RGD Reference Report - Role of interleukin-6 in chronic muscle hyperalgesic priming. - Rat Genome Database

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Role of interleukin-6 in chronic muscle hyperalgesic priming.

Authors: Dina, OA  Green, PG  Levine, JD 
Citation: Dina OA, etal., Neuroscience. 2008 Mar 18;152(2):521-5. Epub 2008 Jan 12.
RGD ID: 5686900
Pubmed: PMID:18280048   (View Abstract at PubMed)
PMCID: PMC2336107   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuroscience.2008.01.006   (Journal Full-text)

After recovery from acute muscle pain even minor subsequent muscle use can initiate recurrence of the same mechanical hyperalgesia months or years after the initial injury. We have recently developed a model of this chronic latent hyperalgesia in the rat. In this study, we have examined the possibility that interleukin-6 (IL-6), an inflammatory mediator produced during acute muscle inflammation, can mediate the production of this chronic latent hyperalgesic state in which subsequent exposure to inflammatory mediators produces a markedly prolonged mechanical hyperalgesia. We now report that i.m. injection of IL-6 produced mechanical hyperalgesia, lasting several hours, that was prevented by intrathecal injection of antisense to glycoprotein 130 (gp130), an IL-6 receptor subunit. Furthermore, following complete recovery from i.m. IL-6-induced hyperalgesia, i.m. prostaglandin E(2) produced a mechanical hyperalgesia that was remarkably prolonged compared with naive controls, indicating the presence of chronic latent hyperalgesia. This ability of IL-6 to produce chronic latent hyperalgesia was prevented by intrathecal administration of antisense for gp130. Furthermore, gp130 antisense also prevented chronic latent hyperalgesia produced by i.m. injection of the inflammogen, carrageenan. These results identify a role for IL-6 in acute inflammatory muscle pain and as a potential target against which therapies might be directed to treat chronic muscle pain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
interleukin-6-mediated signaling pathway  IMP 5686900 RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
interleukin-6 signaling pathway   ISOIl6st (Rattus norvegicus)5686900; 5686900 RGD 
interleukin-6 signaling pathway   IMP 5686900 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Il6st  (interleukin 6 cytokine family signal transducer)

Genes (Mus musculus)
Il6st  (interleukin 6 signal transducer)

Genes (Homo sapiens)
IL6ST  (interleukin 6 cytokine family signal transducer)


Additional Information