INTERLEUKIN-6 SIGNALING PATHWAY (PW:0000516)
Description
Discovered in 1986 as a B-cell differentiation factor, interleukin 6 (Il6) is now known to be the archetypal member of a family of cytokines involved in a broad range of biological processes. Interleukin 6 signaling pathway plays important regulatory roles in immune responses, inflammation, embryonic development, the hematopoietic and nervous systems. Characteristic of Il6 family mediated signaling is the shared use of a co-receptor transducer molecule - Il6st, known as gp130. Il6 is expressed in many cell types while its receptor Il6r displays a rather restricted expression pattern; the transducer is ubiquitously expressed in most/all cell types. Il6 binds the membrane bound receptor Il6r and the binary complex then binds the family shared signal transducer. A soluble form of the receptor exists, resulting primarily from processing by members of the ADAM family of metalloproteases or to a lower extent, from alternative splicing. It binds Il6 with comparable affinity, associates with gp130 and activates target cells that do not express Il6r. Signaling via the membrane-bound Il6r or via the soluble Il6 are referred to as the classic and trans-signaling, respectively. Trans-signaling allows cells that do not express the receptor to mediate the effects of Il6. It could also un-necessarily augment Il6 effects and underlie pathological conditions. A soluble form of gp130 exists which binds the Il6/soluble-Il6r complex acting as an inhibitor of trans-signaling. The crystal structure of a ternary complex reveals a hexameric structure with two molecules of Il6, Il6r and Il6st/gp130. However, whether the hexamer or a postulated tetramer is the biological significant complex, remains to be established. Via gp130, Il6 triggers Jak-Stat and the Raf/Mek/Erk MAPK intracellular pathways, whose independent signaling underlie the many Il6 mediated effects. Once complexed with Il6 and Il6r, Gp130 activates Jak protein kinases leading to the phosphorylation of tyrosine residues on gp130 cytoplasmic domain. Phosphorylated YxxQ motifs recruit Stat(s) (Stat1 and Stat3) which are then phosphorylated by Jak(s) and translocate to the nucleus to activate the transcription of target genes. Phosphorylation of gp130 tyrosine759 (human) leads to recruitment of Ptpn11 (Shp2), which is then phosphorylated by Jak(s). Activated Ptpn11 recruits Grb2 which is constitutively associated with Sos proteins, the GDP/GTP exchangers of Ras. GTP-bound Ras prompts the activation of the first MAP3K tier of the Raf/Mek/Erk cascade. Il6 signaling plays an essential role in regulating the balance between regulatory T cells (Treg) and effector Th17 cells which is crucial for the maintenance of immune homeostasis. Il6, in concert with Tgf-beta signaling, promotes differentiation of Th17 cells while inhibiting the differentiation of Tgf-beta mediated Treg cells. Overexpression of Il-6 and excessive signaling have been associated with a wide variety of conditions. Pathologic roles of Il6 include inflammation and autoimmunity, rheumatoid arthritis, multiple sclerosis and neurodegeneration. Tocilizumab - trade name Acterma, is a humanized anti-Il6 receptor antibody; it binds both the membrane-bound and the soluble receptors inhibiting their interaction with Il6.
To see the ontology report for annotations, GViewer and download, click here [click to see associated GO term - GO:0070102 and entry at Reactome - REACT_27307.1. ]...(less)
Pathway Diagram:
Genes in Pathway:
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A2m
alpha-2-macroglobulin
ISO
PID
PID:200146
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Adam10
ADAM metallopeptidase domain 10
ISO
RGD
PMID:21145125
RGD:5686846
NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
G
Adam17
ADAM metallopeptidase domain 17
ISO
RGD
PMID:22029668 PMID:21145125
RGD:5686834 , RGD:5686846
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200146
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Cebpb
CCAAT/enhancer binding protein beta
ISO
PID
PID:200146
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Cebpd
CCAAT/enhancer binding protein delta
ISO
PID
PID:200146
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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Crp
C-reactive protein
ISO
PID
PID:200146
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
G
Fgg
fibrinogen gamma chain
ISO
PID
PID:200146
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200146
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxo1
forkhead box O1
ISO
PID
PID:200146
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Gab1
GRB2-associated binding protein 1
ISO
PID
PID:200146
NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
G
Gab2
GRB2-associated binding protein 2
ISO
PID
PID:200146
NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
G
Grb2
growth factor receptor bound protein 2
ISO
PID RGD
PMID:22029668
PID:200146, RGD:5686834
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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Hck
HCK proto-oncogene, Src family tyrosine kinase
ISO
PID
PID:200146
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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Hsp90b1
heat shock protein 90 beta family member 1
ISO
PID
PID:200146
NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
G
Il6
interleukin 6
ISO IDA
PID RGD
PMID:12773095 PMID:22029668 PMID:21881215 PMID:23825534 PMID:28186964
PID:200146, RGD:1580493 , RGD:5686834 , RGD:5686839 , RGD:11062097 , RGD:127229952
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Il6r
interleukin 6 receptor
ISO
PID RGD
PMID:22029668 PMID:21881215
PID:200146, RGD:5686834 , RGD:5686839
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
G
Il6st
interleukin 6 cytokine family signal transducer
ISO IMP
PID RGD
PMID:22029668 PMID:21881215 PMID:18280048
PID:200146, RGD:5686834 , RGD:5686839 , RGD:5686900
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
G
Irf1
interferon regulatory factor 1
ISO
PID
PID:200146
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
G
Jak1
Janus kinase 1
ISO
PID RGD
PMID:21881215
PID:200146, RGD:5686839
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
G
Jak2
Janus kinase 2
ISO
PID RGD
PMID:21881215
PID:200146, RGD:5686839
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200146
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200146
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Lbp
lipopolysaccharide binding protein
ISO
PID
PID:200146
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
G
Lmo4
LIM domain only 4
ISO
PID
PID:200146
NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880
G
Map2k4
mitogen activated protein kinase kinase 4
ISO
PID
PID:200146
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
G
Map2k6
mitogen-activated protein kinase kinase 6
ISO
PID
PID:200146
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
G
Mapk11
mitogen-activated protein kinase 11
ISO
PID
PID:200146
NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
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Mapk14
mitogen activated protein kinase 14
ISO
PID
PID:200146
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Mcl1
MCL1 apoptosis regulator, BCL2 family member
ISO
PID
PID:200146
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
G
Mitf
melanocyte inducing transcription factor
ISO
PID
PID:200146
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Myc
MYC proto-oncogene, bHLH transcription factor
ISO
PID
PID:200146
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Pias1
protein inhibitor of activated STAT, 1
ISO
PID
PID:200146
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
G
Pias3
protein inhibitor of activated STAT, 3
ISO
PID
PID:200146
NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
PID
PID:200146
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID
PID:200146
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Prkcd
protein kinase C, delta
ISO
PID
PID:200146
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
G
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
ISO
PID RGD
PMID:22029668
PID:200146, RGD:5686834
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
G
Rac1
Rac family small GTPase 1
ISO
PID
PID:200146
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
G
Socs3
suppressor of cytokine signaling 3
ISO
PID
PID:200146
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
G
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
ISO
PID RGD
PMID:22029668 PMID:9815779
PID:200146, RGD:5686834 , RGD:155631264
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
G
Sos2
SOS Ras/Rho guanine nucleotide exchange factor 2
ISO
RGD
PMID:22029668
RGD:5686834
NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
G
Stat1
signal transducer and activator of transcription 1
ISO
PID RGD
PMID:22029668 PMID:21881215
PID:200146, RGD:5686834 , RGD:5686839
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
G
Stat3
signal transducer and activator of transcription 3
ISO
PID RGD
PMID:22029668 PMID:21881215
PID:200146, RGD:5686834 , RGD:5686839
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Timp1
TIMP metallopeptidase inhibitor 1
ISO
PID
PID:200146
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tnfsf11
TNF superfamily member 11
ISO
PID
PID:200146
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
G
Tyk2
tyrosine kinase 2
ISO
PID RGD
PMID:21881215
PID:200146, RGD:5686839
NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
G
Vav1
vav guanine nucleotide exchange factor 1
ISO
PID
PID:200146
NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937
Pathway Gene Annotations
Disease Annotations Associated with Genes in the interleukin-6 signaling pathway
A2m acute kidney failure , Alzheimer's disease , background diabetic retinopathy , Burns , Cardiomegaly , cerebral infarction , Colonic Neoplasms , COVID-19 , Diabetic Cardiomyopathies , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Liver Cirrhosis , Femur Head Necrosis , Fever , heart disease , hemolytic anemia , hepatocellular adenoma , hepatocellular carcinoma , Hypoalbuminemia , Inflammation , liver cirrhosis , lung disease , Lung Neoplasms , megacolon , membranous glomerulonephritis , multiple sclerosis , nephrotic syndrome , obstructive lung disease , otitis media , Otitis Media with Effusion , Parkinson's disease , peritonitis , rheumatoid arthritis , Sepsis , suppurative otitis media , toxic shock syndrome , trypanosomiasis , Wilson disease Adam10 Alzheimer's disease , Alzheimer's disease 18 , Bloom syndrome , Breast Neoplasms , cardiomyopathy , cataract , Cognitive Dysfunction , colorectal cancer , Dowling-Degos disease , Experimental Arthritis , Fibrosis , Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis , genetic disease , IgA glomerulonephritis , kidney failure , Prenatal Exposure Delayed Effects , reticulate acropigmentation of Kitamura , status epilepticus , thoracic aortic aneurysm , traumatic brain injury , ureteral obstruction Adam17 Alzheimer's disease , atopic dermatitis , Blister , Brain Hypoxia , colitis , congestive heart failure , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Colitis , Experimental Liver Cirrhosis , genetic disease , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , Neonatal Inflammatory Skin and Bowel Disease 1 , NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, NYSTAGMUS, AND SEIZURES , Pneumococcal Meningitis , renal fibrosis , syndromic microphthalmia 5 , thoracic aortic aneurysm , type 2 diabetes mellitus , ureteral obstruction Akt1 Acute