DRD2 (dopamine receptor D2) - Rat Genome Database

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Gene: DRD2 (dopamine receptor D2) Pan paniscus
Analyze
Symbol: DRD2
Name: dopamine receptor D2
RGD ID: 11899196
Description: ENCODES a protein that exhibits dopamine binding (ortholog); dopamine neurotransmitter receptor activity, coupled via Gi/Go (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN acid secretion (ortholog); activation of protein kinase activity (ortholog); adenohypophysis development (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH Alcoholic Intoxication (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN acrosomal vesicle (ortholog); axon (ortholog); axon terminus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: D(2) dopamine receptor; D2 dopamine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
basal ganglia disease  (ISO)
Binge-Eating Disorder  (ISO)
Bradycardia  (ISO)
Brain Concussion  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Catalepsy  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
dementia  (ISO)
Developmental Disabilities  (ISO)
drug psychosis  (ISO)
Drug-Induced Dyskinesia  (ISO)
Dyskinesias  (ISO)
dystonia  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Gilles de la Tourette syndrome  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperkinesis  (ISO)
hyperprolactinemia  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
impulse control disorder  (ISO)
intellectual disability  (ISO)
language disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
migraine with aura  (ISO)
morphine dependence  (ISO)
movement disease  (ISO)
myoclonic dystonia 11  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pituitary Neoplasms  (ISO)
schizophrenia  (ISO)
substance-related disorder  (ISO)
Tachycardia  (ISO)
Tobacco Use Disorder  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
visual epilepsy  (ISO)
Weight Gain  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
activation of protein kinase activity  (ISO)
adenohypophysis development  (IEA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
adult behavior  (IEA,ISO)
adult walking behavior  (IEA,ISO)
arachidonic acid secretion  (IEA)
associative learning  (IEA,ISO)
auditory behavior  (ISO)
autophagy  (ISO)
axonogenesis  (IEA,ISO)
behavioral response to cocaine  (IEA,ISO)
behavioral response to ethanol  (IEA,ISO)
branching morphogenesis of a nerve  (IEA,ISO)
cellular calcium ion homeostasis  (IEA)
cerebral cortex GABAergic interneuron migration  (IEA,ISO)
circadian regulation of gene expression  (IEA,ISO)
dopamine metabolic process  (IEA,ISO)
dopamine receptor signaling pathway  (IEA,ISO)
drinking behavior  (ISO)
feeding behavior  (IEA,ISO)
forebrain development  (ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
grooming behavior  (IEA,ISO)
hyaloid vascular plexus regression  (IEA)
intracellular signal transduction  (ISO)
locomotory behavior  (IEA,ISO)
long-term memory  (ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of adenylate cyclase activity  (ISO)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of cell death  (ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of dopamine receptor signaling pathway  (IEA,ISO)
negative regulation of dopamine secretion  (ISO)
negative regulation of innate immune response  (IEA)
negative regulation of insulin secretion  (ISO)
negative regulation of protein kinase B signaling  (IEA,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein secretion  (IEA)
negative regulation of synaptic transmission  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IEA,ISO)
negative regulation of voltage-gated calcium channel activity  (ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (IEA,ISO)
neuron-neuron synaptic transmission  (IEA,ISO)
orbitofrontal cortex development  (ISO)
peristalsis  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
pigmentation  (IEA,ISO)
positive regulation of cytokinesis  (IEA)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of dopamine uptake involved in synaptic transmission  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glial cell-derived neurotrophic factor production  (IEA)
positive regulation of growth hormone secretion  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urine volume  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (IEA,ISO)
protein localization  (IEA,ISO)
regulation of dopamine secretion  (ISO)
regulation of dopamine uptake involved in synaptic transmission  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of MAPK cascade  (ISO)
regulation of neurotransmitter uptake  (IEA)
regulation of phosphoprotein phosphatase activity  (ISO)
regulation of potassium ion transport  (IEA,ISO)
regulation of secretion by cell  (IEA)
regulation of sodium ion transport  (IEA,ISO)
regulation of synapse structural plasticity  (ISO)
regulation of synaptic transmission, GABAergic  (IEA,ISO)
regulation of synaptic vesicle exocytosis  (IEA)
release of sequestered calcium ion into cytosol  (ISO)
response to amphetamine  (IEA,ISO)
response to axon injury  (ISO)
response to cocaine  (IEA,ISO)
response to ethanol  (ISO)
response to histamine  (IEA)
response to hypoxia  (ISO)
response to inactivity  (ISO)
response to iron ion  (ISO)
response to light stimulus  (IEA,ISO)
response to morphine  (IEA,ISO)
response to nicotine  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of smell  (IEA,ISO)
signal transduction  (IEA)
startle response  (IEA,ISO)
striatum development  (ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IEA)
temperature homeostasis  (IEA,ISO)
visual learning  (IEA,ISO)
Wnt signaling pathway  (ISO)

