MIR125B1 (microRNA 125b-1) - Rat Genome Database

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Gene: MIR125B1 (microRNA 125b-1) Homo sapiens
Analyze
Symbol: MIR125B1
Name: microRNA 125b-1
RGD ID: 1352829
HGNC Page HGNC:31506
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of gene expression; negative regulation of signal transduction; and positive regulation of cell differentiation. Located in extracellular exosome.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-125b-1; MIRN125B1
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,099,757 - 122,099,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,099,757 - 122,099,844 (-)EnsemblGRCh38hg38GRCh38
GRCh3711121,970,465 - 121,970,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611121,475,674 - 121,475,761 (-)NCBINCBI36Build 36hg18NCBI36
Celera11119,131,144 - 119,131,231 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,917,003 - 117,917,090 (-)NCBIHuRef
CHM1_111121,857,766 - 121,857,853 (-)NCBICHM1_1
T2T-CHM13v2.011122,128,759 - 122,128,846 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (ISO)
cellular response to forskolin  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to interleukin-6  (IMP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin D  (IDA)
common myeloid progenitor cell proliferation  (ISO)
hematopoietic stem cell differentiation  (ISO)
juxtaglomerular apparatus development  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA,IMP)
negative regulation of angiogenesis  (IDA)
negative regulation of BMP signaling pathway  (IMP)
negative regulation of gene expression  (IGI)
negative regulation of interleukin-6-mediated signaling pathway  (IDA)
negative regulation of keratinocyte proliferation  (IMP)
negative regulation of monocyte differentiation  (IDA)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of receptor signaling pathway via STAT  (IDA)
negative regulation of tumor necrosis factor production  (IDA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IDA)
ossification  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of keratinocyte differentiation  (IMP)
positive regulation of neuron apoptotic process  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of vascular associated smooth muscle cell differentiation  (IMP)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:15722555   PMID:15800047   PMID:15978578   PMID:16381832   PMID:17604727   PMID:17616659   PMID:17622355   PMID:18548003   PMID:19047678   PMID:19048628   PMID:19437538  
PMID:19471102   PMID:20158877   PMID:20306291   PMID:20347935   PMID:20460378   PMID:20485370   PMID:20549700   PMID:20658525   PMID:20889907   PMID:21037258   PMID:21118986   PMID:21166724  
PMID:21399871   PMID:21412257   PMID:21444677   PMID:21703189   PMID:21785383   PMID:21806957   PMID:21880154   PMID:21903586   PMID:21913998   PMID:21935352   PMID:21969554   PMID:22024720  
PMID:22093834   PMID:22307404   PMID:22391569   PMID:22460089   PMID:22469780   PMID:22550173   PMID:22693547   PMID:22723551   PMID:22824797   PMID:22898264   PMID:22944560   PMID:22991213  
PMID:23099851   PMID:23146892   PMID:23160634   PMID:23305626   PMID:23406982   PMID:23416980   PMID:23418555   PMID:23437196   PMID:23527180   PMID:23585871   PMID:23591197   PMID:23718732  
PMID:23759586   PMID:23835866   PMID:23915977   PMID:23928699   PMID:23977359   PMID:24118912   PMID:24604579   PMID:24627568   PMID:24643683   PMID:24746948   PMID:24762088   PMID:24778468  
PMID:24811246   PMID:24865963   PMID:24878024   PMID:25001178   PMID:25126724   PMID:25155155   PMID:25173609   PMID:25184537   PMID:25240408   PMID:25251470   PMID:25312242   PMID:25323587  
PMID:25416859   PMID:25424744   PMID:25468475   PMID:25539763   PMID:25571789   PMID:25589070   PMID:25605244   PMID:25633049   PMID:25668010   PMID:25738314   PMID:25826415   PMID:25833836  
PMID:25894378   PMID:25944662   PMID:25982911   PMID:25990459   PMID:26017674   PMID:26038573   PMID:26081223   PMID:26248331   PMID:26335100   PMID:26354435   PMID:26435691   PMID:26446730  