Lung Injury , acute promyelocytic leukemia , adenocarcinoma , Alzheimer's disease , amphetamine abuse , amyotrophic lateral sclerosis , Animal Disease Models , atherosclerosis , autosomal recessive polycystic kidney disease , bipolar disorder , bone osteosarcoma , Brain Injuries , brain ischemia , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , Breast Neoplasms , Calcification of Aortic Valve , cannabis abuse , Carcinogenesis , cardiac arrest , Cardiomegaly , cardiomyopathy , Charcot-Marie-Tooth disease axonal type 2O , chronic myeloid leukemia , colon cancer , colon carcinoma , colorectal cancer , Colorectal Neoplasms , coronary artery disease , Cowden syndrome 6 , Diabetic Cardiomyopathies , diabetic retinopathy , Endometrioid Carcinomas , Endotoxemia , epilepsy , esophageal cancer , esophagus squamous cell carcinoma , Experimental Arthritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , familial adenomatous polyposis , Fibrosis , focal segmental glomerulosclerosis 5 , gastric adenocarcinoma , genetic disease , glioblastoma , head and neck squamous cell carcinoma , hepatocellular carcinoma , Hepatomegaly , Hereditary Neoplastic Syndromes , Hyperplasia , hypertension , Hypertriglyceridemia , impotence , in situ carcinoma , Inflammation , intermediate coronary syndrome , interstitial lung disease 2 , Intervertebral Disc Displacement , invasive ductal carcinoma , Kidney Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung oat cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Macrocephaly Mesodermal Hamartoma Spectrum , malignant astrocytoma , melanoma , Memory Disorders , Meningeal Neoplasms , meningioma , muscular atrophy , myocardial infarction , Myocardial Reperfusion Injury , Neointima , obesity , osteosarcoma , ovarian cancer , Ovarian Neoplasms , Pain , pancreatic cancer , pancreatic intraductal papillary-mucinous neoplasm , paraplegia , Parkinson's disease , pre-malignant neoplasm , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Proteus syndrome , pulmonary tuberculosis , renal cell carcinoma , Reperfusion Injury , Right Ventricular Hypertrophy , schizophrenia , skin melanoma , Skin Neoplasms , Spinal Cord Injuries , squamous cell carcinoma , Staphylococcal Pneumonia , steatotic liver disease , Stroke , substance-induced psychosis , T-cell non-Hodgkin lymphoma , Thyroid Neoplasms , transitional cell carcinoma , type 2 diabetes mellitus , ureteral obstruction , urinary bladder cancer , Uterine Cervical Neoplasms , Ventilator-Induced Lung Injury , vulva cancer Cebpb adenocarcinoma , Alzheimer's disease , Bacteremia , Brain Injuries , brain ischemia , Cachexia , Cardiomegaly , Disease Progression , Endotoxemia , Eosinophilia , Female Infertility , Fibrosis , hepatocellular carcinoma , Huntington's disease , Inflammation , listeriosis , oral candidiasis , osteoarthritis , osteochondrodysplasia , peritoneum cancer , Pseudomonas Aeruginosa Keratitis , pulmonary fibrosis , rheumatoid arthritis , Sarcopenia , Sepsis , steatotic liver disease , Stomach Neoplasms , tuberculosis , viral infectious disease Cebpd acute myeloid leukemia , Experimental Liver Cirrhosis , hepatocellular carcinoma , Myocardial Ischemia , prolactinoma , Sepsis Crp abdominal aortic aneurysm , Acute Coronary Syndrome , acute kidney failure , acute stress disorder , Acute Uveitis , aggressive periodontitis , Albuminuria , Alcoholic Fatty Liver , alcoholic liver cirrhosis , Alzheimer's disease , ankylosing spondylitis , antiphospholipid syndrome , anxiety disorder , Arsenic Poisoning , aspergillosis , asthma , atherosclerosis , atrial fibrillation , autoimmune interstitial lung, joint, and kidney disease , Bacteremia , bacterial infectious disease , bacterial meningitis , Behcet's disease , Brain Hypoxia-Ischemia , Brain Injuries , breast cancer , breast carcinoma , bronchiolitis , Burns , Cardiac Arrhythmias , cardiovascular system disease , cerebrovascular disease , Chemical and Drug Induced Liver Injury , Chronic Hepatitis C , chronic obstructive pulmonary disease , colon cancer , congestive heart failure , Contrast-Induced Nephropathy , coronary artery disease , COVID-19 , Crohn's disease , depressive disorder , Diabetic Foot , Diabetic Nephropathies , diabetic retinopathy , disease by infectious agent , disease of metabolism , Drug Hypersensitivity Syndrome , end stage renal disease , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , familial hyperlipidemia , Fever of Unknown Origin , gastrointestinal stromal tumor , heart disease , hepatocellular carcinoma , human immunodeficiency virus infectious disease , Human Influenza , hypertension , hypertensive retinopathy , Hypertriglyceridemia , Hypoxia , Inflammation , inflammatory bowel disease , intermediate coronary syndrome , interstitial cystitis , interstitial nephritis , Intestinal Reperfusion Injury , iron deficiency anemia , juvenile rheumatoid arthritis , Kawasaki disease , kidney failure , Kuhnt-Junius degeneration , Left Ventricular Hypertrophy , leishmaniasis , liver cirrhosis , low tension glaucoma , Lung Neoplasms , lupus nephritis , Lymphatic Metastasis , macular degeneration , malaria , mastoiditis , meningitis , Metabolic Syndrome , mevalonic aciduria , middle cerebral artery infarction , mouth disease , Mycoplasma pneumoniae pneumonia , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , myocarditis , non-arteritic anterior ischemic optic neuropathy , obesity , obstructive sleep apnea , otitis externa , otitis media , overactive bladder syndrome , parathyroid carcinoma , Parkinson's disease , Pasteurellaceae Infections , pelvic inflammatory disease , periodontitis , pharyngoconjunctival fever , Pneumococcal Pneumonia , pneumonia , polymyalgia rheumatica , Polypoidal Choroidal Vasculopathy , Postoperative Atrial Fibrillation , Pseudomonas Infections , psoriasis , pulmonary hypertension , pulmonary sarcoidosis , pulmonary tuberculosis , pyelonephritis , renal cell carcinoma , Renal Colic , renal fibrosis , renal hypertension , retinal vein occlusion , rheumatoid arthritis , secondary hyperparathyroidism , Sepsis , Sjogren's syndrome , Spinal Cord Injuries , status epilepticus , Stevens-Johnson syndrome , systemic lupus erythematosus , temporal arteritis , thrombosis , Tubulointerstitial Nephritis and Uveitis , type 1 diabetes mellitus , type 2 diabetes mellitus , urticaria , uveal melanoma , vestibular neuronitis , visceral leishmaniasis , withdrawal disorder Fgg blood coagulation disease , brain small vessel disease , congenital afibrinogenemia , Congenital Dysfibrinogenemia , Congenital Hypodysfibrinogenemia , Experimental Liver Cirrhosis , genetic disease , Hemorrhage , hemorrhagic disease , hereditary spastic paraplegia 4 , Inflammation , Keloid , Kidney Reperfusion Injury , Liver Injury , multiple myeloma , obesity , pancreatitis , pulmonary embolism , severe acute respiratory syndrome , Stomach Neoplasms , Stroke , thrombocytopenia , Thromboembolism , thrombosis , Thrombotic Microangiopathies , type 2 diabetes mellitus Fos Aberrant Crypt Foci , acute myocardial infarction , alcohol dependence , alcohol use disorder , alcohol withdrawal syndrome , Alcohol-Related Disorders , Alcoholic Intoxication , amphetamine abuse , amyotrophic lateral sclerosis type 1 , Animal Disease Models , anxiety disorder , autosomal dominant polycystic kidney disease , Binge Drinking , Brain Hypoxia-Ischemia , Brain Injuries , Breast Neoplasms , cervical squamous cell carcinoma , cocaine abuse , cocaine dependence , Cocaine-Related Disorders , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , Colorectal Neoplasms , congenital hypothyroidism , congestive heart failure , degenerative disc disease , depressive disorder , endometriosis , epilepsy , Experimental Arthritis , Experimental Liver Cirrhosis , extrahepatic cholestasis , Fetal Growth Retardation , Fibrous Dysplasia of Bone , functional diarrhea , gastric ulcer , glomerulonephritis , Heat Stroke , Hematuria , hemolytic-uremic syndrome , Hemorrhage , hepatocellular carcinoma , Hyperalgesia , Hyperkinesis , hypertension , hypospadias , Inhalant Abuse , intellectual disability , irritable bowel syndrome , juvenile rheumatoid arthritis , Kidney Reperfusion Injury , Lung Neoplasms , middle cerebral artery infarction , migraine , morphine dependence , morphine withdrawal syndrome , myocardial infarction , Neoplastic Cell Transformation , nervous system disease , nicotine dependence , Nociceptive Pain , obesity , ovarian carcinoma , Pick's disease , post-traumatic stress disorder , rectal benign neoplasm , Reperfusion Injury , sleeping sickness , status epilepticus , temporal lobe epilepsy , Tendon Injuries , Tongue Neoplasms , tongue squamous cell carcinoma , toxic encephalopathy , trigeminal neuralgia , Ventilator-Induced Lung Injury , Wernicke encephalopathy , withdrawal disorder Foxo1 acute myeloid leukemia , Alcoholic Fatty Liver , alveolar rhabdomyosarcoma , congestive heart failure , diffuse large B-cell lymphoma , Experimental Liver Cirrhosis , hemangioma , hepatocellular carcinoma , Insulin Resistance , keratoconus , lymphoblastic lymphoma , metabolic dysfunction-associated steatotic liver disease , Premature Aging , prostate cancer , Prostatic Neoplasms , pulmonary hypertension , type 1 diabetes mellitus , type 2 diabetes mellitus Gab1 autosomal recessive nonsyndromic deafness 26 , Experimental Liver Cirrhosis , Helicobacter Infections , polycystic ovary syndrome , sensorineural hearing loss Gab2 chronic myeloid leukemia , intellectual disability , melanoma , Neoplasm Invasiveness , Neoplasm Metastasis Grb2 breast cancer , endometrial carcinoma , prostate adenocarcinoma , prostate cancer Hck acute lymphoblastic leukemia , autoimmune disease , Autoinflammation with Pulmonary and Cutaneous Vasculitis , COVID-19 , disease of cellular proliferation , Experimental Liver Cirrhosis Hsp90b1 Diabetic Cardiomyopathies , lung adenocarcinoma , male infertility due to globozoospermia , Prostatic Neoplasms Il6 Acute Coronary Syndrome , Acute Hepatitis , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute myeloid leukemia , acute myocardial infarction , acute necrotizing pancreatitis , Acute-Phase Reaction , adult T-cell leukemia/lymphoma , aggressive periodontitis , Albuminuria , alcoholic liver cirrhosis , allergic disease , Alveolar Bone Loss , Alzheimer's disease , amnestic disorder , anemia , Animal Toxoplasmosis , ankylosing spondylitis , anogenital venereal wart , aortic valve disease 1 , arteriovenous malformations of the brain , Ascorbic Acid Deficiency , aseptic meningitis , asthma , ataxia telangiectasia , atherosclerosis , atopic dermatitis , autistic disorder , autoimmune disease , autoimmune hepatitis , autoimmune thyroiditis , B-Cell Chronic Lymphocytic Leukemia , bacterial pneumonia , basal cell carcinoma , Behcet's disease , berylliosis , beta thalassemia , Bile Duct Neoplasms , biliary tract benign neoplasm , Brain Concussion , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , bronchiolitis obliterans , Burns , Cachexia , Cadmium Poisoning , Cardiomegaly , cardiomyopathy , Cardiovascular Pregnancy Complications , Castleman disease , celiac disease , central nervous system disease , Cerebral Hemorrhage , cerebral infarction , Chemical and Drug Induced Liver Injury , Chemical Burns , Chemically-Induced Disorders , cholangiocarcinoma , cholestasis , cholesteatoma of middle ear , chorioamnionitis , Chronic Hepatitis C , chronic obstructive pulmonary disease , cochlear disease , colitis , colorectal cancer , colorectal carcinoma , congestive heart failure , conjunctival