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Term:interleukin-12 signaling pathway
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Accession:PW:0000914 term browser browse the term
Definition:Interleukin-12 signaling activates the Jak-Stat intracellular cascade and promotes the differentiation and proliferation of Th1 cells and the production of interferon-gamma.
Synonyms:related_synonym: Il-12 signaling pathway;   PID:200045

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interleukin-12 signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Atf2 activating transcription factor 2 GBrowse link ISO 3 56,403,676 56,496,473 RGD:6484113 PID
G B2m beta-2 microglobulin GBrowse link ISO 3 108,927,919 108,932,718 RGD:6484113 PID
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link ISO 10 71,744,559 71,746,109 RGD:6484113 PID
G Ccl4 chemokine (C-C motif) ligand 4 GBrowse link ISO 10 71,759,643 71,761,115 RGD:6484113 PID
G Ccr5 chemokine (C-C motif) receptor 5 GBrowse link ISO 8 128,907,157 128,912,272 RGD:6484113 PID
G Cd247 Cd247 molecule GBrowse link ISO 13 81,515,383 81,594,699 RGD:6484113 PID
G Cd3d CD3 molecule, delta GBrowse link ISO 8 47,932,151 47,936,744 RGD:6484113 PID
G Cd3e CD3 molecule, epsilon GBrowse link ISO 8 47,947,257 47,958,419 RGD:6484113 PID
G Cd3g CD3 molecule, gamma GBrowse link ISO 8 47,924,369 47,930,550 RGD:6484113 PID
G Cd4 Cd4 molecule GBrowse link ISO 4 160,988,512 161,014,038 RGD:6484113 PID
G Cd8a CD8a molecule GBrowse link ISO 4 104,589,922 104,594,159 RGD:6484113 PID
G Cd8b CD8b molecule GBrowse link ISO 4 104,536,454 104,552,683 RGD:6484113 PID
G Eomes eomesodermin GBrowse link ISO 8 123,376,689 123,383,451 RGD:6484113 PID
G Faslg Fas ligand (TNF superfamily, member 6) GBrowse link ISO 13 77,472,950 77,480,210 RGD:6484113 PID
G Fos FBJ osteosarcoma oncogene GBrowse link ISO 6 109,559,135 109,562,001 RGD:6484113 PID
G Gadd45b growth arrest and DNA-damage-inducible, beta GBrowse link ISO 7 10,289,073 10,291,102 RGD:6484113 PID
G Gadd45g growth arrest and DNA-damage-inducible, gamma GBrowse link ISO 17 19,230,896 19,232,641 RGD:6484113 PID
G Gzma granzyme A GBrowse link ISO 2 44,488,295 44,500,128 RGD:6484113 PID
G Gzmbl2 Granzyme B-like 2 GBrowse link ISO 15 35,061,676 35,074,048 RGD:6484113 PID
G Hlx H2.0-like homeobox GBrowse link ISO 13 100,685,757 100,691,658 RGD:6484113 PID
G Ifng interferon gamma GBrowse link ISO 7 57,621,756 57,625,792 RGD:6484113 PID
G Il12a interleukin 12A GBrowse link ISO 2 158,710,261 158,717,689 RGD:6484113 PID
G Il12b interleukin 12B GBrowse link ISO 10 29,558,955 29,568,331 RGD:6484113 PID
G Il12rb1 interleukin 12 receptor, beta 1 GBrowse link ISO 16 19,126,653 19,137,584 RGD:6484113 PID
G Il12rb2 interleukin 12 receptor, beta 2 GBrowse link ISO 4 96,929,755 96,995,733 RGD:6484113 PID
G Il18 interleukin 18 GBrowse link ISO 8 53,936,584 53,943,228 RGD:6484113 PID
G Il18r1 interleukin 18 receptor 1 GBrowse link ISO 9 39,627,915 39,659,828 RGD:6484113 PID
G Il18rap interleukin 18 receptor accessory protein GBrowse link ISO 9 39,676,026 39,677,475 RGD:6484113 PID
G Il1b interleukin 1 beta GBrowse link ISO 3 116,964,422 116,970,867 RGD:6484113 PID
G Il1r1 interleukin 1 receptor, type I GBrowse link ISO 9 39,434,910 39,473,552 RGD:6484113 PID
G Il2 interleukin 2 GBrowse link ISO 2 123,655,005 123,659,709 RGD:6484113 PID
G Il2ra interleukin 2 receptor, alpha GBrowse link ISO 17 78,050,491 78,097,802 RGD:6484113 PID