PMID:26455324   PMID:26480000   PMID:26482503   PMID:26504803   PMID:26544868   PMID:26603571   PMID:26646586   PMID:26646931   PMID:26782438   PMID:26924666   PMID:27081702   PMID:27112664  
PMID:27133077   PMID:27143441   PMID:27158204   PMID:27255643   PMID:27304919   PMID:27336362   PMID:27363278   PMID:27383536   PMID:27412941   PMID:27576314   PMID:27577856   PMID:27592685  
PMID:27613090   PMID:27637078   PMID:27698350   PMID:27702798   PMID:27763644   PMID:27935985   PMID:27998789   PMID:28032929   PMID:28082316   PMID:28090150   PMID:28122310   PMID:28176874  
PMID:28214897   PMID:28253927   PMID:28256505   PMID:28260044   PMID:28260078   PMID:28267418   PMID:28378642   PMID:28389358   PMID:28412211   PMID:28522697   PMID:28569771   PMID:28724745  
PMID:28798470   PMID:28819321   PMID:28865365   PMID:28926115   PMID:29040578   PMID:29146309   PMID:29169422   PMID:29214735   PMID:29631677   PMID:29689557   PMID:29700305   PMID:29710477  
PMID:29739970   PMID:29749374   PMID:29749531   PMID:29864898   PMID:29901156   PMID:30078007   PMID:30131528   PMID:30177391   PMID:30237497   PMID:30253192   PMID:30459436   PMID:30518922  
PMID:30536969   PMID:30843663   PMID:30878364   PMID:31053727   PMID:31059052   PMID:31103853   PMID:31312654   PMID:31450012   PMID:31518563   PMID:31548167   PMID:31554373   PMID:31554420  
PMID:31557499   PMID:31575334   PMID:31631818   PMID:31696556   PMID:31713992   PMID:31746054   PMID:31758976   PMID:31801944   PMID:31899048   PMID:31926946   PMID:31967348   PMID:32025520  
PMID:32291953   PMID:32466797   PMID:32470446   PMID:32473637   PMID:32609900   PMID:32614608   PMID:32649737   PMID:32705257   PMID:32726711   PMID:32787544   PMID:32859639   PMID:33038923  
PMID:33078418   PMID:33121314   PMID:33155836   PMID:33179091   PMID:33293585   PMID:33311454   PMID:33389830   PMID:33390783   PMID:33400245   PMID:33515562   PMID:33541259   PMID:33660877  
PMID:33836345   PMID:33880592   PMID:33887878   PMID:33949293   PMID:34047481   PMID:34238196   PMID:34374235   PMID:34524260   PMID:34664737   PMID:34875217   PMID:35028929   PMID:35036432  
PMID:35053387   PMID:35055127   PMID:35527652   PMID:35563053   PMID:35931990   PMID:36177494   PMID:36206229   PMID:36243404   PMID:36380260   PMID:36476351   PMID:36617839   PMID:36796652  
PMID:36856212   PMID:37298127   PMID:38071063   PMID:38302925  


Genomics

Comparative Map Data
MIR125B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,099,757 - 122,099,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,099,757 - 122,099,844 (-)EnsemblGRCh38hg38GRCh38
GRCh3711121,970,465 - 121,970,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611121,475,674 - 121,475,761 (-)NCBINCBI36Build 36hg18NCBI36
Celera11119,131,144 - 119,131,231 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,917,003 - 117,917,090 (-)NCBIHuRef
CHM1_111121,857,766 - 121,857,853 (-)NCBICHM1_1
T2T-CHM13v2.011122,128,759 - 122,128,846 (-)NCBIT2T-CHM13v2.0
Mir125b-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,493,222 - 41,493,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,493,222 - 41,493,298 (+)EnsemblGRCm39 Ensembl
GRCm38941,581,926 - 41,582,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,581,926 - 41,582,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv37941,390,009 - 41,390,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera938,821,699 - 38,821,775 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.41NCBI
Mir125b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,850,036 - 50,850,122 (+)NCBIGRCr8
mRatBN7.2841,952,966 - 41,953,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,952,966 - 41,953,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx847,445,457 - 47,445,543 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,724,100 - 45,724,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,591,670 - 43,591,756 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0845,798,260 - 45,798,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,798,260 - 45,798,346 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0844,272,846 - 44,272,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera841,551,438 - 41,551,524 (+)NCBICelera
