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Gene: USP25 (ubiquitin specific peptidase 25) Homo sapiens
Symbol: USP25
Name: ubiquitin specific peptidase 25
RGD ID: 1319103
Description: Exhibits SUMO binding activity; enzyme binding activity; and thiol-dependent ubiquitin-specific protease activity. Involved in negative regulation of ERAD pathway; protein K48-linked deubiquitination; and protein K63-linked deubiquitination. Localizes to cytosol and endoplasmic reticulum.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: deubiquitinating enzyme 25; ubiquitin carboxyl-terminal hydrolase 25; ubiquitin specific protease 25; ubiquitin thioesterase 25; ubiquitin thiolesterase 25; ubiquitin-specific processing protease 25; ubiquitin-specific-processing protease 25; USP on chromosome 21; USP21
Mus musculus (house mouse) : Usp25 (ubiquitin specific peptidase 25)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp25 (ubiquitin specific peptidase 25)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp25 (ubiquitin specific peptidase 25)
Pan paniscus (bonobo/pygmy chimpanzee) : USP25 (ubiquitin specific peptidase 25)
Canis lupus familiaris (dog) : USP25 (ubiquitin specific peptidase 25)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp25 (ubiquitin specific peptidase 25)
Sus scrofa (pig) : USP25 (ubiquitin specific peptidase 25)
Chlorocebus sabaeus (African green monkey) : USP25 (ubiquitin specific peptidase 25)
Heterocephalus glaber (naked mole-rat) : Usp25 (ubiquitin specific peptidase 25)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2115,730,025 - 15,880,069 (+)EnsemblGRCh38hg38GRCh38
GRCh382115,729,947 - 15,880,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372117,102,327 - 17,252,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362116,024,367 - 16,174,248 (+)NCBINCBI36hg18NCBI36
Build 342116,024,366 - 16,174,248NCBI
Celera212,272,740 - 2,422,618 (+)NCBI
Cytogenetic Map21q21.1NCBI
HuRef212,481,855 - 2,631,589 (+)NCBIHuRef
CHM1_12116,662,850 - 16,813,004 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on USP25
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319103
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.