Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cytokine-mediated signaling pathway
go back to main search page
Accession:GO:0001959 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
Synonyms:exact_synonym: regulation of cytokine and chemokine mediated signaling pathway;   regulation of cytokine mediated signalling pathway


show annotations for term's descendants           Sort by:
regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule involved_in ISO
ISS		 (MGI:3614932|PMID:16390867) RGD PMID:16390867 PMID:16390867 MGI:3614932, RGD:8553244 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in ISO (PMID:10383454) RGD PMID:10383454 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 involved_in ISO (PMID:10383454) RGD PMID:10383454 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Mir101-2 microRNA 101-2 involved_in ISO (PMID:27693460) RGD PMID:27693460 NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467 		JBrowse link
G Mir101a microRNA 101a involved_in ISO (PMID:27693460) RGD PMID:27693460 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410 		JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:28972028) RGD PMID:28972028 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Padi2 peptidyl arginine deiminase 2 involved_in ISO
IEA		 (PMID:18645041)
GO_REF:0000107		 RGD
Ensembl		 PMID:18645041 GO_REF:0000107 NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632 		JBrowse link
G Rnf113a1 ring finger protein 113A1 involved_in ISO (PMID:28978524) RGD PMID:28978524 NCBI chr  X:116,427,941...116,429,164
Ensembl chr  X:116,427,684...116,433,762 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (PMID:18829537) RGD PMID:18829537 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in ISO (MGI:3510267|PMID:15337790) RGD PMID:15337790 MGI:3510267 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO
IEA		 (PMID:18829537)
GO_REF:0000107		 RGD
Ensembl		 PMID:18829537 GO_REF:0000107 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Slit3 slit guidance ligand 3 involved_in ISO
IEA		 (PMID:18829537)
GO_REF:0000107		 RGD
Ensembl		 PMID:18829537 GO_REF:0000107 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634 		JBrowse link
negative regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180364 (PMID:12388746)		 Ensembl
RGD		 PMID:12388746 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:21217760)		 Ensembl
RGD		 PMID:21217760 GO_REF:0000107 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Il36rn interleukin 36 receptor antagonist involved_in ISO (PMID:23147407) RGD PMID:23147407 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:28972028) RGD PMID:28972028 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:30106099) RGD PMID:30106099 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:23729669) RGD PMID:23729669 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:23729669) RGD PMID:23729669 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Palm3 paralemmin 3 involved_in ISO
IBA		 (PMID:21187075)
GO_REF:0000033		 RGD
GO_Central		 PMID:21187075 GO_REF:0000033 NCBI chr19:24,121,984...24,126,079
Ensembl chr19:24,122,239...24,130,448 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISS
ISO		 GO_REF:0000024
(MGI:2386427|PMID:11201744)		 UniProt
RGD		 PMID:11201744 GO_REF:0000024 MGI:2386427 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP hepatocyte growth factor/Met signaling RGD PMID:16415345 RGD:1642742 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Sigirr single Ig and TIR domain containing involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:2673012|PMID:12925853)		 HGNC-UCL
Ensembl
RGD		 PMID:12925853 GO_REF:0000024 GO_REF:0000107 MGI:2673012 NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269 		JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r2 interleukin 1 receptor type 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
PR:000045525 (PMID:23395675)		 Ensembl
RGD		 PMID:23395675 GO_REF:0000107 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il1rn interleukin 1 receptor antagonist involved_in ISO
IBA
IEA		 (PMID:2137200), (PMID:2139180)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107		 RGD
GO_Central
TreeGrafter
Ensembl		 PMID:2137200 PMID:2139180 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:5795829 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mir21 microRNA 21 acts_upstream_of_or_within ISO UniProtKB:P01584 (PMID:25327529) RGD PMID:25327529 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir27a microRNA 27a involved_in ISO UniProtKB:P01584 (PMID:25327529) RGD PMID:25327529 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Otud4 OTU deubiquitinase 4 involved_in ISO
