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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:aldosterone signaling pathway
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Accession:PW:0000568 term browser browse the term
Definition:Aldosterone signaling through the mineralocorticoid receptor plays an important role in the balance of fluids and electrolytes in the body. Its biosynthesis is primarily regulated by the renin-angiotensin system and potassium ions concentration.
Synonyms:related_synonym: KEGG:04960
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aldosterone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 IEA KEGG rno:04960 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 IEA KEGG rno:04960 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 IEA KEGG rno:04960 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 IEA KEGG rno:04960 NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 IEA KEGG rno:04960 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 IEA KEGG rno:04960 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 IEA KEGG rno:04960 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 IEA KEGG rno:04960 NCBI chr  X:117,087,284...117,108,023
Ensembl chr  X:117,057,423...117,108,020 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:21784126 RGD:7421504 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Daxx death-domain associated protein ISO RGD PMID:21784126 RGD:7421504 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dhx9 DExH-box helicase 9 ISO RGD PMID:21784126 RGD:7421504 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Ell elongation factor for RNA polymerase II ISO RGD PMID:21784126 RGD:7421504 NCBI chr16:18,843,775...18,891,484
Ensembl chr16:18,843,780...18,891,118 		JBrowse link
G Faf1 Fas associated factor 1 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 ISO RGD PMID:21784126 RGD:7421504 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 IEA KEGG rno:04960 NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 IEA KEGG rno:04960 NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IEA KEGG rno:04960 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IEA KEGG rno:04960 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Igf1 insulin-like growth factor 1 IEA KEGG rno:04960 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ins1 insulin 1 IEA KEGG rno:04960 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 IEA KEGG rno:04960 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor IEA KEGG rno:04960 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 IEA KEGG rno:04960 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 IEA KEGG rno:04960 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Irs3 insulin receptor substrate 3 IEA KEGG rno:04960 NCBI chr12:19,053,148...19,055,286
Ensembl chr12:19,053,148...19,055,286 		JBrowse link
G Irs4 insulin receptor substrate 4 IEA KEGG rno:04960 NCBI chr  X:105,344,020...105,360,004 JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:15932931 RGD:1641841 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 IEA KEGG rno:04960 NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04960 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:04960 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04960 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:21784126 RGD:7421504 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:21784126 RGD:7421504 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase IEA KEGG rno:04960 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137 		JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma ISO RGD PMID:21784126 RGD:7421504 NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 IEA KEGG rno:04960 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IEA
ISO		 KEGG
RGD		 PMID:21784126 rno:04960, RGD:7421504 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IEA KEGG rno:04960 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04960 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04960 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04960 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04960 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04960 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04960 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04960 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:21784126 RGD:7421504 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkca protein kinase C, alpha IEA KEGG rno:04960 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta IEA KEGG rno:04960 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04960 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO RGD PMID:21784126 RGD:7421504 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha IEA KEGG rno:04960 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta IEA KEGG rno:04960 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma IEA KEGG rno:04960 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Sfn stratifin IEA KEGG rno:04960 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 IEA KEGG rno:04960 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I ISO RGD PMID:21784126 RGD:7421504 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      transcription factor mediated signaling pathway 460
        aldosterone signaling pathway 63
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      hormone signaling pathway 624
        lipid hormone signaling pathway 224
          steroid hormone signaling pathway 92
            corticosteroid signaling pathway 73
              mineralocorticoid signaling pathway 63
                aldosterone signaling pathway 63
paths to the root