Notch signaling pathway - Ontology Report

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Term:	Notch signaling pathway	go back to main search page
Accession:	PW:0000204	browse the term
Definition:	Notch signaling pathway regulates processes involved in early embryonic development. It plays an important role in cell fate determination. Target genes of Notch have been implicated in angiogenesis, somitogenesis, gliogenesis. Deregulation of the Notch signaling pathway underlies a broad spectrum of diseases and clinical conditions.
Synonyms:	related_synonym:	KEGG:04330; PID:200015

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Notch signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Adam10	ADAM metallopeptidase domain 10		ISS	8	75,200,657	75,289,572	RGD:2302204	RGD
G	Adam10	ADAM metallopeptidase domain 10		ISS	8	75,200,657	75,289,572	RGD:1300252	RGD
G	Adam10	ADAM metallopeptidase domain 10		ISO	8	75,200,657	75,289,572	RGD:6484113	PID
G	Adam12	ADAM metallopeptidase domain 12		ISO	1	193,384,457	193,650,892	RGD:6484113	PID
G	Adam17	ADAM metallopeptidase domain 17		ISS	6	41,882,432	41,930,755	RGD:2302204	RGD
G	Adam17	ADAM metallopeptidase domain 17		IEA	6	41,882,432	41,930,755	RGD:6907045	KEGG
G	Aph1a	anterior pharynx defective 1 homolog A (C. elegans)		ISS	2	190,679,692	190,683,202	RGD:2302204	RGD
G	Aph1a	anterior pharynx defective 1 homolog A (C. elegans)		IEA	2	190,679,692	190,683,202	RGD:6907045	KEGG
G	Aph1a	anterior pharynx defective 1 homolog A (C. elegans)		ISO	2	190,679,692	190,683,202	RGD:6484113	PID
G	Aph1b	anterior pharynx defective 1 homolog B (C. elegans)		ISS	8	71,122,681	71,143,726	RGD:2302204	RGD
G	Aph1b	anterior pharynx defective 1 homolog B (C. elegans)		IEA	8	71,122,681	71,143,726	RGD:6907045	KEGG
G	Aph1b	anterior pharynx defective 1 homolog B (C. elegans)		ISO	8	71,122,681	71,143,726	RGD:6484113	PID
G	Cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase		ISO	8	47,135,357	47,211,889	RGD:6484113	PID
G	Ccnd1	cyclin D1		ISO	1	205,357,235	205,366,757	RGD:6484113	PID
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		ISO	20	7,376,325	7,386,778	RGD:6484113	PID
G	Cir1	corepressor interacting with RBPJ, 1		IEA	3	55,789,080	55,818,634	RGD:6907045	KEGG
G	Cntn1	contactin 1		ISO	7	130,658,836	130,845,071	RGD:6484113	PID
G	Cntn6	contactin 6		ISO	4	140,078,007	140,450,348	RGD:6484113	PID
G	Crebbp	CREB binding protein		IEA	10	11,598,680	11,724,122	RGD:6907045	KEGG
G	Ctbp1	C-terminal binding protein 1		IEA	14	83,022,824	83,050,335	RGD:6907045	KEGG
G	Ctbp1	C-terminal binding protein 1		ISO	14	83,022,824	83,050,335	RGD:6484113	PID
G	Ctbp2	C-terminal binding protein 2		IEA	1	192,463,615	192,492,935	RGD:6907045	KEGG
G	Cul1	cullin 1		ISO	4	75,636,914	75,705,724	RGD:6484113	PID
G	Dlk1	delta-like 1 homolog (Drosophila)		ISO	6	134,022,016	134,043,058	RGD:6484113	PID
G	Dll1	delta-like 1 (Drosophila)		ISS	1	54,240,395	54,248,183	RGD:2302204	RGD
G	Dll1	delta-like 1 (Drosophila)		TAS	1	54,240,395	54,248,183	RGD:1304491	RGD
G	Dll1	delta-like 1 (Drosophila)		ISO	1	54,240,395	54,248,183	RGD:6484113	PID
G	Dll1	delta-like 1 (Drosophila)		IEA	1	54,240,395	54,248,183	RGD:6907045	KEGG
G	Dll3	delta-like 3 (Drosophila)		TAS	1	83,373,482	83,381,219	RGD:1304491	RGD
