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Term:transforming growth factor-beta Smad dependent signaling pathway
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Accession:PW:0000490 term browser browse the term
Definition:Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized module of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors rleads to activation or repression of many genes.
Synonyms:related_synonym: PID:200227;   TGF-beta Smad dependent signaling pathway
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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G A2m alpha-2-macroglobulin GBrowse link IPM 4 158,103,711 158,153,423 RGD:2298922 RGD
G Arrb2 arrestin, beta 2 GBrowse link ISO 10 57,244,071 57,284,166 RGD:6484113 PID
G Atf3 activating transcription factor 3 GBrowse link ISS 13 107,191,622 107,223,850 RGD:5143919 RGD
G Atf3 activating transcription factor 3 GBrowse link ISS 13 107,191,622 107,223,850 RGD:2302137 RGD
G Axin1 axin 1 GBrowse link ISO 10 15,409,373 15,462,726 RGD:6484113 PID
G Bambi BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis) GBrowse link ISO 17 62,654,385 62,658,641 RGD:6484113 PID
G Camk2a calcium/calmodulin-dependent protein kinase II alpha GBrowse link ISO 18 56,879,247 56,948,537 RGD:6484113 PID
G Cav1 caveolin 1, caveolae protein GBrowse link ISO 4 42,956,102 42,989,057 RGD:6484113 PID
G Creb1 cAMP responsive element binding protein 1 GBrowse link IMP 9 63,170,785 63,234,727 RGD:1625706 RGD
G Crebbp CREB binding protein GBrowse link ISS 10 11,598,680 11,724,122 RGD:5143919 RGD
G Crebbp CREB binding protein GBrowse link ISS 10 11,598,680 11,724,122 RGD:2302137 RGD
G Ctgf connective tissue growth factor GBrowse link ISO 1 21,327,099 21,330,215 RGD:6484113 PID
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link ISO 8 125,978,161 125,987,670 RGD:6484113 PID
G Dact2 dishevelled-binding antagonist of beta-catenin 2 GBrowse link ISO 1 53,084,115 53,093,031 RGD:6484113 PID
G Daxx death-domain associated protein GBrowse link ISO 20 5,121,854 5,127,601 RGD:6484113 PID
G Dcn decorin GBrowse link ISS 7 35,004,234 35,045,191 RGD:2298922 RGD
G Dynlrb1 dynein light chain roadblock-type 1 GBrowse link ISO 3 145,718,890 145,740,187 RGD:6484113 PID
G Eif2a eukaryotic translation initiation factor 2A GBrowse link ISO 2 147,870,265 147,903,411 RGD:6484113 PID
G Fkbp1a FK506 binding protein 1a GBrowse link ISS 3 141,861,237 141,880,797 RGD:2298922 RGD
G Fkbp1a FK506 binding protein 1a GBrowse link ISO 3 141,861,237 141,880,797 RGD:6484113 PID
G Foxh1 forkhead box H1 GBrowse link ISS 7 114,717,890 114,719,455 RGD:5143919 RGD
G Foxh1 forkhead box H1 GBrowse link ISS 7 114,717,890 114,719,455 RGD:2302137 RGD
G Foxo1 forkhead box O1 GBrowse link ISS 2 141,127,345 141,203,446 RGD:5143919 RGD
G Foxo1 forkhead box O1 GBrowse link ISS 2 141,127,345 141,203,446 RGD:2302137 RGD
G Foxo3 forkhead box O3 GBrowse link ISS 20 46,171,784 46,262,818 RGD:5143919 RGD
G Foxo3 forkhead box O3 GBrowse link ISS 20 46,171,784 46,262,818 RGD:2302137 RGD
G Foxo4 forkhead box O4 GBrowse link ISS X 89,332,278 89,338,835 RGD:2302137 RGD
G Foxo4 forkhead box O4 GBrowse link ISS X 89,332,278 89,338,835 RGD:5143919 RGD
G Grb2 growth factor receptor bound protein 2 GBrowse link ISO 10 105,722,014 105,818,649 RGD:6484113 PID
G Itch itchy E3 ubiquitin protein ligase GBrowse link ISO 3 145,644,315 145,707,190 RGD:6484113 PID
G Map3k7 mitogen activated protein kinase kinase kinase 7 GBrowse link ISO 5 48,252,637 48,308,820 RGD:6484113 PID
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase GBrowse link ISO 18 61,134,242 61,477,040 RGD:6484113 PID
G Ocln occludin GBrowse link ISO 2 31,317,090 31,367,485 RGD:6484113 PID
G Pard6a par-6 (partitioning defective 6,) homolog alpha (C. elegans) GBrowse link ISO 19 35,533,395 35,535,711 RGD:6484113 PID
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISO 10 13,329,708 13,394,080 RGD:6484113 PID
