ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:related_synonym: Il-6 signaling pathway;   PID:200146
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interleukin-6 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G A2m alpha-2-macroglobulin GBrowse link ISO 4 158,103,711 158,153,423 RGD:6484113 PID
G Adam10 ADAM metallopeptidase domain 10 GBrowse link ISS 8 75,200,657 75,289,572 RGD:5686846 RGD
G Adam17 ADAM metallopeptidase domain 17 GBrowse link ISS 6 41,882,432 41,930,755 RGD:5686834 RGD
G Adam17 ADAM metallopeptidase domain 17 GBrowse link ISS 6 41,882,432 41,930,755 RGD:5686846 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:6484113 PID
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta GBrowse link ISO 3 158,826,021 158,827,848 RGD:6484113 PID
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta ISO RGD:6484113 PID
G Crp C-reactive protein, pentraxin-related GBrowse link ISO 13 88,702,243 88,703,153 RGD:6484113 PID
G Fgg fibrinogen gamma chain GBrowse link ISO 2 174,727,312 174,734,594 RGD:6484113 PID
G Fos FBJ osteosarcoma oncogene GBrowse link ISO 6 109,559,135 109,562,001 RGD:6484113 PID
G Foxo1 forkhead box O1 GBrowse link ISO 2 141,127,345 141,203,446 RGD:6484113 PID
G Gab1 GRB2-associated binding protein 1 GBrowse link ISO 19 28,980,284 29,088,877 RGD:6484113 PID
G Gab2 GRB2-associated binding protein 2 GBrowse link ISO 1 154,348,777 154,544,906 RGD:6484113 PID
G Grb2 growth factor receptor bound protein 2 GBrowse link ISS 10 105,722,014 105,818,649 RGD:5686834 RGD
G Grb2 growth factor receptor bound protein 2 GBrowse link ISO 10 105,722,014 105,818,649 RGD:6484113 PID
G Hck hemopoietic cell kinase GBrowse link ISO 3 143,447,697 143,490,281 RGD:6484113 PID
G Hsp90b1 heat shock protein 90, beta, member 1 GBrowse link ISO 7 23,332,986 23,347,525 RGD:6484113 PID
G Il6 interleukin 6 GBrowse link ISS 4 456,799 461,376 RGD:5686834 RGD
G Il6 interleukin 6 GBrowse link ISS 4 456,799 461,376 RGD:1580493 RGD
G Il6 interleukin 6 GBrowse link ISS 4 456,799 461,376 RGD:5686839 RGD
G Il6 interleukin 6 GBrowse link ISO 4 456,799 461,376 RGD:6484113 PID
G Il6r interleukin 6 receptor GBrowse link ISS 2 182,078,049 182,128,135 RGD:5686839 RGD
G Il6r interleukin 6 receptor GBrowse link ISS 2 182,078,049 182,128,135 RGD:5686834 RGD
G Il6r interleukin 6 receptor GBrowse link ISO 2 182,078,049 182,128,135 RGD:6484113 PID
G Il6st interleukin 6 signal transducer GBrowse link IMP 2 43,806,301 43,842,365 RGD:5686900 RGD
G Il6st interleukin 6 signal transducer GBrowse link ISS 2 43,806,301 43,842,365 RGD:5686834 RGD
G Il6st interleukin 6 signal transducer GBrowse link ISS 2 43,806,301 43,842,365 RGD:5686839 RGD
G Il6st interleukin 6 signal transducer GBrowse link ISO 2 43,806,301 43,842,365 RGD:6484113 PID
G Irf1 interferon regulatory factor 1 GBrowse link ISO 10 39,220,600 39,227,602 RGD:6484113 PID
G Jak1 Janus kinase 1 GBrowse link ISS 5 121,804,586 121,905,581 RGD:5686839 RGD
G Jak1 Janus kinase 1 GBrowse link ISO 5 121,804,586 121,905,581 RGD:6484113 PID
G Jak2 Janus kinase 2 GBrowse link ISS 1 232,915,995 232,974,763 RGD:5686839 RGD
G Jak2 Janus kinase 2 GBrowse link ISO 1 232,915,995 232,974,763 RGD:6484113 PID
G Jun jun proto-oncogene GBrowse link ISO 5 115,358,166 115,361,259 RGD:6484113 PID
G Junb jun B proto-oncogene GBrowse link ISO 19 24,831,536 24,833,320 RGD:6484113 PID
G Lbp lipopolysaccharide binding protein GBrowse link ISO 3 149,016,605 149,043,530 RGD:6484113 PID
