MIR125B2 (microRNA 125b-2) - Rat Genome Database

Name: MIR125B2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MIR125B2 (microRNA 125b-2) Homo sapiens

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Symbol:

MIR125B2

Name:

microRNA 125b-2

Description:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Type:

ncrna

RefSeq Status:

PROVISIONAL

Also known as:

mir-125b-2; MIRN125B2

Orthologs:

Mus musculus (house mouse) : Mir125b-2 (microRNA 125b-2) MGI Alliance
Rattus norvegicus (Norway rat) : Mir125b2 (microRNA 125b-2) Alliance
Canis lupus familiaris (dog) : MIR125B-2 (microRNA mir-125b-2)

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38 Ensembl	21	16,590,237 - 16,590,325 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	21	16,590,237 - 16,590,325 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	21	17,962,557 - 17,962,645 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	16,884,427 - 16,884,515 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	21	3,132,744 - 3,132,832 (+)	NCBI
Cytogenetic Map	21	q21.1	NCBI
HuRef	21	3,343,306 - 3,343,394 (+)	NCBI		HuRef
CHM1_1	21	17,523,172 - 17,523,260 (+)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

References - curated

References - uncurated

Genomics

Comparative Map Data

miRNA Target Status

Confirmed Targets

Gene Target	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
DGAT1	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	19635812
CEBPG	hsa-miR-125b-5p	Mirtarbase	external_info	CLASH	Functional MTI (Weak)	23622248
BAK1	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	18056640
ERBB3	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Northern blot//qRT-PCR/	Functional MTI	17110380
ERBB2	hsa-miR-125b-5p	Mirtarbase	external_info	Western blot	Functional MTI	19825990
ERBB2	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Microarray//Western blo	Functional MTI	20864407
PIGF	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	21703189
KLF13	hsa-miR-125b-5p	Mirtarbase	external_info	Microarray//qRT-PCR//Western blot	Functional MTI	19396866
BMF	hsa-miR-125b-5p	Mirtarbase	external_info	immunoblot//Luciferase reporter assay//qRT-PCR	Functional MTI	19471102
BCL2	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Western blot	Functional MTI	22293115
BCL3	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	20658525
NTRK3	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Western blot//Reporter	Functional MTI	17483472
LIN28A	hsa-miR-125b-5p	Mirtarbase	external_info	Reporter assay	Functional MTI	18230348
LIN28A	hsa-miR-125b-5p	Mirtarbase	external_info	B-globin reporter assay//Luciferase reporter assay	Functional MTI	16495412
LIN28A	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	16227573
LIN28A	hsa-miR-125b-5p	Mirtarbase	external_info	Immunoblot//Luciferase reporter assay//qRT-PCR	Functional MTI	22366319
CBFB	hsa-miR-125b-5p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	17891175
CBFB	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	22689670
AKT1	hsa-miR-125b-5p	Mirtarbase	external_info	qRT-PCR//Western blot	Functional MTI	18649363
CYP24A1	hsa-miR-125b-5p	Mirtarbase	external_info	qRT-PCR//Luciferase reporter assay//Western blot//	Functional MTI	19570947
RAF1	hsa-miR-125b-5p	Mirtarbase	external_info	Western blot//Western blot;Other	Functional MTI	19825990
PRDM1	hsa-miR-125b-5p	Mirtarbase	external_info	qRT-PCR//Luciferase reporter assay	Functional MTI	20497960
GRIN2A	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR	Functional MTI	20159450
CDKN2A	hsa-miR-125b-5p	Mirtarbase	external_info	Western blot	Functional MTI	20347935
KRT7	hsa-miR-125b-5p	Mirtarbase	external_info	Immunoblot//qRT-PCR	Non-Functional MTI (Weak)	19378336
E2F3	hsa-miR-125b-5p	Mirtarbase	external_info	Immunohistochemistry//Luciferase reporter assay//N	Functional MTI	20549700
E2F3	hsa-miR-125b-5p	Mirtarbase	external_info	Immunohistochemistry//qRT-PCR//Western blot	Functional MTI	22523546
IGF2	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Northern blot//Western	Functional MTI	21200031
LIN28B	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	20827722
BAK1	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	20886540
FGFR2	hsa-miR-125b-5p	Mirtarbase	external_info	Immunohistochemistry//Luciferase reporter assay//q	Functional MTI	21412257
ARID3B	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	22307404
HK2	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR	Functional MTI	22593586
E2F2	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22999819
MMP13	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	22782903
MAPK14	hsa-miR-125b-5p	Mirtarbase	external_info	ChIP-seq//EMSA//Immunoblot//Luciferase reporter as	Functional MTI	22854965
MUC1	hsa-miR-125b-5p	Mirtarbase	external_info	Reporter assay;Western blot	Functional MTI	20729973
NES	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23016664