G Il2rb interleukin 2 receptor, beta ISO RGD:6484113 PID
G Il2rg interleukin 2 receptor, gamma GBrowse link ISO X 89,342,055 89,345,715 RGD:6484113 PID
G Il4 interleukin 4 GBrowse link ISO 10 39,074,582 39,080,134 RGD:6484113 PID
G Jak2 Janus kinase 2 GBrowse link ISO 1 232,915,995 232,974,763 RGD:6484113 PID
G Lck lymphocyte-specific protein tyrosine kinase GBrowse link ISO 5 148,707,505 148,718,296 RGD:6484113 PID
G Map2k3 mitogen activated protein kinase kinase 3 GBrowse link ISO 10 47,075,270 47,096,617 RGD:6484113 PID
G Map2k6 mitogen-activated protein kinase kinase 6 GBrowse link ISO 10 99,859,684 99,974,446 RGD:6484113 PID
G Mapk14 mitogen activated protein kinase 14 GBrowse link ISO 20 6,939,249 7,000,378 RGD:6484113 PID
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link ISO 5 165,531,402 165,640,899 RGD:6484113 PID
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link ISO 2 233,091,013 233,187,501 RGD:6484113 PID
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 GBrowse link ISO 1 251,521,559 251,527,815 RGD:6484113 PID
G Nos2 nitric oxide synthase 2, inducible GBrowse link ISO 10 65,036,884 65,072,453 RGD:6484113 PID
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isozyme GBrowse link ISO 2 234,130,176 234,409,232 RGD:6484113 PID
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme GBrowse link ISO 15 3,986,290 4,030,352 RGD:6484113 PID
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha GBrowse link ISO 14 98,060,302 98,099,092 RGD:6484113 PID
G Rab7a RAB7A, member RAS oncogene family GBrowse link ISO 4 122,202,685 122,220,649 RGD:6484113 PID
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link ISO 1 208,262,669 208,273,148 RGD:6484113 PID
G Relb v-rel reticuloendotheliosis viral oncogene homolog B ISO RGD:6484113 PID
G Ripk2 receptor-interacting serine-threonine kinase 2 GBrowse link ISO 5 30,714,817 30,745,941 RGD:6484113 PID
G RT1-Da RT1 class II, locus Da GBrowse link ISO 20 4,636,310 4,641,282 RGD:6484113 PID
G RT1-Db1 RT1 class II, locus Db1 GBrowse link ISO 20 4,671,489 4,681,058 RGD:6484113 PID
G Socs1 suppressor of cytokine signaling 1 GBrowse link ISO 10 4,819,971 4,820,609 RGD:6484113 PID
G Sphk2 sphingosine kinase 2 GBrowse link ISO 1 96,178,615 96,182,920 RGD:6484113 PID
G Stat1 signal transducer and activator of transcription 1 GBrowse link ISO 9 46,455,635 46,497,560 RGD:6484113 PID
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link ISO 10 89,821,078 89,872,970 RGD:6484113 PID
G Stat4 signal transducer and activator of transcription 4 GBrowse link ISO 9 46,510,251 46,650,076 RGD:6484113 PID
G Stat5a signal transducer and activator of transcription 5A GBrowse link ISO 10 89,795,404 89,819,732 RGD:6484113 PID
G Stat6 signal transducer and activator of transcription 6, interleukin-4 induced GBrowse link ISO 7 67,623,534 67,642,283 RGD:6484113 PID
G Tbx21 T-box 21 GBrowse link ISO 10 85,817,743 85,834,178 RGD:6484113 PID
G Tyk2 tyrosine kinase 2 GBrowse link ISO 8 20,096,969 20,149,004 RGD:6484113 PID
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Term Annotations click to browse term
  Pathway Ontology 17140
    signaling pathway 7465
      signaling pathway pertinent to immunity 1872
        cytokine mediated signaling pathway 879
          Interleukin mediated signaling pathway 459
            interleukin-12 family mediated signaling pathway 122
              interleukin-12 signaling pathway 62
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