IBA		 (PMID:29395066)
GO_REF:0000033
(MGI:6120140|PMID:29395066)		 RGD
GO_Central		 PMID:29395066 GO_REF:0000033 MGI:6120140 NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815 		JBrowse link
negative regulation of interleukin-17-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Usp25 ubiquitin specific peptidase 25 involved_in IEA
ISO		 GO_REF:0000107
(PMID:23042150)		 Ensembl
RGD		 PMID:23042150 GO_REF:0000107 NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348 		JBrowse link
negative regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:6706628|PMID:32424362)		 UniProt
RGD		 PMID:32424362 GO_REF:0000024 MGI:6706628 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3691503|PMID:11909529)
(PMID:11909529)		 UniProt
Ensembl
RGD		 PMID:11909529 GO_REF:0000024 GO_REF:0000107 MGI:3691503 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:17210636)
GO_REF:0000107
(MGI:5493214|PMID:17210636)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17210636 GO_REF:0000024 GO_REF:0000107 MGI:5493214 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 cytokine family signal transducer involved_in ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Mir125a microRNA 125a acts_upstream_of_or_within ISO UniProtKB:P05231 (PMID:30670152) RGD PMID:30670152 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir26a microRNA 26a involved_in ISO (PMID:23389848) RGD PMID:23389848 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir98 microRNA 98 involved_in ISO UniProtKB:P05231 (PMID:26587789), (PMID:31886314) RGD PMID:26587789 PMID:31886314 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Mir99a microRNA 99a involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mirlet7a1 microRNA let-7a-1 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr17:16,113,766...16,113,859
Ensembl chr17:16,113,768...16,113,867 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mirlet7c2 microRNA let7c-2 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr 7:116,803,771...116,803,865
Ensembl chr 7:116,803,771...116,803,865 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:12359225)
GO_REF:0000107
(MGI:4941441|PMID:20484139)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12359225 PMID:20484139 GO_REF:0000024 GO_REF:0000107 MGI:4941441 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
negative regulation of Kit signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (PMID:16533754) RGD PMID:16533754 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in ISO GO:1990782 (MGI:3041996|PMID:14612394) RGD PMID:14612394 MGI:3041996 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3629372|PMID:16705167)		 UniProt
Ensembl
RGD		 PMID:16705167 GO_REF:0000024 GO_REF:0000107 MGI:3629372 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:33097708) RGD PMID:33097708 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO		 GO_REF:0000024
(PMID:10604883)		 UniProt
RGD		 PMID:10604883 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA		 (PMID:21571275)
GO_REF:0000107		 RGD
Ensembl		 PMID:21571275 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606 		JBrowse link
G Ccdc3 coiled-coil domain containing 3 involved_in ISO (PMID:25193116) RGD PMID:25193116 NCBI chr17:73,031,891...73,135,173
Ensembl chr17:73,035,045...73,135,337 		JBrowse link
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (PMID:22437732) RGD PMID:22437732 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351 		JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO
ISS		 (PMID:19657094)
GO_REF:0000024		 RGD
UniProt		 PMID:19657094 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:6148454|PMID:22424771) RGD PMID:22424771 MGI:6148454 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E involved_in ISO (PMID:11859126) RGD PMID:11859126 NCBI chr 2:183,780,583...183,783,030 JBrowse link
G Mir125b1 microRNA 125b-1 acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir130a microRNA 130a acts_upstream_of ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Mir152 microRNA 152 involved_in ISO (PMID:24813629) RGD PMID:24813629 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020 		JBrowse link
G Mir27b microRNA 27b acts_upstream_of_or_within ISO UniProtKB:P01375 (PMID:31124343) RGD PMID:31124343 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5617337|PMID:24440909)		 Ensembl
RGD		 PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (MGI:5707586|PMID:18972444)
