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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cytokine-mediated signaling pathway
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Accession:GO:0001960 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
Synonyms:exact_synonym: down-regulation of cytokine mediated signaling pathway;   downregulation of cytokine mediated signaling pathway;   negative regulation of cytokine and chemokine mediated signaling pathway;   negative regulation of cytokine mediated signalling pathway
 narrow_synonym: inhibition of cytokine mediated signaling pathway


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negative regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12388746) Ensembl
MGI		 PMID:12388746 GO_REF:0000107 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CISH cytokine inducible SH2 containing protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12618484) MGI
Ensembl		 PMID:12618484 GO_REF:0000107 NCBI chr 3:50,606,489...50,611,774
Ensembl chr 3:50,606,489...50,611,774 		JBrowse link
G ECM1 extracellular matrix protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21217760) Ensembl
MGI		 PMID:21217760 GO_REF:0000107 NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789 		JBrowse link
G IL1RN interleukin 1 receptor antagonist involved_in IEA GOC GO_REF:0000108 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL36RN interleukin 36 receptor antagonist involved_in IMP (PMID:23147407) UniProt PMID:23147407 NCBI chr 2:113,058,638...113,064,744
Ensembl chr 2:113,058,638...113,065,382 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 involved_in IC (PMID:12150927) BHF-UCL PMID:12150927 NCBI chr12:66,189,214...66,254,622
Ensembl chr12:66,189,195...66,254,622 		JBrowse link
G MIR125A microRNA 125a acts_upstream_of ISS (PMID:30089723) ARUK-UCL PMID:30089723 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339 		JBrowse link
G MIR20A microRNA 20a involved_in IDA (PMID:28972028) BHF-UCL PMID:28972028 NCBI chr13:91,351,065...91,351,135
Ensembl chr13:91,351,065...91,351,135 		JBrowse link
G MIR21 microRNA 21 involved_in IDA (PMID:30106099) ARUK-UCL PMID:30106099 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR29B1 microRNA 29b-1 acts_upstream_of IDA (PMID:23729669) ARUK-UCL PMID:23729669 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539 		JBrowse link
G MIR29B2 microRNA 29b-2 acts_upstream_of IDA (PMID:23729669) ARUK-UCL PMID:23729669 NCBI chr 1:207,802,443...207,802,523
Ensembl chr 1:207,802,443...207,802,523 		JBrowse link
G MIR520C microRNA 520c involved_in IDA (PMID:29048659) ARUK-UCL PMID:29048659 NCBI chr19:53,707,453...53,707,539
Ensembl chr19:53,707,453...53,707,539 		JBrowse link
G PALM3 paralemmin 3 involved_in IDA
IBA		 (PMID:21187075) UniProt
GO_Central		 PMID:21187075 GO_REF:0000033 NCBI chr19:14,053,367...14,062,076
Ensembl chr19:14,053,363...14,062,076 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,759,342 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO hepatocyte growth factor/Met signaling RGD PMID:16415345 RGD:1642742 NCBI chr 1:43,522,051...43,623,666
Ensembl chr 1:43,525,187...43,623,666 		JBrowse link
G PXDN peroxidasin involved_in IEA GOC GO_REF:0000108 NCBI chr 2:1,631,887...1,744,901
Ensembl chr 2:1,631,887...1,744,852 		JBrowse link
G SIGIRR single Ig and TIR domain containing involved_in IEA
ISS		 Ensembl
HGNC-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:405,716...417,397
Ensembl chr11:405,715...417,455 		JBrowse link
G ZNF675 zinc finger protein 675 involved_in IDA (PMID:11751921) UniProt PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220 		JBrowse link
negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 involved_in IEA GOC GO_REF:0000108 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G MIR101-1 microRNA 101-1 involved_in IDA (PMID:27693460) BHF-UCL PMID:27693460 NCBI chr 1:65,058,434...65,058,508
Ensembl chr 1:65,058,434...65,058,508 		JBrowse link
G MIR101-2 microRNA 101-2 involved_in IDA (PMID:27693460) BHF-UCL PMID:27693460 NCBI chr 9:4,850,297...4,850,375
