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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nuclear factor kappa B signaling pathway
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Accession:PW:0000499 term browser browse the term
Definition:NF-kB signaling plays an essential role in the mammalian immune system. The classical/canonical pathway, downstream but not exclusively of tumor necrosis factor/receptor 1 signaling, is regarded as a paradigm of NF-kB signaling. The classical and the non-classical pathway downstream of a subset of Tnf receptor superfamily, share similar sets of core components, albeit in distinct ways. Collectively they regulate the expression of a vast array of genes.
Synonyms:related_synonym: KEGG:04064;   NF-kB signaling pathway;   NF-kappaB signaling pathway;   PID:200021;   PID:200031;   PID:200048
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nuclear factor kappa B signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 ISO PID PID:200021 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Atm ATM serine/threonine kinase ISO PID PID:200031 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor ISO PID PID:200031 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bcl3 BCL3, transcription coactivator ISO PID PID:200021 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID PID:200031 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:21135871 RGD:5490225 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD		 PMID:18267068 PID:200031 PID:200048, RGD:2292172 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO PID PID:200021 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO PID PID:200021 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Csnk2b casein kinase 2 beta ISO PID PID:200021 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Cul1 cullin 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO PID
RGD		 PMID:23312890 PMID:21119682 PID:200031, RGD:7800734, RGD:7800735 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200031 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD		 PMID:18267068 PID:200021 PID:200031, RGD:2292172 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:18267068 PID:200031, RGD:2292172 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Irf1 interferon regulatory factor 1 IMP RGD PMID:15141302 RGD:5128786 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200021 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Malt1 MALT1 paracaspase ISO PID PID:200031 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 ISO PID
RGD		 PMID:18267068 PID:200048, RGD:2292172 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO RGD PMID:21135871 PMID:30854566 RGD:5490225, RGD:155791647 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200021 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID
RGD		 PMID:18267068 PMID:23975431 PID:200021 PID:200031 PID:200048, RGD:2292172, RGD:40902973 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 ISO PID
RGD		 PMID:18267068 PID:200048, RGD:2292172 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha ISO PID
RGD		 PMID:18267068 PID:200021 PID:200031, RGD:2292172 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta ISO RGD PMID:18267068 RGD:2292172 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nfkbie NFKB inhibitor epsilon ISO RGD PMID:18267068 RGD:2292172 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO PID PID:200031 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200021 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200021 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Prkca protein kinase C, alpha ISO PID PID:200031 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ran RAN, member RAS oncogene family ISO PID PID:200031 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO PID
RGD		 PMID:18267068 PID:200021, RGD:2292172 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID
RGD		 PMID:18267068 PID:200021 PID:200031, RGD:2292172 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO PID PID:200048 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO PID PID:200031 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Rnf31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200021 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Sspo SCO-spondin ISO PID PID:200021 PID:200031 PID:200048 NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412 		JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200021 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:49,972,414...50,044,658
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Tnf tumor necrosis factor ISO PID PID:200031 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO PID PID:200031 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO PID PID:200031 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO PID PID:200031 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 ISO PID PID:200031 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081 		JBrowse link
G Xpo1 exportin 1 ISO PID PID:200031 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      transcription factor mediated signaling pathway 460
        nuclear factor kappa B signaling pathway 52
          altered nuclear factor kappa B signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1752
        transcription pathway 1074
          transcription pathway via transcription factor mediated signaling 460
            nuclear factor kappa B signaling pathway 52
              altered nuclear factor kappa B signaling pathway 0
paths to the root