ONTOLOGY REPORT - ANNOTATIONS

Term:colorectal cancer pathway
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Accession:PW:0000612 term browser browse the term
Definition:Colorectal cancer are malignant tumors of the colon and rectum. Both risk factors usually relating to life style such as physical exercise or use of tobacco and genetics contribute to the development of the condition. Mutations in the components of canonical Wnt and Smad-dependent TGF-beta signaling and of DNA mismatch repair pathways have been associated with the pathogenesis of colorectal cancer pathway.
Synonyms:related_synonym: KEGG:05210;   colorectal neoplasm pathway
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colorectal cancer pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IEA 6 137,640,482 137,657,552 RGD:6907045 KEGG
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link IEA 1 82,686,233 82,726,544 RGD:6907045 KEGG
G Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) GBrowse link IEA 13 92,802,390 93,110,704 RGD:6907045 KEGG
G Apc adenomatous polyposis coli GBrowse link ISS 18 26,732,147 26,790,383 RGD:2293188 RGD
G Apc adenomatous polyposis coli GBrowse link IEA 18 26,732,147 26,790,383 RGD:6907045 KEGG
G Apc2 adenomatosis polyposis coli 2 GBrowse link IEA 7 10,903,675 10,920,010 RGD:6907045 KEGG
G Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 GBrowse link IEA 16 2,180,613 2,227,905 RGD:6907045 KEGG
G Axin1 axin 1 GBrowse link ISS 10 15,409,373 15,462,726 RGD:2293188 RGD
G Axin1 axin 1 GBrowse link IEA 10 15,409,373 15,462,726 RGD:6907045 KEGG
G Axin2 axin 2 GBrowse link ISS 10 98,294,466 98,321,830 RGD:2293188 RGD
G Axin2 axin 2 GBrowse link IEA 10 98,294,466 98,321,830 RGD:6907045 KEGG
G Bad BCL2-associated agonist of cell death GBrowse link IEA 1 209,617,373 209,626,292 RGD:6907045 KEGG
G Bax Bcl2-associated X protein GBrowse link IEA 1 95,933,023 95,938,176 RGD:6907045 KEGG
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link IEA 13 12,730,736 12,905,108 RGD:6907045 KEGG
G Birc5 baculoviral IAP repeat-containing 5 IEA RGD:6907045 KEGG
G Braf v-raf murine sarcoma viral oncogene homolog B1 GBrowse link ISS 4 67,117,759 67,243,058 RGD:2298531 RGD
G Braf v-raf murine sarcoma viral oncogene homolog B1 GBrowse link IEA 4 67,117,759 67,243,058 RGD:6907045 KEGG
G Casp3 caspase 3 GBrowse link IEA 16 48,944,226 48,962,420 RGD:6907045 KEGG
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IEA 5 160,704,234 160,721,796 RGD:6907045 KEGG
G Ccnd1 cyclin D1 GBrowse link IEA 1 205,357,235 205,366,757 RGD:6907045 KEGG
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link ISS 8 125,978,161 125,987,670 RGD:2293188 RGD
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link IEA 8 125,978,161 125,987,670 RGD:6907045 KEGG
G Cycs cytochrome c, somatic GBrowse link IEA 4 78,825,878 78,827,978 RGD:6907045 KEGG
G Cyct cytochrome c, testis GBrowse link IEA 3 59,042,806 59,045,988 RGD:6907045 KEGG
G Dcc deleted in colorectal carcinoma GBrowse link IEA 18 68,026,795 69,140,741 RGD:6907045 KEGG
G Fos FBJ osteosarcoma oncogene GBrowse link IEA 6 109,559,135 109,562,001 RGD:6907045 KEGG
G Gsk3b glycogen synthase kinase 3 beta GBrowse link IEA 11 64,284,731 64,428,698 RGD:6907045 KEGG
G Jun jun proto-oncogene GBrowse link IEA 5 115,358,166 115,361,259 RGD:6907045 KEGG
G Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog GBrowse link TAS 4 182,869,242 182,895,106 RGD:2306732 RGD
G Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog GBrowse link IEA 4 182,869,242 182,895,106 RGD:6907045 KEGG
G Lef1 lymphoid enhancer binding factor 1 GBrowse link IEA 2 228,550,263 228,673,131 RGD:6907045 KEGG
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link IEA 8 68,379,074 68,451,554 RGD:6907045 KEGG
G Mapk1 mitogen activated protein kinase 1 GBrowse link IEA 11 85,968,732 86,030,387 RGD:6907045 KEGG
G Mapk10 mitogen activated protein kinase 10 GBrowse link IEA 14 7,719,595 8,010,694 RGD:6907045 KEGG
G Mapk3 mitogen activated protein kinase 3 GBrowse link IEA 1 185,935,044 185,941,245 RGD:6907045 KEGG
G Mapk8 mitogen-activated protein kinase 8 GBrowse link IEA 16 8,925,133 9,004,897 RGD:6907045 KEGG
G Mapk9 mitogen-activated protein kinase 9 GBrowse link IEA 10 35,353,486 35,384,319 RGD:6907045 KEGG
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link ISS 8 115,616,396 115,653,471 RGD:2306714 RGD
G Mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) GBrowse link IEA 8 115,616,396 115,653,471 RGD:6907045 KEGG
G Msh2 mutS homolog 2 (E. coli) GBrowse link ISS 6 11,199,906 11,258,350 RGD:2306714 RGD
G Msh2 mutS homolog 2 (E. coli) GBrowse link IEA 6 11,199,906 11,258,350 RGD:6907045 KEGG
G Msh3 mutS homolog 3 (E. coli) GBrowse link IEA 2 22,462,934 22,606,874 RGD:6907045 KEGG
G Myc myelocytomatosis oncogene GBrowse link IEA 7 98,953,142 98,958,060 RGD:6907045 KEGG
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link IEA 2 118,640,277 118,672,440 RGD:6907045 KEGG
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link IEA 8 103,886,682 103,957,112 RGD:6907045 KEGG
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link IEA 5 166,735,274 166,761,189 RGD:6907045 KEGG
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link IEA 2 32,602,673 32,675,350 RGD:6907045 KEGG
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link IEA 16 19,171,101 19,179,650 RGD:6907045 KEGG
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link IEA 5 136,497,494 136,566,473 RGD:6907045 KEGG
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 GBrowse link IEA 10 55,227,872 55,248,301 RGD:6907045 KEGG
G Pms1 postmeiotic segregation increased 1 (S. cerevisiae) GBrowse link ISS 9 45,203,344 45,292,624 RGD:2306714 RGD
G Pms2 postmeiotic segregation increased 2 (S. cerevisiae) GBrowse link ISS 12 11,004,507 11,028,754 RGD:2306714 RGD
G Rac1 ras-related C3 botulinum toxin substrate 1 GBrowse link IEA 12 11,380,314 11,400,531 RGD:6907045 KEGG
G Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) GBrowse link IEA 7 116,520,066 116,532,482 RGD:6907045 KEGG
G Raf1 v-raf-leukemia viral oncogene 1 GBrowse link IEA 4 151,752,583 151,775,609 RGD:6907045 KEGG
G Ralgds ral guanine nucleotide dissociation stimulator GBrowse link IEA 3 7,516,054 7,537,651 RGD:6907045 KEGG
G Rhoa ras homolog family member A IEA RGD:6907045 KEGG
G RSA-14-44 RSA-14-44 protein GBrowse link IEA 4 95,635,659 95,637,031 RGD:6907045 KEGG
G Smad2 SMAD family member 2 GBrowse link ISS 18 73,180,520 73,241,707 RGD:2308865 RGD
G Smad2 SMAD family member 2 GBrowse link ISS 18 73,180,520 73,241,707 RGD:2306282 RGD
G Smad2 SMAD family member 2 GBrowse link IEA 18 73,180,520 73,241,707 RGD:6907045 KEGG
G Smad3 SMAD family member 3 GBrowse link ISS 8 67,803,909 67,952,056 RGD:2306282 RGD
G Smad3 SMAD family member 3 GBrowse link IEA 8 67,803,909 67,952,056 RGD:6907045 KEGG
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:2308865 RGD
G Smad4 SMAD family member 4 GBrowse link ISS 18 70,432,705 70,461,541 RGD:2306282 RGD
G Smad4 SMAD family member 4 GBrowse link IEA 18 70,432,705 70,461,541 RGD:6907045 KEGG
G Smad7 SMAD family member 7 GBrowse link ISS 18 72,294,803 72,323,354 RGD:2308865 RGD
G Tcf3 transcription factor 3 GBrowse link IEA 7 10,791,311 10,813,613 RGD:6907045 KEGG
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) GBrowse link IEA 10 37,686,862 37,716,831 RGD:6907045 KEGG
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link IEA 1 262,031,823 262,226,710 RGD:6907045 KEGG
G Tgfb1 transforming growth factor, beta 1 GBrowse link ISS 1 80,894,705 80,911,020 RGD:2306282 RGD
G Tgfb1 transforming growth factor, beta 1 GBrowse link IEA 1 80,894,705 80,911,020 RGD:6907045 KEGG
G Tgfb2 transforming growth factor, beta 2 GBrowse link IEA 13 102,718,703 102,818,768 RGD:6907045 KEGG
G Tgfb3 transforming growth factor, beta 3 GBrowse link IEA 6 110,173,443 110,195,215 RGD:6907045 KEGG
G Tgfbr1 transforming growth factor, beta receptor 1 GBrowse link ISS 5 63,976,868 64,034,058 RGD:2306282 RGD
G Tgfbr1 transforming growth factor, beta receptor 1 GBrowse link IEA 5 63,976,868 64,034,058 RGD:6907045 KEGG
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:2306282 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link ISS 8 120,593,595 120,680,453 RGD:2308865 RGD
G Tgfbr2 transforming growth factor, beta receptor II GBrowse link IEA 8 120,593,595 120,680,453 RGD:6907045 KEGG
G Tp53 tumor protein p53 GBrowse link IEA 10 56,399,721 56,411,150 RGD:6907045 KEGG
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  Pathway Ontology 17140
    disease pathway 3484
      cancer pathway 900
        digestive system cancer pathway 166
          gastrointestinal cancer pathway 80
            colorectal cancer pathway 80
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