RGD Reference Report - Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain. - Rat Genome Database

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Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain.

Authors: Guo, LH  Mittelbronn, M  Brabeck, C  Mueller, CA  Schluesener, HJ 
Citation: Guo LH, etal., J Neuroimmunol 2004 Jan;146(1-2):39-45.
RGD ID: 1354526
Pubmed: (View Article at PubMed) PMID:14698845

Here we report a comparative analysis of interleukin-16 (IL-16) expression by microglial cells of the normal rat brain in trimethyltin (TMT) neurotoxicity, experimental autoimmune uveitis (EAU), encephalomyelitis (EAE), and viral infection (Borna disease, Borna disease virus) by immunohistochemistry. Striking differences were observed. In contrast to the human brain, IL-16 was not expressed constitutively in the rat brain. Remote activation of microglial cells of the optic tract in EAU did not result into IL-16 expression. TMT intoxication induced expression in microglial cells of the hippocampus. In EAE and BDV, massive IL-16(+) microglial cells could be seen. Thus, IL-16 is a descriptor of microglial cell activation that discriminates between different disease models, and might be a valuable marker for the detection of microglia activation in human and rat central nervous system (CNS) diseases.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il16  (interleukin 16)

Genes (Mus musculus)
Il16  (interleukin 16)

Genes (Homo sapiens)
IL16  (interleukin 16)


Additional Information