GO_REF:0000107		 RGD
Ensembl		 PMID:18972444 GO_REF:0000107 MGI:5707586 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:24113711)
MGI:5441750 (PMID:23950925)		 RGD PMID:23950925 PMID:24113711 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 acts_upstream_of_or_within ISO (PMID:20054338) RGD PMID:20054338 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta acts_upstream_of ISO UniProtKB:P01375 (PMID:28159925) RGD PMID:28159925 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3530208|PMID:15696169)		 UniProt
Ensembl
RGD		 PMID:15696169 GO_REF:0000024 GO_REF:0000107 MGI:3530208 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase involved_in ISO
IEA
ISS		 (PMID:18450452)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18450452 GO_REF:0000024 GO_REF:0000107 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Tank TRAF family member-associated NFKB activator involved_in ISO (PMID:8710854) RGD PMID:8710854 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264 		JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) RGD PMID:22437732 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B acts_upstream_of_or_within ISO (PMID:29415886) RGD PMID:29415886 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Traip TRAF-interacting protein involved_in ISO (PMID:19151749) RGD PMID:19151749 NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638 		JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in ISO
IEA		 (PMID:11865055)
GO_REF:0000107		 RGD
Ensembl		 PMID:11865055 GO_REF:0000107 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3828307 (PMID:19060901)		 Ensembl
RGD		 PMID:19060901 GO_REF:0000107 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:8,391,396...8,397,219
Ensembl chr 7:8,391,397...8,396,829 		JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 involved_in ISO (PMID:23386060) RGD PMID:23386060 NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576 		JBrowse link
G Dcst1 DC-STAMP domain containing 1 involved_in ISO (PMID:27782195) RGD PMID:27782195 NCBI chr 2:174,765,203...174,784,023
Ensembl chr 2:174,765,350...174,781,806 		JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 involved_in ISO (PMID:35878012) RGD PMID:35878012 NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 involved_in ISO (PMID:35878012) RGD PMID:35878012 NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO (PMID:28724761) RGD PMID:28724761 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in ISO (PMID:37656786) RGD PMID:37656786 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in ISO (PMID:30559377) RGD PMID:30559377 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:23633945) RGD PMID:23633945 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5583923|PMID:24784232)		 Ensembl
RGD		 PMID:24784232 GO_REF:0000107 MGI:5583923 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:23399697) RGD PMID:23399697 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 involved_in ISO
IBA		 (PMID:20434986)
GO_REF:0000033
(MGI:4454346|PMID:20434986)		 RGD
GO_Central		 PMID:20434986 GO_REF:0000033 MGI:4454346 NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO (PMID:30078389) RGD PMID:30078389 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in ISO
IEA		 (PMID:30078389)
GO_REF:0000107		 RGD
Ensembl		 PMID:30078389 GO_REF:0000107 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:11909529)
GO_REF:0000107
(MGI:3691503|PMID:11909529), (MGI:5493216|PMID:12138178)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:11909529 PMID:12138178 GO_REF:0000024 GO_REF:0000107 MGI:3691503 MGI:5493216 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (PMID:29670289)
(MGI:5521417|PMID:23972988)		 RGD PMID:23972988 PMID:29670289 MGI:5521417 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
G Smim30 small integral membrane protein 30 involved_in ISO (PMID:37656786) RGD PMID:37656786 NCBI chr  X:34,443,180...34,443,365 JBrowse link
G Stat2 signal transducer and activator of transcription 2 involved_in ISO (PMID:28165510)
(MGI:6508512|PMID:28165510)		 RGD PMID:28165510 MGI:6508512 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754 (PMID:18724932) RGD PMID:18724932 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 involved_in ISO (PMID:28011935) RGD PMID:28011935 NCBI chr 7:114,731,890...114,751,237
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 involved_in ISO (PMID:28165510) RGD PMID:28165510 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 involved_in ISO (PMID:30559377) RGD PMID:30559377 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein F3 involved_in ISO (MGI:6316470|PMID:30591559) RGD PMID:30591559 MGI:6316470 NCBI chr 2:98,350,304...98,384,608
