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Term:phosphatidylinositol 3-kinase class I signaling pathway
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Accession:PW:0000963 term browser browse the term
Definition:Phosphatidylinositol kinases represent a family of lipid kinases that phosphorylate the 3' position of the inositol ring in target substrates. They are grouped into three classes: class I further subdivided into subclass A and B, class II and class III. By far the best known and characterized is class I, particularly IA that signals downstream of receptor tyrosine kinases and engages the Akt family of kinases.
Synonyms:related_synonym: PID:200116

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phosphatidylinositol 3-kinase class I signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adap1 ArfGAP with dual PH domains 1 GBrowse link ISO 12 15,825,017 15,877,643 RGD:6484113 PID
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 GBrowse link ISO 18 30,893,720 30,916,965 RGD:6484113 PID
G Arf1 ADP-ribosylation factor 1 GBrowse link ISO 10 45,516,609 45,532,091 RGD:6484113 PID
G Arf5 ADP-ribosylation factor 5 GBrowse link ISO 4 55,293,825 55,296,751 RGD:6484113 PID
G Arf6 ADP-ribosylation factor 6 GBrowse link ISO 6 91,337,496 91,338,644 RGD:6484113 PID
G Blk B lymphoid tyrosine kinase GBrowse link ISO 15 42,643,847 42,682,793 RGD:6484113 PID
G Blnk B-cell linker GBrowse link ISO 1 246,091,335 246,165,075 RGD:6484113 PID
G Btk Bruton agammaglobulinemia tyrosine kinase GBrowse link ISO X 121,998,935 122,030,289 RGD:6484113 PID
G Cyth1 cytohesin 1 GBrowse link ISO 10 108,189,311 108,253,419 RGD:6484113 PID
G Cyth2 cytohesin 2 GBrowse link ISO 1 96,284,658 96,291,450 RGD:6484113 PID
G Cyth3 cytohesin 3 GBrowse link ISO 12 11,169,420 11,198,144 RGD:6484113 PID
G Dapp1 dual adaptor of phosphotyrosine and 3-phosphoinositides GBrowse link ISO 2 235,423,487 235,474,068 RGD:6484113 PID
G Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog GBrowse link ISO 5 152,119,455 152,147,057 RGD:6484113 PID
G Foxo3 forkhead box O3 GBrowse link ISO 20 46,171,784 46,262,818 RGD:6484113 PID
G Fyn FYN oncogene related to SRC, FGR, YES GBrowse link ISO 20 43,501,853 43,695,567 RGD:6484113 PID
G Hck hemopoietic cell kinase GBrowse link ISO 3 143,447,697 143,490,281 RGD:6484113 PID
G Hras Harvey rat sarcoma virus oncogene GBrowse link ISO 1 201,385,705 201,388,987 RGD:6484113 PID
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 GBrowse link ISO 6 135,413,616 135,419,147 RGD:6484113 PID
G Inpp5d inositol polyphosphate-5-phosphatase D GBrowse link ISO 9 86,576,742 86,682,240 RGD:6484113 PID
G Inppl1 inositol polyphosphate phosphatase-like 1 GBrowse link ISO 1 159,278,131 159,292,740 RGD:6484113 PID
G Itk IL2-inducible T-cell kinase GBrowse link ISO 10 31,455,982 31,518,075 RGD:6484113 PID
G Lck lymphocyte-specific protein tyrosine kinase GBrowse link ISO 5 148,707,505 148,718,296 RGD:6484113 PID
G Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog GBrowse link ISO 5 16,933,111 17,054,564 RGD:6484113 PID
G Nras neuroblastoma ras oncogene GBrowse link ISO 2 198,292,650 198,300,286 RGD:6484113 PID
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISO 10 13,329,708 13,394,080 RGD:6484113 PID
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISO 2 118,640,277 118,672,440 RGD:6484113 PID
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link ISO 8 103,886,682 103,957,112 RGD:6484113 PID
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link ISO 5 166,735,274 166,761,189 RGD:6484113 PID
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma GBrowse link ISO 6 50,441,892 50,476,931 RGD:6484113 PID
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISO 2 32,602,673 32,675,350 RGD:6484113 PID
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link ISO 16 19,171,101 19,179,650 RGD:6484113 PID
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link ISO 5 136,497,494 136,566,473 RGD:6484113 PID