Cytogenetic Map8q22NCBI
MIR125B-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1512,097,672 - 12,097,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl512,097,658 - 12,097,745 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha512,152,730 - 12,152,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0512,047,627 - 12,047,687 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl512,047,613 - 12,047,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1512,151,360 - 12,151,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0512,090,768 - 12,090,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0512,129,464 - 12,129,524 (+)NCBIUU_Cfam_GSD_1.0
MIR125B-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,109,435 - 49,109,514 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,109,435 - 49,109,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,334,908 - 54,334,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000050331] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:119433909-134998513)x1 copy number loss See cases [RCV000050905] Chr11:119433909..134998513 [GRCh38]
Chr11:119304619..134868407 [GRCh37]
Chr11:118809829..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:118789765-134998513)x3 copy number gain See cases [RCV000051213] Chr11:118789765..134998513 [GRCh38]
Chr11:118660474..134868407 [GRCh37]
Chr11:118165684..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:119215032-134998654)x1 copy number loss See cases [RCV000052715] Chr11:119215032..134998654 [GRCh38]
Chr11:119085742..134868548 [GRCh37]
Chr11:118590952..134373758 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:120507265-134576266)x1 copy number loss See cases [RCV000052716] Chr11:120507265..134576266 [GRCh38]
Chr11:120377974..134446160 [GRCh37]
Chr11:119883184..133951370 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:120236432-135040246)x3 copy number gain See cases [RCV000053643] Chr11:120236432..135040246 [GRCh38]
Chr11:120107141..134910140 [GRCh37]
Chr11:119612351..134415350 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:120426093-124771213)x1 copy number loss See cases [RCV000134405] Chr11:120426093..124771213 [GRCh38]
Chr11:120296802..124641109 [GRCh37]
Chr11:119802012..124146319 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851372-134998526)x3 copy number gain See cases [RCV000134064] Chr11:116851372..134998526 [GRCh38]
Chr11:116722088..134868420 [GRCh37]
Chr11:116227298..134373630 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.2-25(chr11:112864326-131189315)x3 copy number gain See cases [RCV000137582] Chr11:112864326..131189315 [GRCh38]
Chr11:112832130..131059210 [GRCh37]
Chr11:112240259..130564420 [NCBI36]
Chr11:11q23.2-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116868935-135075271)x3 copy number gain See cases [RCV000137453] Chr11:116868935..135075271 [GRCh38]
Chr11:116739651..134945165 [GRCh37]
Chr11:116244861..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic|conflicting data from submitters
GRCh38/hg38 11q24.1-25(chr11:121780459-135075271)x1 copy number loss See cases [RCV000138014] Chr11:121780459..135075271 [GRCh38]
Chr11:121651167..134945165 [GRCh37]
Chr11:121156377..134450377 [NCBI36]
Chr11:11q24.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:120515759-135075271)x1 copy number loss See cases [RCV000138373] Chr11:120515759..135075271 [GRCh38]
Chr11:120386468..134945165 [GRCh37]
Chr11:119891678..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116806268-135075271)x3 copy number gain See cases [RCV000138307] Chr11:116806268..135075271 [GRCh38]
Chr11:116676984..134945165 [GRCh37]
Chr11:116182194..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:117333952-127709156)x3 copy number gain See cases [RCV000139362] Chr11:117333952..127709156 [GRCh38]
Chr11:117204668..127579051 [GRCh37]
Chr11:116709878..127084261 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q23.3-25(chr11:119424297-135075271)x1 copy number loss See cases [RCV000138947] Chr11:119424297..135075271 [GRCh38]
Chr11:119295007..134945165 [GRCh37]
