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Term:hypoxia inducible factor pathway
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Accession:PW:0000360 term browser browse the term
Definition:The hypoxia inducible transcription factor is activated in response to hypoxic conditions to promote the expression of many genes that play important roles in glucose and energy metabolism, angiogenesis and erythropoiesis.
Synonyms:related_synonym: HIF pathway;   PID:200036;   PID:200202;   the chronic hypoxic response - the HIF-alpha pathway
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hypoxia inducible factor pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link ISO 4 21,709,855 21,796,628 RGD:6484113 PID
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link ISO 4 87,502,584 87,560,017 RGD:6484113 PID
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link ISO 4 87,502,584 87,560,017 RGD:6484113 PID
G Adm adrenomedullin GBrowse link ISO 1 168,380,255 168,382,426 RGD:6484113 PID
G Adora2a adenosine A2a receptor GBrowse link ISO 20 13,815,719 13,834,131 RGD:6484113 PID
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:6484113 PID
G Aldoa aldolase A, fructose-bisphosphate GBrowse link ISO 1 185,970,658 185,974,615 RGD:6484113 PID
G Apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 GBrowse link ISO 15 26,904,124 26,906,224 RGD:6484113 PID
G Arnt aryl hydrocarbon receptor nuclear translocator GBrowse link ISS 2 190,333,978 190,391,015 RGD:6483352 RGD
G Arnt aryl hydrocarbon receptor nuclear translocator GBrowse link ISO 2 190,333,978 190,391,015 RGD:6484113 PID
G Arnt aryl hydrocarbon receptor nuclear translocator GBrowse link ISO 2 190,333,978 190,391,015 RGD:6484113 PID
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 GBrowse link ISS 1 140,535,823 140,646,838 RGD:6483352 RGD
G Bhlhe40 basic helix-loop-helix family, member e40 GBrowse link ISO 4 144,139,486 144,145,186 RGD:6484113 PID
G Bhlhe40 basic helix-loop-helix family, member e40 GBrowse link ISO 4 144,139,486 144,145,186 RGD:6484113 PID
G Bhlhe41 basic helix-loop-helix family, member e41 ISO RGD:6484113 PID
G Bnip3 BCL2/adenovirus E1B interacting protein 3 GBrowse link ISO 1 198,683,009 198,700,075 RGD:6484113 PID
G Car9 carbonic anhydrase 9 GBrowse link ISO 5 59,986,413 59,993,015 RGD:6484113 PID
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link ISO 1 12,721,500 12,723,943 RGD:6484113 PID
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link ISO 1 12,721,500 12,723,943 RGD:6484113 PID
G Cops5 COP9 signalosome subunit 5 GBrowse link ISO 5 8,709,214 8,727,277 RGD:6484113 PID
G Cp ceruloplasmin (ferroxidase) GBrowse link ISO 2 105,086,278 105,135,367 RGD:6484113 PID
G Creb1 cAMP responsive element binding protein 1 GBrowse link ISO 9 63,170,785 63,234,727 RGD:6484113 PID
G Crebbp CREB binding protein GBrowse link ISS 10 11,598,680 11,724,122 RGD:6483358 RGD
G Crebbp CREB binding protein GBrowse link ISS 10 11,598,680 11,724,122 RGD:6483503 RGD
G Crebbp CREB binding protein GBrowse link ISO 10 11,598,680 11,724,122 RGD:6484113 PID
G Crebbp CREB binding protein GBrowse link ISO 10 11,598,680 11,724,122 RGD:6484113 PID
G Cul2 cullin 2 GBrowse link ISS 17 62,701,289 62,741,344 RGD:6483358 RGD
G Cxcl12 chemokine (C-X-C motif) ligand 12 GBrowse link ISO 4 153,503,576 153,516,423 RGD:6484113 PID
G Cxcr4 chemokine (C-X-C motif) receptor 4 GBrowse link ISO 13 41,308,286 41,312,190 RGD:6484113 PID
G Edn1 endothelin 1 GBrowse link ISO 17 28,303,886 28,309,775 RGD:6484113 PID