disease , corneal ulcer , coronary artery disease , Coronavirus infectious disease , COVID-19 , Coxsackievirus Infections , Crohn's disease , cystic fibrosis , depressive disorder , diabetes mellitus , Diabetic Nephropathies , diabetic retinopathy , Diaphragmatic Hernia , diffuse scleroderma , disseminated intravascular coagulation , Drug-Related Side Effects and Adverse Reactions , dry eye syndrome , Eales Disease , eclampsia , Edema , end stage renal disease , Endotoxemia , Entamoebiasis , epididymitis , epilepsy , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , extrahepatic cholestasis , familial Mediterranean fever , Femoral Fractures , Fetal Inflammatory Response Syndrome , Fever , Foot Injuries , gastric adenocarcinoma , gastric dilatation , gestational diabetes , gingivitis , glomerulonephritis , glucosephosphate dehydrogenase deficiency , Graves' disease , Hashimoto Disease , Headache , Hearing Loss, Noise-Induced , Heart Injuries , Heat Stress Disorders , Heat Stroke , Helicobacter Infections , hemarthrosis , Hemifacial Spasm , hemolytic-uremic syndrome , Hemorrhagic Shock , hepatitis B , hepatitis C , hepatocellular carcinoma , HIV Wasting Syndrome , Hodgkin's lymphoma , human immunodeficiency virus infectious disease , Human Influenza , Huntington's disease , Hyperalgesia , hypercalcemia , hyperglycemia , hyperinsulinism , Hyperoxaluria , Hyperoxia , hypertension , Hypoalbuminemia , hypogonadism , hypomyelinating leukodystrophy 5 , Hypotension , idiopathic interstitial pneumonia , impotence , Inflammation , inflammatory bowel disease , Insulin Resistance , Intestinal Reperfusion Injury , intracranial aneurysm , Intracranial Hemorrhages , Intraventricular Hemorrhage , iron deficiency anemia , ischemia , juvenile rheumatoid arthritis , Kaposi's sarcoma , keratitis , keratoconjunctivitis sicca , Kidney Reperfusion Injury , Klebsiella Infections , Kuhnt-Junius degeneration , learning disability , leishmaniasis , lichen disease , liver cirrhosis , Liver Injury , Liver Reperfusion Injury , lung disease , Lung Injury , Lung Neoplasms , Lung Reperfusion Injury , lymphoplasmacytic lymphoma , macular retinal edema , major depressive disorder , malignant mesothelioma , metabolic dysfunction-associated steatohepatitis , metabolic dysfunction-associated steatotic liver disease , Metabolic Syndrome , middle cerebral artery infarction , Middle East respiratory syndrome , mitochondrial myopathy , multiple myeloma , multiple sclerosis , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , myocarditis , Necrosis , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , neovascular glaucoma , neovascular inflammatory vitreoretinopathy , neurodegenerative disease , neuromyelitis optica , nodular goiter , obesity , obstructive sleep apnea , oral squamous cell carcinoma , oral submucous fibrosis , osteoporosis , otitis media , ovarian hyperstimulation syndrome , Ovarian Neoplasms , pancreas disease , pancreatic cancer , Parkinson's disease , perinatal necrotizing enterocolitis , periodontal disease , periodontitis , Peripheral Nerve Injuries , peripheral nervous system disease , peripheral vascular disease , peritonitis , Plaque, Atherosclerotic , pleomorphic xanthoastrocytoma , pleural disease , pleurisy , Pneumococcal Meningitis , Pneumococcal Pneumonia , pneumonia , polymyositis , polyneuropathy , Postmenopausal Osteoporosis , Postoperative Atrial Fibrillation , Postoperative Cognitive Dysfunction , pre-eclampsia , pre-malignant neoplasm , prediabetes syndrome , Premature Birth , Premature Obstetric Labor , primary ciliary dyskinesia , Prostatic Neoplasms , proteinuria , Pseudomonas Aeruginosa Keratitis , Pseudomonas Infections , psoriasis , Pulmonary Contusion , pulmonary fibrosis , pulmonary hypertension , pulmonary tuberculosis , quadriplegia , rectum cancer , renal cell carcinoma , renal hypertension , Reperfusion Injury , respiratory allergy , respiratory syncytial virus infectious disease , Retina Reperfusion Injury , retinal artery occlusion , retinal detachment , retinal vasculitis , retinal vein occlusion , rheumatoid arthritis , Right Ventricular Hypertrophy , Sarcopenia , schizophrenia , sciatic neuropathy , secondary hyperparathyroidism , Sepsis , Septic Peritonitis , severe acute respiratory syndrome , Shwartzman phenomenon , Sjogren's syndrome , skin disease , small cell carcinoma , Spinal Cord Compression , spinal cord disease , Spinal Cord Injuries , Spine Osteoarthritis , spondyloarthropathy , Spontaneous Abortions , squamous cell carcinoma , steatotic liver disease , stomach cancer , Stomach Neoplasms , Streptococcus pneumonia , Stroke , Subarachnoid Hemorrhage , Subretinal Fibrosis , Sudden Cardiac Death , Sudden Hearing Loss , Systemic Juvenile Rheumatoid Arthritis , systemic lupus erythematosus , systemic scleroderma , thrombocytopenia , Thyroid Neoplasms , Tobacco Use Disorder , toxic shock syndrome , Toxoplasma Chorioretinitis , transverse myelitis , Tympanic Membrane Perforation , type 1 diabetes mellitus , type 2 diabetes mellitus , uveitis , Ventricular Dysfunction, Left , Viral Bronchiolitis , Viral Myocarditis , visceral leishmaniasis , Wilson disease , Wounds and Injuries Il6r Acute-Phase Reaction , Alzheimer's disease , arrhythmogenic right ventricular cardiomyopathy , asthma , Charcot-Marie-Tooth disease type 2 , congestive heart failure , depressive disorder , dyschromatosis symmetrica hereditaria , Fever , gastrointestinal stromal tumor , Graves' disease , Hashimoto Disease , Heat Stroke , Huntington's disease , Hyper-IgE Recurrent Infection Syndrome 5 , Hyperalgesia , hypertension , immunodeficiency 42 , Insulin Resistance , lung non-small cell carcinoma , Metabolic Syndrome , MHC class II deficiency , middle cerebral artery infarction , myocardial infarction , Myocardial Reperfusion Injury , obesity , orchitis , osteoporosis , parathyroid carcinoma , Peripheral Nerve Injuries , proliferative diabetic retinopathy , pulmonary tuberculosis , renal cell carcinoma , Reperfusion Injury , Respiratory Tract Infections , rheumatoid arthritis , schizophrenia , sciatic neuropathy , severe congenital neutropenia 3 , severe congenital neutropenia 5 , sleep apnea , stomach cancer , Stomach Neoplasms , Subretinal Fibrosis , Systemic Juvenile Rheumatoid Arthritis , uveitis , visual epilepsy Il6st allergic disease , Alzheimer's disease , Animal Mammary Neoplasms , arteriosclerosis , brain ischemia , carcinoma , Cardiomegaly , Colorectal Neoplasms , Experimental Arthritis , Experimental Mammary Neoplasms , hepatocellular carcinoma , hyper IgE recurrent infection syndrome 1 , hyper IgE recurrent infection syndrome 4 , hyperandrogenism , hypertension , Hypertriglyceridemia , Immunodeficiency 94 with Autoinflammation and Dysmorphic Facies , middle cerebral artery infarction , Myocardial Ischemia , Neurodevelopmental Disorders , Ovarian Neoplasms , Pain , Pituitary Neoplasms , pneumonia , Prostatic Neoplasms , Reperfusion Injury , retinal degeneration , rheumatoid arthritis , Splenomegaly , status epilepticus , stomach cancer , Stuve-Wiedemann Syndrome , Stuve-Wiedemann Syndrome 2 , visual epilepsy Irf1 allergic conjunctivitis , asthma , bacterial pneumonia , Brain Injuries , cystic fibrosis , endometrial adenocarcinoma , familial adenomatous polyposis 1 , gastric adenocarcinoma , hepatitis B , Hereditary Neoplastic Syndromes , Immunodeficiency 117 , lung cancer , lung disease , Lung Neoplasms , lung non-small cell carcinoma , Myocardial Ischemia , Neurodevelopmental Disorders , pulmonary tuberculosis , Reperfusion Injury , respiratory syncytial virus infectious disease , Respiratory Tract Infections , smallpox , Spinal Cord Injuries , stomach cancer , Stomach Neoplasms , Stroke , ureteral obstruction Jak1 Acute Experimental Pancreatitis , Acute Lymphoblastic Leukemia, with Lymphomatous Features , acute myeloid leukemia , Autoinflammation, Immune Dysregulation, and Eosinophilia , Chronic Hepatitis B , colorectal cancer , endometrial cancer , Experimental Arthritis , genetic disease , hepatocellular carcinoma , Hypoxia , intellectual disability , liver cirrhosis , lung non-small cell carcinoma , lupus nephritis , myeloid leukemia associated with Down Syndrome , ovarian cancer , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , periodontitis , polycythemia vera , prostate cancer , Prostatic Neoplasms , sciatic neuropathy , stomach cancer , systemic lupus erythematosus , T-cell acute lymphoblastic leukemia , transient cerebral ischemia , X-Linked Acute Leukemia Jak2 acute kidney failure , Acute Lymphoblastic Leukemia, with Lymphomatous Features , acute myeloid leukemia , adrenocortical carcinoma , alcoholic liver cirrhosis , Alzheimer's disease , anemia , ankylosing spondylitis , atherosclerosis , bacterial gastritis , Brain Injuries , Budd-Chiari syndrome , Cachexia , calcinosis , Cancer Pain , chromosome 9p deletion syndrome , chronic myelogenous leukemia, BCR-ABL1 positive , chronic myeloid leukemia , colon adenocarcinoma , colon cancer , colorectal carcinoma , COVID-19 , Crohn's disease , Diabetic Nephropathies , esophageal carcinoma , esophagus squamous cell carcinoma , essential thrombocythemia , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Colitis , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , familial erythrocytosis 1 , familial erythrocytosis 2 , genetic disease , Genetic Predisposition to Disease , glucose intolerance , Growth Disorders , heart disease , heart valve disease , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , Hyperalgesia , hyperuricemia , Inflammation , Intestinal Reperfusion Injury , leukemia , limited scleroderma , liver cancer , liver cirrhosis , Liver Injury , Liver Reperfusion Injury , lung adenocarcinoma , lung carcinoma , lung non-small cell carcinoma , mesenteric vascular occlusion , metabolic dysfunction-associated steatohepatitis , metabolic dysfunction-associated steatotic liver disease , myelofibrosis , myeloid neoplasm , myeloproliferative neoplasm , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , nasopharynx carcinoma , Neoplasm Metastasis , Neoplastic Cell Transformation , nephrotic syndrome , Niemann-Pick disease type C1 , obesity , polycythemia , polycythemia vera , portal hypertension , Pregnancy Complications , primary biliary cholangitis , primary ovarian insufficiency , Prostatic Neoplasms , Reperfusion Injury , retinal detachment , rheumatoid arthritis , scrapie , Sepsis , Sepsis-Associated Encephalopathy , Spinal Cord Injuries , Splenomegaly , Spontaneous Abortions , steatotic liver disease , stomach cancer , Stroke , systemic lupus erythematosus , Thrombocythemia 3 , thrombocytosis , Thromboembolism , thrombosis , transient cerebral ischemia , ulcerative colitis , urinary bladder cancer , Uterine Cervical Neoplasms , Venous Thrombosis Jun Alcohol-Related Disorders , angiosarcoma , Asphyxia , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , COVID-19 , depressive disorder , endometrial adenocarcinoma , endometrial carcinoma , extrahepatic cholestasis , glaucoma , Heat Stroke , hepatocellular carcinoma , Hodgkin's lymphoma , hypertension , Intestinal Polyps , juvenile rheumatoid arthritis , Liver Neoplasms , Lung Neoplasms , Mercury Poisoning, Nervous System , Nasal Polyps , Neoplastic Cell Transformation , Optic Nerve Injuries , oral squamous cell carcinoma , osteopetrosis , osteosarcoma , peripheral nervous system disease , prostate adenocarcinoma , prostate carcinoma , Prostatic Neoplasms , pulmonary emphysema , pulmonary tuberculosis , renal carcinoma , renal cell carcinoma , Reperfusion