Ensembl chr 9:4,850,297...4,850,375 		JBrowse link
G MIR20A microRNA 20a involved_in IDA (PMID:28972028) ARUK-UCL PMID:28972028 NCBI chr13:91,351,065...91,351,135
Ensembl chr13:91,351,065...91,351,135 		JBrowse link
G PADI2 peptidyl arginine deiminase 2 involved_in IDA (PMID:18645041) UniProt PMID:18645041 NCBI chr 1:17,066,761...17,119,451
Ensembl chr 1:17,066,761...17,119,451 		JBrowse link
G RNF113A ring finger protein 113A involved_in IMP (PMID:28978524) UniProt PMID:28978524 NCBI chr  X:119,870,475...119,871,733
Ensembl chr  X:119,870,475...119,871,733 		JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in IMP (PMID:18829537) BHF-UCL PMID:18829537 NCBI chr 3:78,597,239...79,767,998
Ensembl chr 3:78,597,239...79,767,998 		JBrowse link
G SH2B3 SH2B adaptor protein 3 involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:111,404,730...111,451,623
Ensembl chr12:111,405,923...111,451,623 		JBrowse link
G SLIT2 slit guidance ligand 2 involved_in IMP (PMID:18829537) BHF-UCL PMID:18829537 NCBI chr 4:20,251,905...20,620,561
Ensembl chr 4:20,251,905...20,620,561 		JBrowse link
G SLIT3 slit guidance ligand 3 involved_in IMP (PMID:18829537) BHF-UCL PMID:18829537 NCBI chr 5:168,661,740...169,301,139
Ensembl chr 5:168,661,740...169,301,139 		JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1R2 interleukin 1 receptor type 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23395675) Ensembl
MGI		 PMID:23395675 GO_REF:0000107 NCBI chr 2:101,991,960...102,028,544
Ensembl chr 2:101,991,960...102,028,544 		JBrowse link
G IL1RN interleukin 1 receptor antagonist involved_in IDA
IBA		 (PMID:2137200), (PMID:2139180) BHF-UCL
GO_Central		 PMID:2137200 PMID:2139180 GO_REF:0000033 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL6 interleukin 6 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MIR21 microRNA 21 acts_upstream_of_or_within IGI (PMID:25327529) BHF-UCL PMID:25327529 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR27A microRNA 27a involved_in IGI (PMID:25327529) BHF-UCL PMID:25327529 NCBI chr19:13,836,440...13,836,517
Ensembl chr19:13,836,440...13,836,517 		JBrowse link
G OTUD4 OTU deubiquitinase 4 involved_in IEA
IDA
IBA		 (PMID:29395066) Ensembl
UniProt
GO_Central		 PMID:29395066 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:145,133,650...145,180,589
Ensembl chr 4:145,110,838...145,180,589 		JBrowse link
G PYDC1 pyrin domain containing 1 involved_in IDA (PMID:12656673) ARUK-UCL PMID:12656673 NCBI chr16:31,215,962...31,217,135
Ensembl chr16:31,215,962...31,217,135 		JBrowse link
G SIGIRR single Ig and TIR domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:405,716...417,397
Ensembl chr11:405,715...417,455 		JBrowse link
G ZNF675 zinc finger protein 675 involved_in IDA (PMID:11751921) BHF-UCL PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220 		JBrowse link
negative regulation of interleukin-17-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR135A1 microRNA 135a-1 involved_in IDA (PMID:29734196) ARUK-UCL PMID:29734196 NCBI chr 3:52,294,219...52,294,308
Ensembl chr 3:52,294,219...52,294,308 		JBrowse link
G USP25 ubiquitin specific peptidase 25 involved_in IDA (PMID:23042150) UniProt PMID:23042150 NCBI chr21:15,729,982...15,880,064
Ensembl chr21:15,729,982...15,880,064 		JBrowse link
negative regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935 		JBrowse link
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA
IMP		 (PMID:11909529) Ensembl
UniProt		 PMID:11909529 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IMP
IEA		 (PMID:17210636) UniProt
Ensembl		 PMID:17210636 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in IGI (PMID:12574355) ARUK-UCL PMID:12574355 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,759,342 		JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6ST interleukin 6 cytokine family signal transducer involved_in IDA (PMID:8353278) BHF-UCL PMID:8353278 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G MIR125A microRNA 125a acts_upstream_of_or_within IGI (PMID:30670152) ARUK-UCL PMID:30670152 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339 		JBrowse link