G Efna1 ephrin A1 GBrowse link ISO 2 181,444,599 181,451,944 RGD:6484113 PID
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link ISS 19 55,080,670 55,118,226 RGD:6483358 RGD
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link IDA 19 55,080,670 55,118,226 RGD:727754 RGD
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link TAS 19 55,080,670 55,118,226 RGD:1334466 RGD
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link ISS 19 55,080,670 55,118,226 RGD:6483503 RGD
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link ISO 19 55,080,670 55,118,226 RGD:6484113 PID
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link ISO 19 55,080,670 55,118,226 RGD:6484113 PID
G Egln2 EGL nine homolog 2 (C. elegans) GBrowse link IDA 1 82,233,239 82,240,990 RGD:727754 RGD
G Egln2 EGL nine homolog 2 (C. elegans) GBrowse link ISS 1 82,233,239 82,240,990 RGD:6483503 RGD
G Egln2 EGL nine homolog 2 (C. elegans) GBrowse link ISO 1 82,233,239 82,240,990 RGD:6484113 PID
G Egln3 EGL nine homolog 3 (C. elegans) GBrowse link IDA 6 74,451,038 74,476,506 RGD:727754 RGD
G Egln3 EGL nine homolog 3 (C. elegans) GBrowse link ISS 6 74,451,038 74,476,506 RGD:6483503 RGD
G Egln3 EGL nine homolog 3 (C. elegans) GBrowse link ISO 6 74,451,038 74,476,506 RGD:6484113 PID
G Egln3 EGL nine homolog 3 (C. elegans) GBrowse link ISO 6 74,451,038 74,476,506 RGD:6484113 PID
G Eif3e eukaryotic translation initiation factor 3, subunit E GBrowse link ISO 7 79,013,224 79,045,970 RGD:6484113 PID
G Elk1 ELK1, member of ETS oncogene family GBrowse link ISO X 12,597,863 12,604,248 RGD:6484113 PID
G Eng endoglin ISO RGD:6484113 PID
G Eno1 enolase 1, (alpha) GBrowse link ISO 5 167,394,131 167,405,516 RGD:6484113 PID
G Ep300 E1A binding protein p300 GBrowse link ISS 7 119,938,507 120,008,886 RGD:6483358 RGD
G Ep300 E1A binding protein p300 GBrowse link ISS 7 119,938,507 120,008,886 RGD:6483503 RGD
G Ep300 E1A binding protein p300 GBrowse link ISO 7 119,938,507 120,008,886 RGD:6484113 PID
G Ep300 E1A binding protein p300 GBrowse link ISO 7 119,938,507 120,008,886 RGD:6484113 PID
G Epas1 endothelial PAS domain protein 1 GBrowse link ISS 6 10,203,108 10,297,215 RGD:6483352 RGD
G Epas1 endothelial PAS domain protein 1 GBrowse link ISS 6 10,203,108 10,297,215 RGD:6483503 RGD
G Epas1 endothelial PAS domain protein 1 GBrowse link ISO 6 10,203,108 10,297,215 RGD:6484113 PID
G Epo erythropoietin GBrowse link ISO 12 19,551,768 19,555,208 RGD:6484113 PID
G Epo erythropoietin GBrowse link ISO 12 19,551,768 19,555,208 RGD:6484113 PID
G Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) GBrowse link ISO 8 32,481,694 32,545,237 RGD:6484113 PID
G Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) GBrowse link ISO 8 32,481,694 32,545,237 RGD:6484113 PID
G Fech ferrochelatase GBrowse link ISO 18 60,675,217 60,708,418 RGD:6484113 PID
G Flt1 FMS-related tyrosine kinase 1 GBrowse link ISO 12 7,858,092 8,035,966 RGD:6484113 PID
G Fos FBJ osteosarcoma oncogene GBrowse link ISO 6 109,559,135 109,562,001 RGD:6484113 PID
G Furin furin (paired basic amino acid cleaving enzyme) GBrowse link ISO 1 136,209,969 136,222,057 RGD:6484113 PID
G Fxn frataxin GBrowse link ISO 1 227,647,092 227,671,081 RGD:6484113 PID
G Gata2 GATA binding protein 2 GBrowse link ISO 4 122,279,753 122,288,528 RGD:6484113 PID
G Gck glucokinase GBrowse link ISO 14 86,572,518 86,587,723 RGD:6484113 PID
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link ISS 10 34,067,237 34,072,593 RGD:6483358 RGD
