTCATCCTGAGTCAGCACTGTACTTCCCAACCCA
GCCCTCGGGTTGGGAACCTCATCTCCCAAATCAGGGGCGCCAGAGCCTGGGCCTGTGGAACGTC
CCTTCAGTCTGTCAGTGGGGCAGGAGATGATCCAGTCCAGGCCAGGAAGATCATCAAGCAGCCT
CAGCGTGTGGGAGCCGGTCCCATGAAAAGGGAAAACGGCCTCCATCTTGAAACCCTGCTGGACC
CAGTTGATGACTGCTTTTCAGAAGAGGCCCCAGATGCCACCAAGCACAAGCTGTCCTCCTTCCT
GTCCAGTTACTTGTCTGTGCAGACTAAGAAGAAGACGGTGCGCTCCCTCAGTTGCAACAGTGTG
CCAGTGAGTGCTCAGAAGCCACTGCCCACAGAGGCCTCTGTGAAGAATGGGGGCTCCTCCAGGG
TCAGAATCTTTTCCAGGTTTCCAGAAGAGATGATGATGCTGAAGAAAAGTGCCTTCAAAAAACT
CATCAAATTCTACAGCGTCCCCAGCTTTCCTGAATGCAGCTCTCAATGTGGACTCCAGCTGCCC
TGTTGCCCTCTGCAGGCCATGGTTTAGACCCAGGGCCTTCAGCCAGAGTCTGAGGATATACTTC
AGGGACTCTGTGAACCCCTCACAATTGTATGCTAACTTTGTGTGCTTATGTGTACATGCATTTT
TCTTGGGGTGAGTTCATAATTTTAATCAAATTCTCATAGGGGTTCATGACCCACAATAGGATAC
AAACGAAGAGTTTAAGCCAGCATGATCCAGATGGCTTCAGCAGGCTGGTCAGTGAGAAAGGGCC
GAGGGTAGACAGGCAGCTTCTGTGGTTCAGCTTGTGACATGATATATAACACAGAAATAAATTA
TGCTTGTCTCTGAAACAAAA

hide sequence

RefSeq Acc Id:

XM_034938739 ⟹ XP_034794630

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	15	29,188,297 - 29,212,327 (-)	NCBI

RefSeq Acc Id:

XM_034938740 ⟹ XP_034794631

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	15	29,188,296 - 29,212,102 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003831553	(Get FASTA)	NCBI Sequence Viewer
	XP_034794630	(Get FASTA)	NCBI Sequence Viewer
	XP_034794631	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003831553 ⟸ XM_003831505

- Peptide Label:

isoform X2

- Sequence:

show sequence

MMEPEEYRERGREMVDYICQYLSTLRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERI
IMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLG
LPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQ
AHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCL
SELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKD
KYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEM
AKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRF
TVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGA
GDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLSSYLSVQ
TKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEEMMMLKKSAFKKLIKFYSVP
SFPECSSQCGLQLPCCPLQAMV

hide sequence

RefSeq Acc Id:	XP_034794631 ⟸ XM_034938740
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_034794630 ⟸ XM_034938739
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSPPAP00000030165 ⟸ ENSPPAT00000053023

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038088	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000030165	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000053023	UniProtKB/TrEMBL
Gene3D-CATH	3.40.640.10	UniProtKB/TrEMBL
	3.90.1150.10	UniProtKB/TrEMBL
InterPro	Aromatic_deC	UniProtKB/TrEMBL
	PyrdxlP-dep_de-COase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_dom1	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major	UniProtKB/TrEMBL
	Pyridoxal-P_BS	UniProtKB/TrEMBL
KEGG Report	pps:100968932	UniProtKB/TrEMBL
NCBI Gene	HDC	ENTREZGENE
Pfam	Pyridoxal_deC	UniProtKB/TrEMBL
PRINTS	YHDCRBOXLASE	UniProtKB/TrEMBL
PROSITE	DDC_GAD_HDC_YDC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53383	UniProtKB/TrEMBL
UniProt	A0A2R9BKH8_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB