Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) - Rat Genome Database

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Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) Rattus norvegicus
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Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
RGD ID: 3447
Description: Enables several functions, including insulin receptor substrate binding activity; phospholipase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; and positive regulation of focal adhesion assembly. Located in plasma membrane raft. Part of protein-containing complex. Used to study glaucoma. Biomarker of glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11); PARTICIPATES IN insulin signaling pathway; somatostatin signaling pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: encodes catalytic domain; protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase SYP; PTP-1D; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SHP-2; Shp2; tyrosine-protein phosphatase non-receptor type 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ptpn11em4Mcwi   Ptpn11em1Mcwi  
Genetic Models: SS-Ptpn11em4Mcwi SS-Ptpn11em1Mcwi
Candidate Gene For: Iddm30
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,026,079 - 41,085,577 (+)NCBIGRCr8
mRatBN7.21235,365,436 - 35,424,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,383,144 - 35,424,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,539,721 - 36,599,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,150,921 - 37,210,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,203,373 - 36,263,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
RH 3.4 Map12646.0RGD
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
anogenital venereal wart  (ISO)
aortic valve stenosis  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial heart septal defect 1  (ISO)
atrophic gastritis  (ISO)
autism spectrum disorder  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Brain Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cancer  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (IEP)
cervical cancer  (ISO)
chondroma  (ISO)
chronic lymphocytic leukemia  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniosynostosis  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (ISO,ISS)
disease of metabolism  (ISS)
Duane retraction syndrome  (ISO)
Dwarfism  (ISO)
embryonal rhabdomyosarcoma  (ISO)
Experimental Leukemia  (ISO)
Failure to Thrive  (ISO)
Fetal Growth Retardation  (IEP)
Funnel Chest  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glaucoma  (IEP,IMP,ISO)
Haemophilus Infections  (ISO)
Helicobacter Infections  (ISO)
hemorrhagic disease  (ISO)
hepatocellular adenoma  (ISS)
hereditary multiple exostoses  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
hypertrophic cardiomyopathy  (ISO)
idiopathic scoliosis  (ISS)
influenza  (ISO)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (ISO,ISS)
learning disability  (ISO)
leukemia  (ISO)
lung adenocarcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
metachondromatosis  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibroma  (ISO)
neurofibromatosis-Noonan syndrome  (ISO)
Noonan Like Syndrome  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO,ISS)
Noonan syndrome 3  (ISO)
Noonan syndrome with multiple lentigines  (ISO,ISS)
Noonan syndrome with multiple lentigines 1  (ISO)
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia  (ISO)
Ollier disease  (ISO)
Osteochondroma  (ISO)
Paraproteinemias  (ISO)
patent ductus arteriosus  (ISO)
patent foramen ovale  (ISO)
plasma cell neoplasm  (ISO)
ptosis  (ISO)
RASopathy  (ISO)
Right Ventricular Hypertrophy  (ISO)
scoliosis  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (ISO)
stomach cancer  (ISO)
strabismus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thrombocytopenia  (ISO)
tricuspid valve insufficiency  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calpeptin  (ISO)
capillarisin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chondroitin sulfate  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxazosin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
IC-87114  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
ochratoxin A  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tipifarnib  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trimethyltin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrioventricular canal development  (IEA,ISO)
axonogenesis  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
brain development  (ISO)
cellular response to angiotensin  (IEP)
cellular response to epidermal growth factor stimulus  (IEA,ISO,ISS)
cellular response to hydrogen peroxide  (IEP)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to mechanical stimulus  (IPI)
cellular response to organic substance  (IEA)
cerebellar cortex formation  (IEA,ISO)
DNA damage checkpoint signaling  (IEA,ISO)
ephrin receptor signaling pathway  (IEA,ISO,ISS)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
ERBB signaling pathway  (ISO)
face morphogenesis  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
genitalia development  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
heart development  (ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
hormone metabolic process  (IEA,ISO)
hormone-mediated signaling pathway  (IEA,ISO)
inner ear development  (IEA,ISO)
integrin-mediated signaling pathway  (IEA,ISO)
intestinal epithelial cell migration  (IEA,ISO)
lipid metabolic process  (ISO)
megakaryocyte development  (IEA,ISO)
microvillus organization  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of chondrocyte differentiation  (IEA,ISO,ISS)
negative regulation of cortisol secretion  (IEA,ISO)
negative regulation of growth hormone secretion  (IEA,ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of insulin secretion  (IEA,ISO)
negative regulation of type I interferon production  (IEA,ISO)
neurotrophin TRK receptor signaling pathway  (IEA,ISO)
organ growth  (IEA,ISO)
platelet formation  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO,ISS)
positive regulation of focal adhesion assembly  (IMP)
positive regulation of glucose import  (IEA,ISO)
positive regulation of hormone secretion  (IEA,ISO)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of ossification  (IEA,ISO,ISS)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of signal transduction  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein dephosphorylation  (IDA)
regulation of cell adhesion mediated by integrin  (ISO,ISS)
regulation of MAPK cascade  (ISO)
regulation of protein export from nucleus  (IEA,ISO)
regulation of protein-containing complex assembly  (IEA,ISO)
signal transduction  (ISO)
smooth muscle cell proliferation  (IEP)
triglyceride metabolic process  (IEA,ISO)

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (TAS)
nucleus  (IEA,ISO,ISS)
plasma membrane raft  (IDA)
protein-containing complex  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissue. Ahmad F and Goldstein BJ, Biochim Biophys Acta. 1995 Apr 5;1248(1):57-69.
2. Angiotensin II stimulates tyrosine phosphorylation and activation of insulin receptor substrate 1 and protein-tyrosine phosphatase 1D in vascular smooth muscle cells. Ali MS, etal., J Biol Chem. 1997 May 9;272(19):12373-9. doi: 10.1074/jbc.272.19.12373.
3. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
4. Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. Barrow AD, etal., J Immunol. 2004 May 15;172(10):5838-42.
5. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
6. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Chen B, etal., Nat Genet 2000 Mar;24(3):296-9.
7. Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection. Chitranshi N, etal., Mol Ther. 2019 Feb 6;27(2):424-441. doi: 10.1016/j.ymthe.2018.09.019. Epub 2018 Oct 4.
8. The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants. D'Alessio A, etal., Endocrinology. 2003 Oct;144(10):4298-305. Epub 2003 Jun 19.
9. Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature. De Rocca Serra-Nedelec A, etal., Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27.
10. Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. Digilio MC, etal., Am J Hum Genet. 2002 Aug;71(2):389-94. Epub 2002 Jun 7.
11. Identification of protein-tyrosine phosphatases prevalent in adipocytes by molecular cloning. Ding W, etal., Biochem Biophys Res Commun 1994 Jul 29;202(2):902-7.
12. A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. Duchene J, etal., J Biol Chem. 2002 Oct 25;277(43):40375-83. Epub 2002 Aug 12.
13. Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease. Fiorentini C, etal., Neurobiol Dis. 2013 Jun;54:339-48. doi: 10.1016/j.nbd.2013.01.005. Epub 2013 Jan 14.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot. Goodship JA, etal., Circ Cardiovasc Genet. 2012 Jun;5(3):287-92. doi: 10.1161/CIRCGENETICS.111.962035. Epub 2012 Apr 13.
18. Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. Goto Y, etal., Int J Med Sci. 2006 Nov 1;4(1):1-6. doi: 10.7150/ijms.4.1.
19. Associations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan. Hamajima N, etal., Asian Pac J Cancer Prev. 2008 Apr-Jun;9(2):217-20.
20. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. Hayashi K, etal., J Biol Chem. 2004 Sep 24;279(39):40807-18. Epub 2004 Jul 21.
21. Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese. Hishida A, etal., BMC Gastroenterol. 2009 Jul 9;9:51. doi: 10.1186/1471-230X-9-51.
22. The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Incoronato M, etal., Cell Signal. 2004 Jul;16(7):847-56.
23. Noonan-like syndrome mutations in PTPN11 in patients diagnosed with cherubism. Jafarov T, etal., Clin Genet. 2005 Aug;68(2):190-1.
24. Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population. Jiang J, etal., BMC Gastroenterol. 2012 Jul 12;12:89. doi: 10.1186/1471-230X-12-89.
25. PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience. Keren B, etal., J Med Genet. 2004 Nov;41(11):e117.
26. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
27. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7.
28. Identification of a putative Syp substrate, the PDGF beta receptor. Klinghoffer RA and Kazlauskas A, J Biol Chem. 1995 Sep 22;270(38):22208-17. doi: 10.1074/jbc.270.38.22208.
29. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. Kong M, etal., J Biol Chem. 2000 Nov 17;275(46):36035-42.
30. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Kontaridis MI, etal., Circulation. 2008 Mar 18;117(11):1423-35. doi: 10.1161/CIRCULATIONAHA.107.728865. Epub 2008 Mar 3.
31. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
32. PTPN11 mutations in LEOPARD syndrome. Legius E, etal., J Med Genet. 2002 Aug;39(8):571-4.
33. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Lundby A, etal., Cell. 2019 Oct 3;179(2):543-560.e26. doi: 10.1016/j.cell.2019.09.008.
34. SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates. Maegawa H, etal., Biochem Biophys Res Commun. 1996 Nov 1;228(1):122-7.
35. Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways. Marin TM, etal., Circ Res. 2008 Oct 10;103(8):813-24. doi: 10.1161/CIRCRESAHA.108.179754. Epub 2008 Aug 28.
36. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. Marin TM, etal., J Clin Invest. 2011 Mar;121(3):1026-43. doi: 10.1172/JCI44972. Epub 2011 Feb 21.
37. RNA splicing regulates the activity of a SH2 domain-containing protein tyrosine phosphatase. Mei L, etal., J Biol Chem 1994 Apr 22;269(16):12254-62.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Peroxisome proliferator-activated receptor-gamma agonist improves skeletal muscle insulin signaling in the pregestational intrauterine growth-restricted rat offspring. Oak S, etal., Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E514-24. doi: 10.1152/ajpendo.00008.2009. Epub 2009 Jun 2.
42. Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. Ohnishi H, etal., J Biol Chem 1996 Oct 11;271(41):25569-74.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection. Ouyang W, etal., Cell Prolif. 2020 Jan;53(1):e12721. doi: 10.1111/cpr.12721. Epub 2019 Nov 29.
45. Oxidative stress induces lipid-raft-mediated activation of Src homology 2 domain-containing protein-tyrosine phosphatase 2 in astrocytes. Park SJ, etal., Free Radic Biol Med. 2009 Jun 15;46(12):1694-702. doi: 10.1016/j.freeradbiomed.2009.03.026. Epub 2009 Apr 5.
46. SHP protein tyrosine phosphatase expression in rat uterine tissue. Phillippe M, etal., J Soc Gynecol Investig. 2006 Jul;13(5):338-42.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. Rafiq K, etal., J Biol Chem. 2006 Jul 14;281(28):19781-92. Epub 2006 May 11.
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). Sagawa K, etal., J Biol Chem. 1997 Dec 5;272(49):31086-91.
53. Tyrosine phosphatase activity in mitochondria: presence of Shp-2 phosphatase in mitochondria. Salvi M, etal., Cell Mol Life Sci. 2004 Sep;61(18):2393-404.
54. Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome. Sarkozy A, etal., J Med Genet. 2004 May;41(5):e68.
55. The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Schramm C, etal., Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H231-43. doi: 10.1152/ajpheart.00665.2011. Epub 2011 Nov 4.
56. Role of SRC homology 2-containing tyrosine phosphatase 2 on proliferation of rat smooth muscle cells. Seki N, etal., Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1081-5. doi: 10.1161/01.atv.0000022878.37277.ec.
57. Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. Sobreira NL, etal., PLoS Genet. 2010 Jun 17;6(6):e1000991. doi: 10.1371/journal.pgen.1000991.
58. Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer. Tao XH, etal., Pathol Oncol Res. 2008 Dec;14(4):365-71. doi: 10.1007/s12253-008-9065-5. Epub 2008 Jun 10.
59. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Tartaglia M, etal., Am J Hum Genet. 2002 Jun;70(6):1555-63. Epub 2002 May 1.
60. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Tartaglia M, etal., Nat Genet. 2003 Jun;34(2):148-50.
61. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
62. Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling. Wang Q, etal., J Biol Chem. 2006 Oct 13;281(41):31093-105. doi: 10.1074/jbc.M606392200. Epub 2006 Aug 11.
63. Leptin signaling and obesity: cardiovascular consequences. Yang R and Barouch LA, Circ Res. 2007 Sep 14;101(6):545-59.
64. Shp2 Deficiency Impairs the Inflammatory Response Against Haemophilus influenzae by Regulating Macrophage Polarization. Zhao L, etal., J Infect Dis. 2016 Aug 15;214(4):625-33. doi: 10.1093/infdis/jiw205. Epub 2016 May 24.