Ensembl chr 2:98,350,588...98,384,606 		JBrowse link
negative regulation of type II interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in ISO
IEA		 (PMID:16709924)
GO_REF:0000107		 RGD
Ensembl		 PMID:16709924 GO_REF:0000107 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 involved_in ISO (PMID:11679576) RGD PMID:11679576 NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Otop1 otopetrin 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5750846|PMID:24379350)		 UniProt
RGD		 PMID:24379350 GO_REF:0000024 MGI:5750846 NCBI chr14:72,505,036...72,532,497
Ensembl chr14:72,503,592...72,532,497 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 involved_in ISO (PMID:27796300)
(MGI:5905929|PMID:27796300)		 RGD PMID:27796300 MGI:5905929 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:21268089) RGD PMID:21268089 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in
NOT|involved_in		 ISS
ISO
IEA		 GO_REF:0000024
(PMID:12138178)
GO_REF:0000107
(MGI:5493216|PMID:12138178)		 UniProt
RGD
Ensembl		 PMID:12138178 GO_REF:0000024 GO_REF:0000107 MGI:5493216 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
positive regulation of C-C chemokine receptor CCR7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:11602640) RGD PMID:11602640 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
positive regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 acts_upstream_of ISO (PMID:17178876) RGD PMID:17178876 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of
involved_in		 ISO
IEA		 (PMID:17178876)
GO_REF:0000107		 RGD
Ensembl		 PMID:17178876 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
positive regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Cd74 CD74 molecule involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:4419085|PMID:12782713)
(PMID:12782713)		 BHF-UCL
GO_Central
RGD		 PMID:12782713 GO_REF:0000024 GO_REF:0000033 MGI:4419085 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO
ISS		 (PMID:18840707)
GO_REF:0000024		 RGD
UniProt		 PMID:18840707 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Il7 interleukin 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11418668)		 Ensembl
RGD		 PMID:11418668 GO_REF:0000107 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 acts_upstream_of_or_within ISO (PMID:22073305) RGD PMID:22073305 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (PMID:11894097) RGD PMID:11894097 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Trim44 tripartite motif-containing 44 involved_in ISO
IEA		 (PMID:23460740)
GO_REF:0000107		 RGD
Ensembl		 PMID:23460740 GO_REF:0000107 NCBI chr 3:88,593,619...88,729,085
Ensembl chr 3:88,592,719...88,729,188 		JBrowse link
G Tslp thymic stromal lymphopoietin involved_in ISO
IBA		 (PMID:11418668)
GO_REF:0000033		 RGD
GO_Central		 PMID:11418668 GO_REF:0000033 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 acts_upstream_of_or_within ISO PR:000045524 (PMID:23395675) RGD PMID:23395675 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
positive regulation of interleukin-17-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trim32 tripartite motif-containing 32 acts_upstream_of_or_within ISO (PMID:20054338) RGD PMID:20054338 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp4 caspase 4 involved_in ISO (PMID:33377178)
(MGI:6259277|PMID:30392956)		 RGD PMID:30392956 PMID:33377178 MGI:6259277 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5704237|PMID:26638072), (MGI:6259277|PMID:30392956), (MGI:6833928|PMID:34678144)
(PMID:33377178), (PMID:34161762)		 UniProt
Ensembl
RGD		 PMID:26638072 PMID:30392956 PMID:33377178 PMID:34161762 PMID:34678144 GO_REF:0000024 GO_REF:0000107 MGI:5704237 MGI:6259277 MGI:6833928 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 involved_in ISO (PMID:22685567)
(MGI:5488868|PMID:22685567)		 RGD PMID:22685567 MGI:5488868 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
positive regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300lf Cd300 molecule-like family member F involved_in ISS
ISO		 GO_REF:0000024
(MGI:5660125|PMID:26124135)		 UniProt
RGD		 PMID:26124135 GO_REF:0000024 MGI:5660125 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 involved_in ISO (PMID:27796300)
(MGI:5905929|PMID:27796300)		 RGD PMID:27796300 MGI:5905929 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 involved_in ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO
