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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:prion disease pathway
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Accession:PW:0000019 term browser browse the term
Definition:Prion disease - any of a group of fatal, transmissible neurodegenerative diseases caused by abnormalities of prion protein metabolism, which may result from mutations in the prion protein gene or from infection with pathogenic isoforms of the protein. Characteristics include neuronal loss, gliosis, and extensive vacuolization of the cerebral cortex. Prion diseases may be sporadic, inherited as an autosomal dominant trait, or acquired. Human diseases include Creutzfeldt-Jakob disease, Gerstmann-Strussler syndrome, fatal familial insomnia, and kuru
Synonyms:exact_synonym: prion protein disease pathway;   spongiform encephalopathy pathway;   transmissible spongiform encephalopathy pathway
 related_synonym: KEGG:05020


show annotations for term's descendants           Sort by:
prion disease pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator IEA KEGG rno:05020 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G C1qa complement C1q A chain IEA KEGG rno:05020 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain IEA KEGG rno:05020 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain IEA KEGG rno:05020 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C5 complement C5 IEA KEGG rno:05020 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C6 complement C6 IEA KEGG rno:05020 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C7 complement C7 IEA KEGG rno:05020 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G C8a complement C8 alpha chain IEA KEGG rno:05020 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain IEA KEGG rno:05020 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C8g complement C8 gamma chain IEA KEGG rno:05020 NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G C9 complement C9 IEA KEGG rno:05020 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Casp12 caspase 12 IEA KEGG rno:05020 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEA KEGG rno:05020 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Egr1 early growth response 1 IEA KEGG rno:05020 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elk1 ETS transcription factor ELK1 IEA KEGG rno:05020 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase IEA KEGG rno:05020 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IEA KEGG rno:05020 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEA KEGG rno:05020 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1a interleukin 1 alpha IEA KEGG rno:05020 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta IEA KEGG rno:05020 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:05020 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lamc1 laminin subunit gamma 1 IEA KEGG rno:05020 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:05020 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:05020 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05020 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05020 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 IEA KEGG rno:05020 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ncam2 neural cell adhesion molecule 2 IEA KEGG rno:05020 NCBI chr11:20,104,974...20,592,168
Ensembl chr11:20,104,925...20,591,984 		JBrowse link
G Notch1 notch receptor 1 IEA KEGG rno:05020 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha IEA KEGG rno:05020 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta IEA KEGG rno:05020 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit IEA KEGG rno:05020 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669 		JBrowse link
G Prnp prion protein IEA KEGG rno:05020 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Sod1 superoxide dismutase 1 IEA KEGG rno:05020 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 IEA KEGG rno:05020 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    disease pathway 1954
      nervous system disease pathway 761
        neurodegenerative pathway 366
          prion disease pathway 35
            Creutzfeldt-Jakob disease pathway 0
            Gerstmann-Strussler syndrome, Gerstmann-Strussler-Scheinker syndrome pathway 0
            fatal familial insomnia pathway 0
            kuru 0
paths to the root