65. Chemotherapy Effectiveness and Prognosis of Gastric Cancer Influenced by PTPN11 Polymorphisms. Zhuo C, etal., Cell Physiol Biochem. 2016;39(4):1537-52. doi: 10.1159/000447856. Epub 2016 Sep 12.
Additional References at PubMed
PMID:1382983   PMID:7493946   PMID:9062191   PMID:9415395   PMID:9791008   PMID:9832615   PMID:10206955   PMID:10655584   PMID:10940933   PMID:11704759   PMID:11986327   PMID:12051764  
PMID:12482708   PMID:12937170   PMID:14522994   PMID:15133037   PMID:15162432   PMID:15273746   PMID:15520383   PMID:15985432   PMID:16021628   PMID:16261333   PMID:16481357   PMID:16573649  
PMID:16885344   PMID:17287109   PMID:17562706   PMID:17954568   PMID:18294464   PMID:18305318   PMID:18566342   PMID:18583343   PMID:18827006   PMID:19047464   PMID:19326266   PMID:19359598  
PMID:19948503   PMID:20023173   PMID:20226789   PMID:20682772   PMID:21531714   PMID:21701583   PMID:21903867   PMID:21918362   PMID:21946312   PMID:22118986   PMID:22537548   PMID:22759635  
PMID:22802969   PMID:22878065   PMID:22952679   PMID:23029125   PMID:23325809   PMID:23509158   PMID:23673659   PMID:24225419   PMID:24431450   PMID:24675817   PMID:25802336   PMID:26706435  
PMID:26742426   PMID:27264546   PMID:27417137   PMID:28074573   PMID:28366775   PMID:28768764   PMID:28898718   PMID:30086741   PMID:31201283   PMID:35400714   PMID:35652623  


Genomics

Comparative Map Data
Ptpn11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,026,079 - 41,085,577 (+)NCBIGRCr8
mRatBN7.21235,365,436 - 35,424,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,383,144 - 35,424,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,539,721 - 36,599,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,150,921 - 37,210,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,203,373 - 36,263,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
RH 3.4 Map12646.0RGD
Cytogenetic Map12q16NCBI
PTPN11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,418,947 - 112,509,918 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,418,351 - 112,509,918 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,856,751 - 112,947,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,340,919 - 111,432,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412111,319,255 - 111,410,436NCBI
Celera12112,483,686 - 112,574,781 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12109,868,826 - 109,960,330 (+)NCBIHuRef
CHM1_112112,825,224 - 112,916,404 (+)NCBICHM1_1
T2T-CHM13v2.012112,395,849 - 112,486,820 (+)NCBIT2T-CHM13v2.0
Ptpn11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,268,596 - 121,329,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,268,596 - 121,329,460 (-)EnsemblGRCm39 Ensembl
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,130,533 - 121,191,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBIMGSCv36mm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.72NCBI
Ptpn11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,934,306 - 9,035,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,934,734 - 9,031,230 (+)NCBIChiLan1.0ChiLan1.0
PTPN11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210120,510,774 - 120,601,930 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112120,507,189 - 120,598,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,016,364 - 110,107,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112113,412,077 - 113,503,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,435,669 - 113,503,762 (+)Ensemblpanpan1.1panPan2
PTPN11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,989,218 - 10,072,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,989,425 - 10,067,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,107,654 - 10,190,288 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,229,100 - 10,311,852 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,229,105 - 10,358,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,203,528 - 10,286,110 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,266,437 - 10,349,406 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,314,568 - 10,397,234 (+)NCBIUU_Cfam_GSD_1.0
Ptpn11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,103,369 - 148,189,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366682,628,706 - 2,682,448 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366682,602,261 - 2,687,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,202,169 - 39,292,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,202,165 - 39,292,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,703,693 - 41,793,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,658,495 - 107,754,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,658,453 - 107,752,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,330,748 - 137,428,997 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,721,468 - 19,813,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,721,581 - 19,813,639 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn11