IEA		 (PMID:11060035)
GO_REF:0000107		 RGD
Ensembl		 PMID:11060035 GO_REF:0000107 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:31827280)
(MGI:6401044|PMID:31827281)		 RGD PMID:31827280 PMID:31827281 MGI:6401044 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
positive regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1 colony stimulating factor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19100238)		 Ensembl
RGD		 PMID:19100238 GO_REF:0000107 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
positive regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule involved_in ISO
IEA		 (PMID:19665027)
GO_REF:0000107		 RGD
Ensembl		 PMID:19665027 GO_REF:0000107 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 involved_in ISO (PMID:19665027) RGD PMID:19665027 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
positive regulation of prolactin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor acts_upstream_of_or_within ISO (PMID:23071095) RGD PMID:23071095 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999 		JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO
IEA		 (PMID:24813629)
GO_REF:0000107		 RGD
Ensembl		 PMID:24813629 GO_REF:0000107 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Casp1 caspase 1 involved_in ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp4 caspase 4 involved_in ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cpne1 copine 1 involved_in ISO
IBA
IEA		 (PMID:14674885)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:14674885 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818) RGD PMID:22733818 MGI:6391873 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:6201889|PMID:25049354)		 Ensembl
RGD		 PMID:25049354 PMID:25049354 GO_REF:0000107 MGI:6201889, RGD:13792525 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA
ISS		 (PMID:23453807)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
ParkinsonsUK-UCL		 PMID:23453807 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Rbm12 RNA binding motif protein 12 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:144,609,661...144,629,911
Ensembl chr 3:144,611,623...144,629,915
Ensembl chr 3:144,611,623...144,629,915 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:6271183|PMID:30439713) RGD PMID:30439713 MGI:6271183 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in ISO (MGI:5616328|PMID:11374864) RGD PMID:11374864 MGI:5616328 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Trim32 tripartite motif-containing 32 acts_upstream_of_or_within ISO (PMID:20054338) RGD PMID:20054338 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K involved_in ISO (PMID:26707646) RGD PMID:26707646 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:21109225) RGD PMID:21109225 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in ISO (MGI:5792628|PMID:27129230)
(PMID:24882218)		 RGD PMID:24882218 PMID:27129230 MGI:5792628 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Irf3 interferon regulatory factor 3 acts_upstream_of_or_within ISO (PMID:17618271) RGD PMID:17618271 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf7 interferon regulatory factor 7 acts_upstream_of_or_within ISO (PMID:17618271) RGD PMID:17618271 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor acts_upstream_of_or_within ISO (PMID:22745163) RGD PMID:22745163 NCBI chr 1:86,964,800...87,009,325
Ensembl chr 1:86,964,828...87,009,276 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in ISO (PMID:16127453), (PMID:20451243) RGD PMID:16127453 PMID:20451243 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5583923|PMID:24784232)		 Ensembl
RGD		 PMID:24784232 GO_REF:0000107 MGI:5583923 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 involved_in ISO (PMID:20061403) RGD PMID:20061403 NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121 		JBrowse link
G Rbm47 RNA binding motif protein 47 involved_in ISO (PMID:34160127) RGD PMID:34160127 NCBI chr14:42,053,290...42,191,572
Ensembl chr14:42,154,142...42,189,431 		JBrowse link
G Rnf185 ring finger protein 185 involved_in ISO
IEA
ISS		 (PMID:28273161)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28273161 GO_REF:0000024 GO_REF:0000107 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 involved_in ISO
IEA		 (PMID:23910378)
GO_REF:0000107
(MGI:6827194|PMID:23910378)		 RGD
Ensembl		 PMID:23910378 GO_REF:0000107 MGI:6827194 NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO (MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:5792628 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Trim41 tripartite motif-containing 41 involved_in ISO (PMID:29760876) RGD PMID:29760876 NCBI chr10:33,175,213...33,186,472
