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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11352
Species: Mus musculus
RGD Object: Gene
Symbol: Stat5b
Name: signal transducer and activator of transcription 5B
Acc ID: CHEBI:66919
Term: ruxolitinib
Definition: A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.
Chemical ID: MESH:C540383
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat5bdecreases phosphorylationEXP 6480464CTDruxolitinib results in decreased phosphorylation of STAT5B proteinPMID:29200404
Stat5bdecreases phosphorylationISOSTAT5B (Homo sapiens)6480464CTDruxolitinib results in decreased phosphorylation of STAT5B protein; ruxolitinib results in decreased phosphorylation of STAT5B protein mutant formPMID:29200404
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