Injury , silicosis , Spinal Cord Injuries , status epilepticus , Stomach Neoplasms , tongue squamous cell carcinoma Junb alpha-mannosidosis , anaplastic large cell lymphoma , Charcot-Marie-Tooth disease dominant intermediate B , colon cancer , colorectal adenocarcinoma , colorectal cancer , episodic ataxia type 2 , esophagus squamous cell carcinoma , gallbladder cancer , glutaric acidemia I , head and neck squamous cell carcinoma , Hodgkin's lymphoma , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , melanoma , middle cerebral artery infarction , Myocardial Ischemia , oral squamous cell carcinoma , renal carcinoma , status epilepticus , systemic lupus erythematosus , Tongue Neoplasms , tongue squamous cell carcinoma Lbp Burns , Chemical and Drug Induced Liver Injury , Drug Hypersensitivity Syndrome , Endotoxemia , exanthem , Experimental Liver Cirrhosis , focal epilepsy , Intestinal Reperfusion Injury , liver cirrhosis , Liver Reperfusion Injury , Metabolic Syndrome , Multiple Organ Failure , obesity , obstructive jaundice , periodontitis , Sepsis , Stevens-Johnson syndrome , Weight Gain Lmo4 anencephaly Map2k4 Brain Death , Breast Neoplasms , Cardiac Arrhythmias , chronic obstructive pulmonary disease , colorectal adenoma , colorectal cancer , gastric adenocarcinoma , hepatocellular carcinoma , invasive ductal carcinoma , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , nasopharynx carcinoma , Neoplasm Metastasis , neuroblastoma , Ovarian Neoplasms , ovarian serous carcinoma , pancreatic cancer , papilloma , prostate carcinoma in situ , Prostatic Neoplasms , Retina Reperfusion Injury , Skin Neoplasms , Sleep Deprivation , tongue squamous cell carcinoma , transient cerebral ischemia , urinary bladder cancer Map2k6 allergic disease , Animal Mammary Neoplasms , Brain Death , Cardiomegaly , cervical cancer , Colonic Neoplasms , Edema , Experimental Diabetes Mellitus , Myocardial Reperfusion Injury , ovarian carcinoma , Pick's disease , progressive supranuclear palsy , prostate carcinoma in situ , Prostatic Neoplasms , restrictive cardiomyopathy Mapk11 autism spectrum disorder , cardiomyopathy , chromosome 22q13 duplication syndrome , congenital disorder of glycosylation Ig , intellectual disability , metachromatic leukodystrophy , Phelan-McDermid syndrome Mapk14 alcohol use disorder , Alzheimer's disease , amyotrophic lateral sclerosis , anti-basement membrane glomerulonephritis , Carcinoma, Lewis Lung , cardiomyopathy , cholestasis , Chronic Cerebral Hypoperfusion , chronic myeloid leukemia , cognitive disorder , Colitis-Associated Neoplasms , colon cancer , colorectal cancer , colorectal carcinoma , Diabetic Nephropathies , diabetic neuropathy , Drug-Related Side Effects and Adverse Reactions , Endotoxemia , extrahepatic cholestasis , gastric adenocarcinoma , heart disease , Hepatic Insufficiency , hepatocellular carcinoma , Hepatomegaly , interstitial cystitis , liver cancer , liver cirrhosis , Liver Neoplasms , lung adenocarcinoma , Lung Neoplasms , melanoma , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , nasopharynx carcinoma , osteoporosis , primary biliary cholangitis , proteasome-associated autoinflammatory syndrome 1 , rectum cancer , restrictive cardiomyopathy Mcl1 Barrett's esophagus , colon cancer , colorectal cancer , COVID-19 , gastrointestinal stromal tumor , High Myopia , immunodeficiency 42 , Intestinal Neoplasms , leishmaniasis , lung adenocarcinoma , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , metabolic dysfunction-associated steatohepatitis , MHC class II deficiency , multiple myeloma , parathyroid carcinoma , primary cutaneous T-cell non-Hodgkin lymphoma , sarcoma , severe congenital neutropenia 3 , severe congenital neutropenia 5 , stomach cancer Mitf Camurati-Engelmann disease , COLOBOMA, OSTEOPETROSIS, MICROPHTHALMIA, MACROCEPHALY, ALBINISM, AND DEAFNESS , Deafness , familial melanoma , Hearing Loss , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , Heterochromia Iridis , intellectual disability , melanoma , Neoplastic Cell Transformation , nonsyndromic deafness , ocular albinism with sensorineural deafness , oculocutaneous albinism , oculocutaneous albinism type IV , osteopetrosis , pigmentation disease , renal cell carcinoma , sensorineural hearing loss , syndromic microphthalmia 5 , Tietz syndrome , Tietze's syndrome , Waardenburg syndrome , Waardenburg syndrome type 1 , Waardenburg Syndrome Type 2 , Waardenburg syndrome type 2A , Waardenburg syndrome type 2E Myc Aberrant Crypt Foci , acute kidney failure , acute lymphoblastic leukemia , acute myeloid leukemia , acute promyelocytic leukemia , adenocarcinoma , Alcoholic Liver Diseases , angiosarcoma , Animal Disease Models , atherosclerosis , autosomal dominant polycystic kidney disease , autosomal recessive polycystic kidney disease , B-lymphoblastic leukemia/lymphoma , breast cancer , Breast Neoplasms , Burkitt lymphoma , carcinoma , Cardiomegaly , Carotid Artery Injuries , cholesteatoma of middle ear , Chromosome Breakage , chronic lymphocytic leukemia , clear cell renal cell carcinoma , cleft lip , cleft palate , Colonic Neoplasms , Colorectal Neoplasms , coronary restenosis , COVID-19 , demyelinating disease , diffuse large B-cell lymphoma , disease of cellular proliferation , Disease Progression , Ductal Carcinoma , Endometrial Neoplasms , esophageal carcinoma , Esophageal Neoplasms , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , glioblastoma , Hemorrhagic Shock , hepatitis C , hepatocellular carcinoma , Hodgkin's lymphoma , hyperparathyroidism , hypertrophic cardiomyopathy , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , leiomyoma , liver cirrhosis , Liver Injury , Liver Neoplasms , lung adenocarcinoma , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lung small cell carcinoma , medulloblastoma , Merkel cell carcinoma , myelodysplastic syndrome , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , neuroblastoma , neuroectodermal tumor , non-Hodgkin lymphoma , obesity , osteoporosis , osteosarcoma , Ovarian Neoplasms , pancreatic cancer , pancreatic carcinoma , polycystic kidney disease , polycystic kidney disease 1 , primary ovarian insufficiency , prolactinoma , prostate adenocarcinoma , prostate cancer , prostate carcinoma in situ , prostatic hypertrophy , Prostatic Neoplasms , pulmonary hypertension , renal cell carcinoma , renal fibrosis , rhabdoid cancer , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , squamous cell carcinoma , steatotic liver disease , Stomach Neoplasms , thyroid cancer , thyroid gland papillary carcinoma , Transplant Rejection , trichorhinophalangeal syndrome type I , urinary bladder cancer , Uterine Cervical Neoplasms Pias1 Arsenic Poisoning , Bloom syndrome , Brain Injuries , colorectal cancer , focal segmental glomerulosclerosis , nephronophthisis , neuronal ceroid lipofuscinosis , skin disease Pias3 gastrointestinal stromal tumor , parathyroid carcinoma , schizophrenia , thrombocytopenia-absent radius syndrome , Uterine Cervical Neoplasms Pik3ca adenocarcinoma , adenoid cystic carcinoma , adrenocortical carcinoma , Agenesis of Corpus Callosum , autosomal recessive polycystic kidney disease , Bannayan-Riley-Ruvalcaba syndrome , basal cell carcinoma , Brain Neoplasms , breast adenocarcinoma , breast angiosarcoma , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , Cardiovascular Abnormalities , Cerebral Cavernous Malformation 4 , CLAPO Syndrome , CLOVES syndrome , colon adenocarcinoma , colon carcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , complex cortical dysplasia with other brain malformations , Cowden syndrome , Cowden syndrome 5 , Currarino syndrome , cutaneous Paget's disease , Developmental Disabilities , Diabetic Cardiomyopathies , diaphragmatic eventration , diffuse large B-cell lymphoma , disease of cellular proliferation , Disease Progression , Down syndrome , endometrial carcinoma , Endometrial Neoplasms , epidermal nevus , esophageal cancer , esophageal carcinoma , esophagus adenocarcinoma , estrogen-receptor positive breast cancer , Facial Asymmetry , familial multiple nevi flammei , gallbladder cancer , gallbladder carcinoma , gastric adenocarcinoma , Gastrointestinal Neoplasms , genetic disease , glioblastoma , glycogen storage disease II , Growth Disorders , head and neck cancer , Head and Neck Neoplasms , head and neck squamous cell carcinoma , Hemimegalencephaly , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , high grade glioma , Hyperplasia , Hypertelorism , keratoacanthoma , Klippel-Trenaunay syndrome , liver cancer , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung oat cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , Macrocephaly , medulloblastoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalodactyly , melanoma , Mouth Neoplasms , multiple myeloma , Nasopharyngeal Neoplasms , Neoplasm Metastasis , neuroblastoma , NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES , non-Hodgkin lymphoma , Noonan syndrome 8 , ovarian cancer , Ovarian Neoplasms , ovarian serous cystadenocarcinoma , pancreatic adenocarcinoma , papillary renal cell carcinoma , Paraproteinemias , Penile Neoplasms , plasma cell neoplasm , polycystic kidney disease , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , PTEN hamartoma tumor syndrome , rectal benign neoplasm , renal cell carcinoma , Renal Cell Carcinoma 1 , rosette-forming glioneuronal tumor , sarcoma , seborrheic keratosis , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Stroke , Thyroid Neoplasms , transitional cell carcinoma , urinary bladder cancer , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Vascular Malformations , Ventricular Dysfunction, Left , Weight Gain Pik3r1 agammaglobulinemia 7 , Alzheimer's disease , Animal Mammary Neoplasms , astroblastoma , Brain Neoplasms , Breast Neoplasms , Burkitt lymphoma , carcinoma , CLOVES syndrome , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , disease of cellular proliferation , endometrial adenocarcinoma , endometrial cancer , endometrial carcinoma , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , genetic disease , glioblastoma , glucose intolerance , hepatocellular carcinoma , hypertension , hypoglycemia , immunodeficiency 36 , Insulin Resistance , lung adenocarcinoma , lung small cell carcinoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , melanoma , Nematode Infections , Neurodevelopmental Disorders , obesity , osteoarthritis , Ovarian Neoplasms , portal hypertension , primary immunodeficiency disease , prostate cancer , Prostatic Neoplasms , renal cell carcinoma , Reperfusion Injury , rheumatoid arthritis , Septic Peritonitis , SHORT syndrome , skin melanoma , Smith-Kingsmore Syndrome , type 2 diabetes mellitus , uterine cancer , uterine carcinosarcoma , Vascular Malformations , vitiligo , X-linked agammaglobulinemia Prkcd autoimmune lymphoproliferative syndrome type 3 , brain ischemia , Burns , Cardiomegaly , Chemical and Drug Induced Liver Injury , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Fever , genetic disease , hyperinsulinism , hypertension , Hypothermia , Insulin Resistance , Intestinal Neoplasms , Left Ventricular Hypertrophy , metabolic dysfunction-associated steatotic liver disease , muscular disease , Myocardial Ischemia , Myocardial Reperfusion Injury , obesity , Parkinsonism , portal hypertension , restrictive cardiomyopathy , Right Ventricular Hypertrophy , steatotic liver disease , Stroke , toxic encephalopathy Ptpn11 acute myeloid leukemia , acute promyelocytic leukemia , adenocarcinoma , anogenital venereal