342 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:623
Count of miRNA genes:292
Interacting mature miRNAs:376
Transcripts:ENSRNOT00000046323
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
D84372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,421,476 - 35,421,609 (+)MAPPERmRatBN7.2
Rnor_6.01240,952,551 - 40,952,683NCBIRnor6.0
Rnor_5.01242,819,312 - 42,819,444UniSTSRnor5.0
RGSC_v3.41236,557,823 - 36,557,955UniSTSRGSC3.4
Celera1237,085,812 - 37,085,944UniSTS
Cytogenetic Map12q16UniSTS
RH128659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,424,679 - 35,424,863 (+)MAPPERmRatBN7.2
Rnor_6.01240,955,754 - 40,955,937NCBIRnor6.0
Rnor_5.01242,822,515 - 42,822,698UniSTSRnor5.0
RGSC_v3.41236,561,026 - 36,561,209UniSTSRGSC3.4
Celera1237,089,015 - 37,089,198UniSTS
RH 3.4 Map12617.2UniSTS
Cytogenetic Map12q16UniSTS
RH94825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,421,464 - 35,421,671 (+)MAPPERmRatBN7.2
Rnor_6.01240,952,539 - 40,952,745NCBIRnor6.0
Rnor_5.01242,819,300 - 42,819,506UniSTSRnor5.0
RGSC_v3.41236,557,811 - 36,558,017UniSTSRGSC3.4
Celera1237,085,800 - 37,086,006UniSTS
RH 3.4 Map12646.0UniSTS
Cytogenetic Map12q16UniSTS
Ptpn11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,391,869 - 35,392,434 (+)MAPPERmRatBN7.2
Rnor_6.01240,922,946 - 40,923,510NCBIRnor6.0
Rnor_5.01242,789,707 - 42,790,271UniSTSRnor5.0
Celera1237,056,207 - 37,056,771UniSTS
Cytogenetic Map12q16UniSTS


Genetic Models
This gene Ptpn11 is modified in the following models/strains:
SS-Ptpn11em4Mcwi     SS-Ptpn11em1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046323   ⟹   ENSRNOP00000041842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,383,144 - 35,424,925 (+)Ensembl
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117481   ⟹   ENSRNOP00000090199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,383,901 - 35,424,925 (+)Ensembl
RefSeq Acc Id: NM_001177593   ⟹   NP_001171064
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,026,079 - 41,085,577 (+)NCBI
mRatBN7.21235,365,436 - 35,424,925 (+)NCBI
Rnor_6.01240,895,515 - 40,955,999 (+)NCBI
Rnor_5.01242,762,630 - 42,822,760 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013088   ⟹   NP_037220
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,026,079 - 41,085,577 (+)NCBI
mRatBN7.21235,365,436 - 35,424,925 (+)NCBI
Rnor_6.01240,895,515 - 40,955,999 (+)NCBI
Rnor_5.01242,762,630 - 42,822,760 (+)NCBI
RGSC_v3.41236,501,886 - 36,558,055 (+)RGD
Celera1237,029,879 - 37,089,260 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037220   ⟸   NM_013088
- Peptide Label: isoform 2
- UniProtKB: Q62626 (UniProtKB/Swiss-Prot),   P41499 (UniProtKB/Swiss-Prot),   A6J1G3 (UniProtKB/TrEMBL),   A0A8L2ULP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171064   ⟸   NM_001177593
- Peptide Label: isoform 1
- UniProtKB: A0A8L2ULP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041842   ⟸   ENSRNOT00000046323
RefSeq Acc Id: ENSRNOP00000090199   ⟸   ENSRNOT00000117481
Protein Domains
SH2   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41499-F1-model_v2 AlphaFold P41499 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698660
Promoter ID:EPDNEW_R9185
Type:initiation region
Name:Ptpn11_1
Description:protein tyrosine phosphatase, non-receptor type 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01240,895,525 - 40,895,585EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3447 AgrOrtholog
BioCyc Gene G2FUF-19200 BioCyc
Ensembl Genes ENSRNOG00000030124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046323 ENTREZGENE
  ENSRNOT00000046323.6 UniProtKB/TrEMBL
  ENSRNOT00000117481.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
KEGG Report rno:25622 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25622 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTPN11 RGD
PhenoGen Ptpn11 PhenoGen
PIRSF Tyr-Ptase_nr_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030124 RatGTEx
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GI01_RAT UniProtKB/TrEMBL
  A0A8L2ULP1 ENTREZGENE, UniProtKB/TrEMBL
  A6J1G3 ENTREZGENE, UniProtKB/TrEMBL
  P41499 ENTREZGENE, UniProtKB/Swiss-Prot
  Q62626 ENTREZGENE
UniProt Secondary Q62626 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-10-24 Ptpn11  protein tyrosine phosphatase, non-receptor type 11      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript splice variant PTP1Di has additional amino acid residues Ala-Leu-Leu-Gln in the catalytic domain and has altered kinetics compared to PTP1D 729786