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Term:insulin-like growth factor signaling pathway
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Accession:PW:0000238 term browser browse the term
Definition:Processes regulated by insulin and insulin-like growth factor signaling systems include growth and survival of many tissues; for example, neuron and retina, bone, pancreatic beta-cells. Insulin is best known for its role in the regulation of blood glucose. Deregulation of the systems is implicated in a number of metabolic disorders.
Synonyms:related_synonym: PID:200100

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insulin-like growth factor signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:6484113 PID
G Bad BCL2-associated agonist of cell death GBrowse link ISO 1 209,617,373 209,626,292 RGD:6484113 PID
G Bcar1 breast cancer anti-estrogen resistance 1 GBrowse link ISO 19 41,646,190 41,669,234 RGD:6484113 PID
G Crk v-crk sarcoma virus CT10 oncogene homolog (avian) GBrowse link ISO 10 63,017,662 63,040,420 RGD:6484113 PID
G Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like GBrowse link ISO 11 85,520,244 85,554,667 RGD:6484113 PID
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link ISO 10 34,067,237 34,072,593 RGD:6484113 PID
G Grb10 growth factor receptor bound protein 10 GBrowse link ISO 14 92,814,797 92,911,442 RGD:6484113 PID
G Grb2 growth factor receptor bound protein 2 GBrowse link IMP 10 105,722,014 105,818,649 RGD:1581313 RGD
G Grb2 growth factor receptor bound protein 2 GBrowse link ISO 10 105,722,014 105,818,649 RGD:6484113 PID
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:6484113 PID
G Igf1 insulin-like growth factor 1 GBrowse link ISS 7 24,531,669 24,605,742 RGD:1626333 RGD
G Igf1 insulin-like growth factor 1 GBrowse link IDA 7 24,531,669 24,605,742 RGD:1580473 RGD
G Igf1 insulin-like growth factor 1 GBrowse link ISO 7 24,531,669 24,605,742 RGD:6484113 PID
G Igf1r insulin-like growth factor 1 receptor GBrowse link IMP 1 122,704,976 122,990,007 RGD:1581313 RGD
G Igf1r insulin-like growth factor 1 receptor GBrowse link ISS 1 122,704,976 122,990,007 RGD:1626333 RGD
G Igf1r insulin-like growth factor 1 receptor GBrowse link ISO 1 122,704,976 122,990,007 RGD:6484113 PID
G Igf2 insulin-like growth factor 2 GBrowse link ISS 1 202,906,624 202,915,231 RGD:1626333 RGD
G Igfals insulin-like growth factor binding protein, acid labile subunit GBrowse link ISS 10 14,127,416 14,130,662 RGD:1626333 RGD
G Igfbp1 insulin-like growth factor binding protein 1 GBrowse link ISS 14 87,950,222 87,955,289 RGD:1626333 RGD
G Igfbp2 insulin-like growth factor binding protein 2 GBrowse link ISS 9 71,966,877 71,994,211 RGD:1626333 RGD
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link ISS 14 87,959,153 87,967,085 RGD:1626333 RGD
G Igfbp4 insulin-like growth factor binding protein 4 GBrowse link ISS 10 87,822,429 87,834,315 RGD:1626333 RGD
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link ISS 9 72,003,637 72,016,263 RGD:1626333 RGD
G Igfbp6 insulin-like growth factor binding protein 6 GBrowse link ISS 7 140,885,388 140,890,028 RGD:1626333 RGD
G Irs1 insulin receptor substrate 1 GBrowse link IMP 9 81,585,251 81,638,071 RGD:1581313 RGD
G Irs1 insulin receptor substrate 1 GBrowse link ISO 9 81,585,251 81,638,071 RGD:6484113 PID
G Irs2 insulin receptor substrate 2 GBrowse link ISO 16 83,379,987 83,404,220 RGD:6484113 PID
G Irs4 insulin receptor substrate 4 GBrowse link NAS X 36,881,414 36,885,105 RGD:2301084 RGD
G Nck2 NCK adaptor protein 2 GBrowse link ISO 9 42,650,261 42,776,967 RGD:6484113 PID
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISO 10 13,329,708 13,394,080 RGD:6484113 PID
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISO 2 118,640,277 118,672,440 RGD:6484113 PID
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISO 2 32,602,673 32,675,350 RGD:6484113 PID
G Prkcd protein kinase C, delta GBrowse link ISO 16 5,954,218 5,975,743 RGD:6484113 PID
G Prkcz protein kinase C, zeta GBrowse link ISO 5 172,061,825 172,172,793 RGD:6484113 PID
G Prkd1 protein kinase D1 GBrowse link ISO 6 70,364,135 70,682,006 RGD:6484113 PID
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 GBrowse link ISO 3 159,070,473 159,116,792 RGD:6484113 PID
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 GBrowse link ISO 12 36,501,886 36,558,055 RGD:6484113 PID
G Pxn paxillin GBrowse link ISO 12 42,322,193 42,370,507 RGD:6484113 PID
G Raf1 v-raf-leukemia viral oncogene 1 GBrowse link ISO 4 151,752,583 151,775,609 RGD:6484113 PID
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 GBrowse link ISO 10 76,657,024 76,698,088 RGD:6484113 PID
G Shc1 SHC (Src homology 2 domain containing) transforming protein 1 GBrowse link ISO 2 181,616,581 181,628,144 RGD:6484113 PID
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link ISO 6 3,308,778 3,390,661 RGD:6484113 PID
G Wdr6 WD repeat domain 6 GBrowse link NAS 8 113,618,341 113,624,757 RGD:2301084 RGD
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide GBrowse link ISO 10 63,072,128 63,109,833 RGD:6484113 PID
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide GBrowse link ISO 7 72,283,825 72,306,126 RGD:6484113 PID
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Igf1 insulin-like growth factor 1 GBrowse link IEP 7 24,531,669 24,605,742 RGD:1580474 RGD
Term paths to the root
Path 1
Term Annotations click to browse term
  Pathway Ontology 17140
    signaling pathway 7465
      growth factor signaling pathway 1032
        insulin-like growth factor signaling pathway 46
          altered insulin-like growth factor signaling pathway 1
Path 2
Term Annotations click to browse term
  Pathway Ontology 17140
    signaling pathway 7465
      hormone signaling pathway 1128
        peptide and protein hormone signaling pathway 852
          insulin-like growth factor signaling pathway 46
            altered insulin-like growth factor signaling pathway 1
paths to the root

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