wart , aortic valve stenosis , arrhythmogenic right ventricular cardiomyopathy , atrial heart septal defect 1 , atrophic gastritis , autism spectrum disorder , B-Cell Chronic Lymphocytic Leukemia , Brain Neoplasms , Cafe-au-Lait Spots , cancer , cardiofaciocutaneous syndrome , cardiomyopathy , Cardiovascular Abnormalities , Carotid Artery Injuries , cervical cancer , chondroma , chronic lymphocytic leukemia , Colorectal Neoplasms , Costello syndrome , craniosynostosis , Developmental Disabilities , dilated cardiomyopathy , disease of metabolism , Duane retraction syndrome , Dwarfism , embryonal rhabdomyosarcoma , Experimental Leukemia , Failure to Thrive , Fetal Growth Retardation , Funnel Chest , gastric adenocarcinoma , genetic disease , glaucoma , Haemophilus Infections , Helicobacter Infections , hemorrhagic disease , hepatocellular adenoma , hereditary multiple exostoses , Hereditary Neoplastic Syndromes , high grade glioma , Hydrops Fetalis , hypertrophic cardiomyopathy , idiopathic scoliosis , influenza , intellectual disability , juvenile myelomonocytic leukemia , learning disability , leukemia , lung adenocarcinoma , lung squamous cell carcinoma , lymphoma , malignant astrocytoma , metachondromatosis , microcephaly , multiple myeloma , myeloid leukemia associated with Down Syndrome , neuroblastoma , Neurodevelopmental Disorders , neurofibroma , neurofibromatosis-Noonan syndrome , Noonan Like Syndrome , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , Noonan syndrome with multiple lentigines , Noonan syndrome with multiple lentigines 1 , Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia , Ollier disease , Osteochondroma , Paraproteinemias , patent ductus arteriosus , patent foramen ovale , plasma cell neoplasm , ptosis , RASopathy , Right Ventricular Hypertrophy , scoliosis , spermatogenic failure 57 , squamous cell carcinoma , Staphylococcal Pneumonia , stomach cancer , strabismus , T-cell acute lymphoblastic leukemia , tetralogy of Fallot , thrombocytopenia , tricuspid valve insufficiency , Ventricular Premature Complexes , Ventricular Tachycardia , Werner syndrome Rac1 autosomal dominant intellectual developmental disorder 48 , breast cancer , Cardiomegaly , Cardiotoxicity , colon adenocarcinoma , colon adenoma , colorectal adenocarcinoma , colorectal cancer , colorectal carcinoma , congestive heart failure , Developmental Disabilities , Developmental Disease , diabetes mellitus , dilated cardiomyopathy , extrahepatic bile duct adenocarcinoma , gallbladder carcinoma , gastric adenocarcinoma , genetic disease , head and neck squamous cell carcinoma , hepatocellular carcinoma , Left Ventricular Hypertrophy , liver disease , lung adenocarcinoma , lung cancer , melanoma , nasopharynx carcinoma , Neoplasm Metastasis , Neoplastic Cell Transformation , neurodevelopmental disorder with dysmorphic facies and distal limb anomalies , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , Sepsis , skin melanoma , stomach cancer , uterine cancer , Ventricular Dysfunction, Left Socs3 atherosclerosis , Burns , cholangiocarcinoma , ductal carcinoma in situ , Endometrial Neoplasms , Endotoxemia , Experimental Arthritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Fibrosis , Helicobacter Infections , hepatocellular carcinoma , human immunodeficiency virus infectious disease , Hypertriglyceridemia , Insulin Resistance , invasive ductal carcinoma , liver disease , Lymphatic Metastasis , Myocardial Ischemia , obesity , Reperfusion Injury , Sepsis , status epilepticus , steatotic liver disease , type 2 diabetes mellitus Sos1 arrhythmogenic right ventricular cardiomyopathy , atrial heart septal defect , Atrial Septal Defect, Secundum Type , brain ischemia , Brugada syndrome , Cafe au lait Spots, Multiple , cardiomyopathy , cerebral infarction , cervical cancer , congenital heart disease , dilated cardiomyopathy , Dwarfism , familial hypertrophic cardiomyopathy , genetic disease , gingival fibromatosis , Gingival Fibromatosis 1 , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , intellectual disability , Joubert syndrome 3 , lung adenocarcinoma , Lynch syndrome , male infertility , Muscle Hypotonia , Neurodevelopmental Disorders , Noonan Like Syndrome , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , Noonan syndrome 4 , Nuchal Bleb, Familial , prostate cancer , ptosis , pulmonary valve stenosis , RASopathy , spermatogenic failure 57 , Stroke , Sudden Unexpected Nocturnal Death Syndrome , uterine cancer , Ventricular Tachycardia Sos2 Brain-Lung-Thyroid Syndrome , Developmental Disease , L-2-hydroxyglutaric aciduria , male infertility , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 9 , RASopathy Stat1 angiomyolipoma , Brain Injuries , breast cancer , breast carcinoma , chronic mucocutaneous candidiasis , colon adenocarcinoma , COVID-19 , Cytomegalovirus Infections , disease by infectious agent , Disease Progression , Dwarfism , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Failure to Thrive , gastric adenocarcinoma , genetic disease , Hearing Loss , hepatitis C , hepatocellular carcinoma , Human Influenza , immunodeficiency 31A , immunodeficiency 31B , immunodeficiency 31C , liver cirrhosis , lupus nephritis , lymphangioleiomyomatosis , lymphocytic choriomeningitis , Mycobacterium Infections , Myocardial Reperfusion Injury , Neoplasm Metastasis , nephroblastoma , Nervous System Trauma , Neurodevelopmental Disorders , Nontuberculous Mycobacterium Infections , pancreatic adenocarcinoma , periodontitis , primary immunodeficiency disease , prostate adenocarcinoma , pulmonary fibrosis , Reoviridae Infections , Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , severe acute respiratory syndrome , T-cell acute lymphoblastic leukemia Stat3 acute myeloid leukemia , adenocarcinoma , adenoid cystic carcinoma , adult T-cell leukemia/lymphoma , Alzheimer's disease , anaplastic large cell lymphoma , angiomyolipoma , angiosarcoma , Animal Disease Models , Animal Mammary Neoplasms , atherosclerosis , Atrophy , autistic disorder , autoimmune disease , B-lymphoblastic leukemia/lymphoma , bacterial pneumonia , Behcet's disease , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , carcinoma , Cardiomegaly , cardiomyopathy , cervix uteri carcinoma in situ , Choroidal Neovascularization , Chronic Hepatitis , Chronic Hepatitis C , chronic lymphocytic leukemia , Churg-Strauss syndrome , colon adenocarcinoma , colon cancer , Colonic Neoplasms , colorectal cancer , colorectal carcinoma , congenital diaphragmatic hernia , congestive heart failure , Copper-Overload Cirrhosis , Crohn's disease , depressive disorder , Diabetic Nephropathies , diffuse large B-cell lymphoma , duodenal ulcer , Endometrial Neoplasms , Epidermal Hyperplasia , esophageal carcinoma , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Uveitis , Experimental Autoimmune Uveoretinitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Fever , Fibrosis , follicular dendritic cell sarcoma , gastric adenocarcinoma , genetic disease , glioblastoma , growth hormone insensitivity syndrome with immune dysregulation 1 , head and neck squamous cell carcinoma , heart disease , hepatocellular carcinoma , hyper IgE recurrent infection syndrome 1 , hyper IgE syndrome , Hyperalgesia , hyperuricemia , Inflammation , inflammatory bowel disease , interstitial lung disease 2 , irritant dermatitis , juvenile rheumatoid arthritis , liver cirrhosis , Liver Injury , Liver Neoplasms , lung non-small cell carcinoma , lymphangioleiomyomatosis , Lymphatic Metastasis , lymphoproliferative syndrome , medulloblastoma , Memory Disorders , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , Multisystem Autoimmune Disease, Infantile-Onset, 1 , Myocardial Reperfusion Injury , Nasal Polyps , nasal type extranodal NK/T-cell lymphoma , nasopharynx carcinoma , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , neutropenia , Niemann-Pick disease type C1 , obesity , ovarian cancer , Ovarian Neoplasms , Oxygen-Induced Retinopathy , pancreatic cancer , periodontitis , peripartum cardiomyopathy , pre-malignant neoplasm , primary immunodeficiency disease , prostate cancer , prostate carcinoma , Prostatic Neoplasms , psoriasis , psoriatic arthritis , pulmonary fibrosis , Pyogenic Granuloma , rectum adenocarcinoma , renal cell carcinoma , Reperfusion Injury , Retina Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , Sepsis-Associated Encephalopathy , skin melanoma , Skin Neoplasms , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Subarachnoid Hemorrhage , T-cell acute lymphoblastic leukemia , T-cell non-Hodgkin lymphoma , Tongue Neoplasms , transient cerebral ischemia , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , urinary bladder cancer , Uterine Cervical Neoplasms Timp1 adrenoleukodystrophy , adult respiratory distress syndrome , alcoholic liver cirrhosis , Animal Disease Models , aortic valve insufficiency , atherosclerosis , autistic disorder , autoimmune disease , Brain Injuries , breast cancer , CAKUT2 , calcinosis , cholangitis , cholestasis , chronic obstructive pulmonary disease , congenital disorder of glycosylation type IIm , congestive heart failure , COVID-19 , cystic fibrosis , degenerative disc disease , diabetes mellitus , Down syndrome , Emphysema , endometrial carcinoma , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , extrahepatic cholestasis , Female Urogenital Diseases , gastric ulcer , heart disease , heart valve disease , Hemorrhagic Shock , hyperhomocysteinemia , Hyperoxia , hypertension , IgA glomerulonephritis , immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome , Inflammation , intracranial aneurysm , Kawasaki disease , Lymphatic Metastasis , Neoplasm Invasiveness , Neoplasm Metastasis , neurodegeneration with brain iron accumulation 5 , obesity , oral submucous fibrosis , ovarian cancer , pre-eclampsia , preretinal fibrosis , pulmonary fibrosis , relapsing-remitting multiple sclerosis , renal cell carcinoma , Stroke , syndromic X-linked intellectual disability Lubs type , thoracic aortic aneurysm , transitional cell carcinoma , type 1 diabetes mellitus , type 2 diabetes mellitus , varicose veins , vascular disease , Wilson disease , Wounds and Injuries , X-linked epilepsy with variable learning disabilities and behavior disorders , X-linked severe congenital neutropenia Tnfsf11 Alveolar Bone Loss , autosomal recessive osteopetrosis 2 , B-Cell Chronic Lymphocytic Leukemia , bone resorption disease , Chronic Periodontitis , genetic disease , hypercalcemia , mucopolysaccharidosis VI , myocardial infarction , myocarditis , Osteolysis , osteopetrosis , osteoporosis , osteosclerosis , Tibial Fractures Tyk2 autistic disorder , Cocaine-Related Disorders , COVID-19 , Crohn's disease , genetic disease , immunodeficiency 35 , multiple sclerosis , obesity , Paranoid Disorders , primary biliary cholangitis , psoriasis , rheumatoid arthritis , T-cell acute lymphoblastic leukemia , type 1 diabetes mellitus Vav1 adult T-cell leukemia/lymphoma , autistic disorder , endometriosis , Experimental Liver Cirrhosis , hepatocellular carcinoma , lung adenocarcinoma , lymphopenia , medulloblastoma , mucolipidosis type IV , type 1 diabetes mellitus
