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Heavy Metal Poisoning, Nervous System - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Heavy Metal Poisoning, Nervous System
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Accession:DOID:9001363 term browser browse the term
Definition:Conditions associated with damage or dysfunction of the nervous system caused by exposure to heavy metals, which may cause a variety of central, peripheral, or autonomic nervous system injuries.
Synonyms:exact_synonym: Poisoning, Heavy Metals, Nervous System
 primary_id: MESH:D020260;   RDO:0007319
 xref: EFO:1001815

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Heavy Metal Poisoning, Nervous System term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il16 interleukin 16 ISO protein:increased expression:brain RGD PMID:14698845 RGD:1354526 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
Arsenic Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A kinase anchor protein 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:3,977,410...4,130,204
Ensembl chr 5:3,978,054...4,131,310 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase ISO protein:decreased activity:blood (rat) RGD PMID:19022878 RGD:4144202 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Aqp9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19805235 NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964 		JBrowse link
G As3mt arsenite methyltransferase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21447609 PMID:26366667 PMID:35226250 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538 		JBrowse link
G Atxn7 ataxin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr14:8,358,358...8,508,324
Ensembl chr14:8,362,461...8,508,323 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccrl2 C-C motif chemokine receptor-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 9:110,883,902...110,886,586
Ensembl chr 9:110,883,554...110,886,587 		JBrowse link
G Cd44 CD44 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cd83 CD83 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO protein:increased expression:skin: RGD PMID:11860939 RGD:8662429 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:22521605 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr18:32,373,357...32,403,206
Ensembl chr18:32,373,353...32,403,204 		JBrowse link
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12569548 NCBI chr16:12,927,600...12,969,873
Ensembl chr16:12,927,548...12,968,481 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038 		JBrowse link
G Golga4 golgin A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 9:118,335,280...118,411,587
Ensembl chr 9:118,335,335...118,411,587 		JBrowse link
G Gsr glutathione reductase ISO RGD PMID:25209654 RGD:10401880 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hspa1b heat shock protein 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Id2 inhibitor of DNA binding 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139 		JBrowse link
G Ier3 immediate early response 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr16:21,877,759...21,982,049
Ensembl chr16:21,877,759...21,982,049 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25759212 NCBI chr 7:138,969,025...139,159,568
Ensembl chr 7:138,969,025...139,159,568 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr11:110,956,990...110,967,651
Ensembl chr11:110,956,990...110,967,647 		JBrowse link
G Krt10 keratin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19953893 NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190 		JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr 3:123,161,944...123,179,639
Ensembl chr 3:123,161,946...123,179,757 		JBrowse link
G Minpp1 multiple inositol polyphosphate histidine phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr19:32,463,169...32,492,770
Ensembl chr19:32,463,169...32,492,764 		JBrowse link
G Mir145a microRNA 145a ISO CTD Direct Evidence: marker/mechanism CTD PMID:29705342 NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:serum RGD PMID:27913196 RGD:25314296 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24384392 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G N4bp2l2 NEDD4 binding protein 2-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:150,515,310...150,589,213
Ensembl chr 5:150,531,472...150,589,648 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr19:44,537,010...44,543,881
Ensembl chr19:44,537,011...44,543,879 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Peli1 pellino 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:11,476,241...11,558,882
Ensembl chr 2:11,476,244...11,558,888 		JBrowse link
G Pias1 protein inhibitor of activated STAT 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 9:62,785,648...62,888,161
Ensembl chr 9:62,785,650...62,895,206 		JBrowse link
G Pnp2 purine-nucleoside phosphorylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414634 NCBI chr14:51,193,598...51,202,206
Ensembl chr14:51,193,449...51,202,206 		JBrowse link
G Ptx3 pentraxin related gene ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226 		JBrowse link
G Rfx3 regulatory factor X, 3 (influences HLA class II expression) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr19:27,739,121...27,995,287
Ensembl chr19:27,739,121...27,988,566 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 1:144,120,407...144,124,862
Ensembl chr 1:144,118,034...144,124,980 		JBrowse link
G Rnf20 ring finger protein 20 ISO protein:increased expression:urine (human) RGD PMID:21136906 RGD:9831407 NCBI chr 4:49,632,005...49,656,887
Ensembl chr 4:49,632,006...49,656,887 		JBrowse link
G Rufy3 RUN and FYVE domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:88,711,305...88,799,276
Ensembl chr 5:88,712,899...88,799,251 		JBrowse link
G Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 4:126,914,504...126,944,894