G	Dll3	delta-like 3 (Drosophila)		ISS	1	83,373,482	83,381,219	RGD:2302204	RGD
G	Dll3	delta-like 3 (Drosophila)		ISO	1	83,373,482	83,381,219	RGD:6484113	PID
G	Dll3	delta-like 3 (Drosophila)		IEA	1	83,373,482	83,381,219	RGD:6907045	KEGG
G	Dll4	delta-like 4 (Drosophila)		ISS	3	105,844,671	105,854,738	RGD:2302204	RGD
G	Dll4	delta-like 4 (Drosophila)		ISO	3	105,844,671	105,854,738	RGD:6484113	PID
G	Dll4	delta-like 4 (Drosophila)		IEA	3	105,844,671	105,854,738	RGD:6907045	KEGG
G	Dner	delta/notch-like EGF repeat containing		ISO	9	83,716,070	83,821,294	RGD:6484113	PID
G	Dnm1	dynamin 1		ISO	3	11,434,778	11,478,452	RGD:6484113	PID
G	Dtx2	deltex homolog 2 (Drosophila)		IEA	12	21,758,490	21,798,085	RGD:6907045	KEGG
G	Dtx3	deltex homolog 3 (Drosophila)		IEA	7	67,145,276	67,149,937	RGD:6907045	KEGG
G	Dtx3l	deltex 3-like (Drosophila)		IEA	11	66,649,508	66,659,119	RGD:6907045	KEGG
G	Dtx4	deltex homolog 4 (Drosophila)		IEA	1	215,396,194	215,416,879	RGD:6907045	KEGG
G	Dvl1	dishevelled, dsh homolog 1 (Drosophila)		IEA	5	172,705,951	172,717,626	RGD:6907045	KEGG
G	Dvl3	dishevelled, dsh homolog 3 (Drosophila)		IEA	11	82,597,654	82,622,175	RGD:6907045	KEGG
G	Eno1	enolase 1, (alpha)		ISO	5	167,394,131	167,405,516	RGD:6484113	PID
G	Ep300	E1A binding protein p300		ISO	7	119,938,507	120,008,886	RGD:6484113	PID
G	Ep300	E1A binding protein p300		IEA	7	119,938,507	120,008,886	RGD:6907045	KEGG
G	Eps15	epidermal growth factor receptor pathway substrate 15		ISO	5	130,639,805	130,739,014	RGD:6484113	PID
G	Fbxw7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase		ISO	2	176,675,226	176,750,737	RGD:6484113	PID
G	Furin	furin (paired basic amino acid cleaving enzyme)		ISO	1	136,209,969	136,222,057	RGD:6484113	PID
G	Gata3	GATA binding protein 3		ISO	17	79,991,587	80,011,574	RGD:6484113	PID
G	Hdac1	histone deacetylase 1		IEA	5	148,672,515	148,699,810	RGD:6907045	KEGG
G	Hdac1	histone deacetylase 1		ISO	5	148,672,515	148,699,810	RGD:6484113	PID
G	Hdac1l	histone deacetylase 1-like		IEA	9	78,410,666	78,412,120	RGD:6907045	KEGG
G	Hdac2	histone deacetylase 2		IEA	20	41,162,093	41,186,492	RGD:6907045	KEGG
G	Hes1	hairy and enhancer of split 1 (Drosophila)		ISS	11	72,603,482	72,605,673	RGD:5135539	RGD
G	Hes1	hairy and enhancer of split 1 (Drosophila)		IEA	11	72,603,482	72,605,673	RGD:6907045	KEGG
G	Hes5	hairy and enhancer of split 5 (Drosophila)		ISS	5	171,763,869	171,764,636	RGD:5135539	RGD
G	Hes5	hairy and enhancer of split 5 (Drosophila)		IEA	5	171,763,869	171,764,636	RGD:6907045	KEGG
G	Hes7	hairy and enhancer of split 7 (Drosophila)		ISS	10	55,879,891	55,882,414	RGD:5135539	RGD
G	Hey1	hairy/enhancer-of-split related with YRPW motif 1		ISS	2	95,174,030	95,176,430	RGD:5135539	RGD
G	Hey1	hairy/enhancer-of-split related with YRPW motif 1		IDA	2	95,174,030	95,176,430	RGD:70528	RGD
G	Hey2	hairy/enhancer-of-split related with YRPW motif 2		ISS	1	27,505,117	27,515,204	RGD:5135539	RGD
G	Hey2	hairy/enhancer-of-split related with YRPW motif 2		IDA	1	27,505,117	27,515,204	RGD:70528	RGD
G	Heyl	hairy/enhancer-of-split related with YRPW motif-like		ISS	5	142,544,185	142,561,176	RGD:5135539	RGD
G	Il4	interleukin 4		ISO	10	39,074,582	39,080,134	RGD:6484113	PID
G	Itch	itchy E3 ubiquitin protein ligase		ISO	3	145,644,315	145,707,190	RGD:6484113	PID