abdominal aortic aneurysm Crp Aberrant Crypt Foci Fos , Myc Acute Coronary Syndrome Crp , Il6 Acute Experimental Pancreatitis Jak1 Acute Hepatitis Il6 acute kidney failure A2m , Crp , Il6 , Jak2 , Myc Acute Liver Failure Il6 Acute Lung Injury Akt1 , Il6 acute lymphoblastic leukemia Hck , Myc Acute Lymphoblastic Leukemia, with Lymphomatous Features Jak1 , Jak2 acute myeloid leukemia Cebpd , Foxo1 , Il6 , Jak1 , Jak2 , Myc , Ptpn11 , Stat3 acute myocardial infarction Fos , Il6 acute necrotizing pancreatitis Il6 acute promyelocytic leukemia Akt1 , Myc , Ptpn11 acute stress disorder Crp Acute Uveitis Crp Acute-Phase Reaction Il6 , Il6r adenocarcinoma Akt1 , Cebpb , Myc , Pik3ca , Ptpn11 , Stat3 adenoid cystic carcinoma Pik3ca , Stat3 adrenocortical carcinoma Jak2 , Pik3ca adrenoleukodystrophy Timp1 adult respiratory distress syndrome Timp1 adult T-cell leukemia/lymphoma Il6 , Stat3 , Vav1 agammaglobulinemia 7 Pik3r1 Agenesis of Corpus Callosum Pik3ca aggressive periodontitis Crp , Il6 Albuminuria Crp , Il6 alcohol dependence Fos alcohol use disorder Fos , Mapk14 alcohol withdrawal syndrome Fos Alcohol-Related Disorders Fos , Jun Alcoholic Fatty Liver Crp , Foxo1 Alcoholic Intoxication Fos alcoholic liver cirrhosis Crp , Il6 , Jak2 , Timp1 Alcoholic Liver Diseases Myc allergic conjunctivitis Irf1 allergic disease Il6 , Il6st , Map2k6 alpha-mannosidosis Junb Alveolar Bone Loss Il6 , Tnfsf11 alveolar rhabdomyosarcoma Foxo1 Alzheimer's disease A2m , Adam10 , Adam17 , Akt1 , Cebpb , Crp , Il6 , Il6r , Il6st , Jak2 , Mapk14 , Pik3r1 , Stat3 Alzheimer's disease 18 Adam10 amnestic disorder Il6 amphetamine abuse Akt1 , Fos amyotrophic lateral sclerosis Akt1 , Mapk14 amyotrophic lateral sclerosis type 1 Fos anaplastic large cell lymphoma Junb , Stat3 anemia Il6 , Jak2 anencephaly Lmo4 angiomyolipoma Stat1 , Stat3 angiosarcoma Jun , Myc , Stat3 Animal Disease Models Akt1 , Fos , Myc , Stat3 , Timp1 Animal Mammary Neoplasms Il6st , Map2k6 , Pik3r1 , Stat3 Animal Toxoplasmosis Il6 ankylosing spondylitis Crp , Il6 , Jak2 anogenital venereal wart Il6 , Ptpn11 anti-basement membrane glomerulonephritis Mapk14 antiphospholipid syndrome Crp anxiety disorder Crp , Fos aortic valve disease 1 Il6 aortic valve insufficiency Timp1 aortic valve stenosis Ptpn11 arrhythmogenic right ventricular cardiomyopathy Il6r , Ptpn11 , Sos1 Arsenic Poisoning Crp , Pias1 arteriosclerosis Il6st arteriovenous malformations of the brain Il6 Ascorbic Acid Deficiency Il6 aseptic meningitis Il6 aspergillosis Crp Asphyxia Jun asthma Crp , Il6 , Il6r , Irf1 astroblastoma Pik3r1 ataxia telangiectasia Il6 atherosclerosis Akt1 , Crp , Il6 , Jak2 , Myc , Socs3 , Stat3 , Timp1 atopic dermatitis Adam17 , Il6 atrial fibrillation Crp atrial heart septal defect Sos1 atrial heart septal defect 1 Ptpn11 Atrial Septal Defect, Secundum Type Sos1 atrophic gastritis Ptpn11 Atrophy Stat3 autism spectrum disorder Mapk11 , Ptpn11 autistic disorder Il6 , Stat3 , Timp1 , Tyk2 , Vav1 autoimmune disease Hck , Il6 , Stat3 , Timp1 autoimmune hepatitis Il6 autoimmune interstitial lung, joint, and kidney disease Crp autoimmune lymphoproliferative syndrome type 3 Prkcd autoimmune thyroiditis Il6 Autoinflammation with Pulmonary and Cutaneous Vasculitis Hck Autoinflammation, Immune Dysregulation, and Eosinophilia Jak1 autosomal dominant intellectual developmental disorder 48 Rac1 autosomal dominant polycystic kidney disease Fos , Myc autosomal recessive nonsyndromic deafness 26 Gab1 autosomal recessive osteopetrosis 2 Tnfsf11 autosomal recessive polycystic kidney disease Akt1 , Myc , Pik3ca B-Cell Chronic Lymphocytic Leukemia Il6 , Ptpn11 , Tnfsf11 B-lymphoblastic leukemia/lymphoma Myc , Stat3 background diabetic retinopathy A2m Bacteremia Cebpb , Crp bacterial gastritis Jak2 bacterial infectious disease Crp bacterial meningitis Crp bacterial pneumonia Il6 , Irf1 , Stat3 Bannayan-Riley-Ruvalcaba syndrome Pik3ca Barrett's esophagus Mcl1 basal cell carcinoma Il6 , Pik3ca Behcet's disease Crp , Il6 , Stat3 berylliosis Il6 beta thalassemia Il6 Bile Duct Neoplasms Il6 biliary tract benign neoplasm Il6 Binge Drinking Fos bipolar disorder Akt1 Blister Adam17 blood coagulation disease Fgg Bloom syndrome Adam10 , Pias1 bone osteosarcoma Akt1 bone resorption disease Tnfsf11 Brain Concussion Il6 Brain Death Map2k4 , Map2k6 Brain Hypoxia Adam17 Brain Hypoxia-Ischemia Crp , Fos , Il6 Brain Injuries Akt1 , Cebpb , Crp , Fos , Il6 , Irf1 , Jak2 , Jun , Pias1 , Stat1 , Stat3 , Timp1 brain ischemia Akt1 , Cebpb , Il6 , Il6st , Jun , Prkcd , Sos1 , Stat3 Brain Neoplasms Pik3ca , Pik3r1 , Ptpn11 brain small vessel disease Fgg Brain-Lung-Thyroid Syndrome Sos2 breast adenocarcinoma Akt1 , Pik3ca breast angiosarcoma Pik3ca breast cancer Akt1 , Crp , Grb2 , Il6 , Jun , Myc , Pik3ca , Rac1 , Stat1 , Stat3 , Timp1 Breast Cancer, Familial Akt1 , Pik3ca breast carcinoma Crp , Pik3ca , Stat1 Breast Neoplasms Adam10 , Akt1 , Fos , Il6 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Stat3 bronchiolitis Crp bronchiolitis obliterans Il6 Brugada syndrome Sos1 Budd-Chiari syndrome Jak2 Burkitt lymphoma Myc , Pik3r1 Burns A2m , Crp , Il6 , Lbp , Prkcd , Socs3 Cachexia Cebpb , Il6 , Jak2 Cadmium Poisoning Il6 Cafe au lait Spots, Multiple Sos1 Cafe-au-Lait Spots Ptpn11 CAKUT2 Timp1 Calcification of Aortic Valve Akt1 calcinosis Jak2 , Timp1 Camurati-Engelmann disease Mitf cancer Ptpn11 Cancer Pain Jak2 cannabis abuse Akt1 Carcinogenesis Akt1 carcinoma Il6st , Myc , Pik3r1 , Stat3 Carcinoma, Lewis Lung Mapk14 cardiac arrest Akt1 Cardiac Arrhythmias Crp , Map2k4 cardiofaciocutaneous syndrome Ptpn11 Cardiomegaly A2m , Akt1 , Cebpb , Il6 , Il6st , Map2k6 , Myc , Prkcd , Rac1 , Stat3 cardiomyopathy Adam10 , Akt1 , Il6 , Mapk11 , Mapk14 , Ptpn11 , Sos1 , Stat3 Cardiotoxicity Rac1 Cardiovascular Abnormalities Pik3ca , Ptpn11 Cardiovascular Pregnancy Complications Il6 cardiovascular system disease Crp Carotid Artery Injuries Myc , Ptpn11 Castleman disease Il6 cataract Adam10 celiac disease Il6 central nervous system disease Il6 Cerebral Cavernous Malformation 4 Pik3ca Cerebral Hemorrhage Il6 cerebral infarction A2m , Il6 , Sos1 cerebrovascular disease Crp cervical cancer Map2k6 , Ptpn11 , Sos1 cervical squamous cell carcinoma Fos cervix uteri carcinoma in situ Stat3 Charcot-Marie-Tooth disease axonal type 2O Akt1 Charcot-Marie-Tooth disease dominant intermediate B Junb Charcot-Marie-Tooth disease type 2 Il6r Chemical and Drug Induced Liver Injury Crp , Il6 , Lbp , Prkcd Chemical Burns Il6 Chemically-Induced Disorders Il6 cholangiocarcinoma Il6 , Socs3 cholangitis Timp1 cholestasis Il6 , Mapk14 , Timp1 cholesteatoma of middle ear Il6 , Myc chondroma Ptpn11 chorioamnionitis Il6 Choroidal Neovascularization Stat3 chromosome 22q13 duplication syndrome Mapk11 chromosome 9p deletion syndrome Jak2 Chromosome Breakage Myc Chronic Cerebral Hypoperfusion Mapk14 Chronic Hepatitis Stat3 Chronic Hepatitis B Jak1 Chronic Hepatitis C Crp , Il6 , Stat3 chronic lymphocytic leukemia Myc , Ptpn11 , Stat3 chronic mucocutaneous candidiasis Stat1 chronic myelogenous leukemia, BCR-ABL1 positive Jak2 chronic myeloid leukemia Akt1 , Gab2 , Jak2 , Mapk14 chronic obstructive pulmonary disease Crp , Il6 , Jun , Map2k4 , Timp1 Chronic Periodontitis Tnfsf11 Churg-Strauss syndrome Stat3 CLAPO Syndrome Pik3ca clear cell renal cell carcinoma Myc cleft lip Myc cleft palate Myc CLOVES syndrome Pik3ca , Pik3r1 cocaine abuse Fos cocaine dependence Fos Cocaine-Related Disorders Fos , Tyk2 cochlear disease Il6 cognitive disorder Mapk14 Cognitive Dysfunction Adam10 colitis Adam17 , Il6 Colitis-Associated Neoplasms Mapk14 COLOBOMA, OSTEOPETROSIS, MICROPHTHALMIA, MACROCEPHALY, ALBINISM, AND DEAFNESS Mitf colon adenocarcinoma Jak2 , Pik3ca , Rac1 , Stat1 , Stat3 colon adenoma Rac1 colon cancer Akt1 , Crp , Jak2 , Junb , Mapk14 , Mcl1 , Stat3 colon carcinoma Akt1 , Pik3ca Colonic Neoplasms A2m , Fos , Jun , Map2k6 , Myc , Pik3r1 , Stat3 colorectal adenocarcinoma Fos , Jun , Junb , Rac1 colorectal adenoma Fos , Jun , Map2k4 colorectal cancer Adam10 , Akt1 , Il6 , Jak1 , Junb , Map2k4 , Mapk14 , Mcl1 , Pias1 , Pik3ca , Pik3r1 , Rac1 , Stat3 colorectal carcinoma Il6 , Jak2 , Mapk14 , Pik3ca , Rac1 , Stat3 Colorectal Neoplasms Akt1 , Fos , Il6st , Myc , Pik3ca , Pik3r1 , Ptpn11 complex cortical dysplasia with other brain malformations Pik3ca congenital afibrinogenemia Fgg congenital diaphragmatic hernia Stat3 congenital disorder of glycosylation Ig Mapk11 congenital disorder of glycosylation type IIm Timp1 Congenital Dysfibrinogenemia Fgg congenital heart disease Sos1 Congenital Hypodysfibrinogenemia Fgg congenital hypothyroidism Fos congestive heart failure Adam17 , Crp , Fos , Foxo1 , Il6 , Il6r , Rac1 , Stat3 , Timp1 conjunctival disease Il6 Contrast-Induced Nephropathy Crp Copper-Overload Cirrhosis Stat3 corneal ulcer Il6 coronary artery disease Akt1 , Crp , Il6 coronary restenosis Myc Coronavirus infectious disease Il6 Costello syndrome Ptpn11 COVID-19 A2m , Crp , Hck , Il6 , Jak2 , Jun , Mcl1 , Myc , Stat1 , Timp1 , Tyk2 Cowden syndrome Pik3ca Cowden syndrome 5 Pik3ca Cowden syndrome 6 Akt1 Coxsackievirus Infections Il6 craniosynostosis Ptpn11 Crohn's disease Crp , Il6 , Jak2 , Stat3 , Tyk2 Currarino syndrome Pik3ca cutaneous Paget's disease Pik3ca cystic fibrosis Il6 , Irf1 , Timp1 Cytomegalovirus Infections Stat1 Deafness Mitf degenerative disc disease Fos , Timp1 demyelinating disease Myc depressive disorder Crp , Fos , Il6 , Il6r , Jun , Stat3 Developmental Disabilities Pik3ca , Ptpn11 , Rac1 Developmental Disease Rac1 , Sos2 diabetes mellitus Il6 , Rac1 , Timp1 Diabetic Cardiomyopathies A2m , Akt1 , Hsp90b1 , Pik3ca Diabetic Foot Crp Diabetic Nephropathies Crp , Il6 , Jak2 , Mapk14 , Stat3 diabetic neuropathy Mapk14 diabetic retinopathy Akt1 , Crp , Il6 diaphragmatic eventration Pik3ca Diaphragmatic Hernia Il6 diffuse large B-cell lymphoma Foxo1 , Myc , Pik3ca , Stat3 diffuse scleroderma Il6 dilated cardiomyopathy Ptpn11 , Rac1 , Sos1 disease by infectious agent Crp , Stat1 disease of cellular proliferation Hck , Myc , Pik3ca , Pik3r1 disease of metabolism Crp , Ptpn11 Disease Progression Cebpb , Myc , Pik3ca , Stat1 disseminated intravascular coagulation Il6 Dowling-Degos disease Adam10 Down syndrome Pik3ca , Timp1 Drug Hypersensitivity Syndrome Crp , Lbp Drug-Related Side Effects and Adverse Reactions Il6 , Mapk14 dry eye syndrome Il6 Duane retraction syndrome Ptpn11 Ductal Carcinoma Myc ductal carcinoma in situ Socs3 duodenal ulcer Stat3 Dwarfism Ptpn11 , Sos1 , Stat1 dyschromatosis symmetrica hereditaria Il6r Eales Disease Il6 eclampsia Il6 Edema Il6 , Map2k6 embryonal rhabdomyosarcoma Ptpn11 Emphysema Timp1 end stage renal disease Crp , Il6 endometrial adenocarcinoma Irf1 , Jun , Pik3r1 endometrial cancer Jak1 , Pik3r1 endometrial carcinoma Grb2 , Jun , Pik3ca , Pik3r1 , Timp1 Endometrial Neoplasms Myc , Pik3ca , Socs3 , Stat3 Endometrioid Carcinomas Akt1 endometriosis Fos , Vav1 Endotoxemia Akt1 , Cebpb , Il6 , Lbp , Mapk14 , Socs3 Entamoebiasis Il6 Eosinophilia Cebpb Epidermal Hyperplasia Stat3 epidermal nevus Pik3ca epididymitis Il6 epilepsy Akt1 , Fos , Il6 episodic ataxia type 2 Junb esophageal cancer Akt1 , Pik3ca esophageal carcinoma Jak2 , Myc , Pik3ca , Stat3 Esophageal Neoplasms Myc esophagus adenocarcinoma Pik3ca esophagus squamous cell carcinoma Akt1 , Jak2 , Junb essential thrombocythemia Jak2 estrogen-receptor positive breast cancer Pik3ca exanthem Lbp Experimental Arthritis A2m , Adam10 , Adam17 , Akt1 , Crp , Fos , Il6 , Il6st , Jak1 , Jak2 , Socs3 , Stat1 , Stat3 Experimental Autoimmune Encephalomyelitis A2m , Adam17 , Il6 , Jak2 , Stat1 , Stat3 Experimental Autoimmune Myocarditis Il6 Experimental Autoimmune Uveitis Stat3 Experimental Autoimmune Uveoretinitis Stat3 Experimental Colitis Adam17 , Akt1 , Il6 , Jak2 , Socs3 Experimental Diabetes Mellitus Akt1 , Crp , Il6 , Map2k6 , Myc , Pik3r1 , Prkcd , Socs3 , Stat1 , Stat3 , Timp1 Experimental Leukemia Ptpn11 Experimental Liver