Chr11:118800217..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic|likely benign
GRCh38/hg38 11q23.3-24.2(chr11:120080142-125829106)x1 copy number loss See cases [RCV000140070] Chr11:120080142..125829106 [GRCh38]
Chr11:119950851..125699001 [GRCh37]
Chr11:119456061..125204211 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q24.1-25(chr11:121689052-135075271)x1 copy number loss See cases [RCV000139622] Chr11:121689052..135075271 [GRCh38]
Chr11:121559760..134945165 [GRCh37]
Chr11:121064970..134450377 [NCBI36]
Chr11:11q24.1-25
pathogenic|likely benign
GRCh38/hg38 11q24.1-25(chr11:121806547-135068576)x1 copy number loss See cases [RCV000142210] Chr11:121806547..135068576 [GRCh38]
Chr11:121677255..134938470 [GRCh37]
Chr11:121182465..134443680 [NCBI36]
Chr11:11q24.1-25
pathogenic
GRCh38/hg38 11q24.1-25(chr11:121611476-135068576)x1 copy number loss See cases [RCV000142185] Chr11:121611476..135068576 [GRCh38]
Chr11:121482185..134938470 [GRCh37]
Chr11:120987395..134443680 [NCBI36]
Chr11:11q24.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000148276] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:119807473-134868407)x1 copy number loss See cases [RCV000240237] Chr11:119807473..134868407 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120615374-134868407)x1 copy number loss See cases [RCV000239781] Chr11:120615374..134868407 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:121416261-134938470)x1 copy number loss See cases [RCV000511335] Chr11:121416261..134938470 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116691675-134889485) copy number gain not provided [RCV000767667] Chr11:116691675..134889485 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000449449] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:119513909-134938470)x1 copy number loss See cases [RCV000447077] Chr11:119513909..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:121501072-134868348)x1 copy number loss See cases [RCV000445814] Chr11:121501072..134868348 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116684163-134938470)x3 copy number gain See cases [RCV000447848] Chr11:116684163..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q24.1-25(chr11:121559102-134938470)x1 copy number loss See cases [RCV000449003] Chr11:121559102..134938470 [GRCh37]
Chr11:11q24.1-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120527021-134938470)x1 copy number loss See cases [RCV000511283] Chr11:120527021..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:121136603-134938470)x1 copy number loss See cases [RCV000510856] Chr11:121136603..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000512291] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:119538664-134938470)x1 copy number loss not provided [RCV000683371] Chr11:119538664..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain not provided [RCV000683373] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
Single allele duplication Schizophrenia [RCV000754124] Chr11:118989374..135076622 [GRCh38]
Chr11:11q23.3-25
likely pathogenic
GRCh37/hg19 11q23.3-25(chr11:116697066-134934063)x3 copy number gain not provided [RCV000737686] Chr11:116697066..134934063 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116700253-134904063) copy number gain not provided [RCV000767816] Chr11:116700253..134904063 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:117830263-134938470)x3 copy number gain not provided [RCV000848151] Chr11:117830263..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120576984-134934063)x1 copy number loss See cases [RCV000790567] Chr11:120576984..134934063 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120742540-134938470)x1 copy number loss not provided [RCV001006452] Chr11:120742540..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
Single allele deletion Short stature [RCV001003892] Chr11:114433313..131230466 [GRCh37]
Chr11:11q23.2-25
likely pathogenic
NC_000011.9:g.104288964_134937416dup duplication Distal trisomy 11q [RCV001250234] Chr11:104288964..134937416 [GRCh37]
Chr11:11q22.3-25
pathogenic
GRCh37/hg19 11q23.1-24.3(chr11:112375478-128785742)x3 copy number gain not provided [RCV001829187] Chr11:112375478..128785742 [GRCh37]