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 GBrowse link ISO 10 55,227,872 55,248,301 RGD:6484113 PID
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 GBrowse link ISO 10 55,270,065 55,303,503 RGD:6484113 PID
G Plcg1 phospholipase C, gamma 1 GBrowse link ISO 3 151,522,949 151,553,998 RGD:6484113 PID
G Plcg2 phospholipase C, gamma 2 GBrowse link ISO 19 47,875,572 47,947,573 RGD:6484113 PID
G Plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 GBrowse link ISO 1 190,187,202 190,238,309 RGD:6484113 PID
G Plekha2 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 ISO RGD:6484113 PID
G Pten phosphatase and tensin homolog GBrowse link ISO 1 236,771,027 236,837,261 RGD:6484113 PID
G Rac1 ras-related C3 botulinum toxin substrate 1 GBrowse link ISO 12 11,380,314 11,400,531 RGD:6484113 PID
G Rap1a RAP1A, member of RAS oncogene family GBrowse link ISO 2 200,980,324 201,001,561 RGD:6484113 PID
G Rhoa ras homolog family member A ISO RGD:6484113 PID
G Sgk1 serum/glucocorticoid regulated kinase 1 GBrowse link ISO 1 23,501,257 23,506,651 RGD:6484113 PID
G Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) GBrowse link ISO 3 148,157,256 148,170,524 RGD:6484113 PID
G Syk spleen tyrosine kinase GBrowse link ISO 17 18,440,672 18,498,001 RGD:6484113 PID
G Yes1 Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 GBrowse link ISO 9 112,516,831 112,564,072 RGD:6484113 PID
G Zap70 zeta-chain (TCR) associated protein kinase 70 GBrowse link ISO 9 35,693,089 35,715,071 RGD:6484113 PID
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISS 6 137,640,482 137,657,552 RGD:2313763 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISS 6 137,640,482 137,657,552 RGD:5133243 RGD
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link ISS 1 82,686,233 82,726,544 RGD:2313763 RGD
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link ISS 1 82,686,233 82,726,544 RGD:5490965 RGD
G Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) GBrowse link ISS 13 92,802,390 93,110,704 RGD:2313763 RGD
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISS 2 118,640,277 118,672,440 RGD:2313763 RGD
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISS 2 118,640,277 118,672,440 RGD:4143515 RGD
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISS 2 118,640,277 118,672,440 RGD:5133242 RGD
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISS 2 118,640,277 118,672,440 RGD:5133243 RGD
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:2313763 RGD
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:2326139 RGD
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:4143515 RGD
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:5133242 RGD
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:5490965 RGD
phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISS 6 137,640,482 137,657,552 RGD:2290458 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IMP 6 137,640,482 137,657,552 RGD:625444 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link ISO 6 137,640,482 137,657,552 RGD:6484113 PID
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link ISS 1 82,686,233 82,726,544 RGD:2290458 RGD
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link IMP 1 82,686,233 82,726,544 RGD:632179 RGD
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link ISO 1 82,686,233 82,726,544 RGD:6484113 PID
G Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) GBrowse link ISS 13 92,802,390 93,110,704 RGD:2290458 RGD
G Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) GBrowse link ISO 13 92,802,390 93,110,704 RGD:6484113 PID
G Bad BCL2-associated agonist of cell death GBrowse link ISO 1 209,617,373 209,626,292 RGD:6484113 PID
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link ISO 5 160,704,234 160,721,796 RGD:6484113 PID
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link ISO 20 7,376,325 7,386,778 RGD:6484113 PID
G Cdkn1b cyclin-dependent kinase inhibitor 1B GBrowse link ISO 4 171,841,705 171,846,506 RGD:6484113 PID
G Chuk conserved helix-loop-helix ubiquitous kinase GBrowse link ISO 1 249,122,845 249,158,369 RGD:6484113 PID
