Ercc4 (excision repair cross-complementing rodent repair deficiency, complementation group 4) - Rat Genome Database

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Gene: Ercc4 (excision repair cross-complementing rodent repair deficiency, complementation group 4) Mus musculus
Analyze
Symbol: Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
RGD ID: 1312518
MGI Page MGI
Description: Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Acts upstream of or within DNA repair; UV protection; and regulation of autophagy. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Is expressed in central nervous system and retina. Used to study xeroderma pigmentosum group F. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; Xp; Xpf
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391612,927,600 - 12,969,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1612,927,548 - 12,968,481 (+)EnsemblGRCm39 Ensembl
GRCm381613,109,366 - 13,152,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,109,684 - 13,150,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,109,829 - 13,152,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,023,314 - 13,062,312 (+)NCBIMGSCv36mm8
Celera1613,713,278 - 13,755,555 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map168.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
chloroethene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
coumarin  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
glucose  (ISO)
indometacin  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nimustine  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
veliparib  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inter-individual variation in nucleotide excision repair pathway is modulated by non-synonymous polymorphisms in ERCC4 and MBD4 genes. Allione A, etal., Mutat Res. 2013 Nov-Dec;751-752:49-54. doi: 10.1016/j.mrfmmm.2013.08.005. Epub 2013 Sep 1.
2. Nucleotide excision repair: new tricks with old bricks. Kamileri I, etal., Trends Genet. 2012 Nov;28(11):566-73. doi: 10.1016/j.tig.2012.06.004. Epub 2012 Jul 22.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Prognostic Value of Excision Repair Cross-Complementing mRNA Expression in Gastric Cancer. Luo SS, etal., Biomed Res Int. 2018 Oct 17;2018:6204684. doi: 10.1155/2018/6204684. eCollection 2018.
5. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. McWilliams RR, etal., Cancer Res. 2008 Jun 15;68(12):4928-35. Epub 2008 Jun 10.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The multi-replication protein A (RPA) system--a new perspective. Sakaguchi K, etal., FEBS J. 2009 Feb;276(4):943-63. doi: 10.1111/j.1742-4658.2008.06841.x. Epub 2009 Jan 12.
16. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Sijbers AM, etal., Cell. 1996 Sep 6;86(5):811-22.
17. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Wang C, etal., Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
18. Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy. West H, etal., JCO Precis Oncol. 2018 Nov;2:1-18. doi: 10.1200/PO.18.00090.
19. DNA repair pathway profiling and microsatellite instability in colorectal cancer. Yu J, etal., Clin Cancer Res. 2006 Sep 1;12(17):5104-11. doi: 10.1158/1078-0432.CCR-06-0547.
Additional References at PubMed
PMID:10349636   PMID:10644440   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12466305   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14690602   PMID:14729965   PMID:15199134  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:16142233   PMID:16602821   PMID:16769089   PMID:18443001   PMID:18541667   PMID:18799693   PMID:19124610   PMID:21522133   PMID:21677750  
PMID:21873635   PMID:22234173   PMID:22323595   PMID:23435420   PMID:24726326   PMID:25538220   PMID:28190767   PMID:28368372   PMID:32325033   PMID:35941380   PMID:38355793  


Genomics

Comparative Map Data
Ercc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391612,927,600 - 12,969,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1612,927,548 - 12,968,481 (+)EnsemblGRCm39 Ensembl
GRCm381613,109,366 - 13,152,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,109,684 - 13,150,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,109,829 - 13,152,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,023,314 - 13,062,312 (+)NCBIMGSCv36mm8
Celera1613,713,278 - 13,755,555 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map168.93NCBI
ERCC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381613,920,154 - 13,952,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1613,920,138 - 13,952,348 (+)EnsemblGRCh38hg38GRCh38
