ONTOLOGY REPORT - ANNOTATIONS


Term:type 2 diabetes mellitus pathway
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Accession:PW:0000208 term browser browse the term
Definition:Diabetes mellitus is characterized by abnormally high levels of glucose in the blood. Hereditary and environmental factors are likely contributors but the exact mechanisms are not well understood. Type 2 diabetes mellitus, characterized by insulin resistance, involves alterations in insulin secretion and signaling and impaired glucose homeostasis pathways.
Synonyms:exact_synonym: T2D pathway
 related_synonym: KEGG:04930;   type II diabetes mellitus pathway

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type 2 diabetes mellitus pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2313628
RGD:6907045
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313408
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6907045
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6907045
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6907045
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6907045
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6907045
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6907045
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:6907045
G Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
RGD:6907045
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694
RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6907045
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6907045
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:6907045
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
G Kcnj11 potassium voltage-gated channel subfamily J member 11 JBrowse link 1 102,103,093 102,107,134 RGD:2313610
RGD:2313628
RGD:6907045
G Mafa MAF bZIP transcription factor A JBrowse link 7 116,779,368 116,781,815 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mtor mechanistic target of rapamycin JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pklr pyruvate kinase, liver and RBC JBrowse link 2 188,449,158 188,458,034 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6907045
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6907045
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:6907045
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 88948
    disease pathway 21054
      cardiovascular system disease pathway 1192
        metabolic syndrome pathway 164
          type 2 diabetes mellitus pathway 161
Path 2
Term Annotations click to browse term
  pathway 88948
    disease pathway 21054
      nutritional and metabolic disease pathway 9716
        metabolic disease pathway 9583
          glucose metabolism disease pathway 463
            diabetes pathway 421
              type 2 diabetes mellitus pathway 161
paths to the root