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Gene: RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase) Homo sapiens
Symbol: RFFL
Name: ring finger and FYVE like domain containing E3 ubiquitin protein ligase
RGD ID: 1605590
Description: Exhibits enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Localizes to endosome membrane and plasma membrane; PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 14-Deoxy-11,12-didehydroandrographolide; 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CARP-2; CARP2; caspase 8 and 10 associated RING protein-2; caspase regulator CARP2; caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin-protein ligase rififylin; FRING; FYVE-RING finger protein SAKURA; RIFIFYLIN; ring finger and FYVE-like domain containing 1; ring finger and FYVE-like domain containing E3 ubiquitin protein ligase; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like; RING-type E3 ubiquitin transferase rififylin; RNF189; RNF34L
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1735,005,990 - 35,089,319 (-)EnsemblGRCh38hg38GRCh38
GRCh381735,005,990 - 35,089,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371733,336,131 - 33,416,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,360,244 - 30,440,407 (-)NCBINCBI36hg18NCBI36
Celera1730,246,327 - 30,326,489 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1729,522,054 - 29,601,016 (-)NCBIHuRef
CHM1_11733,400,524 - 33,480,727 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RFFL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605590
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.