Cirrhosis A2m , Adam17 , Cebpd , Crp , Fgg , Fos , Foxo1 , Gab1 , Hck , Il6 , Jak2 , Lbp , Myc , Prkcd , Stat3 , Timp1 , Vav1 Experimental Liver Neoplasms Il6 , Jak2 , Myc , Stat3 Experimental Mammary Neoplasms Akt1 , Il6st , Myc , Pik3r1 , Socs3 , Stat1 , Stat3 Experimental Neoplasms Stat3 extrahepatic bile duct adenocarcinoma Rac1 extrahepatic cholestasis Fos , Il6 , Jun , Mapk14 , Timp1 Facial Asymmetry Pik3ca Failure to Thrive Ptpn11 , Stat1 familial adenomatous polyposis Akt1 familial adenomatous polyposis 1 Irf1 familial erythrocytosis 1 Jak2 familial erythrocytosis 2 Jak2 familial hyperlipidemia Crp familial hypertrophic cardiomyopathy Sos1 familial Mediterranean fever Il6 familial melanoma Mitf familial multiple nevi flammei Pik3ca Female Infertility Cebpb Female Urogenital Diseases Timp1 Femoral Fractures Il6 Femur Head Necrosis A2m Fetal Growth Retardation Fos , Ptpn11 Fetal Inflammatory Response Syndrome Il6 Fever A2m , Il6 , Il6r , Prkcd , Stat3 Fever of Unknown Origin Crp Fibrosis Adam10 , Akt1 , Cebpb , Socs3 , Stat3 Fibrous Dysplasia of Bone Fos focal epilepsy Lbp focal segmental glomerulosclerosis Pias1 focal segmental glomerulosclerosis 5 Akt1 follicular dendritic cell sarcoma Stat3 Foot Injuries Il6 Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis Adam10 functional diarrhea Fos Funnel Chest Ptpn11 gallbladder cancer Junb , Pik3ca gallbladder carcinoma Pik3ca , Rac1 gastric adenocarcinoma Akt1 , Il6 , Irf1 , Map2k4 , Mapk14 , Pik3ca , Ptpn11 , Rac1 , Stat1 , Stat3 gastric dilatation Il6 gastric ulcer Fos , Timp1 Gastrointestinal Neoplasms Pik3ca gastrointestinal stromal tumor Crp , Il6r , Mcl1 , Pias3 genetic disease Adam10 , Adam17 , Akt1 , Fgg , Jak1 , Jak2 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Sos1 , Stat1 , Stat3 , Tnfsf11 , Tyk2 Genetic Predisposition to Disease Jak2 gestational diabetes Il6 gingival fibromatosis Sos1 Gingival Fibromatosis 1 Sos1 gingivitis Il6 glaucoma Jun , Ptpn11 glioblastoma Akt1 , Myc , Pik3ca , Pik3r1 , Stat3 glomerulonephritis Fos , Il6 glucose intolerance Jak2 , Pik3r1 glucosephosphate dehydrogenase deficiency Il6 glutaric acidemia I Junb glycogen storage disease II Pik3ca Graves' disease Il6 , Il6r Growth Disorders Jak2 , Pik3ca growth hormone insensitivity syndrome with immune dysregulation 1 Stat3 Haemophilus Infections Ptpn11 Hashimoto Disease Il6 , Il6r head and neck cancer Pik3ca Head and Neck Neoplasms Pik3ca head and neck squamous cell carcinoma Akt1 , Junb , Pik3ca , Rac1 , Stat3 Headache Il6 Hearing Loss Mitf , Stat1 Hearing Loss, Noise-Induced Il6 heart disease A2m , Crp , Jak2 , Mapk14 , Stat3 , Timp1 Heart Injuries Il6 heart valve disease Jak2 , Timp1 Heat Stress Disorders Il6 Heat Stroke Fos , Il6 , Il6r , Jun Helicobacter Infections Gab1 , Il6 , Ptpn11 , Socs3 hemangioma Foxo1 hemarthrosis Il6 Hematuria Fos Hemifacial Spasm Il6 Hemimegalencephaly Pik3ca hemolytic anemia A2m hemolytic-uremic syndrome Fos , Il6 Hemorrhage Fgg , Fos hemorrhagic disease Fgg , Ptpn11 Hemorrhagic Shock Il6 , Myc , Timp1 Hepatic Insufficiency Mapk14 hepatitis B Il6 , Irf1 hepatitis C Il6 , Myc , Stat1 hepatocellular adenoma A2m , Ptpn11 hepatocellular carcinoma A2m , Akt1 , Cebpb , Cebpd , Crp , Fos , Foxo1 , Il6 , Il6st , Jak1 , Jak2 , Jun , Map2k4 , Mapk14 , Myc , Pik3ca , Pik3r1 , Rac1 , Socs3 , Stat1 , Stat3 , Vav1 Hepatomegaly Akt1 , Mapk14 hereditary breast ovarian cancer syndrome Jak2 , Mitf hereditary multiple exostoses Ptpn11 Hereditary Neoplastic Syndromes Akt1 , Irf1 , Mitf , Pik3ca , Ptpn11 hereditary spastic paraplegia 4 Fgg Heterochromia Iridis Mitf high grade glioma Pik3ca , Ptpn11 High Myopia Mcl1 HIV Wasting Syndrome Il6 Hodgkin's lymphoma Il6 , Jun , Junb , Myc human immunodeficiency virus infectious disease Crp , Il6 , Socs3 Human Influenza Crp , Il6 , Stat1 Huntington's disease Cebpb , Il6 , Il6r Hydrops Fetalis Ptpn11 hyper IgE recurrent infection syndrome 1 Il6st , Stat3 hyper IgE recurrent infection syndrome 4 Il6st hyper IgE syndrome Stat3 Hyper-IgE Recurrent Infection Syndrome 5 Il6r Hyperalgesia Fos , Il6 , Il6r , Jak2 , Stat3 hyperandrogenism Il6st hypercalcemia Il6 , Tnfsf11 hyperglycemia Il6 hyperhomocysteinemia Timp1 hyperinsulinism Il6 , Prkcd Hyperkinesis Fos Hyperoxaluria Il6 Hyperoxia Il6 , Timp1 hyperparathyroidism Myc Hyperplasia Akt1 , Pik3ca Hypertelorism Pik3ca hypertension Akt1 , Crp , Fos , Il6 , Il6r , Il6st , Jun , Pik3r1 , Prkcd , Timp1 hypertensive retinopathy Crp Hypertriglyceridemia Akt1 , Crp , Il6st , Socs3 hypertrophic cardiomyopathy Myc , Ptpn11 , Sos1 hypertrophic cardiomyopathy 1 Sos1 hyperuricemia Jak2 , Stat3 Hypoalbuminemia A2m , Il6 hypoglycemia Pik3r1 hypogonadism Il6 hypomyelinating leukodystrophy 5 Il6 hypospadias Fos Hypotension Il6 Hypothermia Prkcd Hypoxia Crp , Jak1 idiopathic interstitial pneumonia Il6 idiopathic scoliosis Ptpn11 IgA glomerulonephritis Adam10 , Timp1 immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome Timp1 Immunodeficiency 117 Irf1 immunodeficiency 31A Stat1 immunodeficiency 31B Stat1 immunodeficiency 31C Stat1 immunodeficiency 35 Tyk2 immunodeficiency 36 Pik3r1 immunodeficiency 42 Il6r , Mcl1 Immunodeficiency 94 with Autoinflammation and Dysmorphic Facies Il6st impotence Akt1 , Il6 in situ carcinoma Akt1 Inflammation A2m , Akt1 , Cebpb , Crp , Fgg , Il6 , Jak2 , Stat3 , Timp1 inflammatory bowel disease Crp , Il6 , Stat3 influenza Ptpn11 Inhalant Abuse Fos Insulin Resistance Foxo1 , Il6 , Il6r , Pik3r1 , Prkcd , Socs3 intellectual disability Fos , Gab2 , Jak1 , Mapk11 , Mitf , Ptpn11 , Sos1 intermediate coronary syndrome Akt1 , Crp interstitial cystitis Crp , Mapk14 interstitial lung disease 2 Akt1 , Stat3 interstitial nephritis Crp Intervertebral Disc Displacement Akt1 Intestinal Neoplasms Mcl1 , Prkcd Intestinal Polyps Jun Intestinal Reperfusion Injury Crp , Il6 , Jak2 , Lbp intracranial aneurysm Il6 , Timp1 Intracranial Hemorrhages Il6 Intraventricular Hemorrhage Il6 invasive ductal carcinoma Akt1 , Map2k4 , Socs3 iron deficiency anemia Crp , Il6 irritable bowel syndrome Fos irritant dermatitis Stat3 ischemia Il6 Joubert syndrome 3 Sos1 juvenile myelomonocytic leukemia Ptpn11 juvenile rheumatoid arthritis Crp , Fos , Il6 , Jun , Stat3 Kaposi's sarcoma Il6 Kawasaki disease Crp , Timp1 Keloid Fgg keratitis Il6 keratoacanthoma Pik3ca keratoconjunctivitis sicca Il6 keratoconus Foxo1 kidney failure Adam10 , Crp Kidney Neoplasms Akt1 Kidney Reperfusion Injury Adam17 , Fgg , Fos , Il6 , Myc Klebsiella Infections Il6 Klippel-Trenaunay syndrome Pik3ca Kuhnt-Junius degeneration Crp , Il6 L-2-hydroxyglutaric aciduria Sos2 laryngeal squamous cell carcinoma Map2k4 learning disability Il6 , Ptpn11 Left Ventricular Hypertrophy Adam17 , Crp , Myc , Prkcd , Rac1 leiomyoma Myc leishmaniasis Crp , Il6 , Mcl1 leukemia Jak2 , Ptpn11 lichen disease Il6 limited scleroderma Jak2 listeriosis Cebpb liver cancer Jak2 , Mapk14 , Pik3ca liver cirrhosis A2m , Crp , Il6 , Jak1 , Jak2 , Lbp , Mapk14 , Myc , Stat1 , Stat3 liver disease Rac1 , Socs3 Liver Injury Fgg , Il6 , Jak2 , Myc , Stat3 Liver Neoplasms Jun , Mapk14 , Myc , Stat3 Liver Reperfusion Injury Il6 , Jak2 , Lbp low tension glaucoma Crp lung adenocarcinoma Akt1 , Hsp90b1 , Jak2 , Junb , Map2k4 , Mapk14 , Mcl1 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Rac1 , Sos1 , Vav1 lung cancer Irf1 , Map2k4 , Mcl1 , Myc , Pik3ca , Rac1 lung carcinoma Jak2 , Pik3ca lung disease A2m , Il6 , Irf1 Lung Injury Il6 Lung Neoplasms A2m , Akt1 , Crp , Fos , Il6 , Irf1 , Jun , Junb , Mapk14 , Mcl1 , Myc , Pik3ca lung non-small cell carcinoma Akt1 , Il6r , Irf1 , Jak1 , Jak2 , Junb , Map2k4 , Mcl1 , Myc , Pik3ca , Stat3 lung oat cell carcinoma Akt1 , Pik3ca Lung Reperfusion Injury Il6 , Myc lung small cell carcinoma Akt1 , Myc , Pik3ca , Pik3r1 lung squamous cell carcinoma Akt1 , Pik3ca , Ptpn11 lupus nephritis Crp , Jak1 , Stat1 lymphangioleiomyomatosis Stat1 , Stat3 Lymphatic Metastasis Crp , Pik3ca , Socs3 , Stat3 , Timp1 lymphoblastic lymphoma Foxo1 lymphocytic choriomeningitis Stat1 lymphoma Ptpn11 lymphopenia Vav1 lymphoplasmacytic lymphoma Il6 lymphoproliferative syndrome Stat3 Lynch syndrome Sos1 Macrocephaly Pik3ca Macrocephaly Mesodermal Hamartoma Spectrum Akt1 macular degeneration Crp macular retinal edema Il6 major depressive disorder Il6 malaria Crp male infertility Sos1 , Sos2 male infertility due to globozoospermia Hsp90b1 malignant astrocytoma Akt1 , Ptpn11 malignant mesothelioma Il6 mastoiditis Crp medulloblastoma Myc , Pik3ca , Stat3 , Vav1 megacolon A2m Megalencephaly - Cutis Marmorata Telangiectatica Congenita Pik3ca , Pik3r1 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Pik3ca Megalodactyly Pik3ca melanoma Akt1 , Gab2 , Junb , Mapk14 , Mitf , Pik3ca , Pik3r1 , Rac1 membranous glomerulonephritis A2m Memory Disorders Akt1 , Stat3 Meningeal Neoplasms Akt1 meningioma Akt1 meningitis Crp Mercury Poisoning, Nervous System Jun Merkel cell carcinoma Myc mesenteric vascular occlusion Jak2 metabolic dysfunction-associated steatohepatitis Il6 , Jak2 , Mcl1 metabolic dysfunction-associated steatotic liver disease Foxo1 , Il6 , Jak2 , Prkcd , Stat3 Metabolic Syndrome Crp , Il6 , Il6r , Lbp metachondromatosis Ptpn11 metachromatic leukodystrophy Mapk11 mevalonic aciduria Crp MHC class II deficiency Il6r , Mcl1 microcephaly Ptpn11 middle cerebral artery infarction Crp , Fos , Il6 , Il6r , Il6st , Junb , Stat3 Middle East respiratory syndrome Il6 migraine Fos mitochondrial myopathy Il6 morphine dependence Fos morphine withdrawal syndrome Fos mouth disease Crp Mouth Neoplasms Pik3ca mucolipidosis type IV Vav1 mucopolysaccharidosis VI Tnfsf11 multiple myeloma Fgg , Il6 , Mcl1 , Pik3ca , Ptpn11 Multiple Organ Failure Lbp multiple sclerosis A2m , Il6 , Tyk2 Multisystem Autoimmune Disease, Infantile-Onset, 1 Stat3 Muscle Hypotonia Sos1 muscular atrophy Akt1 muscular disease Prkcd Mycobacterium Infections Stat1 Mycoplasma pneumoniae pneumonia Crp myelodysplastic syndrome Myc myelofibrosis Jak2 myeloid leukemia associated with Down Syndrome Jak1 , Ptpn11 myeloid neoplasm Jak2 myeloproliferative neoplasm Jak2 myocardial infarction Akt1 , Crp , Fos , Il6 , Il6r , Jak2 , Mapk14 , Tnfsf11 Myocardial Ischemia Cebpd , Crp , Il6 , Il6st , Irf1 , Jak2 , Junb , Mapk14 , Prkcd , Socs3 Myocardial Reperfusion Injury Akt1 , Crp , Il6 , Il6r , Jak2 , Map2k6 , Mapk14 , Prkcd , Stat1 , Stat3 myocarditis Crp , Il6 , Tnfsf11 Nasal Polyps Jun , Stat3 nasal type extranodal NK/T-cell lymphoma Stat3 Nasopharyngeal Neoplasms Pik3ca nasopharynx carcinoma Jak2 , Map2k4 , Mapk14 , Rac1 , Stat3 Necrosis Il6 Nematode Infections Pik3r1 Neointima Akt1 Neonatal Inflammatory Skin and Bowel Disease 1 Adam17 Neoplasm Invasiveness Gab2 , Il6 , Stat3 , Timp1 Neoplasm Metastasis Gab2 , Il6 , Jak2 , Map2k4 , Myc , Pik3ca , Rac1 , Stat1 , Stat3 , Timp1 Neoplastic Cell Transformation Fos , Il6 , Jak2 , Jun , Mitf , Myc , Rac1 , Stat3 neovascular glaucoma Il6 neovascular inflammatory vitreoretinopathy Il6 nephroblastoma Myc , Stat1 , Stat3 nephronophthisis Pias1 nephrotic syndrome A2m , Jak2 nervous system disease Fos Nervous System Trauma Stat1 neuroblastoma Map2k4 , Myc , Pik3ca , Ptpn11 neurodegeneration with brain iron accumulation 5 Timp1 neurodegenerative disease Il6 neurodevelopmental disorder with dysmorphic facies and distal limb anomalies Rac1 NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES Pik3ca NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, NYSTAGMUS, AND SEIZURES Adam17 Neurodevelopmental Disorders Il6st , Irf1 , Pik3r1 , Ptpn11 , Sos1 , Stat1 neuroectodermal tumor Myc neurofibroma Ptpn11 neurofibromatosis-Noonan