insulin signaling pathway - Ontology Report

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ONTOLOGY REPORT - ANNOTATIONS

Term:	insulin signaling pathway	go back to main search page
Accession:	PW:0000143	browse the term
Definition:	Processes regulated by insulin and insulin-like growth factor signaling systems include growth and survival of many tissues; for example, neuron and retina, bone, pancreatic beta-cells. Insulin is best known for its role in the regulation of blood glucose. Disregulation of the systems is implicated in a number of metabolic disorders.
Synonyms:	related_synonym:	KEGG:04910; PID:200014

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insulin signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Acaca	acetyl-CoA carboxylase alpha		IEA	10	72,483,772	72,677,134	RGD:6907045	KEGG
G	Acacb	acetyl-CoA carboxylase beta		IEA	12	43,388,679	43,492,993	RGD:6907045	KEGG
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		IEA	6	137,640,482	137,657,552	RGD:6907045	KEGG
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		ISO	6	137,640,482	137,657,552	RGD:6484113	PID
G	Akt2	v-akt murine thymoma viral oncogene homolog 2		IEA	1	82,686,233	82,726,544	RGD:6907045	KEGG
G	Akt2	v-akt murine thymoma viral oncogene homolog 2		ISO	1	82,686,233	82,726,544	RGD:6484113	PID
G	Akt3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)		IEA	13	92,802,390	93,110,704	RGD:6907045	KEGG
G	Bad	BCL2-associated agonist of cell death		IEA	1	209,617,373	209,626,292	RGD:6907045	KEGG
G	Braf	v-raf murine sarcoma viral oncogene homolog B1		IEA	4	67,117,759	67,243,058	RGD:6907045	KEGG
G	Calm1	calmodulin 1		IEA	6	124,477,601	124,485,669	RGD:6907045	KEGG
G	Calm2	calmodulin 2		IEA	6	64,161,641	64,162,751	RGD:6907045	KEGG
G	Calm3	calmodulin 3		IEA	1	77,245,609	77,252,717	RGD:6907045	KEGG
G	Calml3	calmodulin-like 3		IEA	17	77,594,514	77,595,889	RGD:6907045	KEGG
G	Calml5	calmodulin-like 5		IEA	17	77,567,314	77,571,711	RGD:6907045	KEGG
G	Cav1	caveolin 1, caveolae protein		ISO	4	42,956,102	42,989,057	RGD:6484113	PID
G	Cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase		IEA	8	47,135,357	47,211,889	RGD:6907045	KEGG
G	Cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase		ISO	8	47,135,357	47,211,889	RGD:6484113	PID
G	Cblb	Cbl proto-oncogene, E3 ubiquitin protein ligase B		IEA	11	49,690,402	49,856,762	RGD:6907045	KEGG
G	Cblc	Cbl proto-oncogene, E3 ubiquitin protein ligase C		IEA	1	79,091,412	79,108,189	RGD:6907045	KEGG
G	Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)		IEA	10	63,017,662	63,040,420	RGD:6907045	KEGG
G	Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like		IEA	11	85,520,244	85,554,667	RGD:6907045	KEGG
G	Dok1	docking protein 1		ISO	4	117,242,746	117,245,209	RGD:6484113	PID
G	Eif4e	eukaryotic translation initiation factor 4E		IEA	2	236,072,748	236,104,714	RGD:6907045	KEGG
