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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ruxolitinib
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Accession:CHEBI:66919 term browser browse the term
Definition:A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.
Synonyms:exact_synonym: (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
 related_synonym: Formula=C17H18N6;   INCB018424;   InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1;   InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N;   SMILES=N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
 xref: CAS:941678-49-5;   Drug_Central:4190;   KEGG:D09959;   LINCS:LSM-1139
 xref_mesh: MESH:C540383
 xref: PMID:21602517;   PMID:21919691;   PMID:21926964;   PMID:22034658;   PMID:22227528;   PMID:22279053;   PMID:22281165;   PMID:22375970;   PMID:22375971;   PMID:22399854;   PMID:22422826;   PMID:22474318;   PMID:22544377;   PMID:22718840;   PMID:22830345;   Patent:US2008312258;   Patent:US2010190981;   Reaxys:18703668;   Wikipedia:Ruxolitinib


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ruxolitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:30012499 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of ATM protein CTD PMID:30012499 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP
ISO		 ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
[ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BAX mRNA		 CTD PMID:24973641 PMID:30012499 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA CTD PMID:30012499 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA CTD PMID:30012499 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA CTD PMID:30012499 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Cat catalase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CAT mRNA CTD PMID:30012499 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CCND1 mRNA CTD PMID:30012499 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in decreased expression of CDH1 mRNA] CTD PMID:24820114 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in increased expression of CDH2 mRNA] CTD PMID:24820114 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CDK2 mRNA CTD PMID:30012499 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased phosphorylation of CHEK2 protein CTD PMID:30012499 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression		 ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]
ruxolitinib results in decreased expression of CXCL10 mRNA		 CTD PMID:22941906 PMID:28365849 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 multiple interactions
decreases expression		 ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]
ruxolitinib results in decreased expression of CXCL11 mRNA		 CTD PMID:22941906 PMID:28365849 NCBI chr 5:92,507,403...92,511,155
Ensembl chr 5:92,507,403...92,513,344 		JBrowse link
G Edn1 endothelin 1 decreases phosphorylation ISO ruxolitinib results in decreased phosphorylation of EDN1 protein CTD PMID:30670587 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:24973641 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of GSR mRNA CTD PMID:30012499 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein CTD PMID:30012499 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Ifna1 interferon alpha 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF1 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF9 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of SP100 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA] CTD PMID:28365849 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL10 protein] CTD PMID:24973641 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL13 protein] CTD PMID:32725971 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein] CTD PMID:24973641 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]
ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]		 CTD PMID:24973641 PMID:32725971 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO ruxolitinib inhibits the reaction [Particulate Matter results in increased secretion of IL5 protein] CTD PMID:32725971 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF1 mRNA] CTD PMID:28365849 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO ruxolitinib results in decreased expression of IRF7 mRNA CTD PMID:22941906 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Irf9 interferon regulatory factor 9 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of IRF9 mRNA] CTD PMID:28365849 NCBI chr14:55,841,442...55,847,487
Ensembl chr14:55,841,028...55,847,487 		JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions ISO ruxolitinib inhibits the reaction [DDT results in increased expression of ITGB1 mRNA] CTD PMID:24820114 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Jak1 Janus kinase 1 decreases activity
multiple interactions		 ISO ruxolitinib results in decreased activity of JAK1 protein
ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]		 CTD PMID:24820114 PMID:24883332 PMID:26300391 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jak2 Janus kinase 2 affects response to substance
decreases activity
multiple interactions		 ISO JAK2 gene mutant form affects the susceptibility to ruxolitinib
ruxolitinib results in decreased activity of JAK2 protein
[ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of JAK2 protein		 CTD PMID:24883332 PMID:26300391 PMID:30012499 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO ruxolitinib promotes the reaction [TNF protein affects the localization of JUN protein] CTD PMID:22941906 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:24973641 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of MYC mRNA CTD PMID:30012499 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions ISO ruxolitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein] CTD PMID:22941906 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein] CTD PMID:22941906 NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of NOX1 mRNA CTD PMID:30012499 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of RAC1 mRNA CTD PMID:30012499 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of RELA protein] CTD PMID:24973641 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B multiple interactions ISO ruxolitinib inhibits the reaction [TNF protein affects the localization of RELB protein] CTD PMID:22941906 NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of SOD1 mRNA CTD PMID:30012499 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sp100 nuclear antigen Sp100 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of SP100 mRNA] CTD PMID:28365849 NCBI chr 1:85,577,683...85,637,719
Ensembl chr 1:85,577,709...85,637,719 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases phosphorylation
decreases expression
multiple interactions		 ISO ruxolitinib results in decreased phosphorylation of STAT1 protein
ruxolitinib results in decreased expression of STAT1 mRNA
ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT1 mRNA]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]		 CTD PMID:22941906 PMID:28365849 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO ruxolitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein]; ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of STAT2 mRNA]; ruxolitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 PMID:28365849 NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of STAT3 protein; ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein] CTD PMID:24820114 PMID:30012499 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases phosphorylation ISO
EXP		 ruxolitinib results in decreased phosphorylation of STAT5B protein; ruxolitinib results in decreased phosphorylation of STAT5B protein mutant form CTD PMID:29200404 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO ruxolitinib inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA] CTD PMID:28365849 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of TNF protein]
ruxolitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein]; ruxolitinib inhibits the reaction [TNF protein affects the localization of RELB protein]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]; ruxolitinib inhibits the reaction [TNF protein results in increased expression of IFIT1 mRNA]; ruxolitinib promotes the reaction [TNF protein affects the localization of JUN protein]; ruxolitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein]		 CTD PMID:22941906 PMID:24973641 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of TP53 mRNA; [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of TP53 protein CTD PMID:30012499 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of TXNRD1 mRNA CTD PMID:30012499 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) increases expression ISO ruxolitinib results in increased expression of UCP1 mRNA CTD PMID:25487280 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO ruxolitinib results in increased expression of VEGFA mRNA CTD PMID:26300391 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22192
    chemical entity 22191
      group 22086
        pseudohalo group 4676
          cyano group 4676
            nitrile 4676
              ruxolitinib 53
                ruxolitinib phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    p-block element atom 22118
                      carbon group element atom 21918
                        carbon atom 21844
                          organic molecular entity 21844
                            organic molecule 21660
                              organic cyclic compound 21266
                                organic heterocyclic compound 20339
                                  heteroarene 17900
                                    monocyclic heteroarene 15321
                                      azole 14859
                                        diazole 10551
                                          pyrazoles 2348
                                            ruxolitinib 53
                                              ruxolitinib phosphate 0
paths to the root