syndrome Ptpn11 neuromyelitis optica Il6 neuronal ceroid lipofuscinosis Pias1 neutropenia Stat3 nicotine dependence Fos Niemann-Pick disease type C1 Jak2 , Stat3 Nociceptive Pain Fos nodular goiter Il6 non-arteritic anterior ischemic optic neuropathy Crp non-Hodgkin lymphoma Myc , Pik3ca nonsyndromic deafness Mitf Nontuberculous Mycobacterium Infections Stat1 Noonan Like Syndrome Ptpn11 , Sos1 Noonan syndrome Ptpn11 , Sos1 , Sos2 Noonan syndrome 1 Ptpn11 , Sos1 , Sos2 Noonan syndrome 3 Ptpn11 , Sos1 Noonan syndrome 4 Sos1 Noonan syndrome 8 Pik3ca Noonan syndrome 9 Sos2 Noonan syndrome with multiple lentigines Ptpn11 Noonan syndrome with multiple lentigines 1 Ptpn11 Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia Ptpn11 Nuchal Bleb, Familial Sos1 obesity Akt1 , Crp , Fgg , Fos , Il6 , Il6r , Jak2 , Lbp , Myc , Pik3r1 , Prkcd , Socs3 , Stat3 , Timp1 , Tyk2 obstructive jaundice Lbp obstructive lung disease A2m obstructive sleep apnea Crp , Il6 ocular albinism with sensorineural deafness Mitf oculocutaneous albinism Mitf oculocutaneous albinism type IV Mitf Ollier disease Ptpn11 Optic Nerve Injuries Jun oral candidiasis Cebpb oral squamous cell carcinoma Il6 , Jun , Junb oral submucous fibrosis Il6 , Timp1 orchitis Il6r osteoarthritis Cebpb , Pik3r1 osteochondrodysplasia Cebpb Osteochondroma Ptpn11 Osteolysis Tnfsf11 osteopetrosis Jun , Mitf , Tnfsf11 osteoporosis Il6 , Il6r , Mapk14 , Myc , Tnfsf11 osteosarcoma Akt1 , Jun , Myc osteosclerosis Tnfsf11 otitis externa Crp otitis media A2m , Crp , Il6 Otitis Media with Effusion A2m ovarian cancer Akt1 , Jak1 , Pik3ca , Stat3 , Timp1 ovarian carcinoma Fos , Map2k6 ovarian hyperstimulation syndrome Il6 Ovarian Neoplasms Akt1 , Il6 , Il6st , Map2k4 , Myc , Pik3ca , Pik3r1 , Stat3 ovarian serous carcinoma Map2k4 ovarian serous cystadenocarcinoma Pik3ca overactive bladder syndrome Crp Oxygen-Induced Retinopathy Stat3 Pain Akt1 , Il6st pancreas disease Il6 pancreatic adenocarcinoma Jak1 , Pik3ca , Rac1 , Stat1 pancreatic cancer Akt1 , Il6 , Map2k4 , Myc , Stat3 pancreatic carcinoma Myc pancreatic ductal adenocarcinoma Jak1 , Rac1 pancreatic intraductal papillary-mucinous neoplasm Akt1 pancreatitis Fgg papillary renal cell carcinoma Pik3ca papilloma Map2k4 Paranoid Disorders Tyk2 paraplegia Akt1 Paraproteinemias Pik3ca , Ptpn11 parathyroid carcinoma Crp , Il6r , Mcl1 , Pias3 Parkinson's disease A2m , Akt1 , Crp , Il6 Parkinsonism Prkcd Pasteurellaceae Infections Crp patent ductus arteriosus Ptpn11 patent foramen ovale Ptpn11 pelvic inflammatory disease Crp Penile Neoplasms Pik3ca perinatal necrotizing enterocolitis Il6 periodontal disease Il6 periodontitis Crp , Il6 , Jak1 , Lbp , Stat1 , Stat3 peripartum cardiomyopathy Stat3 Peripheral Nerve Injuries Il6 , Il6r peripheral nervous system disease Il6 , Jun peripheral vascular disease Il6 peritoneum cancer Cebpb peritonitis A2m , Il6 pharyngoconjunctival fever Crp Phelan-McDermid syndrome Mapk11 Pick's disease Fos , Map2k6 pigmentation disease Mitf Pituitary Neoplasms Il6st Plaque, Atherosclerotic Il6 plasma cell neoplasm Pik3ca , Ptpn11 pleomorphic xanthoastrocytoma Il6 pleural disease Il6 pleurisy Il6 Pneumococcal Meningitis Adam17 , Il6 Pneumococcal Pneumonia Crp , Il6 pneumonia Crp , Il6 , Il6st polycystic kidney disease Myc , Pik3ca polycystic kidney disease 1 Myc polycystic ovary syndrome Gab1 polycythemia Jak2 polycythemia vera Jak1 , Jak2 polymyalgia rheumatica Crp polymyositis Il6 polyneuropathy Il6 Polypoidal Choroidal Vasculopathy Crp portal hypertension Jak2 , Pik3r1 , Prkcd post-traumatic stress disorder Fos Postmenopausal Osteoporosis Il6 Postoperative Atrial Fibrillation Crp , Il6 Postoperative Cognitive Dysfunction Il6 pre-eclampsia Il6 , Timp1 pre-malignant neoplasm Akt1 , Il6 , Stat3 prediabetes syndrome Il6 Pregnancy Complications Jak2 Premature Aging Foxo1 Premature Birth Il6 Premature Obstetric Labor Il6 Prenatal Exposure Delayed Effects Adam10 preretinal fibrosis Timp1 primary biliary cholangitis Jak2 , Mapk14 , Tyk2 primary ciliary dyskinesia Il6 primary cutaneous T-cell non-Hodgkin lymphoma Mcl1 primary immunodeficiency disease Pik3r1 , Stat1 , Stat3 primary ovarian insufficiency Jak2 , Myc progressive supranuclear palsy Map2k6 prolactinoma Cebpd , Myc proliferative diabetic retinopathy Il6r prostate adenocarcinoma Akt1 , Grb2 , Jun , Myc , Pik3ca , Stat1 prostate cancer Akt1 , Foxo1 , Grb2 , Jak1 , Myc , Pik3ca , Pik3r1 , Sos1 , Stat3 prostate carcinoma Jun , Stat3 prostate carcinoma in situ Map2k4 , Map2k6 , Myc prostatic hypertrophy Myc Prostatic Neoplasms Akt1 , Foxo1 , Hsp90b1 , Il6 , Il6st , Jak1 , Jak2 , Jun , Map2k4 , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat3 proteasome-associated autoinflammatory syndrome 1 Mapk14 proteinuria Il6 Proteus syndrome Akt1 Pseudomonas Aeruginosa Keratitis Cebpb , Il6 Pseudomonas Infections Crp , Il6 psoriasis Crp , Il6 , Stat3 , Tyk2 psoriatic arthritis Stat3 PTEN hamartoma tumor syndrome Pik3ca ptosis Ptpn11 , Sos1 Pulmonary Contusion Il6 pulmonary embolism Fgg pulmonary emphysema Jun pulmonary fibrosis Cebpb , Il6 , Stat1 , Stat3 , Timp1 pulmonary hypertension Crp , Foxo1 , Il6 , Myc pulmonary sarcoidosis Crp pulmonary tuberculosis Akt1 , Crp , Il6 , Il6r , Irf1 , Jun pulmonary valve stenosis Sos1 pyelonephritis Crp Pyogenic Granuloma Stat3 quadriplegia Il6 RASopathy Ptpn11 , Sos1 , Sos2 rectal benign neoplasm Fos , Pik3ca rectum adenocarcinoma Stat3 rectum cancer Il6 , Mapk14 relapsing-remitting multiple sclerosis Timp1 renal carcinoma Jun , Junb renal cell carcinoma Akt1 , Crp , Il6 , Il6r , Jun , Mitf , Myc , Pik3ca , Pik3r1 , Stat3 , Timp1 Renal Cell Carcinoma 1 Pik3ca Renal Colic Crp renal fibrosis Adam17 , Crp , Myc renal hypertension Crp , Il6 Reoviridae Infections Stat1 Reperfusion Injury Akt1 , Fos , Il6 , Il6r , Il6st , Irf1 , Jak2 , Jun , Pik3r1 , Socs3 , Stat1 , Stat3 respiratory allergy Il6 respiratory syncytial virus infectious disease Il6 , Irf1 Respiratory Tract Infections Il6r , Irf1 restrictive cardiomyopathy Map2k6 , Mapk14 , Prkcd reticulate acropigmentation of Kitamura Adam10 Retina Reperfusion Injury Il6 , Map2k4 , Stat3 retinal artery occlusion Il6 retinal degeneration Il6st retinal detachment Il6 , Jak2 retinal vasculitis Il6 retinal vein occlusion Crp , Il6 rhabdoid cancer Myc rheumatoid arthritis A2m , Cebpb , Crp , Il6 , Il6r , Il6st , Jak2 , Pik3r1 , Stat1 , Stat3 , Tyk2 Right Ventricular Hypertrophy Akt1 , Il6 , Prkcd , Ptpn11 rosette-forming glioneuronal tumor Pik3ca sarcoma Mcl1 , Pik3ca Sarcopenia Cebpb , Il6 schizophrenia Akt1 , Il6 , Il6r , Pias3 sciatic neuropathy Il6 , Il6r , Jak1 scoliosis Ptpn11 scrapie Jak2 , Stat1 , Stat3 seborrheic keratosis Pik3ca secondary hyperparathyroidism Crp , Il6 sensorineural hearing loss Gab1 , Mitf Sepsis A2m , Cebpb , Cebpd , Crp , Il6 , Jak2 , Lbp , Rac1 , Socs3 , Stat1 , Stat3 Sepsis-Associated Encephalopathy Jak2 , Stat3 Septic Peritonitis Il6 , Pik3r1 severe acute respiratory syndrome Fgg , Il6 , Stat1 severe congenital neutropenia 3 Il6r , Mcl1 severe congenital neutropenia 5 Il6r , Mcl1 SHORT syndrome Pik3r1 Shwartzman phenomenon Il6 silicosis Jun Sjogren's syndrome Crp , Il6 skin disease Il6 , Pias1 skin melanoma Akt1 , Myc , Pik3ca , Pik3r1 , Rac1 , Stat3 Skin Neoplasms Akt1 , Map2k4 , Stat3 sleep apnea Il6r Sleep Deprivation Map2k4 sleeping sickness Fos small cell carcinoma Il6 smallpox Irf1 Smith-Kingsmore Syndrome Pik3r1 spermatogenic failure 57 Ptpn11 , Sos1 Spinal Cord Compression Il6 spinal cord disease Il6 Spinal Cord Injuries Akt1 , Crp , Il6 , Irf1 , Jak2 , Jun Spine Osteoarthritis Il6 Splenomegaly Il6st , Jak2 spondyloarthropathy Il6 Spontaneous Abortions Il6 , Jak2 Sporadic Papillary Renal Cell Carcinoma Myc , Pik3ca squamous cell carcinoma Akt1 , Il6 , Myc , Pik3ca , Ptpn11 , Stat3 Staphylococcal Pneumonia Akt1 , Ptpn11 status epilepticus Adam10 , Crp , Fos , Il6st , Jun , Junb , Socs3 steatotic liver disease Akt1 , Cebpb , Il6 , Jak2 , Myc , Prkcd , Socs3 Stevens-Johnson syndrome Crp , Lbp stomach cancer Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Mcl1 , Pik3ca , Ptpn11 , Rac1 , Stat3 Stomach Neoplasms Cebpb , Fgg , Il6 , Il6r , Irf1 , Jun , Myc , Pik3ca , Stat3 strabismus Ptpn11 Streptococcus pneumonia Il6 Stroke Akt1 , Fgg , Il6 , Irf1 , Jak2 , Pik3ca , Prkcd , Sos1 , Timp1 Stuve-Wiedemann Syndrome Il6st Stuve-Wiedemann Syndrome 2 Il6st Subarachnoid Hemorrhage Il6 , Stat3 Subretinal Fibrosis Il6 , Il6r substance-induced psychosis Akt1 Sudden Cardiac Death Il6 Sudden Hearing Loss Il6 Sudden Unexpected Nocturnal Death Syndrome Sos1 suppurative otitis media A2m syndromic microphthalmia 5 Adam17 , Mitf syndromic X-linked intellectual disability Lubs type Timp1 Systemic Juvenile Rheumatoid Arthritis Il6 , Il6r systemic lupus erythematosus Crp , Il6 , Jak1 , Jak2 , Junb systemic scleroderma Il6 T-cell acute lymphoblastic leukemia Jak1 , Ptpn11 , Stat1 , Stat3 , Tyk2 T-cell non-Hodgkin lymphoma Akt1 , Stat3 temporal arteritis Crp temporal lobe epilepsy Fos Tendon Injuries Fos tetralogy of Fallot Ptpn11 thoracic aortic aneurysm Adam10 , Adam17 , Timp1 Thrombocythemia 3 Jak2 thrombocytopenia Fgg , Il6 , Ptpn11 thrombocytopenia-absent radius syndrome Pias3 thrombocytosis Jak2 Thromboembolism Fgg , Jak2 thrombosis Crp , Fgg , Jak2 Thrombotic Microangiopathies Fgg thyroid cancer Myc thyroid gland papillary carcinoma Myc Thyroid Neoplasms Akt1 , Il6 , Pik3ca Tibial Fractures Tnfsf11 Tietz syndrome Mitf Tietze's syndrome Mitf Tobacco Use Disorder Il6 Tongue Neoplasms Fos , Junb , Stat3 tongue squamous cell carcinoma Fos , Jun , Junb , Map2k4 toxic encephalopathy Fos , Prkcd toxic shock syndrome A2m , Il6 Toxoplasma Chorioretinitis Il6 transient cerebral ischemia Jak1 , Jak2 , Map2k4 , Stat3 transitional cell carcinoma Akt1 , Pik3ca , Timp1 Transplant Rejection Myc transverse myelitis Il6 traumatic brain injury Adam10 trichorhinophalangeal syndrome type I Myc tricuspid valve insufficiency Ptpn11 trigeminal neuralgia Fos trypanosomiasis A2m tuberculosis Cebpb Tubulointerstitial Nephritis and Uveitis Crp Tympanic Membrane Perforation Il6 type 1 diabetes mellitus Crp , Foxo1 , Il6 , Stat3 , Timp1 , Tyk2 , Vav1 type 2 diabetes mellitus Adam17 , Akt1 , Crp , Fgg , Foxo1 , Il6 , Pik3r1 , Socs3 , Stat3 , Timp1 ulcerative colitis Jak2 , Stat3 ureteral obstruction Adam10 , Adam17 , Akt1 , Irf1 urinary bladder cancer Akt1 , Jak2 , Map2k4 , Myc , Pik3ca , Stat3 urticaria Crp uterine cancer Pik3ca , Pik3r1 , Rac1 , Sos1 uterine carcinosarcoma Pik3ca , Pik3r1 Uterine Cervical Neoplasms Akt1 , Jak2 , Myc , Pias3 , Pik3ca , Stat3 uveal melanoma Crp uveitis Il6 , Il6r varicose veins Timp1 vascular disease Timp1 Vascular Malformations Pik3ca , Pik3r1 Venous Thrombosis Jak2 Ventilator-Induced Lung Injury Akt1 , Fos Ventricular Dysfunction, Left Il6 , Pik3ca , Rac1 Ventricular Premature Complexes Ptpn11 Ventricular Tachycardia Ptpn11 , Sos1 vestibular neuronitis Crp Viral Bronchiolitis Il6 viral infectious disease Cebpb Viral Myocarditis Il6 visceral leishmaniasis Crp , Il6 visual epilepsy Il6r , Il6st vitiligo Pik3r1 vulva cancer Akt1 Waardenburg syndrome Mitf Waardenburg syndrome type 1 Mitf Waardenburg Syndrome Type 2 Mitf Waardenburg syndrome type 2A Mitf Waardenburg syndrome type 2E Mitf Weight Gain Lbp , Pik3ca Werner syndrome Ptpn11 Wernicke encephalopathy Fos Wilson disease A2m , Il6 , Timp1 withdrawal disorder Crp , Fos Wounds and Injuries Il6 , Timp1 X-Linked Acute Leukemia Jak1 X-linked agammaglobulinemia Pik3r1 X-linked epilepsy with variable learning disabilities and behavior disorders Timp1 X-linked severe congenital neutropenia Timp1