Gene: Pias3 (protein inhibitor of activated STAT, 3)
Rattus norvegicus
Symbol:
Pias3
Name:
protein inhibitor of activated STAT, 3
Description:
ENCODES a protein that exhibits potassium channel regulator activity; protein C-terminus binding; protein N-terminus binding; INVOLVED IN positive regulation of gene expression; positive regulation of membrane potential; response to hormone stimulus; PARTICIPATES IN sentrinization pathway; interleukin-6 signaling pathway; Jak-Stat signaling pathway; FOUND IN dendrite; nucleus; synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
E3 SUMO-protein ligase PIAS3; KChAP; LOC83614; potassium channel regulatory protein KChAP; potassium channel-associated protein; protein inhibitor of activated STAT 3; protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3
Orthologs:
Homo sapiens : PIAS3
(protein inhibitor of activated STAT, 3)
HGNC
Pias3
(protein inhibitor of activated STAT 3)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 2 q34 NCBI RGSC Genome Assembly v5.0 2 218,310,303 - 218,318,467 + NCBI RGSC Genome Assembly v3.4 2 191,499,057 - 191,507,221 + NCBI Rat Celera Assembly 2 176,757,800 - 176,765,964 + NCBI Genome Assembly 3.1 2 191,461,810 - 191,469,975 + NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of PIAS3 mRNA CTD PMID:16079270 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of PIAS3 mRNA CTD PMID:12075121 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIAS3 mRNA] CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1332134 6480464 Tetrachlorodibenzodioxin affects the expression of PIAS3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIAS3 mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of PIAS3 mRNA CTD PMID:21346803 4,4'-diaminodiphenylmethane increases expression ISO RGD:1332134 6480464 4,4'-diaminodiphenylmethane results in increased expression of PIAS3 mRNA CTD PMID:18648102 aflatoxin B1 increases expression ISO RGD:1332134 6480464 Aflatoxin B1 results in increased expression of PIAS3 mRNA CTD PMID:19770486 aflatoxin B1 increases expression ISO RGD:1344818 6480464 Aflatoxin B1 results in increased expression of PIAS3 mRNA CTD PMID:22100608 alendronic acid affects expression EXP 6480464 Alendronate affects the expression of PIAS3 mRNA CTD PMID:16079270 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PIAS3 mRNA CTD PMID:16483693 benzo[a]pyrene increases expression ISO RGD:1332134 6480464 Benzo(a)pyrene results in increased expression of PIAS3 mRNA CTD PMID:19770486 bisphenol A decreases expression ISO RGD:1344818 6480464 bisphenol A results in decreased expression of PIAS3 mRNA CTD PMID:16029874 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PIAS3 mRNA CTD PMID:12075121 ciguatoxin CTX1B affects expression ISO RGD:1332134 6480464 Ciguatoxins affects the expression of PIAS3 mRNA CTD PMID:18353800 cobalt dichloride decreases expression ISO RGD:1344818 6480464 cobaltous chloride results in decreased expression of PIAS3 mRNA CTD PMID:19320972 copper(2+) sulfate increases expression ISO RGD:1344818 6480464 Copper Sulfate results in increased expression of PIAS3 mRNA CTD PMID:19549813 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of PIAS3 mRNA CTD PMID:21266533 genistein decreases expression EXP 6480464 Genistein results in decreased expression of PIAS3 mRNA CTD PMID:12075121 paracetamol affects expression ISO RGD:1332134 6480464 Acetaminophen affects the expression of PIAS3 mRNA CTD PMID:17562736 pirinixic acid decreases expression ISO RGD:1332134 6480464 pirinixic acid results in decreased expression of PIAS3 mRNA CTD PMID:20813756 raloxifene affects expression EXP 6480464 Raloxifene affects the expression of PIAS3 mRNA CTD PMID:16079270 resveratrol affects localization ISO RGD:1344818 6480464 resveratrol affects the localization of PIAS3 protein CTD PMID:22096581 trans-resveratrol affects localization ISO RGD:1344818 6480464 resveratrol affects the localization of PIAS3 protein CTD PMID:22096581 valproic acid affects expression ISO RGD:1332134 6480464 Valproic Acid affects the expression of PIAS3 mRNA CTD PMID:17963808 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PIAS3 mRNA CTD PMID:21318169
Gene Ontology Annotations