G MIR125B1 microRNA 125b-1 involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844 		JBrowse link
G MIR125B2 microRNA 125b-2 involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr21:16,590,237...16,590,325
Ensembl chr21:16,590,237...16,590,325 		JBrowse link
G MIR146A microRNA 146a involved_in IMP (PMID:28433754) ARUK-UCL PMID:28433754 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MIR26A1 microRNA 26a-1 involved_in IDA (PMID:23389848) ARUK-UCL PMID:23389848 NCBI chr 3:37,969,404...37,969,480
Ensembl chr 3:37,969,404...37,969,480 		JBrowse link
G MIR26A2 microRNA 26a-2 involved_in IDA (PMID:23389848) ARUK-UCL PMID:23389848 NCBI chr12:57,824,609...57,824,692
Ensembl chr12:57,824,609...57,824,692 		JBrowse link
G MIR98 microRNA 98 involved_in IDA
IGI		 (PMID:26587789)
(PMID:31886314)		 ARUK-UCL PMID:26587789 PMID:31886314 NCBI chr  X:53,556,223...53,556,341
Ensembl chr  X:53,556,223...53,556,341 		JBrowse link
G MIR99A microRNA 99a involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr21:16,539,089...16,539,169
Ensembl chr21:16,539,089...16,539,169 		JBrowse link
G MIRLET7A1 microRNA let-7a-1 involved_in IDA (PMID:19878981) ARUK-UCL PMID:19878981 NCBI chr 9:94,175,957...94,176,036
Ensembl chr 9:94,175,957...94,176,036 		JBrowse link
G MIRLET7A2 microRNA let-7a-2 involved_in IDA (PMID:19878981) ARUK-UCL PMID:19878981 NCBI chr11:122,146,522...122,146,593
Ensembl chr11:122,146,522...122,146,593 		JBrowse link
G MIRLET7A3 microRNA let-7a-3 involved_in IDA (PMID:19878981) ARUK-UCL PMID:19878981 NCBI chr22:46,112,749...46,112,822
Ensembl chr22:46,112,749...46,112,822 		JBrowse link
G MIRLET7C microRNA let-7c involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr21:16,539,828...16,539,911
Ensembl chr21:16,539,828...16,539,911 		JBrowse link
G MIRLET7E microRNA let-7e acts_upstream_of_or_within IGI
IDA		 (PMID:30670152) ARUK-UCL PMID:30670152 NCBI chr19:51,692,786...51,692,864
Ensembl chr19:51,692,786...51,692,864 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IMP
IEA		 (PMID:12359225) UniProt
Ensembl		 PMID:12359225 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
negative regulation of Kit signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RABGEF1 RAB guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16533754) Ensembl
MGI		 PMID:16533754 GO_REF:0000107 NCBI chr 7:66,654,567...66,811,464
Ensembl chr 7:66,682,164...66,811,464 		JBrowse link
G SH2B3 SH2B adaptor protein 3 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:111,404,730...111,451,623
Ensembl chr12:111,405,923...111,451,623 		JBrowse link
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:67,558,727...67,607,337
Ensembl chr 4:67,558,727...67,607,337 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IMP (PMID:33097708) ARUK-UCL PMID:33097708 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IDA (PMID:10604883) BHF-UCL PMID:10604883 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G APOA1 apolipoprotein A1 involved_in IDA (PMID:21571275) BHF-UCL PMID:21571275 NCBI chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 involved_in IDA (PMID:11865055) UniProt PMID:11865055 NCBI chr20:63,235,905...63,240,495
Ensembl chr20:63,235,883...63,240,495 		JBrowse link
G CARD16 caspase recruitment domain family member 16 involved_in IMP (PMID:16920334) UniProt PMID:16920334 NCBI chr11:105,041,563...105,045,335
Ensembl chr11:105,039,092...105,101,431 		JBrowse link
G CARD8 caspase recruitment domain family member 8 involved_in IMP (PMID:11821383) UniProt PMID:11821383 NCBI chr19:48,203,148...48,255,946
Ensembl chr19:48,180,770...48,255,946 		JBrowse link
G CCDC3 coiled-coil domain containing 3 involved_in IMP (PMID:25193116) UniProt PMID:25193116 NCBI chr10:12,896,625...13,099,989
Ensembl chr10:12,896,625...13,099,652 		JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655 		JBrowse link
