ONTOLOGY REPORT - ANNOTATIONS


Term:type 2 diabetes mellitus pathway
go back to main search page
Accession:PW:0000208 term browser browse the term
Definition:Diabetes mellitus is characterized by abnormally high levels of glucose in the blood. Hereditary and environmental factors are likely contributors but the exact mechanisms are not well understood. Type 2 diabetes mellitus, characterized by insulin resistance, involves alterations in insulin secretion and signaling and impaired glucose homeostasis pathways.
Synonyms:exact_synonym: T2D pathway
 related_synonym: KEGG:04930;   type II diabetes mellitus pathway

View Interactive Diagram


  • Rat
  • Mouse
  • Human
  • All
  • show annotations for term's descendants
  •     Sort by:
  • view all columns
type 2 diabetes mellitus pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 GBrowse link 1 96,622,574 96,703,723 RGD:2313628
RGD:6907045
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link 11 79,908,291 79,911,065 RGD:6907045
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link 1 82,686,233 82,726,544 RGD:2313408
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit GBrowse link 19 25,188,170 25,424,495 RGD:6907045
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit GBrowse link 3 2,842,948 3,039,747 RGD:6907045
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit GBrowse link 4 154,895,691 155,517,389 RGD:6907045
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit GBrowse link 16 5,383,259 5,703,361 RGD:6907045
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit GBrowse link 13 69,367,254 69,683,943 RGD:6907045
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit GBrowse link 10 83,043,636 83,112,886 RGD:6907045
G Gck glucokinase GBrowse link 14 86,572,518 86,587,723 RGD:6907045
G Hk1 hexokinase 1 RGD:6907045
G Hk2 hexokinase 2 GBrowse link 4 116,925,725 116,975,211 RGD:6907045
G Hk3 hexokinase 3 (white cell) GBrowse link 17 15,651,953 15,669,109 RGD:6907045
G Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta GBrowse link 16 73,804,730 73,858,510 RGD:6907045
G Ins1 insulin 1 GBrowse link 1 258,001,134 258,001,688 RGD:6907045
G Ins2 insulin 2 GBrowse link 1 202,935,548 202,936,379 RGD:2313694
RGD:6907045
G Insr insulin receptor GBrowse link 12 2,934,967 3,087,691 RGD:2313694
RGD:6907045
G Irs1 insulin receptor substrate 1 GBrowse link 9 81,585,251 81,638,071 RGD:6907045
G Irs2 insulin receptor substrate 2 GBrowse link 16 83,379,987 83,404,220 RGD:6907045
G Irs3 insulin receptor substrate 3 GBrowse link 12 19,709,141 19,711,279 RGD:6907045
G Irs4 insulin receptor substrate 4 GBrowse link X 36,881,414 36,885,105 RGD:6907045
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 GBrowse link 1 96,614,960 96,617,993 RGD:2313610
RGD:2313628
RGD:6907045
G Mafa v-maf avian musculoaponeurotic fibrosarcoma oncogene A GBrowse link 7 113,707,043 113,708,128 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 GBrowse link 11 85,968,732 86,030,387 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 GBrowse link 14 7,719,595 8,010,694 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 GBrowse link 1 185,935,044 185,941,245 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 GBrowse link 16 8,925,133 9,004,897 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 GBrowse link 10 35,353,486 35,384,319 RGD:6907045
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link 5 165,531,402 165,640,899 RGD:6907045
G Pdx1 pancreatic and duodenal homeobox 1 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link 2 118,640,277 118,672,440 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link 8 103,886,682 103,957,112 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link 5 166,735,274 166,761,189 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link 2 32,602,673 32,675,350 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link 16 19,171,101 19,179,650 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link 5 136,497,494 136,566,473 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 GBrowse link 10 55,227,872 55,248,301 RGD:6907045
G Pklr pyruvate kinase, liver and RBC GBrowse link 2 181,214,853 181,223,505 RGD:6907045
G Prkcd protein kinase C, delta GBrowse link 16 5,954,218 5,975,743 RGD:6907045
G Prkce protein kinase C, epsilon GBrowse link 6 9,631,234 10,097,311 RGD:6907045
G Prkcz protein kinase C, zeta GBrowse link 5 172,061,825 172,172,793 RGD:6907045
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 GBrowse link 2 116,036,501 116,065,834 RGD:6907045
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 GBrowse link 10 56,786,705 56,792,209 RGD:6907045
G Socs1 suppressor of cytokine signaling 1 GBrowse link 10 4,819,971 4,820,609 RGD:6907045
G Socs2 suppressor of cytokine signaling 2 GBrowse link 7 32,605,714 32,608,323 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 GBrowse link 10 107,958,468 107,959,330 RGD:6907045
G Socs4 suppressor of cytokine signaling 4 GBrowse link 15 23,229,083 23,243,568 RGD:6907045
G Tnf tumor necrosis factor GBrowse link 20 3,661,000 3,663,618 RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 18089
    disease pathway 3533
      cardiovascular system disease pathway 398
        metabolic syndrome pathway 54
          type 2 diabetes mellitus pathway 53
paths to the root