G	Jag1	jagged 1		ISS	3	125,181,063	125,216,481	RGD:2302204	RGD
G	Jag1	jagged 1		IDA	3	125,181,063	125,216,481	RGD:69863	RGD
G	Jag1	jagged 1		IMP	3	125,181,063	125,216,481	RGD:1334443	RGD
G	Jag1	jagged 1		ISO	3	125,181,063	125,216,481	RGD:6484113	PID
G	Jag1	jagged 1		IEA	3	125,181,063	125,216,481	RGD:6907045	KEGG
G	Jag2	jagged 2		TAS	6	137,909,633	137,931,120	RGD:69864	RGD
G	Jag2	jagged 2		ISS	6	137,909,633	137,931,120	RGD:2302204	RGD
G	Jag2	jagged 2		ISO	6	137,909,633	137,931,120	RGD:6484113	PID
G	Jag2	jagged 2		IEA	6	137,909,633	137,931,120	RGD:6907045	KEGG
G	Kat2a	K(lysine) acetyltransferase 2A		IEA	10	89,642,002	89,649,953	RGD:6907045	KEGG
G	Kdm1a	lysine (K)-specific demethylase 1A		ISO	5	155,299,289	155,358,404	RGD:6484113	PID
G	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		ISS	12	14,497,704	14,505,723	RGD:727405	RGD
G	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		ISS	12	14,497,704	14,505,723	RGD:2302204	RGD
G	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		IEA	12	14,497,704	14,505,723	RGD:6907045	KEGG
G	Lnx1	ligand of numb-protein X 1, E3 ubiquitin protein ligase		ISO	14	35,888,702	35,992,436	RGD:6484113	PID
G	Maml1	mastermind like 1 (Drosophila)		ISS	10	35,814,839	35,850,122	RGD:2302204	RGD
G	Maml1	mastermind like 1 (Drosophila)		ISO	10	35,814,839	35,850,122	RGD:6484113	PID
G	Maml1	mastermind like 1 (Drosophila)		IEA	10	35,814,839	35,850,122	RGD:6907045	KEGG
G	Maml2	mastermind like 2 (Drosophila)		ISS	8	10,161,588	10,523,668	RGD:2302204	RGD
G	Maml2	mastermind like 2 (Drosophila)		ISO	8	10,161,588	10,523,668	RGD:6484113	PID
G	Maml2	mastermind like 2 (Drosophila)		IEA	8	10,161,588	10,523,668	RGD:6907045	KEGG
G	Maml3	mastermind like 3 (Drosophila)		ISS	2	140,574,982	140,740,461	RGD:2302204	RGD
G	Mark2	MAP/microtubule affinity-regulating kinase 2		ISO	1	209,958,902	210,022,099	RGD:6484113	PID
G	Mfap2	microfibrillar-associated protein 2		ISO	5	159,868,933	159,874,481	RGD:6484113	PID
G	Mfap5	microfibrillar associated protein 5		ISO	4	158,959,286	158,981,967	RGD:6484113	PID
G	Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		ISS	7	116,717,405	116,735,280	RGD:2302204	RGD
G	Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		ISS	7	116,717,405	116,735,280	RGD:1302739	RGD
G	Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		IEA	7	116,717,405	116,735,280	RGD:6907045	KEGG
G	Mib1	mindbomb E3 ubiquitin protein ligase 1		ISS	18	2,106,102	2,224,819	RGD:1334454	RGD
G	Mib1	mindbomb E3 ubiquitin protein ligase 1		ISO	18	2,106,102	2,224,819	RGD:6484113	PID
G	Myc	myelocytomatosis oncogene		ISO	7	98,953,142	98,958,060	RGD:6484113	PID
G	Mycbp	c-myc binding protein		ISO	5	143,196,136	143,203,083	RGD:6484113	PID
G	Ncor1	nuclear receptor co-repressor 1		ISO	10	48,481,110	48,628,538	RGD:6484113	PID
G	Ncor2	nuclear receptor co-repressor 2		ISO	12	32,617,643	32,725,753	RGD:6484113	PID
G	Ncor2	nuclear receptor co-repressor 2		IEA	12	32,617,643	32,725,753	RGD:6907045	KEGG
G	Ncstn	nicastrin		ISS	13	88,060,484	88,076,493	RGD:2302204	RGD
G	Ncstn	nicastrin		TAS	13	88,060,484	88,076,493	RGD:724403	RGD
G	Ncstn	nicastrin		IEA	13	88,060,484	88,076,493	RGD:6907045	KEGG
G	Ncstn	nicastrin		ISO	13	88,060,484	88,076,493	RGD:6484113	PID
G	Neurl1a	neuralized homolog 1A (Drosophila)		ISS	1	252,502,664	252,573,249	RGD:1334462	RGD