G DICER1 dicer 1, ribonuclease III acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IDA (PMID:19781631) UniProt PMID:19781631 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IDA (PMID:19657094) UniProt PMID:19657094 NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:7,312,661...7,315,360
Ensembl chr17:7,311,324...7,315,564 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in IC (PMID:16636664) BHF-UCL PMID:16636664 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G H2BC11 H2B clustered histone 11 involved_in IDA (PMID:11859126) UniProt PMID:11859126 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,122,657...27,132,795 		JBrowse link
G MIR125B1 microRNA 125b-1 acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844 		JBrowse link
G MIR125B2 microRNA 125b-2 acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr21:16,590,237...16,590,325
Ensembl chr21:16,590,237...16,590,325 		JBrowse link
G MIR130A microRNA 130a acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr11:57,641,198...57,641,286
Ensembl chr11:57,641,198...57,641,286 		JBrowse link
G MIR152 microRNA 152 involved_in IDA (PMID:24813629) BHF-UCL PMID:24813629 NCBI chr17:48,037,161...48,037,247
Ensembl chr17:48,037,161...48,037,247 		JBrowse link
G MIR24-1 microRNA 24-1 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 9:95,086,021...95,086,088
Ensembl chr 9:95,086,021...95,086,088 		JBrowse link
G MIR24-2 microRNA 24-2 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:13,836,287...13,836,359
Ensembl chr19:13,836,287...13,836,359 		JBrowse link
G MIR27B microRNA 27b acts_upstream_of_or_within IGI (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein involved_in IDA (PMID:11865055) UniProt PMID:11865055 NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,166...71,025,339 		JBrowse link
G NLRP2B NLR family pyrin domain containing 2B involved_in IMP (PMID:24871464) UniProt PMID:24871464 NCBI chr  X:57,677,067...57,680,260
Ensembl chr  X:57,677,067...57,680,260 		JBrowse link
G NOL3 nucleolar protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:67,170,538...67,175,737
Ensembl chr16:67,170,154...67,175,737 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within IMP (PMID:24113711) MGI PMID:24113711 NCBI chr11:66,466,327...66,477,337
Ensembl chr11:66,466,327...66,477,337 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr19:4,007,736...4,039,386
Ensembl chr19:4,007,736...4,039,386 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta acts_upstream_of IGI (PMID:28159925) ARUK-UCL PMID:28159925 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
G PYDC1 pyrin domain containing 1 involved_in IMP
IDA		 (PMID:24871464)
(PMID:12656673)		 UniProt
HGNC-UCL		 PMID:12656673 PMID:24871464 NCBI chr16:31,215,962...31,217,135
Ensembl chr16:31,215,962...31,217,135 		JBrowse link
G PYDC2 pyrin domain containing 2 involved_in IMP (PMID:17339483), (PMID:24871464) UniProt PMID:17339483 PMID:24871464 NCBI chr 3:191,461,163...191,461,456
Ensembl chr 3:191,461,163...191,461,456 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IMP (PMID:18450452) UniProt PMID:18450452 NCBI chr17:35,005,990...35,089,226
Ensembl chr17:35,005,990...35,089,319 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 9:69,121,264...69,255,208
Ensembl chr 9:69,121,264...69,274,615 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TRAIP TRAF interacting protein involved_in IDA (PMID:19151749) CACAO PMID:19151749 NCBI chr 3:49,828,601...49,856,564
Ensembl chr 3:49,828,601...49,856,574 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IDA (PMID:11865055) UniProt PMID:11865055 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G ZNF675 zinc finger protein 675 involved_in IDA (PMID:11751921) BHF-UCL PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220 		JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19060901) Ensembl
MGI		 PMID:19060901 GO_REF:0000107 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013 		JBrowse link
G CACTIN cactin, spliceosome C complex subunit involved_in IMP (PMID:20829348) UniProt PMID:20829348 NCBI chr19:3,610,645...3,626,790
Ensembl chr19:3,610,645...3,626,815 		JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 involved_in IMP (PMID:23386060) UniProt PMID:23386060 NCBI chr 8:17,224,966...17,246,857