GRCh371614,014,011 - 14,046,205 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361613,921,524 - 13,949,705 (+)NCBINCBI36Build 36hg18NCBI36
Build 341613,921,523 - 13,949,705NCBI
Celera1614,189,206 - 14,221,394 (+)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1613,931,501 - 13,963,699 (+)NCBIHuRef
CHM1_11614,013,994 - 14,046,211 (+)NCBICHM1_1
T2T-CHM13v2.01613,957,393 - 13,989,586 (+)NCBIT2T-CHM13v2.0
Ercc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,926,085 - 2,958,176 (-)NCBIGRCr8
mRatBN7.2102,416,259 - 2,448,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl102,419,038 - 2,448,369 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0102,010,140 - 2,037,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl102,010,648 - 2,037,891 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010897,883 - 925,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4102,144,262 - 2,177,554NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map10q11NCBI
Ercc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,831,721 - 4,861,122 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,833,453 - 4,861,201 (-)NCBIChiLan1.0ChiLan1.0
ERCC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21814,450,518 - 14,488,695 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,233,313 - 18,271,502 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01612,848,334 - 12,880,480 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11614,272,417 - 14,304,496 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1614,272,417 - 14,304,496 (+)Ensemblpanpan1.1panPan2
ERCC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1629,193,192 - 29,226,935 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl629,196,421 - 29,226,887 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha630,549,605 - 30,589,551 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0629,350,548 - 29,390,623 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl629,356,743 - 29,390,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1629,153,426 - 29,193,360 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0629,040,862 - 29,080,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0629,458,540 - 29,498,483 (-)NCBIUU_Cfam_GSD_1.0
Ercc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,203,183 - 114,231,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,300,835 - 2,329,351 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,301,072 - 2,329,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl329,269,989 - 29,306,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1329,266,234 - 29,306,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2330,352,659 - 30,377,491 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERCC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1513,378,282 - 13,410,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl513,378,401 - 13,406,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606816,647,372 - 16,679,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247824,512,650 - 4,537,701 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247824,508,758 - 4,537,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ercc4
1340 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2086
Count of miRNA genes:786
Interacting mature miRNAs:1052
Transcripts:ENSMUST00000023206, ENSMUST00000129049, ENSMUST00000138527, ENSMUST00000141024, ENSMUST00000156393
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
MHAa27a7.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381613,132,390 - 13,132,572UniSTSGRCm38
MGSCv371613,132,483 - 13,132,665UniSTSGRCm37
Celera1613,735,931 - 13,736,113UniSTS
Cytogenetic Map16A1UniSTS
Whitehead_YAC16 UniSTS
UniSTS:237435  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381613,148,531 - 13,148,731UniSTSGRCm38
MGSCv371613,148,624 - 13,148,824UniSTSGRCm37
Celera1613,752,077 - 13,752,277UniSTS
Cytogenetic Map16A1UniSTS
AI606920  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381613,148,523 - 13,148,615UniSTSGRCm38
MGSCv371613,148,616 - 13,148,708UniSTSGRCm37
Celera1613,752,069 - 13,752,161UniSTS
Cytogenetic Map16A1UniSTS
Whitehead/MRC_RH16108.67UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_015769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF189285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ559127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD352377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO433666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX210668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000023206   ⟹   ENSMUSP00000023206