G Hdac7 histone deacetylase 7 GBrowse link ISO 7 136,501,738 136,523,073 RGD:6484113 PID
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 6 96,419,024 96,463,891 RGD:2301848 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISS 6 96,419,024 96,463,891 RGD:6483352 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 6 96,419,024 96,463,891 RGD:1580561 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IDA 6 96,419,024 96,463,891 RGD:628389 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISS 6 96,419,024 96,463,891 RGD:6483503 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISO 6 96,419,024 96,463,891 RGD:6484113 PID
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link ISS 1 249,607,945 249,618,000 RGD:6483352 RGD
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link ISS 1 249,607,945 249,618,000 RGD:1334466 RGD
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link ISS 1 249,607,945 249,618,000 RGD:6483358 RGD
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link ISO 1 249,607,945 249,618,000 RGD:6484113 PID
G Hif3a hypoxia inducible factor 3, alpha subunit GBrowse link ISS 1 77,377,465 77,408,704 RGD:6483352 RGD
G Hif3a hypoxia inducible factor 3, alpha subunit GBrowse link TAS 1 77,377,465 77,408,704 RGD:68201 RGD
G Hk1 hexokinase 1 ISO RGD:6484113 PID
G Hk2 hexokinase 2 GBrowse link ISO 4 116,925,725 116,975,211 RGD:6484113 PID
G Hmox1 heme oxygenase (decycling) 1 GBrowse link ISO 19 13,963,139 13,969,960 RGD:6484113 PID
G Hnf4a hepatocyte nuclear factor 4, alpha GBrowse link ISO 3 154,459,863 154,482,825 RGD:6484113 PID
G Id2 inhibitor of DNA binding 2 GBrowse link ISO 6 42,781,476 42,783,307 RGD:6484113 PID
G Igfbp1 insulin-like growth factor binding protein 1 GBrowse link ISO 14 87,950,222 87,955,289 RGD:6484113 PID
G Itgb2 integrin, beta 2 GBrowse link ISO 20 11,446,521 11,485,009 RGD:6484113 PID
G Jun jun proto-oncogene GBrowse link ISO 5 115,358,166 115,361,259 RGD:6484113 PID
G Kdr kinase insert domain receptor ISO RGD:6484113 PID
G Ldha lactate dehydrogenase A GBrowse link ISO 1 97,403,077 97,412,547 RGD:6484113 PID
G Lep leptin GBrowse link ISO 4 55,943,837 55,945,938 RGD:6484113 PID
G Mcl1 myeloid cell leukemia sequence 1 ISO RGD:6484113 PID
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) GBrowse link ISO 15 32,493,852 32,503,077 RGD:6484113 PID
G Ncoa1 nuclear receptor coactivator 1 GBrowse link ISO 6 27,224,396 27,473,926 RGD:6484113 PID
G Ncoa2 nuclear receptor coactivator 2 GBrowse link ISO 5 5,197,891 5,275,776 RGD:6484113 PID
G Ndrg1 N-myc downstream regulated 1 GBrowse link ISO 7 104,302,038 104,344,842 RGD:6484113 PID
G Nos2 nitric oxide synthase 2, inducible GBrowse link ISO 10 65,036,884 65,072,453 RGD:6484113 PID
G Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) GBrowse link ISO 10 18,051,990 18,062,714 RGD:6484113 PID
G Nt5e 5' nucleotidase, ecto GBrowse link ISO 8 93,591,630 93,635,481 RGD:6484113 PID
G Os9 osteosarcoma amplified 9 GBrowse link ISS 7 67,046,802 67,073,355 RGD:6483358 RGD
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 GBrowse link ISO 17 78,241,182 78,268,272 RGD:6484113 PID
G Pfkl phosphofructokinase, liver GBrowse link ISO 20 11,009,359 11,032,511 RGD:6484113 PID
G Pgk1 phosphoglycerate kinase 1 GBrowse link ISO X 94,324,219 94,340,193 RGD:6484113 PID
G Pgk1 phosphoglycerate kinase 1 GBrowse link ISO X 94,324,219 94,340,193 RGD:6484113 PID
G Pgm1 phosphoglucomutase 1 GBrowse link ISO 5 120,595,650 120,655,915 RGD:6484113 PID