G Lmo4 LIM domain only 4 GBrowse link ISO 2 242,498,074 242,515,160 RGD:6484113 PID
G Map2k4 mitogen activated protein kinase kinase 4 GBrowse link ISO 10 52,009,149 52,041,599 RGD:6484113 PID
G Map2k6 mitogen-activated protein kinase kinase 6 GBrowse link ISO 10 99,859,684 99,974,446 RGD:6484113 PID
G Mapk11 mitogen-activated protein kinase 11 GBrowse link ISO 7 127,444,055 127,449,990 RGD:6484113 PID
G Mapk14 mitogen activated protein kinase 14 GBrowse link ISO 20 6,939,249 7,000,378 RGD:6484113 PID
G Mcl1 myeloid cell leukemia sequence 1 ISO RGD:6484113 PID
G Mitf microphthalmia-associated transcription factor GBrowse link ISO 4 132,534,187 132,745,669 RGD:6484113 PID
G Myc myelocytomatosis oncogene GBrowse link ISO 7 98,953,142 98,958,060 RGD:6484113 PID
G Pias1 protein inhibitor of activated STAT, 1 GBrowse link ISO 8 67,025,248 67,123,016 RGD:6484113 PID
G Pias3 protein inhibitor of activated STAT, 3 GBrowse link ISO 2 191,499,057 191,507,221 RGD:6484113 PID
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISO 2 118,640,277 118,672,440 RGD:6484113 PID
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISO 2 32,602,673 32,675,350 RGD:6484113 PID
G Prkcd protein kinase C, delta GBrowse link ISO 16 5,954,218 5,975,743 RGD:6484113 PID
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 GBrowse link ISS 12 36,501,886 36,558,055 RGD:5686834 RGD
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 GBrowse link ISO 12 36,501,886 36,558,055 RGD:6484113 PID
G Rac1 ras-related C3 botulinum toxin substrate 1 GBrowse link ISO 12 11,380,314 11,400,531 RGD:6484113 PID
G Socs3 suppressor of cytokine signaling 3 GBrowse link ISO 10 107,958,468 107,959,330 RGD:6484113 PID
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link ISS 6 3,308,778 3,390,661 RGD:5686834 RGD
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link ISO 6 3,308,778 3,390,661 RGD:6484113 PID
G Sos2 son of sevenless homolog 2 (Drosophila) GBrowse link ISS 6 91,609,463 91,722,481 RGD:5686834 RGD
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISS 9 46,455,635 46,497,560 RGD:5686834 RGD
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISS 9 46,455,635 46,497,560 RGD:5686839 RGD
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISO 9 46,455,635 46,497,560 RGD:6484113 PID
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link ISS 10 89,821,078 89,872,970 RGD:5686839 RGD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link ISS 10 89,821,078 89,872,970 RGD:5686834 RGD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link ISO 10 89,821,078 89,872,970 RGD:6484113 PID
G Timp1 TIMP metallopeptidase inhibitor 1 GBrowse link ISO X 12,542,496 12,547,094 RGD:6484113 PID
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 GBrowse link ISO 15 59,397,837 59,428,014 RGD:6484113 PID
G Tyk2 tyrosine kinase 2 GBrowse link ISS 8 20,096,969 20,149,004 RGD:5686839 RGD
G Tyk2 tyrosine kinase 2 GBrowse link ISO 8 20,096,969 20,149,004 RGD:6484113 PID
G Vav1 vav 1 guanine nucleotide exchange factor ISO RGD:6484113 PID
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  Pathway Ontology 17140
    signaling pathway 7465
      cytokine and chemokine mediated signaling pathway 1049
        cytokine mediated signaling pathway 879
          Interleukin mediated signaling pathway 459
            interleukin-6 family mediated signaling pathway 67
              interleukin-6 signaling pathway 67
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