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1612,927,548 - 12,966,598 (+)Ensembl
GRCm38.p6 Ensembl1613,109,684 - 13,148,734 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129049   ⟹   ENSMUSP00000114639
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1612,929,658 - 12,968,481 (+)Ensembl
GRCm38.p6 Ensembl1613,111,794 - 13,150,617 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138527
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1612,927,781 - 12,941,713 (+)Ensembl
GRCm38.p6 Ensembl1613,109,917 - 13,123,849 (+)Ensembl
Ensembl Acc Id: ENSMUST00000141024   ⟹   ENSMUSP00000118553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1612,927,799 - 12,945,494 (+)Ensembl
GRCm38.p6 Ensembl1613,109,935 - 13,127,630 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156393
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1612,950,255 - 12,962,355 (+)Ensembl
GRCm38.p6 Ensembl1613,132,391 - 13,144,491 (+)Ensembl
RefSeq Acc Id: NM_015769   ⟹   NP_056584
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391612,927,600 - 12,969,873 (+)NCBI
GRCm381613,109,736 - 13,152,009 (+)NCBI
MGSCv371613,109,829 - 13,152,102 (+)RGD
Celera1613,713,278 - 13,755,555 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_190181
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391612,927,763 - 12,969,857 (+)NCBI
RefSeq Acc Id: NP_056584   ⟸   NM_015769
- UniProtKB: O54810 (UniProtKB/Swiss-Prot),   Q8R0I3 (UniProtKB/Swiss-Prot),   Q9QZD4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000114639   ⟸   ENSMUST00000129049
Ensembl Acc Id: ENSMUSP00000118553   ⟸   ENSMUST00000141024
Ensembl Acc Id: ENSMUSP00000023206   ⟸   ENSMUST00000023206
Protein Domains
ERCC4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZD4-F1-model_v2 AlphaFold Q9QZD4 1-917 view protein structure

Promoters
RGD ID:6827026
Promoter ID:MM_KWN:20153
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000059540,   UC007YFV.1,   UC007YFW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361613,109,654 - 13,110,154 (+)MPROMDB
RGD ID:8685482
Promoter ID:EPDNEW_M20772
Type:initiation region
Name:Ercc4_1
Description:Mus musculus excision repair cross-complementing rodent repairdeficiency, complementation group 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20773  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381613,109,659 - 13,109,719EPDNEW
RGD ID:8685484
Promoter ID:EPDNEW_M20773
Type:initiation region
Name:Ercc4_2
Description:Mus musculus excision repair cross-complementing rodent repairdeficiency, complementation group 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20772  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381613,109,901 - 13,109,961EPDNEW
RGD ID:6847308
Promoter ID:MM_ACW:19850
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:ERCC4.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361613,147,594 - 13,148,094 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354163 AgrOrtholog
Ensembl Genes ENSMUSG00000022545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023206 ENTREZGENE
  ENSMUST00000023206.14 UniProtKB/Swiss-Prot
  ENSMUST00000129049.2 UniProtKB/TrEMBL
  ENSMUST00000141024.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10130 UniProtKB/Swiss-Prot
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot
InterPro ERCC4_domain UniProtKB/Swiss-Prot
  Restrct_endonuc-II-like UniProtKB/Swiss-Prot
  RuvA_2-like UniProtKB/Swiss-Prot
  XPF UniProtKB/Swiss-Prot
  XPF_nuclease UniProtKB/Swiss-Prot
KEGG Report mmu:50505 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1354163 ENTREZGENE
NCBI Gene 50505 ENTREZGENE
PANTHER DNA REPAIR ENDONUCLEASE XPF UniProtKB/Swiss-Prot
  DNA REPAIR ENDONUCLEASE XPF UniProtKB/Swiss-Prot
  DNA REPAIR ENDONUCLEASE XPF UniProtKB/TrEMBL
  DNA REPAIR ENDONUCLEASE XPF UniProtKB/TrEMBL
Pfam ERCC4 UniProtKB/Swiss-Prot
PharmGKB ERCC4 RGD
PhenoGen Ercc4 PhenoGen
SMART ERCC4 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47781 UniProtKB/Swiss-Prot
  SSF52980 UniProtKB/Swiss-Prot
UniProt D6RHP2_MOUSE UniProtKB/TrEMBL
  F7A043_MOUSE UniProtKB/TrEMBL
  O54810 ENTREZGENE
  Q3UEU6_MOUSE UniProtKB/TrEMBL
  Q3UUC1_MOUSE UniProtKB/TrEMBL
  Q8R0I3 ENTREZGENE
  Q9CXC7_MOUSE UniProtKB/TrEMBL
  Q9QZD4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O54810 UniProtKB/Swiss-Prot
  Q8R0I3 UniProtKB/Swiss-Prot