G	Eif4e2	eukaryotic translation initiation factor 4E family member 2		IEA	9	86,020,090	86,034,739	RGD:6907045	KEGG
G	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1		IEA	16	69,110,522	69,123,895	RGD:6907045	KEGG
G	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1		ISO	16	69,110,522	69,123,895	RGD:6484113	PID
G	Elk1	ELK1, member of ETS oncogene family		IEA	X	12,597,863	12,604,248	RGD:6907045	KEGG
G	Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1		ISS	1	21,223,678	21,287,411	RGD:1625124	RGD
G	Exoc2	exocyst complex component 2		ISO	17	39,951,129	40,125,385	RGD:6484113	PID
G	Exoc3	exocyst complex component 3		ISO	1	29,897,536	29,928,281	RGD:6484113	PID
G	Exoc4	exocyst complex component 4		ISO	4	60,406,942	61,284,294	RGD:6484113	PID
G	Exoc5	exocyst complex component 5		ISO	15	25,008,521	25,053,098	RGD:6484113	PID
G	Exoc6	exocyst complex component 6		ISO	1	241,964,047	242,008,416	RGD:6484113	PID
G	Exoc7	exocyst complex component 7		IEA	10	106,400,889	106,419,793	RGD:6907045	KEGG
G	Exoc7	exocyst complex component 7		ISO	10	106,400,889	106,419,793	RGD:6484113	PID
G	F2rl2	coagulation factor II (thrombin) receptor-like 2		ISO	2	26,073,852	26,078,618	RGD:6484113	PID
G	Fasn	fatty acid synthase		IEA				RGD:6907045	KEGG
G	Fbp1	fructose-1,6-bisphosphatase 1		IEA	17	7,795,717	7,818,041	RGD:6907045	KEGG
G	Fbp2	fructose-1,6-bisphosphatase 2		IEA	17	7,824,298	7,841,661	RGD:6907045	KEGG
G	Flot1	flotillin 1		IEA	20	3,065,792	3,076,166	RGD:6907045	KEGG
G	Flot2	flotillin 2		IEA	10	64,081,463	64,104,166	RGD:6907045	KEGG
G	Foxo1	forkhead box O1		IEA	2	141,127,345	141,203,446	RGD:6907045	KEGG
G	Foxo3	forkhead box O3		ISO	20	46,171,784	46,262,818	RGD:6484113	PID
G	G6pc	glucose-6-phosphatase, catalytic subunit		IEA	10	90,393,531	90,403,485	RGD:6907045	KEGG
G	Gck	glucokinase		IEA	14	86,572,518	86,587,723	RGD:6907045	KEGG
G	Grb10	growth factor receptor bound protein 10		ISS	14	92,814,797	92,911,442	RGD:1625124	RGD
G	Grb10	growth factor receptor bound protein 10		ISO	14	92,814,797	92,911,442	RGD:6484113	PID
G	Grb14	growth factor receptor bound protein 14		IDA	3	46,832,380	46,952,670	RGD:61620	RGD
G	Grb14	growth factor receptor bound protein 14		ISS	3	46,832,380	46,952,670	RGD:1625124	RGD
G	Grb14	growth factor receptor bound protein 14		ISO	3	46,832,380	46,952,670	RGD:6484113	PID
G	Grb2	growth factor receptor bound protein 2		IDA	10	105,722,014	105,818,649	RGD:1299201	RGD
G	Grb2	growth factor receptor bound protein 2		IEA	10	105,722,014	105,818,649	RGD:6907045	KEGG
G	Grb2	growth factor receptor bound protein 2		ISO	10	105,722,014	105,818,649	RGD:6484113	PID
G	Gsk3b	glycogen synthase kinase 3 beta		IEA	11	64,284,731	64,428,698	RGD:6907045	KEGG
G	Gys1	glycogen synthase 1, muscle		IEA	1	95,907,458	95,928,150	RGD:6907045	KEGG
G	Gys2	glycogen synthase 2		IEA	4	179,984,036	180,018,819	RGD:6907045	KEGG
G	Hk1	hexokinase 1		IEA				RGD:6907045	KEGG
G	Hk2	hexokinase 2		IEA	4	116,925,725	116,975,211	RGD:6907045	KEGG