Ensembl chr 8:17,224,966...17,246,878 		JBrowse link
G DCST1 DC-STAMP domain containing 1 involved_in IMP (PMID:27782195) UniProt PMID:27782195 NCBI chr 1:155,033,806...155,050,930
Ensembl chr 1:155,033,824...155,050,930 		JBrowse link
G EIF4E2 eukaryotic translation initiation factor 4E family member 2 involved_in IDA (PMID:35878012) UniProt PMID:35878012 NCBI chr 2:232,550,689...232,583,644
Ensembl chr 2:232,550,659...232,583,644 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in IDA (PMID:35878012) UniProt PMID:35878012 NCBI chr 2:232,697,331...232,860,605
Ensembl chr 2:232,697,299...232,860,605 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier involved_in IMP (PMID:28724761) ARUK-UCL PMID:28724761 NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IMP (PMID:37656786) UniProt PMID:37656786 NCBI chr20:3,846,834...3,876,118
Ensembl chr20:3,846,799...3,876,123 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in IMP (PMID:30559377) UniProt PMID:30559377 NCBI chr14:21,498,138...21,511,340
Ensembl chr14:21,498,133...21,511,342 		JBrowse link
G MIR21 microRNA 21 involved_in IDA (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IMP (PMID:23399697) UniProt PMID:23399697 NCBI chr 1:20,499,448...20,508,151
Ensembl chr 1:20,499,448...20,508,151 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IDA
IBA
IEA		 (PMID:20434986) UniProt
GO_Central
Ensembl		 PMID:20434986 GO_REF:0000033 GO_REF:0000107 NCBI chr16:56,989,557...57,083,520
Ensembl chr16:56,989,485...57,083,531 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IMP (PMID:30078389) ARUK-UCL PMID:30078389 NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219 		JBrowse link
G OAS3 2'-5'-oligoadenylate synthetase 3 involved_in IMP (PMID:30078389) ARUK-UCL PMID:30078389 NCBI chr12:112,938,474...112,973,251
Ensembl chr12:112,938,051...112,976,460 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA
IMP		 (PMID:11909529) Ensembl
UniProt		 PMID:11909529 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA
IDA		 (PMID:29670289) Ensembl
UniProt		 PMID:29670289 GO_REF:0000107 NCBI chr20:36,889,773...36,951,708
Ensembl chr20:36,890,229...36,951,893 		JBrowse link
G SMIM30 small integral membrane protein 30 involved_in IMP
IBA		 (PMID:37656786) UniProt
GO_Central		 PMID:37656786 GO_REF:0000033 NCBI chr 7:113,116,718...113,118,554
Ensembl chr 7:113,116,718...113,118,560 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 involved_in IMP (PMID:28165510) UniProt PMID:28165510 NCBI chr12:56,341,597...56,360,107
Ensembl chr12:56,341,597...56,360,203 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18724932) Ensembl
MGI		 PMID:18724932 GO_REF:0000107 NCBI chr 3:48,465,830...48,467,645
Ensembl chr 3:48,465,811...48,467,645 		JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 involved_in IMP (PMID:28011935) UniProt PMID:28011935 NCBI chr22:43,166,622...43,187,134
Ensembl chr22:43,166,622...43,187,134 		JBrowse link
G USP18 ubiquitin specific peptidase 18 involved_in IDA (PMID:28165510) UniProt PMID:28165510 NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,149,843...18,177,397 		JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 involved_in IMP (PMID:30559377) UniProt PMID:30559377 NCBI chr 1:28,736,624...28,769,775
Ensembl chr 1:28,736,621...28,769,775 		JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein F3 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:63,168,553...63,212,788
Ensembl chr 8:63,168,553...63,212,786 		JBrowse link
negative regulation of type II interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG1 arginase 1 involved_in IMP (PMID:16709924) UniProt PMID:16709924 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 involved_in IDA (PMID:11679576) UniProt PMID:11679576 NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 involved_in NAS (PMID:21268089) BHF-UCL PMID:21268089 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 involved_in NAS (PMID:21268089) BHF-UCL PMID:21268089 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G OTOP1 otopetrin 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:4,188,726...4,226,929
