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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Rho/Rac/Cdc42 mediated signaling pathway
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Accession:PW:0000105 term browser browse the term
Definition:Members of the Ras related Rho family of proteins control diverse processes such as actin cytoskeletal rearrangements, morphogenesis of dendritic spines, gene expression. Of note is the fact that cytoskeletal rearrangements, primarily actin remodeling have a role to play in vesicular trafficking, a process regulated by Rab proteins.


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Rho/Rac/Cdc42 mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18306009 RGD:5129131 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:24613967 RGD:10053654 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134 		JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:24613967 RGD:10053654 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cdc42 cell division cycle 42 IMP RGD PMID:9487126 RGD:2293350 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:24613967 RGD:10053654 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein IDA RGD PMID:7835339 RGD:68218 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:16543720 RGD:4892323 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Flna filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IMP RGD PMID:9487126 RGD:2293350 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Limk2 LIM domain kinase 2 ISS RGD PMID:10613909 RGD:1549432 NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:9487126 RGD:2293350 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IMP RGD PMID:9487126 RGD:2293350 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Plekhg4 pleckstrin homology and RhoGEF domain containing G4 ISO RGD PMID:24613967 RGD:10053654 NCBI chr19:33,251,788...33,266,490
Ensembl chr19:33,249,706...33,266,357 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit IMP RGD PMID:16549782 RGD:8693756 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:15158121 RGD:1642626 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rac1 Rac family small GTPase 1 IMP
ISO		 RGD PMID:9487126 PMID:24613967 RGD:2293350, RGD:10053654 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rhoa ras homolog family member A TAS
ISO		 RGD PMID:12782387 PMID:12239094 RGD:1299238, RGD:7207227 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhoq ras homolog family member Q ISO RGD PMID:24613967 RGD:10053654 NCBI chr 6:7,613,632...7,652,047 JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      G protein mediated signaling pathway 160
        Ras superfamily mediated signaling pathway 79
          Rho/Rac/Cdc42 mediated signaling pathway 25
paths to the root