Chr11:11q23.1-24.3
pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:120531028-134257553) copy number loss 11q partial monosomy syndrome [RCV003236728] Chr11:120531028..134257553 [GRCh37]
Chr11:11q23.3-25
pathogenic
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25
pathogenic
GRCh37/hg19 11q23.3-24.1(chr11:119688645-122861792)x3 copy number gain not provided [RCV003484853] Chr11:119688645..122861792 [GRCh37]
Chr11:11q23.3-24.1
uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
TNFAIP3hsa-miR-125b-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22550173
RPS6KA1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//ELISA//GFP reporter assFunctional MTI21643012
BMPR1Bhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19738052
EIF4EBP1hsa-miR-125b-5pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)17891175
HMGA2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17563749
GLI1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18756266
NKIRAS2hsa-miR-125b-5pMirtarbaseexternal_infoELISA//qRT-PCR//Luciferase reporter assay//WesternFunctional MTI20351193
ETS1hsa-miR-125b-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI21444677
SMOhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
SMOhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18756266
TP53hsa-miR-125b-5pMirtarbaseexternal_infoIn situ hybridization//Luciferase reporter assay//Functional MTI19293287
TP53hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23497288
LIFhsa-miR-125b-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
VDRhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19437538
DGAT1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19635812
CEBPGhsa-miR-125b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
BAK1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18056640
ERBB3hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI17110380
ERBB2hsa-miR-125b-5pMirtarbaseexternal_infoWestern blotFunctional MTI19825990
ERBB2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
PIGFhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21703189
KLF13hsa-miR-125b-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI19396866
BMFhsa-miR-125b-5pMirtarbaseexternal_infoimmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI19471102
BCL2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22293115
BCL3hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20658525
NTRK3hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI17483472
LIN28Ahsa-miR-125b-5pMirtarbaseexternal_infoReporter assayFunctional MTI18230348
LIN28Ahsa-miR-125b-5pMirtarbaseexternal_infoB-globin reporter assay//Luciferase reporter assayFunctional MTI16495412
LIN28Ahsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI16227573
LIN28Ahsa-miR-125b-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22366319
CBFBhsa-miR-125b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17891175
CBFBhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22689670
AKT1hsa-miR-125b-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI18649363
CYP24A1hsa-miR-125b-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI19570947
RAF1hsa-miR-125b-5pMirtarbaseexternal_infoWestern blot//Western blot;OtherFunctional MTI19825990
PRDM1hsa-miR-125b-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assayFunctional MTI20497960
GRIN2Ahsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI20159450
CDKN2Ahsa-miR-125b-5pMirtarbaseexternal_infoWestern blotFunctional MTI20347935
KRT7hsa-miR-125b-5pMirtarbaseexternal_infoImmunoblot//qRT-PCRNon-Functional MTI (Weak)19378336
E2F3hsa-miR-125b-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//NFunctional MTI20549700
E2F3hsa-miR-125b-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI22523546
IGF2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//Western Functional MTI21200031
LIN28Bhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20827722
BAK1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20886540
FGFR2hsa-miR-125b-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI21412257