G Pml promyelocytic leukemia GBrowse link ISO 8 62,020,438 62,051,927 RGD:6484113 PID
G Ppp1ca protein phosphatase 1, catalytic subunit, alpha isozyme GBrowse link ISO 1 206,774,719 206,778,336 RGD:6484113 PID
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A GBrowse link ISO 1 95,994,023 95,997,080 RGD:6484113 PID
G Ppp2ca protein phosphatase 2, catalytic subunit, alpha isozyme GBrowse link ISO 10 37,621,256 37,641,008 RGD:6484113 PID
G Ppp2cb protein phosphatase 2, catalytic subunit, beta isozyme GBrowse link ISO 16 62,330,513 62,351,968 RGD:6484113 PID
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha GBrowse link ISO 15 46,546,447 46,605,977 RGD:6484113 PID
G Rhoa ras homolog family member A ISO RGD:6484113 PID
G Rnf111 ring finger protein 111 GBrowse link ISO 8 74,909,360 74,983,363 RGD:6484113 PID
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 GBrowse link ISO 10 76,657,024 76,698,088 RGD:6484113 PID
G Runx1 runt-related transcription factor 1 GBrowse link IPM 11 32,623,461 32,725,404 RGD:5143919 RGD
G Runx1 runt-related transcription factor 1 GBrowse link IPM 11 32,623,461 32,725,404 RGD:2302137 RGD
G Runx2 runt-related transcription factor 2 GBrowse link ISS 9 11,869,234 12,025,219 RGD:5143919 RGD
G Runx2 runt-related transcription factor 2 GBrowse link ISS 9 11,869,234 12,025,219 RGD:2302137 RGD
G Runx3 runt-related transcription factor 3 GBrowse link ISS 5 153,950,116 153,973,141 RGD:5143919 RGD
G Runx3 runt-related transcription factor 3 GBrowse link ISS 5 153,950,116 153,973,141 RGD:2302137 RGD
G Shc1 SHC (Src homology 2 domain containing) transforming protein 1 GBrowse link ISO 2 181,616,581 181,628,144 RGD:6484113 PID
G Skil SKI-like oncogene GBrowse link ISO 2 116,669,375 116,691,472 RGD:6484113 PID
G Smad2 SMAD family member 2 GBrowse link IDA 18 73,180,520 73,241,707 RGD:1599906 RGD
G Smad2 SMAD family member 2 GBrowse link IMP 18 73,180,520 73,241,707 RGD:2302517 RGD
G Smad2 SMAD family member 2 GBrowse link ISS 18 73,180,520 73,241,707 RGD:2298922 RGD
G Smad2 SMAD family member 2 GBrowse link ISO 18 73,180,520 73,241,707 RGD:6484113 PID
G Smad3 SMAD family member 3 GBrowse link IDA 8 67,803,909 67,952,056 RGD:1299323 RGD
G Smad3 SMAD family member 3 GBrowse link IDA 8 67,803,909 67,952,056 RGD:1599906 RGD
G Smad3 SMAD family member 3 GBrowse link IMP 8 67,803,909 67,952,056 RGD:1625706 RGD
G Smad3 SMAD family member 3 GBrowse link ISS 8 67,803,909 67,952,056 RGD:2298922 RGD
G Smad3 SMAD family member 3 GBrowse link ISO 8 67,803,909 67,952,056 RGD:6484113 PID
G Smad4 SMAD family member 4 GBrowse link IDA 18 70,432,705 70,461,541 RGD:1599906 RGD
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:2298922 RGD
G Smad4 SMAD family member 4 GBrowse link ISO 18 70,432,705 70,461,541 RGD:6484113 PID
G Smad7 SMAD family member 7 GBrowse link ISS 18 72,294,803 72,323,354 RGD:2298922 RGD
G Smad7 SMAD family member 7 GBrowse link ISO 18 72,294,803 72,323,354 RGD:6484113 PID
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 GBrowse link ISS 12 9,950,304 10,042,391 RGD:2298922 RGD
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 GBrowse link ISO 12 9,950,304 10,042,391 RGD:6484113 PID
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 GBrowse link ISS 10 96,170,590 96,269,365 RGD:2298922 RGD
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 GBrowse link ISO 10 96,170,590 96,269,365 RGD:6484113 PID
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link ISO 6 3,308,778 3,390,661 RGD:6484113 PID
G Sptbn1 spectrin, beta, non-erythrocytic 1 GBrowse link ISO 14 111,076,741 111,246,286 RGD:6484113 PID
G Strap serine/threonine kinase receptor associated protein GBrowse link ISO 4 174,863,502 174,877,750 RGD:6484113 PID
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 GBrowse link ISO 7 118,368,997 118,402,928 RGD:6484113 PID
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 GBrowse link ISO 1 2,568,536 2,617,742 RGD:6484113 PID