References

Genomics

Comparative Map Data
DRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0panPan3
DRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11113,409,605 - 113,475,691 (-)EnsemblGRCh38hg38GRCh38
GRCh3811113,409,605 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711113,280,327 - 113,346,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
Drd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,251,633 - 49,319,477 (+)NCBIGRCm39mm39
GRCm39 Ensembl949,251,927 - 49,319,477 (+)Ensembl
GRCm38949,340,360 - 49,408,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,340,627 - 49,408,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv37949,148,767 - 49,215,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36949,092,857 - 49,160,407 (+)NCBImm8
Celera946,638,220 - 46,705,025 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.72NCBI
Drd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,708,903 - 49,772,888 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl849,708,927 - 49,772,875 (+)Ensembl
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
Drd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,054,038 - 15,114,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,054,255 - 15,114,558 (-)NCBIChiLan1.0ChiLan1.0
DRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,704,390 - 19,715,716 (+)NCBI
ROS_Cfam_1.0519,803,212 - 19,815,852 (+)NCBI
ROS_Cfam_1.0 Ensembl519,754,070 - 19,815,870 (+)Ensembl
UMICH_Zoey_3.1519,865,917 - 19,877,447 (+)NCBI
UNSW_CanFamBas_1.0519,767,231 - 19,778,550 (+)NCBI
UU_Cfam_GSD_1.0519,814,856 - 19,826,385 (+)NCBI
Drd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBI
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,774,632 - 104,843,417 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1104,774,180 - 104,842,736 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604321,144,996 - 21,236,456 (+)NCBIVero_WHO_p1.0
Drd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247848,828,589 - 8,906,617 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000036327   ⟹   ENSPPAP00000013654
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11112,132,703 - 112,168,583 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000036336   ⟹   ENSPPAP00000013663
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11112,133,837 - 112,198,935 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000036343   ⟹   ENSPPAP00000013670
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11112,133,837 - 112,147,715 (-)Ensembl
RefSeq Acc Id: XM_034933707   ⟹   XP_034789598
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBI
RefSeq Acc Id: XM_034933708   ⟹   XP_034789599
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,357,168 (-)NCBI
RefSeq Acc Id: XM_034933709   ⟹   XP_034789600
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,357,170 (-)NCBI
RefSeq Acc Id: XM_034933710   ⟹   XP_034789601
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,355,700 (-)NCBI
RefSeq Acc Id: XM_034933711   ⟹   XP_034789602
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,355,242 (-)NCBI
RefSeq Acc Id: XM_034933712   ⟹   XP_034789603
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,325,802 (-)NCBI
RefSeq Acc Id: XM_034933714   ⟹   XP_034789605
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,355,830 (-)NCBI
RefSeq Acc Id: XM_034933715   ⟹   XP_034789606
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v011108,289,838 - 108,355,711 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_034789598   ⟸   XM_034933707
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034789600   ⟸   XM_034933709
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034789599   ⟸   XM_034933708
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034789605   ⟸   XM_034933714
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034789606   ⟸   XM_034933715
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034789601   ⟸   XM_034933710
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034789602   ⟸   XM_034933711
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034789603   ⟸   XM_034933712
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000013663   ⟸   ENSPPAT00000036336
RefSeq Acc Id: ENSPPAP00000013654   ⟸   ENSPPAT00000036327
RefSeq Acc Id: ENSPPAP00000013670   ⟸   ENSPPAT00000036343
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029985 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000013654 UniProtKB/TrEMBL
  ENSPPAP00000013663 UniProtKB/TrEMBL
  ENSPPAP00000013670 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036327 UniProtKB/TrEMBL
  ENSPPAT00000036336 UniProtKB/TrEMBL
  ENSPPAT00000036343 UniProtKB/TrEMBL
InterPro Dopamine_D2_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report pps:100980993 UniProtKB/TrEMBL
NCBI Gene DRD2 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED2R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt A0A2R9A8Q0_PANPA UniProtKB/TrEMBL
  A0A2R9A8S2_PANPA UniProtKB/TrEMBL
  A0A2R9ADS5_PANPA UniProtKB/TrEMBL
  Q3HNE0_PANPA UniProtKB/TrEMBL
  Q9BDC9_PANPA UniProtKB/TrEMBL