Ensembl chr10:33,175,213...33,186,694 		JBrowse link
G Trim56 tripartite motif containing 56 involved_in ISO (PMID:29426904)
(MGI:6119245|PMID:29426904)		 RGD PMID:29426904 MGI:6119245 NCBI chr12:19,544,913...19,567,324
Ensembl chr12:19,551,521...19,567,462 		JBrowse link
G Trim6 tripartite motif containing 6 involved_in ISO (PMID:24882218)
(MGI:5645191|PMID:24882218)		 RGD PMID:24882218 MGI:5645191 NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K involved_in ISO (PMID:24882218) RGD PMID:24882218 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
G Usp27x ubiquitin specific peptidase 27, X-linked involved_in ISO (PMID:31534008) RGD PMID:31534008 NCBI chr  X:15,123,620...15,126,855
Ensembl chr  X:15,124,596...15,125,912 		JBrowse link
G Usp29 ubiquitin specific peptidase 29 involved_in ISO (MGI:6761183|PMID:32457395) RGD PMID:32457395 MGI:6761183 NCBI chr 1:66,874,216...67,097,731
Ensembl chr 1:66,874,017...67,097,686 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA		 (PMID:19399181)
GO_REF:0000107		 RGD
Ensembl		 PMID:19399181 GO_REF:0000107 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000002
(PMID:17618271)
GO_REF:0000033
GO_REF:0000118		 InterPro
RGD
GO_Central
TreeGrafter		 PMID:17618271 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
positive regulation of type II interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpx hemopexin acts_upstream_of_or_within ISO MGI:2447193 (PMID:18641331) RGD PMID:18641331 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:16888103)
(MGI:3656111|PMID:16888103)		 RGD PMID:16888103 MGI:3656111 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:2176946|MGI:3511276 (PMID:18339625) RGD PMID:18339625 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 involved_in ISO (PMID:20061403), (PMID:20639463) RGD PMID:20061403 PMID:20639463 NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 involved_in ISO
IBA		 (PMID:27796300)
GO_REF:0000033
(MGI:5905929|PMID:27796300)		 RGD
GO_Central		 PMID:27796300 GO_REF:0000033 MGI:5905929 NCBI chr11:64,780,977...64,814,995
Ensembl chr11:64,780,981...64,815,455 		JBrowse link
G Txk TXK tyrosine kinase involved_in ISO (PMID:11859127) RGD PMID:11859127 NCBI chr14:35,463,369...35,519,448
Ensembl chr14:35,463,944...35,519,448 		JBrowse link
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vrk2 VRK serine/threonine kinase 2 involved_in ISO (PMID:18286207) RGD PMID:18286207 NCBI chr14:100,313,771...100,434,520
Ensembl chr14:100,313,601...100,434,527 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6394181|PMID:31630209)		 UniProt
RGD		 PMID:31630209 GO_REF:0000024 MGI:6394181 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20060382)		 Ensembl
RGD		 PMID:20060382 GO_REF:0000107 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5912943|PMID:28701375)
(PMID:26997266), (PMID:27458237), (PMID:27591049)		 UniProt
RGD		 PMID:26997266 PMID:27458237 PMID:27591049 PMID:28701375 GO_REF:0000024 MGI:5912943 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (PMID:29415886) RGD PMID:29415886 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in ISO
IEA		 (PMID:15701637)
GO_REF:0000107		 RGD
Ensembl		 PMID:15701637 GO_REF:0000107 NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902 		JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like 1 acts_upstream_of_or_within ISO MGI:1314884|MGI:1919216 (PMID:25220458) RGD PMID:25220458 NCBI chr15:7,493,531...7,503,758
Ensembl chr15:7,493,531...7,503,854 		JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras-like 2 acts_upstream_of_or_within ISO MGI:1314884|MGI:1916971 (PMID:25220458) RGD PMID:25220458 NCBI chr10:85,554,704...85,562,072
Ensembl chr10:85,557,944...85,562,072 		JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity involved_in ISO
IBA		 (PMID:26997266)
GO_REF:0000033
(MGI:5804663|PMID:27523608), (MGI:6192867|PMID:29950720)		 RGD
GO_Central		 PMID:26997266 PMID:27523608 PMID:29950720 GO_REF:0000033 MGI:5804663 MGI:6192867 NCBI chr 2:78,290,437...78,316,633
Ensembl chr 2:78,290,959...78,316,422 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17442941)		 Ensembl
RGD		 PMID:17442941 GO_REF:0000107 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Sharpin SHANK-associated RH domain interactor involved_in ISO
ISS		 (PMID:21455173)
GO_REF:0000024
(MGI:4947438|PMID:21455180), (MGI:4947439|PMID:21455173)		 RGD