G	Hk3	hexokinase 3 (white cell)		IEA	17	15,651,953	15,669,109	RGD:6907045	KEGG
G	Hras	Harvey rat sarcoma virus oncogene		IEA	1	201,385,705	201,388,987	RGD:6907045	KEGG
G	Hras	Harvey rat sarcoma virus oncogene		ISO	1	201,385,705	201,388,987	RGD:6484113	PID
G	Ikbkb	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta		IEA	16	73,804,730	73,858,510	RGD:6907045	KEGG
G	Inpp5d	inositol polyphosphate-5-phosphatase D		IEA	9	86,576,742	86,682,240	RGD:6907045	KEGG
G	Inpp5d	inositol polyphosphate-5-phosphatase D		ISO	9	86,576,742	86,682,240	RGD:6484113	PID
G	Ins1	insulin 1		ISS	1	258,001,134	258,001,688	RGD:1625124	RGD
G	Ins1	insulin 1		IEA	1	258,001,134	258,001,688	RGD:6907045	KEGG
G	Ins2	insulin 2		ISS	1	202,935,548	202,936,379	RGD:1625124	RGD
G	Ins2	insulin 2		IEA	1	202,935,548	202,936,379	RGD:6907045	KEGG
G	Ins2	insulin 2		ISO	1	202,935,548	202,936,379	RGD:6484113	PID
G	Insr	insulin receptor		IDA	12	2,934,967	3,087,691	RGD:1299201	RGD
G	Insr	insulin receptor		IMP	12	2,934,967	3,087,691	RGD:1580595	RGD
G	Insr	insulin receptor		ISS	12	2,934,967	3,087,691	RGD:1625124	RGD
G	Insr	insulin receptor		IEA	12	2,934,967	3,087,691	RGD:6907045	KEGG
G	Insr	insulin receptor		ISO	12	2,934,967	3,087,691	RGD:6484113	PID
G	Irs1	insulin receptor substrate 1		IDA	9	81,585,251	81,638,071	RGD:1581310	RGD
G	Irs1	insulin receptor substrate 1		IMP	9	81,585,251	81,638,071	RGD:1580595	RGD
G	Irs1	insulin receptor substrate 1		IEA	9	81,585,251	81,638,071	RGD:6907045	KEGG
G	Irs1	insulin receptor substrate 1		ISO	9	81,585,251	81,638,071	RGD:6484113	PID
G	Irs2	insulin receptor substrate 2		IDA	16	83,379,987	83,404,220	RGD:1299201	RGD
G	Irs2	insulin receptor substrate 2		IMP	16	83,379,987	83,404,220	RGD:1580595	RGD
G	Irs2	insulin receptor substrate 2		IEA	16	83,379,987	83,404,220	RGD:6907045	KEGG
G	Irs3	insulin receptor substrate 3		IDA	12	19,709,141	19,711,279	RGD:1581310	RGD
G	Irs3	insulin receptor substrate 3		IEA	12	19,709,141	19,711,279	RGD:6907045	KEGG
G	Irs4	insulin receptor substrate 4		IEA	X	36,881,414	36,885,105	RGD:6907045	KEGG
G	Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog		IEA	4	182,869,242	182,895,106	RGD:6907045	KEGG
G	Lipe	lipase, hormone sensitive		IEA	1	80,663,791	80,682,480	RGD:6907045	KEGG
G	Map2k1	mitogen activated protein kinase kinase 1		IEA	8	68,379,074	68,451,554	RGD:6907045	KEGG
G	Map2k2	mitogen activated protein kinase kinase 2		IEA	7	10,074,654	10,094,003	RGD:6907045	KEGG
G	Mapk1	mitogen activated protein kinase 1		IEA	11	85,968,732	86,030,387	RGD:6907045	KEGG
G	Mapk10	mitogen activated protein kinase 10		IEA	14	7,719,595	8,010,694	RGD:6907045	KEGG
G	Mapk3	mitogen activated protein kinase 3		IEA	1	185,935,044	185,941,245	RGD:6907045	KEGG
G	Mapk8	mitogen-activated protein kinase 8		IEA	16	8,925,133	9,004,897	RGD:6907045	KEGG
G	Mapk9	mitogen-activated protein kinase 9		IEA	10	35,353,486	35,384,319	RGD:6907045	KEGG
