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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:transforming growth factor-beta Smad dependent signaling pathway
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Accession:PW:0000490 term browser browse the term
Definition:Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized modules of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of the Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors leads to activation or repression of many genes.
Synonyms:related_synonym: TGF- beta signaling pathway - SMAD dependent;   TGF-beta Smad dependent signaling pathway
 alt_id: PID:200227;   Reactome:R-HSA-170834
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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IMP RGD PMID:12809600 RGD:2298922 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Arrb2 arrestin, beta 2 ISO PID PID:200227 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Atf3 activating transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Axin1 axin 1 ISO PID PID:200227 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200227 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200227 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200227 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16891311 RGD:1625706 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200227 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO PID PID:200227 NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096 		JBrowse link
G Daxx death-domain associated protein ISO PID PID:200227 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dcn decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 3:143,742,427...143,764,227
Ensembl chr 3:143,742,586...143,764,227 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049 		JBrowse link
G Foxo1 forkhead box O1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxo4 forkhead box O4 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137 		JBrowse link
G Ocln occludin ISO PID PID:200227 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200227 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200227 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200227 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO PID PID:200227 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO PID PID:200227 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO PID PID:200227 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200227 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rnf111 ring finger protein 111 ISO PID PID:200227 NCBI chr 8:71,103,967...71,180,172
Ensembl chr 8:71,103,973...71,145,070 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200227 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Runx1 RUNX family transcription factor 1 IMP RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Runx3 RUNX family transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200227 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Skil SKI-like proto-oncogene ISO PID PID:200227 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
G Smad2 SMAD family member 2 IDA
ISO
IMP		 PID
RGD		 PMID:16959941 PMID:12809600 PMID:18684975 PID:200227, RGD:1599906, RGD:2298922, RGD:2302517 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 ISO
IDA
IMP		 PID
RGD		 PMID:12809600 PMID:12702545 PMID:16891311 PID:200227, RGD:2298922, RGD:1299323, RGD:1625706 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 IDA
ISO		 PID
RGD		 PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad7 SMAD family member 7 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507 		JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200227 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200227 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO
IMP		 RGD PMID:12809600 PMID:18684975 RGD:2298922, RGD:2302517 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO
IMP		 PID
RGD		 PMID:15109563 PMID:14729511 PMID:18684975 PID:200227, RGD:2298921, RGD:1579921, RGD:2302517 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tgfbrap1 transforming growth factor, beta receptor associated protein 1 ISO PID PID:200227 NCBI chr 9:45,320,975...45,371,329
Ensembl chr 9:45,320,930...45,371,311 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046 		JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200227 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO PID PID:200227 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200227 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO PID PID:200227 NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990 		JBrowse link
G Zfyve9 zinc finger FYVE-type containing 9 ISO PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:123,370,677...123,529,699
Ensembl chr 5:123,370,677...123,529,699 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to development 536
        transforming growth factor-beta Smad dependent signaling pathway 66
          altered transforming growth factor-beta Smad dependent signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      growth factor signaling pathway 523
        transforming growth factor-beta superfamily mediated signaling pathway 150
          transforming growth factor-beta signaling pathway 68
            transforming growth factor-beta Smad dependent signaling pathway 66
              altered transforming growth factor-beta Smad dependent signaling pathway 7
paths to the root