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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:angiotensin II signaling pathway via AT1 receptor
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Accession:PW:0000527 term browser browse the term
Definition:Angiotensin II signaling through the angiotensin type 1 receptor (AT1) activates downstream signaling pathways and elicits a broad range of physiological responses. It is involved in the regulation of blood pressure and volume, water and electrolyte balance and exerts a potent vasoconstrictive effect.
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angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IDA
IMP		 RGD PMID:10977869 PMID:14559250 PMID:9287353 PMID:12446719 RGD:1581825, RGD:2316188, RGD:5133683, RGD:629553 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtrap angiotensin II receptor-associated protein IMP RGD PMID:17875818 RGD:2314353 NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 IDA RGD PMID:14559250 RGD:2316188 NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Jak2 Janus kinase 2 IDA
IMP		 RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Tyk2 tyrosine kinase 2 IMP RGD PMID:9314843 RGD:6478796 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          angiotensin signaling pathway 41
            angiotensin II signaling pathway 34
              angiotensin II signaling pathway via AT1 receptor 16
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        cardiovascular system homeostasis pathway 423
          renin-angiotensin cascade pathway 52
            angiotensin signaling pathway 41
              angiotensin II signaling pathway 34
                angiotensin II signaling pathway via AT1 receptor 16
paths to the root