RGD Reference Report - Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. - Rat Genome Database

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.

Authors: Jones, SA  Scheller, J  Rose-John, S 
Citation: Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
RGD ID: 5686839
Pubmed: PMID:21881215   (View Abstract at PubMed)
PMCID: PMC3163962   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI57158   (Journal Full-text)

The successful treatment of certain autoimmune conditions with the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the beta-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)
Il6r  (interleukin 6 receptor)
Il6st  (interleukin 6 cytokine family signal transducer)
Jak1  (Janus kinase 1)
Jak2  (Janus kinase 2)
Stat1  (signal transducer and activator of transcription 1)
Stat3  (signal transducer and activator of transcription 3)
Tyk2  (tyrosine kinase 2)

Genes (Mus musculus)
Il6  (interleukin 6)
Il6ra  (interleukin 6 receptor, alpha)
Il6st  (interleukin 6 signal transducer)
Jak1  (Janus kinase 1)
Jak2  (Janus kinase 2)
Stat1  (signal transducer and activator of transcription 1)
Stat3  (signal transducer and activator of transcription 3)
Tyk2  (tyrosine kinase 2)

Genes (Homo sapiens)
IL6  (interleukin 6)
IL6R  (interleukin 6 receptor)
IL6ST  (interleukin 6 cytokine family signal transducer)
JAK1  (Janus kinase 1)
JAK2  (Janus kinase 2)
STAT1  (signal transducer and activator of transcription 1)
STAT3  (signal transducer and activator of transcription 3)
TYK2  (tyrosine kinase 2)


Additional Information