G	Neurl2	neuralized homolog 2 (Drosophila)		ISS	3	155,863,669	155,865,955	RGD:1334462	RGD
G	Notch1	notch 1		IED	3	4,631,797	4,677,640	RGD:1358543	RGD
G	Notch1	notch 1		IDA	3	4,631,797	4,677,640	RGD:2306423	RGD
G	Notch1	notch 1		IDA	3	4,631,797	4,677,640	RGD:724389	RGD
G	Notch1	notch 1		IMP	3	4,631,797	4,677,640	RGD:1334443	RGD
G	Notch1	notch 1		ISS	3	4,631,797	4,677,640	RGD:2302204	RGD
G	Notch1	notch 1		ISO	3	4,631,797	4,677,640	RGD:6484113	PID
G	Notch1	notch 1		IEA	3	4,631,797	4,677,640	RGD:6907045	KEGG
G	Notch2	notch 2		TAS	2	192,839,350	192,986,589	RGD:69906	RGD
G	Notch2	notch 2		ISS	2	192,839,350	192,986,589	RGD:2302204	RGD
G	Notch2	notch 2		ISO	2	192,839,350	192,986,589	RGD:6484113	PID
G	Notch2	notch 2		IEA	2	192,839,350	192,986,589	RGD:6907045	KEGG
G	Notch3	notch 3		ISS	7	12,688,267	12,740,015	RGD:2302204	RGD
G	Notch3	notch 3		IDA	7	12,688,267	12,740,015	RGD:2306423	RGD
G	Notch3	notch 3		IDA	7	12,688,267	12,740,015	RGD:625426	RGD
G	Notch3	notch 3		ISO	7	12,688,267	12,740,015	RGD:6484113	PID
G	Notch3	notch 3		IEA	7	12,688,267	12,740,015	RGD:6907045	KEGG
G	Notch4	notch 4		IDA	20	4,263,205	4,287,312	RGD:1304484	RGD
G	Notch4	notch 4		ISS	20	4,263,205	4,287,312	RGD:2302204	RGD
G	Notch4	notch 4		ISO	20	4,263,205	4,287,312	RGD:6484113	PID
G	Notch4	notch 4		IEA	20	4,263,205	4,287,312	RGD:6907045	KEGG
G	Numb	numb homolog (Drosophila)		TAS	6	107,838,216	107,882,302	RGD:724390	RGD
G	Numb	numb homolog (Drosophila)		ISO	6	107,838,216	107,882,302	RGD:6484113	PID
G	Numb	numb homolog (Drosophila)		IEA	6	107,838,216	107,882,302	RGD:6907045	KEGG
G	Numbl	numb homolog (Drosophila)-like		ISS	1	82,333,804	82,356,657	RGD:1334451	RGD
G	Numbl	numb homolog (Drosophila)-like		IEA	1	82,333,804	82,356,657	RGD:6907045	KEGG
G	Pcaf	p300/CBP-associated factor		IEA	9	882,928	889,661	RGD:6907045	KEGG
G	Pofut1	protein O-fucosyltransferase 1		ISS	3	143,592,269	143,614,466	RGD:2302204	RGD
G	Pofut1	protein O-fucosyltransferase 1		ISS	3	143,592,269	143,614,466	RGD:1334453	RGD
G	Psen1	presenilin 1		ISS	6	107,737,543	107,776,357	RGD:2302204	RGD
G	Psen1	presenilin 1		TAS	6	107,737,543	107,776,357	RGD:724403	RGD
G	Psen1	presenilin 1		IEA	6	107,737,543	107,776,357	RGD:6907045	KEGG
G	Psen1	presenilin 1		ISO	6	107,737,543	107,776,357	RGD:6484113	PID
G	Psen2	presenilin 2		ISS	13	95,934,674	95,951,836	RGD:2302204	RGD
G	Psen2	presenilin 2		IEA	13	95,934,674	95,951,836	RGD:6907045	KEGG
G	Psenen	presenilin enhancer 2 homolog (C. elegans)		ISS	1	85,607,051	85,608,248	RGD:2302204	RGD
G	Psenen	presenilin enhancer 2 homolog (C. elegans)		ISO	1	85,607,051	85,608,248	RGD:6484113	PID
G	Psenen	presenilin enhancer 2 homolog (C. elegans)		IEA	1	85,607,051	85,608,248	RGD:6907045	KEGG
G	Ptcra	pre T-cell antigen receptor alpha		IEA				RGD:6907045	KEGG
G	Rab11a	RAB11a, member RAS oncogene family		ISO	8	68,931,925	68,979,514	RGD:6484113	PID
G	Rbbp8	retinoblastoma binding protein 8		ISO	18	3,266,565	3,333,153	RGD:6484113	PID
G	Rbpj	recombination signal binding protein for immunoglobulin kappa J region		IDA				RGD:2306423	RGD
G	Rbpj	recombination signal binding protein for immunoglobulin kappa J region		ISO				RGD:6484113	PID
G	Rbpj	recombination signal binding protein for immunoglobulin kappa J region		IEA				RGD:6907045	KEGG
