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Term:interleukin-2 signaling pathway
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Accession:PW:0000907 term browser browse the term
Definition:Interleukin-2 is the prototypical member of the interleukin-2 family of cytokines. The signaling pathway initiated by Il-2 and the other family members activates the Jak-Stat intracellular cascade to regulate T cell, innate and adaptive immune responses.
Synonyms:related_synonym: Il-2 signaling pathway;   PID:200098

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interleukin-2 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link ISO 13 12,730,736 12,905,108 RGD:6484113 PID
G Cdk2 cyclin dependent kinase 2 GBrowse link ISO 7 2,000,196 2,007,682 RGD:6484113 PID
G Cish cytokine inducible SH2-containing protein GBrowse link ISO 8 112,541,034 112,545,982 RGD:6484113 PID
G Dok2 docking protein 2 GBrowse link ISO 15 51,171,277 51,174,337 RGD:6484113 PID
G Fos FBJ osteosarcoma oncogene GBrowse link ISO 6 109,559,135 109,562,001 RGD:6484113 PID
G Fyn FYN oncogene related to SRC, FGR, YES GBrowse link ISO 20 43,501,853 43,695,567 RGD:6484113 PID
G Gab2 GRB2-associated binding protein 2 GBrowse link ISO 1 154,348,777 154,544,906 RGD:6484113 PID
G Grb2 growth factor receptor bound protein 2 GBrowse link ISO 10 105,722,014 105,818,649 RGD:6484113 PID
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:6484113 PID
G Ifng interferon gamma GBrowse link ISO 7 57,621,756 57,625,792 RGD:6484113 PID
G Ikzf3 IKAROS family zinc finger 3 GBrowse link ISO 10 87,275,051 87,365,273 RGD:6484113 PID
G Il2 interleukin 2 GBrowse link ISO 2 123,655,005 123,659,709 RGD:6484113 PID
G Il2ra interleukin 2 receptor, alpha GBrowse link ISO 17 78,050,491 78,097,802 RGD:6484113 PID
G Il2rb interleukin 2 receptor, beta ISO RGD:6484113 PID
G Il2rg interleukin 2 receptor, gamma GBrowse link ISO X 89,342,055 89,345,715 RGD:6484113 PID
G Irs1 insulin receptor substrate 1 GBrowse link ISO 9 81,585,251 81,638,071 RGD:6484113 PID
G Irs2 insulin receptor substrate 2 GBrowse link ISO 16 83,379,987 83,404,220 RGD:6484113 PID
G Jak1 Janus kinase 1 GBrowse link ISO 5 121,804,586 121,905,581 RGD:6484113 PID
G Jak3 Janus kinase 3 GBrowse link ISO 16 18,878,139 18,889,441 RGD:6484113 PID
G Jun jun proto-oncogene GBrowse link ISO 5 115,358,166 115,361,259 RGD:6484113 PID
G Lck lymphocyte-specific protein tyrosine kinase GBrowse link ISO 5 148,707,505 148,718,296 RGD:6484113 PID
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link ISO 8 68,379,074 68,451,554 RGD:6484113 PID
G Map2k2 mitogen activated protein kinase kinase 2 GBrowse link ISO 7 10,074,654 10,094,003 RGD:6484113 PID
G Mapk1 mitogen activated protein kinase 1 GBrowse link ISO 11 85,968,732 86,030,387 RGD:6484113 PID
G Mapk11 mitogen-activated protein kinase 11 GBrowse link ISO 7 127,444,055 127,449,990 RGD:6484113 PID
G Mapk14 mitogen activated protein kinase 14 GBrowse link ISO 20 6,939,249 7,000,378 RGD:6484113 PID
G Mapk3 mitogen activated protein kinase 3 GBrowse link ISO 1 185,935,044 185,941,245 RGD:6484113 PID
G Mapk8 mitogen-activated protein kinase 8 GBrowse link ISO 16 8,925,133 9,004,897 RGD:6484113 PID
G Mapk9 mitogen-activated protein kinase 9 GBrowse link ISO 10 35,353,486 35,384,319 RGD:6484113 PID
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 GBrowse link ISO 13 43,994,943 44,041,504 RGD:6484113 PID
G Myc myelocytomatosis oncogene GBrowse link ISO 7 98,953,142 98,958,060 RGD:6484113 PID
G Nras neuroblastoma ras oncogene GBrowse link ISO 2 198,292,650 198,300,286 RGD:6484113 PID
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISO 2 118,640,277 118,672,440 RGD:6484113 PID
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISO 2 32,602,673 32,675,350 RGD:6484113 PID
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta GBrowse link ISO 9 10,054,005 10,078,501 RGD:6484113 PID
G Prkcb protein kinase C, beta GBrowse link ISO 1 181,117,512 181,459,856 RGD:6484113 PID
G Prkce protein kinase C, epsilon GBrowse link ISO 6 9,631,234 10,097,311 RGD:6484113 PID
G Ptk2b protein tyrosine kinase 2 beta GBrowse link ISO 15 45,589,222 45,717,866 RGD:6484113 PID
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 GBrowse link ISO 12 36,501,886 36,558,055 RGD:6484113 PID
G Raf1 v-raf-leukemia viral oncogene 1 GBrowse link ISO 4 151,752,583 151,775,609 RGD:6484113 PID
G Rasa1 RAS p21 protein activator (GTPase activating protein) 1 GBrowse link ISO 2 14,203,815 14,287,824 RGD:6484113 PID
G Rhoa ras homolog family member A ISO RGD:6484113 PID
G Shc1 SHC (Src homology 2 domain containing) transforming protein 1 GBrowse link ISO 2 181,616,581 181,628,144 RGD:6484113 PID
G Socs1 suppressor of cytokine signaling 1 GBrowse link ISO 10 4,819,971 4,820,609 RGD:6484113 PID
G Socs2 suppressor of cytokine signaling 2 GBrowse link ISO 7 32,605,714 32,608,323 RGD:6484113 PID
G Socs3 suppressor of cytokine signaling 3 GBrowse link ISO 10 107,958,468 107,959,330 RGD:6484113 PID
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link ISO 6 3,308,778 3,390,661 RGD:6484113 PID
G Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 GBrowse link ISO 17 88,276,082 88,321,955 RGD:6484113 PID
G Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 GBrowse link ISO 3 34,213,013 34,259,375 RGD:6484113 PID
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISO 9 46,455,635 46,497,560 RGD:6484113 PID
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link ISO 10 89,821,078 89,872,970 RGD:6484113 PID
G Stat5a signal transducer and activator of transcription 5A GBrowse link ISO 10 89,795,404 89,819,732 RGD:6484113 PID
G Stat5b signal transducer and activator of transcription 5B GBrowse link ISO 10 89,716,624 89,743,134 RGD:6484113 PID
G Syk spleen tyrosine kinase GBrowse link ISO 17 18,440,672 18,498,001 RGD:6484113 PID
Term paths to the root
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Term Annotations click to browse term
  Pathway Ontology 17140
    signaling pathway 7465
      signaling pathway pertinent to immunity 1872
        cytokine mediated signaling pathway 879
          Interleukin mediated signaling pathway 459
            interleukin-2 family mediated signaling pathway 113
              interleukin-2 signaling pathway 54
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