G Pkm pyruvate kinase, muscle GBrowse link ISO 8 63,486,492 63,508,016 RGD:6484113 PID
G Plin2 perilipin 2 GBrowse link ISO 5 105,718,496 105,732,817 RGD:6484113 PID
G Pou5f1 POU class 5 homeobox 1 ISO RGD:6484113 PID
G Rbx1 ring-box 1, E3 ubiquitin protein ligase GBrowse link ISS 7 119,794,976 119,805,104 RGD:6483358 RGD
G Sat1 spermidine/spermine N1-acetyl transferase 1 GBrowse link ISS X 61,634,964 61,638,247 RGD:6483358 RGD
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 GBrowse link ISS 10 56,440,651 56,442,403 RGD:6483358 RGD
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link ISO 12 20,931,996 20,942,374 RGD:6484113 PID
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link ISO 12 20,931,996 20,942,374 RGD:6484113 PID
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 GBrowse link ISO 7 139,094,505 139,127,427 RGD:6484113 PID
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 GBrowse link ISO 5 139,690,801 139,719,021 RGD:6484113 PID
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 GBrowse link ISO 5 139,690,801 139,719,021 RGD:6484113 PID
G Smad3 SMAD family member 3 GBrowse link ISO 8 67,803,909 67,952,056 RGD:6484113 PID
G Smad4 SMAD family member 4 GBrowse link ISO 18 70,432,705 70,461,541 RGD:6484113 PID
G Sp1 Sp1 transcription factor GBrowse link ISO 7 141,164,180 141,194,509 RGD:6484113 PID
G Sp1 Sp1 transcription factor GBrowse link ISO 7 141,164,180 141,194,509 RGD:6484113 PID
G Tceb1 transcription elongation factor B (SIII), polypeptide 1 GBrowse link ISS 5 1,961,106 1,966,991 RGD:6483358 RGD
G Tceb1 transcription elongation factor B (SIII), polypeptide 1 GBrowse link ISO 5 1,961,106 1,966,991 RGD:6484113 PID
G Tceb2 transcription elongation factor B (SIII), polypeptide 2 GBrowse link ISS 10 13,084,817 13,089,619 RGD:6483358 RGD
G Tceb2 transcription elongation factor B (SIII), polypeptide 2 GBrowse link ISO 10 13,084,817 13,089,619 RGD:6484113 PID
G Tert telomerase reverse transcriptase GBrowse link ISO 1 30,445,180 30,465,942 RGD:6484113 PID
G Tf transferrin GBrowse link ISO 8 108,217,774 108,244,487 RGD:6484113 PID
G Tff3 trefoil factor 3, intestinal GBrowse link ISO 20 9,469,888 9,474,604 RGD:6484113 PID
G Tfrc transferrin receptor GBrowse link ISO 11 69,976,258 69,998,098 RGD:6484113 PID
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link ISO 6 52,605,869 52,607,863 RGD:6484113 PID
G Vegfa vascular endothelial growth factor A GBrowse link ISO 9 10,520,730 10,536,071 RGD:6484113 PID
G Vegfa vascular endothelial growth factor A GBrowse link ISO 9 10,520,730 10,536,071 RGD:6484113 PID
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link ISS 4 149,529,396 149,536,289 RGD:6483358 RGD
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link IDA 4 149,529,396 149,536,289 RGD:1580561 RGD
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link ISS 4 149,529,396 149,536,289 RGD:1358257 RGD
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link ISO 4 149,529,396 149,536,289 RGD:6484113 PID
altered hypoxia inducible factor pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link ISS 4 149,529,396 149,536,289 RGD:6907133 RGD
Term paths to the root
Path 1
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  Pathway Ontology 17140
    regulatory pathway 5692
      homeostasis pathway 2069
        oxygen homeostasis pathway 137
          hypoxia inducible factor pathway 136
            altered hypoxia inducible factor pathway 1
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