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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Oxygen-Induced Retinopathy
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Accession:DOID:9002909 term browser browse the term
Definition:A noninflammatory disorder of the retina, involving neuronal damage induced by hypoxic conditions, that is a widely used animal model of retinopathy of prematurity (ROP).
Synonyms:exact_synonym: OIP;   OIR
 primary_id: RDO:9000037


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Oxygen-Induced Retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:19342600 RGD:7394795 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 treatment ISO RGD PMID:26553931 RGD:14392781 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment ISO
IDA		 mRNA:increased expression:retina (mouse) RGD PMID:16710171 PMID:19038868 RGD:8548878, RGD:11526145 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO RGD PMID:16651637 RGD:11565123 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO RGD PMID:16651637 RGD:11565123 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Csnk2b casein kinase 2 beta ISO RGD PMID:16651637 RGD:11565123 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 treatment IEP RGD PMID:26670826 RGD:155663663 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Efnb2 ephrin B2 IEP mRNA:increased expression:retina RGD PMID:26670826 RGD:155663663 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Ephb4 EPH receptor B4 treatment IEP RGD PMID:26670826 RGD:155663663 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:retina RGD PMID:17102953 RGD:12903974 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand ISO RGD PMID:17102953 RGD:12903974 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide IEP RGD PMID:21642627 RGD:12904963 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Ghsr growth hormone secretagogue receptor treatment IMP RGD PMID:21642627 RGD:12904963 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment
ameliorates		 ISO mRNA:increased expression:retina (mouse) RGD PMID:18087198 PMID:20220049 PMID:35445044 RGD:8695923, RGD:9068455, RGD:329812014 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:24371837 RGD:10402057 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP protein:decreased expression:serum (rat) RGD PMID:18344903 RGD:12910457 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kdr kinase insert domain receptor treatment IEP
IMP		 RGD PMID:17349140 PMID:15951738 RGD:8549715, RGD:1581593 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:19433784 RGD:10412674 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mir126a microRNA 126a ameliorates ISO RGD PMID:21586283 RGD:401850785 NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mir145 microRNA 145 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein IEP mRNA:decreased expression:retina: RGD PMID:21350694 RGD:10401135 NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563 		JBrowse link
G Ndp norrin cystine knot growth factor NDP treatment ISO RGD PMID:20053900 RGD:8694208 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Ntn1 netrin 1 treatment IEP RGD PMID:26670826 RGD:155663663 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO protein:decreased expression:retina (mouse) RGD PMID:18806296 RGD:2301844 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:12356842 RGD:10041062 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP protein:increased expression:retina (rat) RGD PMID:12821538 RGD:9850261 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Serpine1 serpin family E member 1 severity
treatment		 ISO
IEP		 mRNA, protein:increased expression:retina (mouse) RGD PMID:19443721 PMID:19443721 PMID:11133880 RGD:8547749, RGD:8547749, RGD:13208592 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 treatment
susceptibility		 ISO
IEP		 human gene in a mouse model
mRNA, protein:decreased expression:retina (rat)		 RGD PMID:21281801 PMID:11916948 RGD:8554878, RGD:8655544 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sod1 superoxide dismutase 1 ISO RGD PMID:16741961 RGD:8655606 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:16303927 RGD:8694296 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor ameliorates ISO RGD PMID:15681845 PMID:19342600 PMID:35445044 RGD:7394799, RGD:7394795, RGD:329812014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tug1 taurine up-regulated 1 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927 		JBrowse link
G Vegfa vascular endothelial growth factor A ameliorates IEP
ISO		 mRNA:increased expression:retina: RGD PMID:15303088 PMID:35445044 RGD:7483624, RGD:329812014 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    sensory system disease 6960
      eye disease 3490
        retinal disease 1221
          retinopathy of prematurity 56
            Oxygen-Induced Retinopathy 37
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18248
      nervous system disease 14089
        Neurologic Manifestations 10052
          sensory system disease 6960
            eye disease 3490
              retinal disease 1221
                retinopathy of prematurity 56
                  Oxygen-Induced Retinopathy 37
paths to the root