Ensembl chr 4:126,915,117...126,930,806 		JBrowse link
G Skil SKI-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sox18 SRY (sex determining region Y)-box 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433 		JBrowse link
G Srp68 signal recognition particle 68 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr11:116,135,992...116,165,043
Ensembl chr11:116,135,992...116,165,043 		JBrowse link
G Ssbp1 single-stranded DNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:40,448,302...40,458,757
Ensembl chr 6:40,448,286...40,461,634 		JBrowse link
G Taf1d TATA-box binding protein associated factor, RNA polymerase I, D ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 9:15,217,485...15,228,293
Ensembl chr 9:15,217,510...15,228,287 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:28,317,362...28,724,734
Ensembl chr 3:28,317,363...28,730,007 		JBrowse link
G Tra2a transformer 2 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 6:49,220,855...49,241,182
Ensembl chr 6:49,220,858...49,240,967 		JBrowse link
G Trappc10 trafficking protein particle complex 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr10:78,021,256...78,080,479
Ensembl chr10:78,022,559...78,080,475 		JBrowse link
G Trp53 transformation related protein 53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18621066 PMID:19203779 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr14:4,137,852...4,186,967
Ensembl chr14:4,137,837...4,186,974 		JBrowse link
G Uso1 USO1 vesicle docking factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 5:92,285,770...92,350,659
Ensembl chr 5:92,285,797...92,350,657 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:32,870,432...32,992,224
Ensembl chr 3:32,871,695...32,992,220 		JBrowse link
G Zfand6 zinc finger, AN1-type domain 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 7:84,264,253...84,339,224
Ensembl chr 7:84,262,974...84,339,167 		JBrowse link
G Zfp267 zinc finger protein 267 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16835338 NCBI chr 3:36,205,233...36,224,491
Ensembl chr 3:36,205,166...36,224,491 		JBrowse link
Manganese Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate, delta-, dehydratase ISO protein:decreased activity:striatum (rat) RGD PMID:18778733 RGD:4144152 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Atp13a2 ATPase type 13A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22285144 NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19442826 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12171760 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Htt huntingtin ISO CTD Direct Evidence: therapeutic CTD PMID:19845833 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:18041089 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18041089 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Mfn2 mitofusin 2 ISO protein:decreased expression:striatum (rat) RGD PMID:28232070 RGD:12910738 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:15010209 PMID:22174044 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO CTD Direct Evidence: therapeutic CTD PMID:20089134 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28860195 PMID:29429640 NCBI chr 1:185,187,045...185,200,959
Ensembl chr 1:185,187,045...185,200,959 		JBrowse link
G Slc31a1 solute carrier family 31, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22465424 NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006 		JBrowse link
G Slc39a14 solute carrier family 39 (zinc transporter), member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28860195 NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874 		JBrowse link
G Slc39a8 solute carrier family 39 (metal ion transporter), member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29429640 NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333 		JBrowse link
G Snca synuclein, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:23934647 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18041089 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Mercury Poisoning, Nervous System term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsb cathepsin B ISO RGD PMID:18638529 RGD:2315510 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Jun jun proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:15515958 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G S100b S100 protein, beta polypeptide, neural ISO CTD Direct Evidence: marker/mechanism CTD PMID:30076900 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
Nervous System Lead Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate, delta-, dehydratase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21439310 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA:increased expression:hippocampus RGD PMID:24291742 RGD:9588309 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
Nervous System Lead Poisoning, Adult term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 ISO protein:increased expression:brain, synaptosome RGD PMID:15149801 RGD:1643208 NCBI chr 6:114,259,735...114,294,491
Ensembl chr 6:114,259,596...114,294,493 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16263
    syndrome 10899
      toxic encephalopathy 208
        Heavy Metal Poisoning, Nervous System 85
          Arsenic Poisoning 66
          Manganese Poisoning 16
          Mercury Poisoning, Nervous System + 3
          Nervous System Lead Poisoning + 3
Path 2
Term Annotations click to browse term
  disease 16263
    disease of anatomical entity 15856
      nervous system disease 13790
        toxic encephalopathy 208
          Heavy Metal Poisoning, Nervous System 85
            Arsenic Poisoning 66
            Manganese Poisoning 16
            Mercury Poisoning, Nervous System + 3
            Nervous System Lead Poisoning + 3
paths to the root