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Gene: TTLL12 (tubulin tyrosine ligase like 12) Homo sapiens
Symbol: TTLL12
Name: tubulin tyrosine ligase like 12
Description: Exhibits H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Localizes to cytoplasm; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dJ526I14.2; FLJ41795; inactive tubulin--tyrosine ligase-like protein 12; KIAA0153; tubulin tyrosine ligase-like family member 12; tubulin tyrosine ligase-like family, member 12; tubulin--tyrosine ligase-like protein 12
Mus musculus (house mouse) : Ttll12 (tubulin tyrosine ligase-like family, member 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ttll12 (tubulin tyrosine ligase like 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ttll12 (tubulin tyrosine ligase like 12)
Pan paniscus (bonobo/pygmy chimpanzee) : TTLL12 (tubulin tyrosine ligase like 12)
Canis lupus familiaris (dog) : TTLL12 (tubulin tyrosine ligase like 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ttll12 (tubulin tyrosine ligase like 12)
Sus scrofa (pig) : TTLL12 (tubulin tyrosine ligase like 12)
Chlorocebus sabaeus (African green monkey) : TTLL12 (tubulin tyrosine ligase like 12)
Heterocephalus glaber (naked mole-rat) : Ttll12 (tubulin tyrosine ligase like 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2243,166,622 - 43,187,134 (-)EnsemblGRCh38hg38GRCh38
GRCh382243,166,622 - 43,187,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,562,628 - 43,583,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,892,572 - 41,913,051 (-)NCBINCBI36hg18NCBI36
Celera2227,473,015 - 27,493,525 (-)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2226,520,840 - 26,541,320 (-)NCBIHuRef
CHM1_12243,521,891 - 43,542,376 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TTLL12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604381
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.