MUC1	hsa-miR-125b-5p	Tarbase	external_info	Reporter Gene	POSITIVE
MUC1	hsa-miR-125b-5p	Tarbase	external_info	Westernblit	POSITIVE
IL6	hsa-miR-125b-5p	Tarbase	external_info	Other	NEGATIVE
TP53	hsa-miR-125b-5p	Tarbase	external_info	qPCR	POSITIVE
ERBB3	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	23437196
MMP13	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	23425975
TACSTD2	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	23416980
PIK3CD	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	23160634
E2F2	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22999819
MCL1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22942733
MCL1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22824797
JUN	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22797068
MMP13	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22782903
STARD13	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22693547
TNFAIP3	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22550173
SIRT7	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	23079745
ARID3A	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22469780
ERBB2	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22460089
ARID3B	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22307404
BCL2	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22293115
BCL2	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22139839
TP53INP1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	21970405
BAK1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	21880154
BAK1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	21823019
PGF	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	21703189
ETS1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	21444677
MUC1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	21308711
TP53	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	20886540
STAT3	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	22093834
LIN28B	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	20827722
MUC1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	20729973
BCL3	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	20658525
E2F3	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	20549700
BAK1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	20460378
CYP24A1	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	19570947
BMF	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	19471102
VDR	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	19437538
NTRK3	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	17483472
ERBB2	hsa-miR-125b-5p	OncomiRDB	external_info	NA	NA	17110380
JPT2	hsa-miR-125b-2-3p	Mirtarbase	external_info	CLASH	Functional MTI (Weak)	23622248
TNFAIP3	hsa-miR-125b-5p	Mirtarbase	external_info	qRT-PCR//Western blot	Functional MTI	22550173
RPS6KA1	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//ELISA//GFP reporter ass	Functional MTI	21643012
BMPR1B	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	19738052
EIF4EBP1	hsa-miR-125b-5p	Mirtarbase	external_info	Microarray//qRT-PCR	Functional MTI (Weak)	17891175
HMGA2	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	17563749
GLI1	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	18756266
NKIRAS2	hsa-miR-125b-5p	Mirtarbase	external_info	ELISA//qRT-PCR//Luciferase reporter assay//Western	Functional MTI	20351193
ETS1	hsa-miR-125b-5p	Mirtarbase	external_info	Immunoblot//Luciferase reporter assay	Functional MTI	21444677
SMO	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Western blot	Functional MTI	20216554
SMO	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Western blot	Functional MTI	18756266
TP53	hsa-miR-125b-5p	Mirtarbase	external_info	In situ hybridization//Luciferase reporter assay//	Functional MTI	19293287
TP53	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23497288
LIF	hsa-miR-125b-5p	Mirtarbase	external_info	ELISA	Non-Functional MTI (Weak)	19011087
VDR	hsa-miR-125b-5p	Mirtarbase	external_info	Luciferase reporter assay//Western blot	Functional MTI	19437538
LIN28AP1	hsa-miR-125b-5p	Tarbase	external_info	Other	POSITIVE

Predicted Targets

	Summary Value
Count of predictions:	28991
Count of gene targets:	11570
Count of transcripts:	23104
Interacting mature miRNAs:	hsa-miR-125b-2-3p, hsa-miR-125b-5p
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	adipose tissue	appendage	entire extraembryonic component
High
Medium	1		2	1	1	1		1		1	14	3
Low	21	5	85	50	62	50	36	34	129	85	116	105	1	2	12
Below cutoff	18	6	9	1	10	1	25	12	77	21	18	14		3	6	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences

Clinical Variants

Additional Information

External Database Links

More on MIR125B2
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1342678
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2020-03-31
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - ClinVar

Imported Annotations - CTD