Ensembl chr 4:4,188,726...4,226,929 		JBrowse link
G PARP14 poly(ADP-ribose) polymerase family member 14 involved_in IMP
IBA
IEA		 (PMID:27796300) UniProt
GO_Central
Ensembl		 PMID:27796300 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:122,680,839...122,730,840
Ensembl chr 3:122,680,839...122,730,840 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma involved_in IMP (PMID:21268089) BHF-UCL PMID:21268089 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in
NOT|involved_in		 IEA
IMP
IDA
ISS		 (PMID:12138178) Ensembl
UniProt		 PMID:12138178 GO_REF:0000024 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19699
    negative regulation of biological process 6502
      negative regulation of signaling 1750
        negative regulation of signal transduction 1602
          negative regulation of cytokine-mediated signaling pathway 113
            negative regulation of Kit signaling pathway 2
            negative regulation of chemokine-mediated signaling pathway + 10
            negative regulation of interleukin-1-mediated signaling pathway 9
            negative regulation of interleukin-17-mediated signaling pathway 2
            negative regulation of interleukin-18-mediated signaling pathway 1
            negative regulation of interleukin-2-mediated signaling pathway 1
            negative regulation of interleukin-27-mediated signaling pathway 0
            negative regulation of interleukin-35-mediated signaling pathway 0
            negative regulation of interleukin-4-mediated signaling pathway 2
            negative regulation of interleukin-6-mediated signaling pathway 15
            negative regulation of macrophage colony-stimulating factor signaling pathway 3
            negative regulation of macrophage migration inhibitory factor signaling pathway 0
            negative regulation of prolactin signaling pathway 0
            negative regulation of tumor necrosis factor-mediated signaling pathway 37
            negative regulation of type I interferon-mediated signaling pathway 24
            negative regulation of type II interferon-mediated signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 19699
    response to stimulus 10247
      response to chemical 5038
        response to peptide 1385
          response to cytokine 1361
            cellular response to cytokine stimulus 1231
              cytokine-mediated signaling pathway 619
                regulation of cytokine-mediated signaling pathway 200
                  negative regulation of cytokine-mediated signaling pathway 113
                    negative regulation of Kit signaling pathway 2
                    negative regulation of chemokine-mediated signaling pathway + 10
                    negative regulation of interleukin-1-mediated signaling pathway 9
                    negative regulation of interleukin-17-mediated signaling pathway 2
                    negative regulation of interleukin-18-mediated signaling pathway 1
                    negative regulation of interleukin-2-mediated signaling pathway 1
                    negative regulation of interleukin-27-mediated signaling pathway 0
                    negative regulation of interleukin-35-mediated signaling pathway 0
                    negative regulation of interleukin-4-mediated signaling pathway 2
                    negative regulation of interleukin-6-mediated signaling pathway 15
                    negative regulation of macrophage colony-stimulating factor signaling pathway 3
                    negative regulation of macrophage migration inhibitory factor signaling pathway 0
                    negative regulation of prolactin signaling pathway 0
                    negative regulation of tumor necrosis factor-mediated signaling pathway 37
                    negative regulation of type I interferon-mediated signaling pathway 24
                    negative regulation of type II interferon-mediated signaling pathway 8
paths to the root