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Gene: MIR125B2 (microRNA 125b-2) Homo sapiens
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Symbol: MIR125B2
Name: microRNA 125b-2
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-125b-2; MIRN125B2
Orthologs:
Mus musculus (house mouse) : Mir125b-2 (microRNA 125b-2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mir125b2 (microRNA 125b-2)  Alliance
Canis lupus familiaris (dog) : MIR125B-2 (microRNA mir-125b-2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2116,590,237 - 16,590,325 (+)EnsemblGRCh38hg38GRCh38
GRCh382116,590,237 - 16,590,325 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372117,962,557 - 17,962,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362116,884,427 - 16,884,515 (+)NCBINCBI36hg18NCBI36
Celera213,132,744 - 3,132,832 (+)NCBI
Cytogenetic Map21q21.1NCBI
HuRef213,343,306 - 3,343,394 (+)NCBIHuRef
CHM1_12117,523,172 - 17,523,260 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MIR125B2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1342678
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.