G Tgfb1 transforming growth factor, beta 1 GBrowse link ISS 1 80,894,705 80,911,020 RGD:2298921 RGD
G Tgfb1 transforming growth factor, beta 1 GBrowse link ISO 1 80,894,705 80,911,020 RGD:6484113 PID
G Tgfb2 transforming growth factor, beta 2 GBrowse link ISS 13 102,718,703 102,818,768 RGD:2298921 RGD
G Tgfb2 transforming growth factor, beta 2 GBrowse link ISO 13 102,718,703 102,818,768 RGD:6484113 PID
G Tgfb3 transforming growth factor, beta 3 GBrowse link ISS 6 110,173,443 110,195,215 RGD:2298922 RGD
G Tgfb3 transforming growth factor, beta 3 GBrowse link ISO 6 110,173,443 110,195,215 RGD:6484113 PID
G Tgfbr1 transforming growth factor, beta receptor 1 GBrowse link IMP 5 63,976,868 64,034,058 RGD:2302517 RGD
G Tgfbr1 transforming growth factor, beta receptor 1 GBrowse link ISS 5 63,976,868 64,034,058 RGD:2298922 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link IMP 8 120,593,595 120,680,453 RGD:2302517 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:2298921 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISO 8 120,593,595 120,680,453 RGD:6484113 PID
G Tgfbr3 transforming growth factor, beta receptor III GBrowse link ISS 14 3,051,039 3,240,286 RGD:2298922 RGD
G Tgfbr3 transforming growth factor, beta receptor III GBrowse link ISO 14 3,051,039 3,240,286 RGD:6484113 PID
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 GBrowse link ISO 5 34,238,505 34,325,951 RGD:6484113 PID
G Xiap X-linked inhibitor of apoptosis GBrowse link ISO X 3,011,520 3,047,798 RGD:6484113 PID
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide GBrowse link ISO 10 63,072,128 63,109,833 RGD:6484113 PID
G Zfyve16 zinc finger, FYVE domain containing 16 GBrowse link ISO 2 22,725,949 22,769,174 RGD:6484113 PID
G Zfyve9 zinc finger, FYVE domain containing 9 GBrowse link ISS 5 129,924,320 130,083,310 RGD:2298922 RGD
G Zfyve9 zinc finger, FYVE domain containing 9 GBrowse link ISO 5 129,924,320 130,083,310 RGD:6484113 PID
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Smad2 SMAD family member 2 GBrowse link ISS 18 73,180,520 73,241,707 RGD:2308865 RGD
G Smad2 SMAD family member 2 GBrowse link ISS 18 73,180,520 73,241,707 RGD:2306282 RGD
G Smad3 SMAD family member 3 GBrowse link ISS 8 67,803,909 67,952,056 RGD:2306282 RGD
G Smad3 SMAD family member 3 GBrowse link ISS 8 67,803,909 67,952,056 RGD:5490966 RGD
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:2308865 RGD
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:2306282 RGD
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:5490966 RGD
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:5490965 RGD
G Smad7 SMAD family member 7 GBrowse link ISS 18 72,294,803 72,323,354 RGD:2308865 RGD
G Tgfb1 transforming growth factor, beta 1 GBrowse link ISS 1 80,894,705 80,911,020 RGD:2306282 RGD
G Tgfb1 transforming growth factor, beta 1 GBrowse link ISS 1 80,894,705 80,911,020 RGD:2299005 RGD
G Tgfbr1 transforming growth factor, beta receptor 1 GBrowse link ISS 5 63,976,868 64,034,058 RGD:2306282 RGD
G Tgfbr1 transforming growth factor, beta receptor 1 GBrowse link ISS 5 63,976,868 64,034,058 RGD:2299005 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:2306282 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:2308865 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:2299005 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:5490966 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:5490965 RGD
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  Pathway Ontology 17154
    signaling pathway 7601
      growth factor signaling pathway 1032
        transforming growth factor-beta superfamily mediated signaling pathway 250
          transforming growth factor-beta signaling pathway 115
            transforming growth factor-beta Smad dependent signaling pathway 112
              altered transforming growth factor-beta Smad dependent signaling pathway 18
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