interleukin-1 signaling pathway - Ontology Report

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Term:	interleukin-1 signaling pathway	go back to main search page
Accession:	PW:0000883	browse the term
Definition:	Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.
Synonyms:	related_synonym:	Il-1 signaling pathway; PID:200089

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interleukin-1 signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Aim2	absent in melanoma 2		ISS	13	89,631,797	89,640,265	RGD:5490211	RGD
G	Casp1	caspase 1		ISS	8	2,027,976	2,036,872	RGD:5490211	RGD
G	Casp1	caspase 1		ISS	8	2,027,976	2,036,872	RGD:5490210	RGD
G	Casp1	caspase 1		ISO	8	2,027,976	2,036,872	RGD:6484113	PID
G	Chuk	conserved helix-loop-helix ubiquitous kinase		ISO	1	249,122,845	249,158,369	RGD:6484113	PID
G	Erc1	ELKS/RAB6-interacting/CAST family member 1		ISO	4	155,931,377	156,221,104	RGD:6484113	PID
G	Ikbkb	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta		ISO	16	73,804,730	73,858,510	RGD:6484113	PID
G	Ikbkg	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma		ISO	X	160,386,558	160,420,190	RGD:6484113	PID
G	Il1a	interleukin 1 alpha		ISS	3	116,913,612	116,924,114	RGD:5490209	RGD
G	Il1a	interleukin 1 alpha		ISO	3	116,913,612	116,924,114	RGD:6484113	PID
G	Il1b	interleukin 1 beta		ISS	3	116,964,422	116,970,867	RGD:5490209	RGD
G	Il1b	interleukin 1 beta		ISO	3	116,964,422	116,970,867	RGD:6484113	PID
G	Il1r1	interleukin 1 receptor, type I		IMP	9	39,434,910	39,473,552	RGD:5130945	RGD
G	Il1r1	interleukin 1 receptor, type I		ISS	9	39,434,910	39,473,552	RGD:5490209	RGD
G	Il1r1	interleukin 1 receptor, type I		ISO	9	39,434,910	39,473,552	RGD:6484113	PID
G	Il1r2	interleukin 1 receptor, type II		ISS	9	39,279,397	39,319,672	RGD:5490209	RGD
G	Il1r2	interleukin 1 receptor, type II		ISO	9	39,279,397	39,319,672	RGD:6484113	PID
G	Il1rap	interleukin 1 receptor accessory protein		ISS	11	76,092,252	76,222,576	RGD:5490209	RGD
G	Il1rn	interleukin 1 receptor antagonist		ISS	3	2,607,800	2,613,216	RGD:5490209	RGD
G	Il1rn	interleukin 1 receptor antagonist		ISO	3	2,607,800	2,613,216	RGD:6484113	PID
G	Irak1	interleukin-1 receptor-associated kinase 1		ISS	X	159,960,184	159,969,180	RGD:5490215	RGD
G	Irak1	interleukin-1 receptor-associated kinase 1		ISS	X	159,960,184	159,969,180	RGD:5490218	RGD
G	Irak1	interleukin-1 receptor-associated kinase 1		ISO	X	159,960,184	159,969,180	RGD:6484113	PID
G	Irak2	interleukin-1 receptor-associated kinase 2		ISS	4	149,543,029	149,599,463	RGD:5490215	RGD
G	Irak3	interleukin-1 receptor-associated kinase 3		ISO	7	59,408,198	59,467,821	RGD:6484113	PID
G	Irak4	interleukin-1 receptor-associated kinase 4		ISS	7	133,055,185	133,081,614	RGD:5490215	RGD
G	Irak4	interleukin-1 receptor-associated kinase 4		ISS	7	133,055,185	133,081,614	RGD:5490218	RGD
G	Irak4	interleukin-1 receptor-associated kinase 4		ISO	7	133,055,185	133,081,614	RGD:6484113	PID
G	Jun	jun proto-oncogene		ISO	5	115,358,166	115,361,259	RGD:6484113	PID
G	Map2k6	mitogen-activated protein kinase kinase 6		ISO	10	99,859,684	99,974,446	RGD:6484113	PID
G	Map3k3	mitogen activated protein kinase kinase kinase 3		ISO	10	95,482,303	95,551,065	RGD:6484113	PID
G	Map3k7	mitogen activated protein kinase kinase kinase 7		ISS	5	48,252,637	48,308,820	RGD:5490218	RGD
G	Map3k7	mitogen activated protein kinase kinase kinase 7		ISS	5	48,252,637	48,308,820	RGD:5490215	RGD
G	Map3k7	mitogen activated protein kinase kinase kinase 7		ISO	5	48,252,637	48,308,820	RGD:6484113	PID
G	Mapk8	mitogen-activated protein kinase 8		ISO	16	8,925,133	9,004,897	RGD:6484113	PID
G	Myd88	myeloid differentiation primary response 88		ISS	8	124,299,729	124,303,798	RGD:5490218	RGD
G	Myd88	myeloid differentiation primary response 88		ISS	8	124,299,729	124,303,798	RGD:5490215	RGD