G	Mknk1	MAP kinase-interacting serine/threonine kinase 1		IEA	5	136,100,236	136,141,344	RGD:6907045	KEGG
G	Mknk2	MAP kinase-interacting serine/threonine kinase 2		IEA	7	10,550,040	10,561,100	RGD:6907045	KEGG
G	Mtor	mechanistic target of rapamycin (serine/threonine kinase)		IEA	5	165,531,402	165,640,899	RGD:6907045	KEGG
G	Nck1	NCK adaptor protein 1		ISO	8	105,346,933	105,409,843	RGD:6484113	PID
G	Nck2	NCK adaptor protein 2		ISO	9	42,650,261	42,776,967	RGD:6484113	PID
G	Nras	neuroblastoma ras oncogene		IEA	2	198,292,650	198,300,286	RGD:6907045	KEGG
G	Pard6a	par-6 (partitioning defective 6,) homolog alpha (C. elegans)		ISO	19	35,533,395	35,535,711	RGD:6484113	PID
G	Pck1	phosphoenolpyruvate carboxykinase 1 (soluble)		IEA	3	164,012,410	164,018,359	RGD:6907045	KEGG
G	Pck2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)		IEA	15	33,671,834	33,680,613	RGD:6907045	KEGG
G	Pde3a	phosphodiesterase 3A, cGMP inhibited		IEA	4	178,658,896	178,930,417	RGD:6907045	KEGG
G	Pde3b	phosphodiesterase 3B, cGMP-inhibited		IEA	1	172,409,282	172,577,108	RGD:6907045	KEGG
G	Pdpk1	3-phosphoinositide dependent protein kinase-1		IEA	10	13,329,708	13,394,080	RGD:6907045	KEGG
G	Pdpk1	3-phosphoinositide dependent protein kinase-1		ISO	10	13,329,708	13,394,080	RGD:6484113	PID
G	Phka1	phosphorylase kinase, alpha 1		IEA	X	90,553,527	90,692,073	RGD:6907045	KEGG
G	Phka2	phosphorylase kinase, alpha 2		IEA	X	55,463,178	55,580,783	RGD:6907045	KEGG
G	Phkb	phosphorylase kinase, beta		IEA	19	22,373,355	22,561,509	RGD:6907045	KEGG
G	Phkg1	phosphorylase kinase, gamma 1		IEA	12	28,029,616	28,043,499	RGD:6907045	KEGG
G	Phkg2	phosphorylase kinase, gamma 2 (testis)		IEA	1	186,858,077	186,870,601	RGD:6907045	KEGG
G	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha		IEA	2	118,640,277	118,672,440	RGD:6907045	KEGG
G	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha		ISO	2	118,640,277	118,672,440	RGD:6484113	PID
G	Pik3cb	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta		IEA	8	103,886,682	103,957,112	RGD:6907045	KEGG
G	Pik3cd	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta		IEA	5	166,735,274	166,761,189	RGD:6907045	KEGG
G	Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		IDA	2	32,602,673	32,675,350	RGD:1299201	RGD
G	Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		IEA	2	32,602,673	32,675,350	RGD:6907045	KEGG
G	Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		ISO	2	32,602,673	32,675,350	RGD:6484113	PID
G	Pik3r2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)		IEA	16	19,171,101	19,179,650	RGD:6907045	KEGG
G	Pik3r3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)		IEA	5	136,497,494	136,566,473	RGD:6907045	KEGG
G	Pik3r5	phosphoinositide-3-kinase, regulatory subunit 5		IEA	10	55,227,872	55,248,301	RGD:6907045	KEGG
G	Pklr	pyruvate kinase, liver and RBC		IEA	2	181,214,853	181,223,505	RGD:6907045	KEGG
