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DNA lesions, induced by endogenous or exogenous agents, affect the faithful replication of the genome resulting in genetic aberrations that can be deleterious to the cell and organism. Multiple systems have evolved to detect single and double-strand DNA lesions, initiate signals that can be amplified and propagated, and set in motion effectors that can impinge upon DNA repair and checkpoint, various signaling and/or regulatory pathways, as necessary. Together, this vast response mechanism is kn

Pathway Diagram:

Ariadne Genomics Inc. Trichothiodystrophy Syndromes Cockayne Syndrome Xeroderma Pigmentosum Ercc2 ---> Trichothiodystrophy Syndromes Ercc2 ---> Xeroderma Pigmentosum Ercc2 Xpc ---> Xeroderma Pigmentosum Xpc Ddb1 ---> Xeroderma Pigmentosum Ddb1 Ercc3 ---> Trichothiodystrophy Syndromes Ercc4 ---> Xeroderma Pigmentosum Ercc5 ---> Xeroderma Pigmentosum Ercc5 Xpa ---> Xeroderma Pigmentosum Xpa Ercc4 Ercc3 ---> Xeroderma Pigmentosum Ercc3 Ercc8 ---> Cockayne Syndrome Ercc8 Ercc6 ---> Cockayne Syndrome Ercc6 Ddb2 pold complex Rpa complex Hmgn1 Gtf2h1 pole complex stalled polrII complex pole complex ---- Rpa complex pold complex ---- Rpa complex Polk ---- Rpa complex Xrcc1 Lig1 Lig3 ---- Xrcc1 Lig3 TFIIH complex Xab2 Pcna ---- Rfc complex Pcna ---- pole complex Cetn2 Rad23b Pcna ---- pold complex Pcna Polk Pcna ---- Polk Ercc1 Gtf2h2 Rfc complex chromatin modification/remodeling pathway

Genes in Pathway:

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altered nucleotide excision repair pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddb1 damage-specific DNA binding protein 1 JBrowse link 1 226,657,561 226,683,356 RGD:7246919
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:7246919
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit JBrowse link 18 25,037,668 25,068,380 RGD:7246919
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:7246919
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:7246919
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:7246919
G Ercc8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 39,434,617 39,473,392 RGD:7246919
G Xpa XPA, DNA damage recognition and repair factor JBrowse link 5 61,749,767 61,793,641 RGD:7246919
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:7246919

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the altered nucleotide excision repair pathway

References Associated with the altered nucleotide excision repair pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: