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Gene: Htt (huntingtin) Mus musculus
Symbol: Htt
Name: huntingtin
Description: Exhibits diazepam binding activity and transcription factor binding activity. Involved in several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Localizes to several cellular components, including centriole; glutamatergic synapse; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256365; C430023I11Rik; Hd; HD protein homolog; Hdh; hunti; Huntington disease gene homolog; huntington disease protein homolog; IT1; IT15
Homo sapiens (human) : HTT (huntingtin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Htt (huntingtin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htt (huntingtin)
Pan paniscus (bonobo/pygmy chimpanzee) : HTT (huntingtin)
Canis lupus familiaris (dog) : HTT (huntingtin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htt (huntingtin)
Sus scrofa (pig) : HTT (huntingtin)
Chlorocebus sabaeus (African green monkey) : HTT (huntingtin)
Heterocephalus glaber (naked mole-rat) : Htt (huntingtin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl534,761,740 - 34,912,534 (+)EnsemblGRCm38mm10GRCm38
GRCm38534,761,721 - 34,912,534 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37535,104,389 - 35,252,045 (+)NCBIGRCm37mm9NCBIm37
MGSCv36535,078,597 - 35,226,253 (+)NCBImm8
Celera532,235,862 - 32,383,257 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Htt
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68473
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.