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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:kallikrein-kinin cascade pathway
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Accession:PW:0000526 term browser browse the term
Definition:The kallikrein-kinin system (KKS) cascade generates several bioactive kinins with roles in vasodilation, release of inflammatory mediators and stimulation of sensory neurons. Kinins also play a role in the renal handling of sodium and water metabolism. In the latter case, the system parallels renin-angiotensin (RAS); the two systems can cross-talk.
Synonyms:related_synonym: KKS system signaling pathway;   tissue kallikrein-kinin cascade
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kallikrein-kinin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:16177542 RGD:7401223 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Ace angiotensin I converting enzyme ISO RGD PMID:16177542 RGD:7401223 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Cpm carboxypeptidase M ISO RGD PMID:16177542 RGD:7401223 NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220 		JBrowse link
G Cpn1 carboxypeptidase N subunit 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465 		JBrowse link
G F12 coagulation factor XII ISO RGD PMID:16177542 RGD:7401223 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Klk1 kallikrein 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Klkb1 kallikrein B1 ISO RGD PMID:18396440 PMID:16177542 RGD:7401224, RGD:7401223 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Kng1 kininogen 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kng2 kininogen 2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Mme membrane metallo-endopeptidase ISO RGD PMID:16177542 RGD:7401223 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Prcp prolylcarboxypeptidase ISO RGD PMID:18396440 RGD:7401224 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Serpina4 serpin family A member 4 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082 		JBrowse link
G Serping1 serpin family G member 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Xpnpep1 X-prolyl aminopeptidase 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 1:252,001,366...252,052,077
Ensembl chr 1:252,001,367...252,051,479 		JBrowse link
G Xpnpep2 X-prolyl aminopeptidase 2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr  X:127,287,765...127,317,036
Ensembl chr  X:127,287,979...127,317,223 		JBrowse link
kinin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO RGD PMID:21145390 RGD:7411621 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:21145390 RGD:7411621 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 PMID:15734727 RGD:7401223, RGD:7401225 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO
TAS		 RGD PMID:16177542 PMID:15734727 RGD:7401223, RGD:7401225 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15734727 RGD:7401225 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693 		JBrowse link
G Kng1 kininogen 1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kng2 kininogen 2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to immunity 793
        kallikrein-kinin cascade pathway 20
          kinin signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to the brain and nervous system 465
        sensory system signaling pathway 79
          kallikrein-kinin cascade pathway 20
            kinin signaling pathway 7
paths to the root