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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:interleukin-4 signaling pathway
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Accession:PW:0000912 term browser browse the term
Definition:Interleukin-4 is a member of the interleukin 2 family of cytokines whose signaling is important for the differentiation of naive T helper cells.
Synonyms:exact_synonym: Il-4 signaling pathway
 related_synonym: interleukin-4-mediated signaling pathway


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interleukin-4 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase ISO PID PID:200022 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200022 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO PID PID:200022 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Arg1 arginase 1 ISO PID PID:200022 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bcl6 BCL6, transcription repressor ISO PID PID:200022 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200022 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO PID PID:200022 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO PID PID:200022 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 ISO PID PID:200022 NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335 		JBrowse link
G Cd40lg CD40 ligand ISO PID PID:200022 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO PID PID:200022 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO PID PID:200022 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO PID PID:200022 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Dok2 docking protein 2 ISO PID PID:200022 NCBI chr15:45,826,984...45,841,409
Ensembl chr15:45,827,398...45,841,402 		JBrowse link
G Egr2 early growth response 2 ISO PID PID:200022 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO PID PID:200022 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Fcer2 Fc epsilon receptor II ISO PID PID:200022 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase ISO PID PID:200022 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200022 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gtf3a general transcription factor III A ISO PID PID:200022 NCBI chr12:8,136,746...8,144,690
Ensembl chr12:8,136,747...8,144,690 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO PID PID:200022 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon ISO PID PID:200022
G Ighg1 immunoglobulin heavy constant gamma 1 ISO PID PID:200022 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Il10 interleukin 10 ISO PID PID:200022 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO PID PID:200022 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il13ra1-ps1 interleukin 13 receptor subunit alpha 1, pseudogene 1 ISO PID PID:200022 NCBI chr11:71,255,035...71,258,723
Ensembl chr11:71,254,928...71,258,678 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO PID PID:200022 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma ISO PID PID:200022 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il4 interleukin 4 ISO PID PID:200022 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor ISO PID PID:200022 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il5 interleukin 5 ISO PID PID:200022 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO PID PID:200022 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Irf4 interferon regulatory factor 4 ISO PID PID:200022 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200022 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO PID PID:200022 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200022 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jak1 Janus kinase 1 ISO PID PID:200022 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200022 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jak3 Janus kinase 3 ISO PID PID:200022 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lta lymphotoxin alpha ISO PID PID:200022 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200022 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID PID:200022 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myb MYB proto-oncogene, transcription factor ISO PID PID:200022 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 ISO PID PID:200022 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO PID PID:200022 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO PID PID:200022 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
G Pigr polymeric immunoglobulin receptor ISO PID PID:200022 NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200022 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200022 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO PID PID:200022 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Retnlb resistin like beta ISO PID PID:200022 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200022 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Selp selectin P ISO PID PID:200022 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200022 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO PID PID:200022 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO PID PID:200022 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO PID PID:200022 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Sp1 Sp1 transcription factor ISO PID PID:200022 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Spi1 Spi-1 proto-oncogene ISO PID PID:200022 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO PID PID:200022 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO PID PID:200022 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO PID PID:200022 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tff3 trefoil factor 3 ISO PID PID:200022 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Thy1 Thy-1 cell surface antigen ISO PID PID:200022 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to immunity 793
        cytokine mediated signaling pathway 485
          Interleukin mediated signaling pathway 256
            interleukin-2 family mediated signaling pathway 103
              interleukin-4 signaling pathway 64
paths to the root