ARID3Bhsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22307404
HK2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22593586
E2F2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22999819
MMP13hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22782903
MAPK14hsa-miR-125b-5pMirtarbaseexternal_infoChIP-seq//EMSA//Immunoblot//Luciferase reporter asFunctional MTI22854965
MUC1hsa-miR-125b-5pMirtarbaseexternal_infoReporter assay;Western blotFunctional MTI20729973
NEShsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23016664
MUC1hsa-miR-125b-5pTarbaseexternal_infoReporter GenePOSITIVE
MUC1hsa-miR-125b-5pTarbaseexternal_infoWesternblitPOSITIVE
IL6hsa-miR-125b-5pTarbaseexternal_infoOtherNEGATIVE
TP53hsa-miR-125b-5pTarbaseexternal_infoqPCRPOSITIVE
ERBB3hsa-miR-125b-5pOncomiRDBexternal_infoNANA23437196
MMP13hsa-miR-125b-5pOncomiRDBexternal_infoNANA23425975
TACSTD2hsa-miR-125b-5pOncomiRDBexternal_infoNANA23416980
PIK3CDhsa-miR-125b-5pOncomiRDBexternal_infoNANA23160634
SIRT7hsa-miR-125b-5pOncomiRDBexternal_infoNANA23079745
E2F2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22999819
MCL1hsa-miR-125b-5pOncomiRDBexternal_infoNANA22942733
MCL1hsa-miR-125b-5pOncomiRDBexternal_infoNANA22824797
JUNhsa-miR-125b-5pOncomiRDBexternal_infoNANA22797068
MMP13hsa-miR-125b-5pOncomiRDBexternal_infoNANA22782903
STARD13hsa-miR-125b-5pOncomiRDBexternal_infoNANA22693547
TNFAIP3hsa-miR-125b-5pOncomiRDBexternal_infoNANA22550173
ARID3Ahsa-miR-125b-5pOncomiRDBexternal_infoNANA22469780
ERBB2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22460089
ARID3Bhsa-miR-125b-5pOncomiRDBexternal_infoNANA22307404
BCL2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22293115
BCL2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22139839
STAT3hsa-miR-125b-5pOncomiRDBexternal_infoNANA22093834
TP53INP1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21970405
BAK1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21880154
BAK1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21823019
PGFhsa-miR-125b-5pOncomiRDBexternal_infoNANA21703189
ETS1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21444677
MUC1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21308711
TP53hsa-miR-125b-5pOncomiRDBexternal_infoNANA20886540
LIN28Bhsa-miR-125b-5pOncomiRDBexternal_infoNANA20827722
MUC1hsa-miR-125b-5pOncomiRDBexternal_infoNANA20729973
BCL3hsa-miR-125b-5pOncomiRDBexternal_infoNANA20658525
E2F3hsa-miR-125b-5pOncomiRDBexternal_infoNANA20549700
BAK1hsa-miR-125b-5pOncomiRDBexternal_infoNANA20460378
CYP24A1hsa-miR-125b-5pOncomiRDBexternal_infoNANA19570947
BMFhsa-miR-125b-5pOncomiRDBexternal_infoNANA19471102
VDRhsa-miR-125b-5pOncomiRDBexternal_infoNANA19437538
NTRK3hsa-miR-125b-5pOncomiRDBexternal_infoNANA17483472
ERBB2hsa-miR-125b-5pOncomiRDBexternal_infoNANA17110380
LIN28AP1hsa-miR-125b-5pTarbaseexternal_infoOtherPOSITIVE

Predicted Targets
Summary Value
Count of predictions:6405
Count of gene targets:3515
Count of transcripts:5629
Interacting mature miRNAs:hsa-miR-125b-1-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 5 8 2 6 8 23 1 18 27 2
Low 50 25 81 42 46 44 82 44 85 60 91 140 6 3 14 1
Below cutoff 25 23 9 2 3 4 13 25 13 8 21 14 9 7 1

Sequence


RefSeq Acc Id: ENST00000385236
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11122,099,757 - 122,099,844 (-)Ensembl
RefSeq Acc Id: NR_029671
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811122,099,757 - 122,099,844 (-)NCBI
GRCh3711121,970,465 - 121,970,552 (-)ENTREZGENE
HuRef11117,917,003 - 117,917,090 (-)ENTREZGENE
CHM1_111121,857,766 - 121,857,853 (-)NCBI
T2T-CHM13v2.011122,128,759 - 122,128,846 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31506 AgrOrtholog
COSMIC MIR125B1 COSMIC
Ensembl Genes ENSG00000207971 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385236 ENTREZGENE
GTEx ENSG00000207971 GTEx
HGNC ID HGNC:31506 ENTREZGENE
Human Proteome Map MIR125B1 Human Proteome Map
miRBase MI0000446 ENTREZGENE
NCBI Gene 406911 ENTREZGENE
OMIM 610104 OMIM
PharmGKB PA164722402 PharmGKB
RNAcentral URS0000209905 RNACentral
  URS00002A66E1 RNACentral
  URS00002DABEA RNACentral