UniProt		 PMID:21455173 PMID:21455180 GO_REF:0000024 MGI:4947438 MGI:4947439 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Spata2 spermatogenesis associated 2 involved_in ISO
IBA
IEA
ISS		 (PMID:27307491), (PMID:27458237), (PMID:27545878), (PMID:27591049)
GO_REF:0000033
GO_REF:0000118
(MGI:5912943|PMID:28701375)
GO_REF:0000024		 RGD
GO_Central
TreeGrafter
UniProt		 PMID:27307491 PMID:27458237 PMID:27545878 PMID:27591049 PMID:28701375 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:5912943 NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
IEA
ISS
IMP		 (PMID:20577214)
GO_REF:0000107
GO_REF:0000024
PMID:28284343		 RGD
Ensembl
UniProt		 PMID:20577214 PMID:28284343 GO_REF:0000024 GO_REF:0000107, RGD:14397556 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA		 (PMID:19151749)
GO_REF:0000107		 RGD
Ensembl		 PMID:19151749 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A acts_upstream_of_or_within ISO MGI:1916971|MGI:1919216 (PMID:25220458) RGD PMID:25220458 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16280321)
GO_REF:0000107		 RGD
Ensembl		 PMID:16280321 GO_REF:0000107 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
regulation of type II interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16280321)
GO_REF:0000107		 RGD
Ensembl		 PMID:16280321 GO_REF:0000107 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      signal transduction 7209
        regulation of signal transduction 3220
          regulation of cytokine-mediated signaling pathway 164
            negative regulation of cytokine-mediated signaling pathway + 93
            positive regulation of cytokine-mediated signaling pathway + 59
            regulation of Kit signaling pathway + 2
            regulation of chemokine-mediated signaling pathway + 13
            regulation of interleukin-1-mediated signaling pathway + 9
            regulation of interleukin-17-mediated signaling pathway + 2
            regulation of interleukin-18-mediated signaling pathway + 4
            regulation of interleukin-2-mediated signaling pathway + 1
            regulation of interleukin-27-mediated signaling pathway + 0
            regulation of interleukin-35-mediated signaling pathway + 0
            regulation of interleukin-4-mediated signaling pathway + 3
            regulation of interleukin-6-mediated signaling pathway + 14
            regulation of macrophage colony-stimulating factor signaling pathway + 4
            regulation of macrophage migration inhibitory factor signaling pathway + 3
            regulation of prolactin signaling pathway + 1
            regulation of tumor necrosis factor-mediated signaling pathway + 55
            regulation of type I interferon-mediated signaling pathway + 42
            regulation of type II interferon-mediated signaling pathway + 13
Path 2
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      response to chemical 6021
        response to organic substance 3701
          response to cytokine 1224
            cellular response to cytokine stimulus 1086
              cytokine-mediated signaling pathway 492
                regulation of cytokine-mediated signaling pathway 164
                  negative regulation of cytokine-mediated signaling pathway + 93
                  positive regulation of cytokine-mediated signaling pathway + 59
                  regulation of Kit signaling pathway + 2
                  regulation of chemokine-mediated signaling pathway + 13
                  regulation of interleukin-1-mediated signaling pathway + 9
                  regulation of interleukin-17-mediated signaling pathway + 2
                  regulation of interleukin-18-mediated signaling pathway + 4
                  regulation of interleukin-2-mediated signaling pathway + 1
                  regulation of interleukin-27-mediated signaling pathway + 0
                  regulation of interleukin-35-mediated signaling pathway + 0
                  regulation of interleukin-4-mediated signaling pathway + 3
                  regulation of interleukin-6-mediated signaling pathway + 14
                  regulation of macrophage colony-stimulating factor signaling pathway + 4
                  regulation of macrophage migration inhibitory factor signaling pathway + 3
                  regulation of prolactin signaling pathway + 1
                  regulation of tumor necrosis factor-mediated signaling pathway + 55
                  regulation of type I interferon-mediated signaling pathway + 42
                  regulation of type II interferon-mediated signaling pathway + 13
paths to the root