1578671 Bmd10 Bone mineral density QTL 10 5.4 Bone mineral density femoral neck cortical vBMD 2 9670332 227150249 Rat 1358913 Cm41 Cardiac mass QTL 41 2.73 Cardiac mass 2 24474447 212169089 Rat 1358917 Cm42 Cardiac mass QTL 42 2.82 Cardiac mass 2 24474447 212169089 Rat 61467 Bp14 Blood pressure QTL 14 2.2 Blood pressure 2 42866342 210636008 Rat 631266 Bp132 Blood pressure QTL 132 .0005 Blood pressure systolic 2 46542246 210636169 Rat 1331760 Bp206 Blood pressure QTL 206 3.62454 Blood pressure time series calculation 2 56214854 210636169 Rat 1298080 Bp163 Blood pressure QTL 163 .02 Blood pressure systolic 2 66680022 210636169 Rat 1354648 Bp239 Blood pressure QTL 239 .001 Blood pressure systolic 2 66680209 235799396 Rat 1354605 Rf48 Renal function QTL 48 2.9 Creatinine level serum 2 75806326 214989298 Rat 61374 Edpm2 Estrogen-dependent pituitary mass QTL 2 4.42 .86 Gland mass pituitary 2 77630629 210636169 Rat 724534 Uae6 Urinary albumin excretion QTL 6 10 Renal function urine albumin level 2 79796833 227150249 Rat 1581569 Uae32 Urinary albumin excretion QTL 32 .0001 Renal function urine albumin level 2 79796977 227150051 Rat 1581576 Pur7 Proteinuria QTL 7 .0001 Renal function urine protein level 2 79796977 227150051 Rat 1354622 Kidm16 Kidney mass QTL 16 3 Kidney mass left kidney mass 2 82826122 231465091 Rat 1354649 Kidm17 Kidney mass QTL 17 2.9 Kidney mass left kidney mass adjujsted for tibia length 2 82826122 236153712 Rat 631507 Bp105 Blood pressure QTL 105 .001 Blood pressure 2 116874922 221284686 Rat 634308 Sach6 Saccharin preference QTL 6 4.9 Consumption level saccharin preference 2 116874922 221284686 Rat 1578648 Bss11 Bone structure and strength QTL 11 4.7 Bone structure femoral neck cortical area 2 118264490 220244597 Rat 1554319 Bmd2 Bone mineral density QTL 2 13.4 .0001 Bone mineral density spine area by pQCT 2 118264840 221131552 Rat 1300165 Rf9 Renal function QTL 9 3.28 Renal function hypertension related glomerular damage 2 138700979 210636169 Rat 70175 BpQTLCluster3 Blood pressure QTL cluster 3 2.76 Blood pressure 2 140403692 210636008 Rat 1581502 Esta3 Estrogen-induced thymic atrophy QTL 3 Gland mass thymus 2 141755026 197256313 Rat 1359022 Ppulsi1 Prepulse inhibition QTL 1 3.63 Prepulse inhibition 2 141755026 222281918 Rat 1331805 Cm29 Cardiac mass QTL 29 3.50746 Cardiac mass 2 146228221 232307864 Rat 1331794 Bp202 Blood pressure QTL 202 3.66819 Blood pressure systolic 2 146228221 232307864 Rat 71113 Cari2 Carrageenan-induced inflammation QTL 2 2.7 .009 Carrageenan-induced inflammation 2 146659370 210636169 Rat 1581578 Cm49 Cardiac mass QTL 49 4.9 .01 Cardiac mass left ventricle 2 148790600 227150249 Rat 61401 Niddm2 Non-insulin dependent diabetes mellitus QTL 2 4.54 Glucose level postprandial 2 152256313 197256313 Rat 1598833 Bp295 Blood pressure QTL 295 3.5 Blood pressure systolic 2 154238265 199238265 Rat 1641925 Alcrsp2 Alcohol response QTL 2 Alcohol response loss of righting reflex 2 155101972 230157845 Rat 1641891 Alcrsp17 Alcohol response QTL 17 Alcohol response loss of righting reflex 2 155101972 247295816 Rat 1598805 Memor8 Memory QTL 8 3 Memory navigation-spatial 2 155920709 197555821 Rat 631501 Bp101 Blood pressure QTL 101 2.4 Blood pressure systolic 2 155920808 210636008 Rat 1354609 Niddm62 Non-insulin dependent diabetes mellitus QTL 62 4.72 .000006 Insulin level post-pancreatectomy 2 156142685 210636169 Rat 2301966 Bp322 Blood pressure QTL 322 3.58 Blood pressure systolic 2 156142685 210636169 Rat 724568 Uae13 Urinary albumin excretion QTL 13 4.4 Renal function urine albumin level 2 161170272 218568266 Rat 1359032 Hrtrt18 Heart rate QTL 18 Heart rate salt-induced bradycardia 2 163154227 200390471 Rat 1302793 Bw16 Body weight QTL 16 5 .0001 Body weight 2 163154358 210636008 Rat 1358900 Bw48 Body weight QTL 48 4.88 Body weight 2 163154358 227150051 Rat 1298074 Bp164 Blood pressure QTL 164 .003 Blood pressure salt-loaded systolic 2 165636169 210636169 Rat 1298076 Bp166 Blood pressure QTL 166 .0009 Blood pressure systolic 2 165636169 210636169 Rat 1298085 Bp165 Blood pressure QTL 165 .0006 Blood pressure salt-loaded systolic 2 165636169 210636169 Rat 1358356 Srcrt1 Stress Responsive Cort QTL1 3.66 Hypothalamic-pituitary-adrenal axis corticosterone post-stress 2 167857161 231465091 Rat 2306901 Bp337 Blood pressure QTL 337 .01 Blood pressure salt-loaded systolic 2 170338294 236153712 Rat 1549833 Bp257 Blood pressure QTL 257 .003 Blood pressure mean arterial 2 174727312 192363025 Rat 1331734 Bp204 Blood pressure QTL 204 3.61192 Blood pressure mean arterial 2 174730375 232307864 Rat 61469 Bp16 Blood pressure QTL 16 5.64 Blood pressure 2 177484675 222484675 Rat 70162 Bp63 Blood pressure QTL 63 5.64 Blood pressure 2 177484675 222484675 Rat 2293084 Iddm26 Insulin dependent diabetes mellitus QTL 26 2.9 Glucose level insulin-dependent 2 181710214 222281918 Rat 1359031 Bp275 Blood pressure QTL 275 Blood pressure systolic 2 183664122 228664122 Rat 2300189 Bmd48 Bone mineral density QTL 48 5.8 .0001 Bone mineral density 2 187512114 232512114 Rat 61417 Cia10 Collagen induced arthritis QTL 10 3.4 Joint/bone inflammation type II collagen induced 2 188136088 233136088 Rat 4889834 Pur24 Proteinuria QTL 24 5.8 .014 Renal function urine protein level 2 191378142 210636169 Rat
Gene Ontology Annotations