G	Ppargc1a	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha		IEA	14	64,278,115	64,370,912	RGD:6907045	KEGG
G	Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isozyme		IEA	1	206,774,719	206,778,336	RGD:6907045	KEGG
G	Ppp1cb	protein phosphatase 1, catalytic subunit, beta isozyme		IEA	6	24,067,544	24,099,280	RGD:6907045	KEGG
G	Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isozyme		IEA	12	35,580,169	35,598,249	RGD:6907045	KEGG
G	Ppp1r3a	protein phosphatase 1, regulatory subunit 3A		IEA	4	40,195,325	40,235,913	RGD:6907045	KEGG
G	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B		IEA	16	60,552,431	60,564,789	RGD:6907045	KEGG
G	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C		IEA	1	240,991,884	240,996,887	RGD:6907045	KEGG
G	Ppp1r3d	protein phosphatase 1, regulatory subunit 3D		IEA	3	167,505,678	167,508,749	RGD:6907045	KEGG
G	Prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit		IEA	2	54,327,821	54,360,462	RGD:6907045	KEGG
G	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit		IEA	5	126,007,672	126,074,012	RGD:6907045	KEGG
G	Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit		IEA	12	41,840,866	41,851,241	RGD:6907045	KEGG
G	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit		IEA	2	192,498,430	192,510,624	RGD:6907045	KEGG
G	Prkaca	protein kinase, cAMP-dependent, catalytic, alpha		IEA	19	25,840,795	25,864,786	RGD:6907045	KEGG
G	Prkacb	protein kinase, cAMP dependent, catalytic, beta		IEA	2	244,949,303	245,035,266	RGD:6907045	KEGG
G	Prkag1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit		IEA	7	137,582,341	137,599,762	RGD:6907045	KEGG
G	Prkag2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit		IEA	4	5,620,992	5,667,438	RGD:6907045	KEGG
G	Prkag3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit		IEA	9	74,069,811	74,079,055	RGD:6907045	KEGG
G	Prkar1a	protein kinase, cAMP-dependent, regulatory, type I, alpha		IEA	10	148,642,200	148,642,454	RGD:6907045	KEGG
G	Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha		IEA	8	113,746,384	113,805,476	RGD:6907045	KEGG
G	Prkar2b	protein kinase, cAMP dependent regulatory, type II beta		IEA	6	50,234,979	50,325,298	RGD:6907045	KEGG
G	Prkca	protein kinase C, alpha		ISS	10	97,367,196	97,638,910	RGD:1625124	RGD
G	Prkcb	protein kinase C, beta		ISS	1	181,117,512	181,459,856	RGD:1625124	RGD
G	Prkcg	protein kinase C, gamma		ISS	1	64,145,749	64,172,712	RGD:1625124	RGD
G	Prkci	protein kinase C, iota		IEA	2	116,739,625	116,801,084	RGD:6907045	KEGG
G	Prkci	protein kinase C, iota		ISO	2	116,739,625	116,801,084	RGD:6484113	PID
G	Prkcq	protein kinase C, theta		ISS	17	78,486,998	78,566,741	RGD:1625124	RGD
G	Prkcz	protein kinase C, zeta		IEA	5	172,061,825	172,172,793	RGD:6907045	KEGG
G	Prkcz	protein kinase C, zeta		ISO	5	172,061,825	172,172,793	RGD:6484113	PID
G	Prkx	protein kinase, X-linked		IEA	X	63,484,553	63,533,858	RGD:6907045	KEGG
G	Ptpn1	protein tyrosine phosphatase, non-receptor type 1		IMP	3	159,070,473	159,116,792	RGD:1580595	RGD