G	Myd88	myeloid differentiation primary response 88		ISO	8	124,299,729	124,303,798	RGD:6484113	PID
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		ISO	2	233,091,013	233,187,501	RGD:6484113	PID
G	Nlrp1a	NLR family, pyrin domain containing 1A		ISS	10	57,963,708	58,007,925	RGD:5490211	RGD
G	Nlrp3	NLR family, pyrin domain containing 3		ISS	10	45,850,224	45,874,533	RGD:5490211	RGD
G	Nlrp3	NLR family, pyrin domain containing 3		ISS	10	45,850,224	45,874,533	RGD:5490210	RGD
G	Peli1	pellino E3 ubiquitin protein ligase 1		ISS	14	101,870,272	101,924,228	RGD:5490215	RGD
G	Peli2	pellino E3 ubiquitin protein ligase family member 2		ISS	15	24,227,734	24,371,242	RGD:5490215	RGD
G	Peli3	pellino E3 ubiquitin protein ligase family member 3		ISS	1	207,548,086	207,558,715	RGD:5490215	RGD
G	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha		ISO	2	118,640,277	118,672,440	RGD:6484113	PID
G	Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		ISO	2	32,602,673	32,675,350	RGD:6484113	PID
G	Prkci	protein kinase C, iota		ISO	2	116,739,625	116,801,084	RGD:6484113	PID
G	Prkcz	protein kinase C, zeta		ISO	5	172,061,825	172,172,793	RGD:6484113	PID
G	Pycard	PYD and CARD domain containing		ISS	1	187,276,089	187,277,122	RGD:5490211	RGD
G	Pycard	PYD and CARD domain containing		ISS	1	187,276,089	187,277,122	RGD:5490210	RGD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		ISO	1	208,262,669	208,273,148	RGD:6484113	PID
G	Sigirr	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain		ISS	1	201,288,417	201,297,160	RGD:5490209	RGD
G	Sqstm1	sequestosome 1		ISO	10	35,751,300	35,762,630	RGD:6484113	PID
G	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1		ISS	7	118,368,997	118,402,928	RGD:5490218	RGD
G	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1		ISS	7	118,368,997	118,402,928	RGD:5490215	RGD
G	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1		ISO	7	118,368,997	118,402,928	RGD:6484113	PID
G	Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2		ISS	1	2,568,536	2,617,742	RGD:5490215	RGD
G	Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2		ISS	1	2,568,536	2,617,742	RGD:5490218	RGD
G	Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2		ISO	1	2,568,536	2,617,742	RGD:6484113	PID
G	Ticam2	toll-like receptor adaptor molecule 2		ISO	18	40,776,776	40,793,784	RGD:6484113	PID
G	Tollip	toll interacting protein		ISS	1	202,008,799	202,029,669	RGD:5490218	RGD
G	Tollip	toll interacting protein		ISO	1	202,008,799	202,029,669	RGD:6484113	PID
G	Traf6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase		IMP	3	86,827,582	86,847,408	RGD:5130945	RGD
G	Traf6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase		ISS	3	86,827,582	86,847,408	RGD:5490215	RGD
G	Traf6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase		ISS	3	86,827,582	86,847,408	RGD:5490218	RGD
G	Traf6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase		ISO	3	86,827,582	86,847,408	RGD:6484113	PID
G	Ube2n	ubiquitin-conjugating enzyme E2N		ISS	7	32,719,959	32,750,002	RGD:5490218	RGD
G	Ube2n	ubiquitin-conjugating enzyme E2N		ISS	7	32,719,959	32,750,002	RGD:5490215	RGD
G	Ube2n	ubiquitin-conjugating enzyme E2N		ISO	7	32,719,959	32,750,002	RGD:6484113	PID
G	Ube2v1	ubiquitin-conjugating enzyme E2 variant 1		ISS	3	158,745,873	158,768,725	RGD:5490215	RGD
G	Ube2v1	ubiquitin-conjugating enzyme E2 variant 1		ISS	3	158,745,873	158,768,725	RGD:5490218	RGD
G	Ube2v1	ubiquitin-conjugating enzyme E2 variant 1		ISO	3	158,745,873	158,768,725	RGD:6484113	PID

Term paths to the root

Path 1
Term	Annotations
Pathway Ontology	17140
signaling pathway	7465
cytokine and chemokine mediated signaling pathway	1049
cytokine mediated signaling pathway	879
Interleukin mediated signaling pathway	459
interleukin-1 family mediated signaling pathway	73
interleukin-1 signaling pathway	73