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ONTOLOGY REPORT - ANNOTATIONS


Term:norepinephrine metabolic process
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Accession:GO:0042415 term browser browse the term
Definition:The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
Synonyms:exact_synonym: levarterenol metabolic process;   levarterenol metabolism;   noradrenaline metabolic process;   noradrenaline metabolism;   norepinephrine metabolism


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norepinephrine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B ISO RGD PMID:10424772 RGD:8548769 NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095
JBrowse link
G ATP7A ATPase copper transporting alpha ISO (MGI:MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:MGI:53851, MGI:MGI:71923 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756
JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO (MGI:MGI:1313089|PMID:9808618) MGI PMID:9808618 MGI:MGI:1313089 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560
JBrowse link
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:3945626 RGD:5130757 NCBI chr17:17,618,399...17,620,691
Ensembl chr17:17,835,277...17,837,180
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO (MGI:MGI:3047192|PMID:15249681) MGI PMID:15249681 MGI:MGI:3047192 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
JBrowse link
G RNF180 ring finger protein 180 ISO (MGI:MGI:5505713|PMID:23926250) MGI PMID:23926250 MGI:MGI:5505713 NCBI chr 5:49,624,452...49,841,741
Ensembl chr 5:51,280,064...51,454,750
JBrowse link
G RTL4 retrotransposon Gag like 4 ISO (MGI:MGI:5749620|PMID:26402067) MGI PMID:26402067 MGI:MGI:5749620 NCBI chr  X:101,191,619...101,570,815 JBrowse link
G SPR sepiapterin reductase ISO (MGI:MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:MGI:3722569 NCBI chr2A:72,939,621...72,944,669
Ensembl chr2A:74,433,056...74,438,105
JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISO (MGI:MGI:53940|PMID:4858102)
(MGI:MGI:53801|PMID:4405722)
MGI PMID:4405722, PMID:4858102 MGI:MGI:53801, MGI:MGI:53940 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756
JBrowse link
G DBH dopamine beta-hydroxylase ISO (MGI:MGI:1203930|PMID:9603211), (MGI:MGI:1332340|PMID:10051631)
(MGI:MGI:5787847|PMID:27148966), (MGI:MGI:72180|PMID:7715704)
(PMID:27148966)
RGD
MGI
UniProtKB
PMID:7715704, PMID:9603211, PMID:10051631, PMID:10573542, PMID:27148966 MGI:MGI:1203930, MGI:MGI:1332340, MGI:MGI:5787847, MGI:MGI:72180, RGD:1625403 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697
JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560
JBrowse link
G GATA3 GATA binding protein 3 ISO (MGI:MGI:1859081|PMID:10835639) MGI PMID:10835639 MGI:MGI:1859081 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272
JBrowse link
G INSM1 INSM transcriptional repressor 1 ISO (MGI:MGI:3772428|PMID:18094025) UniProtKB PMID:18094025 MGI:MGI:3772428 NCBI chr20:20,317,060...20,320,051 JBrowse link
G KL klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458
JBrowse link
G TH tyrosine hydroxylase ISO (PMID:12457228) BHF-UCL PMID:12457228 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAND2 heart and neural crest derivatives expressed 2 ISO (MGI:MGI:4413411|PMID:19008477) BHF-UCL PMID:19008477 MGI:MGI:4413411 NCBI chr 4:165,755,000...165,758,735 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    metabolic process 7977
      nitrogen compound metabolic process 6694
        organonitrogen compound metabolic process 4652
          catecholamine metabolic process 53
            norepinephrine metabolic process 14
              norepinephrine biosynthetic process + 8
              norepinephrine catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 12561
    metabolic process 7977
      cellular metabolic process 7333
        cellular aromatic compound metabolic process 3878
          phenol-containing compound metabolic process 107
            catechol-containing compound metabolic process 53
              catecholamine metabolic process 53
                norepinephrine metabolic process 14
                  norepinephrine biosynthetic process + 8
                  norepinephrine catabolic process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.