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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:sphingosine 1-phosphate signaling pathway
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Accession:PW:0000960 term browser browse the term
Definition:Sphingosine 1-phosphate (S1P), a sphingolipid metabolite, can signal intracellularly as a second messenger or extracellularly as a ligand for five G-protein-coupled receptors. The S1P pathway plays important roles in processes such as cell migration, proliferation and survival. The five receptors engage similar G-proteins but their expression varies.
Synonyms:related_synonym: S1P signaling pathway;   sphingosine-1-phosphate receptor signaling pathway


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sphingosine 1-phosphate signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 ISO PID PID:200085 PID:200123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200046 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO PID PID:200046 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Cdc42 cell division cycle 42 ISO PID PID:200054 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh5 cadherin 5 ISO PID PID:200211 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO PID PID:200046 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Elk1 ETS transcription factor ELK1 ISO PID PID:200211 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO PID PID:200046 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200211 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO PID PID:200046 PID:200123 PID:200211 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gna12 G protein subunit alpha 12 ISO PID PID:200046 PID:200054 PID:200076 PID:200123 PID:200211 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255 		JBrowse link
G Gna13 G protein subunit alpha 13 ISO PID PID:200046 PID:200054 PID:200123 PID:200211 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gna14 G protein subunit alpha 14 ISO PID PID:200046 PID:200123 PID:200211 NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423 		JBrowse link
G Gna15 G protein subunit alpha 15 ISO PID PID:200046 PID:200123 PID:200211 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO PID PID:200046 PID:200054 PID:200076 PID:200085 PID:200123 PID:200211 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO PID PID:200046 PID:200054 PID:200076 PID:200085 PID:200123 PID:200211 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO PID PID:200046 PID:200054 PID:200076 PID:200085 PID:200123 PID:200211 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gnao1 G protein subunit alpha o1 ISO PID PID:200046 PID:200054 PID:200076 PID:200085 PID:200123 PID:200211 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gnaq G protein subunit alpha q ISO PID PID:200046 PID:200123 PID:200211 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gnaz G protein subunit alpha z ISO PID PID:200046 PID:200054 PID:200076 PID:200085 PID:200123 PID:200211 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200211 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Itgav integrin subunit alpha V ISO PID PID:200046 PID:200085 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200046 PID:200085 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200046 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200211 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor ISO PID PID:200085 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200046 PID:200054 PID:200085 PID:200211 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200211 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200046 PID:200054 PID:200085 PID:200211 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200211 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO PID PID:200211 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO PID PID:200046 PID:200085 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO PID PID:200046 PID:200085 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Plcb2 phospholipase C, beta 2 ISO PID PID:200085 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200054 PID:200085 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO PID PID:200085 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200046 PID:200085 PID:200211 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200046 PID:200054 PID:200076 PID:200085 PID:200211 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO PID PID:200046 PID:200085 PID:200123 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 ISO PID PID:200046 PID:200123 PID:200211 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 ISO PID PID:200046 PID:200123 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G S1pr4 sphingosine-1-phosphate receptor 4 ISO PID PID:200054 PID:200123 NCBI chr 7:8,207,767...8,210,043
Ensembl chr 7:8,208,098...8,211,893 		JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 ISO PID PID:200054 PID:200076 PID:200123 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795 		JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 ISO PID PID:200123 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084 		JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 ISO PID PID:200123 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534 		JBrowse link
G Sphk1 sphingosine kinase 1 ISO PID PID:200085 PID:200123 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Sphk2 sphingosine kinase 2 ISO PID PID:200123 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200046 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO PID PID:200046 PID:200085 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      lipid signaling pathway 276
        sphingosine 1-phosphate signaling pathway 49
paths to the root