G Foxo1 forkhead box O1 GBrowse link ISO 2 141,127,345 141,203,446 RGD:6484113 PID
G Foxo3 forkhead box O3 GBrowse link ISO 20 46,171,784 46,262,818 RGD:6484113 PID
G Foxo4 forkhead box O4 GBrowse link ISO X 89,332,278 89,338,835 RGD:6484113 PID
G Gsk3a glycogen synthase kinase 3 alpha GBrowse link ISO 1 80,505,517 80,514,139 RGD:6484113 PID
G Gsk3b glycogen synthase kinase 3 beta GBrowse link ISO 11 64,284,731 64,428,698 RGD:6484113 PID
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 GBrowse link ISO 6 135,413,616 135,419,147 RGD:6484113 PID
G Inpp5d inositol polyphosphate-5-phosphatase D GBrowse link ISS 9 86,576,742 86,682,240 RGD:2302068 RGD
G Inppl1 inositol polyphosphate phosphatase-like 1 GBrowse link ISS 1 159,278,131 159,292,740 RGD:2302068 RGD
G Kpna1 karyopherin alpha 1 GBrowse link ISO 11 66,555,859 66,595,898 RGD:6484113 PID
G Map3k5 mitogen-activated protein kinase kinase kinase 5 GBrowse link ISO 1 15,205,361 15,346,422 RGD:6484113 PID
G Mapkap1 mitogen-activated protein kinase associated protein 1 GBrowse link ISO 3 13,439,919 13,643,105 RGD:6484113 PID
G Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) GBrowse link ISO 10 13,725,510 13,731,261 RGD:6484113 PID
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link ISO 5 165,531,402 165,640,899 RGD:6484113 PID
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISS 10 13,329,708 13,394,080 RGD:2290458 RGD
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link ISO 10 13,329,708 13,394,080 RGD:6484113 PID
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISS 2 118,640,277 118,672,440 RGD:2290458 RGD
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link ISS 8 103,886,682 103,957,112 RGD:2290458 RGD
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link ISS 5 166,735,274 166,761,189 RGD:2290458 RGD
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link ISS 2 32,602,673 32,675,350 RGD:2290458 RGD
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link ISS 16 19,171,101 19,179,650 RGD:2290458 RGD
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link ISS 5 136,497,494 136,566,473 RGD:2290458 RGD
G Prkaca protein kinase, cAMP-dependent, catalytic, alpha GBrowse link ISO 19 25,840,795 25,864,786 RGD:6484113 PID
G Prkdc protein kinase, DNA activated, catalytic polypeptide GBrowse link ISO 11 86,951,420 87,169,229 RGD:6484113 PID
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:2290458 RGD
G Raf1 v-raf-leukemia viral oncogene 1 GBrowse link ISO 4 151,752,583 151,775,609 RGD:6484113 PID
G Rictor RPTOR independent companion of MTOR, complex 2 GBrowse link ISO 2 55,982,784 56,071,528 RGD:6484113 PID
G Sfn stratifin GBrowse link ISO 5 151,475,395 151,479,996 RGD:6484113 PID
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 GBrowse link ISO 10 56,786,705 56,792,209 RGD:6484113 PID
G Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) GBrowse link ISO 3 148,157,256 148,170,524 RGD:6484113 PID
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide GBrowse link ISO 3 154,926,025 154,948,297 RGD:6484113 PID
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide GBrowse link ISO 10 63,072,128 63,109,833 RGD:6484113 PID
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide GBrowse link ISO 12 21,859,804 21,888,050 RGD:6484113 PID
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide GBrowse link ISO 14 83,448,395 83,457,778 RGD:6484113 PID
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide GBrowse link ISO 6 41,945,769 41,976,123 RGD:6484113 PID
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide GBrowse link ISO 7 72,283,825 72,306,126 RGD:6484113 PID
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  Pathway Ontology 17140
    signaling pathway 7465
      signaling pathway involving second messengers 543
        phosphatidylinositol 3-kinase signaling pathway 183
          phosphatidylinositol 3-kinase class I signaling pathway 109
            phosphatidylinositol 3-kinase-Akt signaling pathway + 62
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