TDO2 (tryptophan 2,3-dioxygenase) - Rat Genome Database
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Gene: TDO2 (tryptophan 2,3-dioxygenase) Pan paniscus
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Symbol: TDO2
Name: tryptophan 2,3-dioxygenase
RGD ID: 11776611
Description: ENCODES a protein that exhibits amino acid binding (ortholog); heme binding (ortholog); identical protein binding (ortholog); INVOLVED IN protein homotetramerization (ortholog); response to nitroglycerin (ortholog); tryptophan catabolic process to acetyl-CoA (ortholog); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); Endotoxemia (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14160,085,840 - 160,102,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,085,645 - 160,102,266 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,269,097 - 148,285,533 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
TDO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14160,085,840 - 160,102,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,085,645 - 160,102,266 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,269,097 - 148,285,533 (+)NCBIMhudiblu_PPA_v0panPan3
TDO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4155,854,738 - 155,920,406 (+)EnsemblGRCh38hg38GRCh38
GRCh384155,903,696 - 155,920,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374156,824,845 - 156,841,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,044,297 - 157,061,000 (+)NCBINCBI36hg18NCBI36
Build 344157,182,451 - 157,199,155NCBI
Celera4154,156,425 - 154,173,133 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,563,673 - 152,580,472 (+)NCBIHuRef
CHM1_14156,802,468 - 156,819,210 (+)NCBICHM1_1
Tdo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,865,719 - 81,883,035 (-)NCBIGRCm39mm39
GRCm38381,958,412 - 81,975,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,957,090 - 81,976,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,762,334 - 81,779,650 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,044,339 - 82,061,655 (-)NCBImm8
Celera381,983,687 - 82,001,014 (-)NCBICelera
Cytogenetic Map3E3NCBI
Tdo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02180,897,059 - 180,914,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,897,011 - 180,914,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,305,349 - 200,323,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,594,020 - 173,611,833 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,544,125 - 173,561,939 (-)NCBI
Celera2161,299,362 - 161,317,278 (-)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21078.8RGD
Tdo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,229,273 - 11,245,375 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,229,795 - 11,245,255 (-)NCBIChiLan1.0ChiLan1.0
TDO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1553,405,957 - 53,423,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11553,406,110 - 53,424,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tdo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365762,537,702 - 2,555,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,708,746 - 44,740,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,708,722 - 44,725,954 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,704,213 - 46,721,456 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TDO2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,467,075 - 102,485,434 (+)NCBI
ChlSab1.1 Ensembl7102,467,640 - 102,485,394 (+)Ensembl
Tdo2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248482,380,827 - 2,395,807 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003822560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000023058   ⟹   ENSPPAP00000005041
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4160,085,645 - 160,102,266 (+)Ensembl
RefSeq Acc Id: XM_003822560   ⟹   XP_003822608
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14160,085,840 - 160,102,266 (+)NCBI
Mhudiblu_PPA_v04148,269,097 - 148,285,533 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003822608 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003822608   ⟸   XM_003822560
- Sequence:
RefSeq Acc Id: ENSPPAP00000005041   ⟸   ENSPPAT00000023058


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000021027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000005041 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000023058 UniProtKB/TrEMBL
InterPro Trp/Indoleamine_2_3_dOase-like UniProtKB/TrEMBL
  Trp_2_3_dOase UniProtKB/TrEMBL
KEGG Report pps:100984006 UniProtKB/TrEMBL
NCBI Gene TDO2 ENTREZGENE
PANTHER PTHR10138 UniProtKB/TrEMBL
Pfam Trp_dioxygenase UniProtKB/TrEMBL
Superfamily-SCOP SSF140959 UniProtKB/TrEMBL
UniProt A0A2R8ZQE8_PANPA UniProtKB/TrEMBL