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Term:type 2 diabetes mellitus pathway
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Accession:PW:0000208 term browser browse the term
Definition:Diabetes mellitus is characterized by abnormally high levels of glucose in the blood. Hereditary and environmental factors are likely contributors but the exact mechanisms are not well understood. Type 2 diabetes mellitus, characterized by insulin resistance, involves alterations in insulin secretion and signaling and impaired glucose homeostasis pathways.
Synonyms:exact_synonym: T2D pathway
 related_synonym: KEGG:04930;   type II diabetes mellitus pathway

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type 2 diabetes mellitus pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 GBrowse link 1 103,194,473 103,275,508 RGD:2313628
RGD:6907045
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link 11 84,363,940 84,382,663 RGD:6907045
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link 1 85,617,612 85,667,423 RGD:2313408
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit GBrowse link 19 36,502,533 36,727,039 RGD:6907045
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit GBrowse link 3 1,727,915 1,910,475 RGD:6907045
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit GBrowse link 4 216,562,477 217,184,927 RGD:6907045
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit GBrowse link 16 6,044,524 6,339,170 RGD:6907045
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit GBrowse link 13 76,843,146 77,473,206 RGD:6907045
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit GBrowse link 10 81,950,594 82,017,885 RGD:6907045
G Gck glucokinase GBrowse link 14 86,832,735 86,875,295 RGD:6907045
G Hk1 hexokinase 1 GBrowse link 20 33,703,472 33,770,598 RGD:6907045
G Hk2 hexokinase 2 GBrowse link 4 178,237,866 178,288,251 RGD:6907045
G Hk3 hexokinase 3 (white cell) GBrowse link 17 12,243,962 12,261,662 RGD:6907045
G Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta GBrowse link 16 73,809,854 73,863,636 RGD:6907045
G Ins1 insulin 1 GBrowse link 1 280,213,615 280,214,182 RGD:6907045
G Ins2 insulin 2 GBrowse link 1 222,751,786 222,756,821 RGD:2313694
RGD:6907045
G Insr insulin receptor GBrowse link 12 3,848,670 3,989,302 RGD:2313694
RGD:6907045
G Irs1 insulin receptor substrate 1 GBrowse link 9 87,782,499 87,835,248 RGD:6907045
G Irs2 insulin receptor substrate 2 GBrowse link 16 83,287,185 83,311,239 RGD:6907045
G Irs3 insulin receptor substrate 3 GBrowse link 12 24,137,698 24,142,470 RGD:6907045
G Irs4 insulin receptor substrate 4 GBrowse link X 111,457,261 111,471,505 RGD:6907045
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 GBrowse link 1 103,186,859 103,190,535 RGD:2313610
RGD:2313628
RGD:6907045
G Mafa v-maf avian musculoaponeurotic fibrosarcoma oncogene A GBrowse link 7 116,670,579 116,673,032 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 GBrowse link 11 91,260,412 91,325,570 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 GBrowse link 14 8,053,697 8,344,225 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 GBrowse link 1 205,172,641 205,178,843 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 GBrowse link 16 11,579,503 11,662,858 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 GBrowse link 10 35,105,633 35,147,516 RGD:6907045
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link 5 168,920,414 169,030,568 RGD:6907045
G Pdx1 pancreatic and duodenal homeobox 1 GBrowse link 12 11,609,488 11,614,655 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link 2 138,491,967 138,521,934 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link 8 106,700,158 106,788,063 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link 5 170,248,202 170,274,177 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link 2 50,891,225 50,965,217 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link 16 20,273,500 20,282,051 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link 5 138,858,124 138,930,177 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 GBrowse link 10 54,757,809 54,822,968 RGD:6907045
G Pklr pyruvate kinase, liver and RBC GBrowse link 2 207,865,529 207,874,394 RGD:6907045
G Prkcd protein kinase C, delta GBrowse link 16 6,588,990 6,608,725 RGD:6907045
G Prkce protein kinase C, epsilon GBrowse link 6 9,404,548 9,883,579 RGD:6907045
G Prkcz protein kinase C, zeta GBrowse link 5 176,116,787 176,228,206 RGD:6907045
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 GBrowse link 2 134,112,829 134,144,459 RGD:6907045
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 GBrowse link 10 56,298,102 56,303,687 RGD:6907045
G Socs1 suppressor of cytokine signaling 1 GBrowse link 10 3,782,936 3,783,574 RGD:6907045
G Socs2 suppressor of cytokine signaling 2 GBrowse link 7 36,558,014 36,560,623 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 GBrowse link 10 106,611,459 106,616,694 RGD:6907045
G Socs4 suppressor of cytokine signaling 4 GBrowse link 15 27,997,125 28,011,610 RGD:6907045
G Tnf tumor necrosis factor GBrowse link 20 6,936,229 6,938,847 RGD:6907045

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  pathway 52399
    disease pathway 10889
      cardiovascular system disease pathway 1190
        metabolic syndrome pathway 164
          type 2 diabetes mellitus pathway 161
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