G	Ptpn1	protein tyrosine phosphatase, non-receptor type 1		IEA	3	159,070,473	159,116,792	RGD:6907045	KEGG
G	Ptpn1	protein tyrosine phosphatase, non-receptor type 1		ISS	3	159,070,473	159,116,792	RGD:1625124	RGD
G	Ptpn1	protein tyrosine phosphatase, non-receptor type 1		IDA	3	159,070,473	159,116,792	RGD:2293185	RGD
G	Ptpn1	protein tyrosine phosphatase, non-receptor type 1		ISO	3	159,070,473	159,116,792	RGD:6484113	PID
G	Ptpn11	protein tyrosine phosphatase, non-receptor type 11		IDA	12	36,501,886	36,558,055	RGD:2293185	RGD
G	Ptpn11	protein tyrosine phosphatase, non-receptor type 11		IDA	12	36,501,886	36,558,055	RGD:1299201	RGD
G	Ptpn11	protein tyrosine phosphatase, non-receptor type 11		ISO	12	36,501,886	36,558,055	RGD:6484113	PID
G	Ptpra	protein tyrosine phosphatase, receptor type, A		ISO	3	118,061,713	118,171,300	RGD:6484113	PID
G	Ptprf	protein tyrosine phosphatase, receptor type, F		ISS	5	138,671,725	138,739,002	RGD:1625124	RGD
G	Ptprf	protein tyrosine phosphatase, receptor type, F		IEA	5	138,671,725	138,739,002	RGD:6907045	KEGG
G	Ptprf	protein tyrosine phosphatase, receptor type, F		IDA	5	138,671,725	138,739,002	RGD:2293185	RGD
G	Pygb	phosphorylase, glycogen; brain		IEA	3	141,421,421	141,468,094	RGD:6907045	KEGG
G	Pygl	phosphorylase, glycogen, liver		IEA	6	92,298,339	92,341,347	RGD:6907045	KEGG
G	Pygm	phosphorylase, glycogen, muscle		IEA	1	209,166,701	209,181,588	RGD:6907045	KEGG
G	Raf1	v-raf-leukemia viral oncogene 1		IEA	4	151,752,583	151,775,609	RGD:6907045	KEGG
G	Rapgef1	Rap guanine nucleotide exchange factor (GEF) 1		IEA	3	8,634,764	8,680,197	RGD:6907045	KEGG
G	Rasa1	RAS p21 protein activator (GTPase activating protein) 1		ISO	2	14,203,815	14,287,824	RGD:6484113	PID
G	Rheb	Ras homolog enriched in brain		IEA				RGD:6907045	KEGG
G	Rhoq	ras homolog family member Q		IEA	6	10,414,042	10,449,472	RGD:6907045	KEGG
G	Rhoq	ras homolog family member Q		ISO	6	10,414,042	10,449,472	RGD:6484113	PID
G	Rps6	ribosomal protein S6		IEA	5	106,165,612	106,168,472	RGD:6907045	KEGG
G	Rps6kb1	ribosomal protein S6 kinase, polypeptide 1		IEA	10	76,657,024	76,698,088	RGD:6907045	KEGG
G	Rps6kb1	ribosomal protein S6 kinase, polypeptide 1		ISO	10	76,657,024	76,698,088	RGD:6484113	PID
G	Rps6kb2	ribosomal protein S6 kinase, polypeptide 2		IEA	1	206,740,966	206,747,653	RGD:6907045	KEGG
G	Rptor	regulatory associated protein of MTOR, complex 1		IEA	10	109,000,666	109,302,700	RGD:6907045	KEGG
G	Sgk1	serum/glucocorticoid regulated kinase 1		ISO	1	23,501,257	23,506,651	RGD:6484113	PID
G	Sh2b2	SH2B adaptor protein 2		ISS	12	21,544,434	21,572,232	RGD:1625124	RGD
G	Sh2b2	SH2B adaptor protein 2		IEA	12	21,544,434	21,572,232	RGD:6907045	KEGG
G	Sh2b2	SH2B adaptor protein 2		ISO	12	21,544,434	21,572,232	RGD:6484113	PID
G	Shc1	SHC (Src homology 2 domain containing) transforming protein 1		ISS	2	181,616,581	181,628,144	RGD:1625124	RGD