G	Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like		IEA	3	155,425,120	155,437,490	RGD:6907045	KEGG
G	Rbpjl2	recombination signal binding protein for immunoglobulin kappa J region-like 2		IEA	5	4,663,833	4,665,775	RGD:6907045	KEGG
G	Rfng	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		ISS				RGD:2302204	RGD
G	Rfng	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		IMP				RGD:633801	RGD
G	Rfng	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase		IEA				RGD:6907045	KEGG
G	Skp1	S-phase kinase-associated protein 1		ISO	10	37,665,417	37,680,338	RGD:6484113	PID
G	Skp2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase		ISO	2	58,769,164	58,797,229	RGD:6484113	PID
G	Snw1	SNW domain containing 1		IEA	6	111,688,742	111,712,826	RGD:6907045	KEGG
G	Spen	spen homolog, transcriptional regulator (Drosophila)		ISO	5	160,359,738	160,414,311	RGD:6484113	PID
G	Sspo	SCO-spondin		ISO	4	76,533,300	76,587,372	RGD:6484113	PID
G	Yy1	YY1 transcription factor		ISO	6	133,132,419	133,156,686	RGD:6484113	PID
altered Notch signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Dll1	delta-like 1 (Drosophila)		ISS	1	54,240,395	54,248,183	RGD:1304492	RGD
G	Dll3	delta-like 3 (Drosophila)		ISS	1	83,373,482	83,381,219	RGD:1304493	RGD
G	Hey1	hairy/enhancer-of-split related with YRPW motif 1		ISS	2	95,174,030	95,176,430	RGD:1334460	RGD
G	Jag1	jagged 1		ISS	3	125,181,063	125,216,481	RGD:1304484	RGD
G	Jag2	jagged 2		ISS	6	137,909,633	137,931,120	RGD:1304492	RGD
G	Notch1	notch 1		ISS	3	4,631,797	4,677,640	RGD:724389	RGD
G	Notch2	notch 2		ISS	2	192,839,350	192,986,589	RGD:69906	RGD
G	Notch3	notch 3		TAS	7	12,688,267	12,740,015	RGD:625426	RGD
G	Notch4	notch 4		ISS	20	4,263,205	4,287,312	RGD:1304484	RGD
G	Numb	numb homolog (Drosophila)		ISS	6	107,838,216	107,882,302	RGD:1334451	RGD
G	Pofut1	protein O-fucosyltransferase 1		ISS	3	143,592,269	143,614,466	RGD:1334453	RGD
altered Notch signaling pathway involving promoters
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Hey1	hairy/enhancer-of-split related with YRPW motif 1		ISS	2	95,174,030	95,176,430	RGD:1334460	RGD
altered Notch signaling pathway involving the macromolecules modifying the main players
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Numb	numb homolog (Drosophila)		ISS	6	107,838,216	107,882,302	RGD:1334451	RGD
G	Pofut1	protein O-fucosyltransferase 1		ISS	3	143,592,269	143,614,466	RGD:1334453	RGD
G	Psen2	presenilin 2		ISS	13	95,934,674	95,951,836	RGD:2302525	RGD
altered Notch signaling pathway involving the main players
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Dll3	delta-like 3 (Drosophila)		ISS	1	83,373,482	83,381,219	RGD:1304493	RGD
G	Jag1	jagged 1		ISS	3	125,181,063	125,216,481	RGD:1334443	RGD
G	Notch1	notch 1		ISS	3	4,631,797	4,677,640	RGD:1334450	RGD
G	Notch3	notch 3		ISS	7	12,688,267	12,740,015	RGD:1334442	RGD

Term paths to the root

Path 1
Term	Annotations
Pathway Ontology	17140
signaling pathway	7465
signaling pathway pertinent to development	696
Notch signaling pathway	180
altered Notch signaling pathway +	19
Path 2
Term	Annotations
Pathway Ontology	17140
signaling pathway	7465
cell adhesion signaling pathway	712
cell-cell signaling pathway	447
Notch signaling pathway	180
altered Notch signaling pathway +	19