G	Shc1	SHC (Src homology 2 domain containing) transforming protein 1		IEA	2	181,616,581	181,628,144	RGD:6907045	KEGG
G	Shc1	SHC (Src homology 2 domain containing) transforming protein 1		ISO	2	181,616,581	181,628,144	RGD:6484113	PID
G	Shc2	SHC (Src homology 2 domain containing) transforming protein 2		IEA	7	11,583,380	11,605,675	RGD:6907045	KEGG
G	Shc3	SHC (Src homology 2 domain containing) transforming protein 3		IEA	17	19,520,861	19,649,482	RGD:6907045	KEGG
G	Shc4	SHC (Src homology 2 domain containing) family, member 4		IEA	3	112,938,164	113,030,092	RGD:6907045	KEGG
G	Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4		IEA	10	56,786,705	56,792,209	RGD:6907045	KEGG
G	Socs1	suppressor of cytokine signaling 1		ISS	10	4,819,971	4,820,609	RGD:1625125	RGD
G	Socs1	suppressor of cytokine signaling 1		IEA	10	4,819,971	4,820,609	RGD:6907045	KEGG
G	Socs2	suppressor of cytokine signaling 2		IEA	7	32,605,714	32,608,323	RGD:6907045	KEGG
G	Socs3	suppressor of cytokine signaling 3		ISS	10	107,958,468	107,959,330	RGD:1625125	RGD
G	Socs3	suppressor of cytokine signaling 3		IEA	10	107,958,468	107,959,330	RGD:6907045	KEGG
G	Socs4	suppressor of cytokine signaling 4		IEA	15	23,229,083	23,243,568	RGD:6907045	KEGG
G	Socs6	suppressor of cytokine signaling 6		ISS	18	85,722,868	85,725,214	RGD:1625125	RGD
G	Socs7	suppressor of cytokine signaling 7		ISS	10	86,090,339	86,134,313	RGD:1625125	RGD
G	Sorbs1	sorbin and SH3 domain containing 1		IEA	1	245,419,532	245,527,846	RGD:6907045	KEGG
G	Sorbs1	sorbin and SH3 domain containing 1		ISO	1	245,419,532	245,527,846	RGD:6484113	PID
G	Sos1	Son of sevenless homolog 1 (Drosophila)		IDA	6	3,308,778	3,390,661	RGD:1299201	RGD
G	Sos1	Son of sevenless homolog 1 (Drosophila)		IEA	6	3,308,778	3,390,661	RGD:6907045	KEGG
G	Sos1	Son of sevenless homolog 1 (Drosophila)		ISO	6	3,308,778	3,390,661	RGD:6484113	PID
G	Sos2	son of sevenless homolog 2 (Drosophila)		IDA	6	91,609,463	91,722,481	RGD:1299201	RGD
G	Sos2	son of sevenless homolog 2 (Drosophila)		IEA	6	91,609,463	91,722,481	RGD:6907045	KEGG
G	Srebf1	sterol regulatory element binding transcription factor 1		IEA	10	46,461,684	46,483,646	RGD:6907045	KEGG
G	Trip10	thyroid hormone receptor interactor 10		IEA				RGD:6907045	KEGG
G	Trip10	thyroid hormone receptor interactor 10		ISO				RGD:6484113	PID
G	Tsc1	tuberous sclerosis 1		IEA	3	7,645,313	7,672,944	RGD:6907045	KEGG
G	Tsc2	tuberous sclerosis 2		IEA	10	13,848,210	13,883,189	RGD:6907045	KEGG
altered insulin signaling pathway
	Symbol	Object Name	GBrowse	Evidence	Chr	Start	Stop	Reference	Source
G	Ins2	insulin 2		ISS	1	202,935,548	202,936,379	RGD:2313694	RGD
G	Insr	insulin receptor		ISS	12	2,934,967	3,087,691	RGD:2313694	RGD

Term paths to the root

Path 1
Term	Annotations
Pathway Ontology	17140
regulatory pathway	5692
homeostasis pathway	2069
energy homeostasis pathway	521
insulin signaling pathway	210
altered insulin signaling pathway	2