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Term:cellular response to hypoxia
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Accession:GO:0071456 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Comment:Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
Synonyms:exact_synonym: cellular response to hypoxic stress;   cellular response to lowered oxygen tension

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cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adam8 ADAM metallopeptidase domain 8 GBrowse link ISO 1 199,780,772 199,791,855 RGD:1624291 RGD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IDA 6 137,640,482 137,657,552 RGD:5509097 RGD
G Angpt4 angiopoietin 4 GBrowse link IEA 3 142,249,115 142,282,307 RGD:1600115 ENSEMBL
G Angpt4 angiopoietin 4 GBrowse link ISO 3 142,249,115 142,282,307 RGD:1624291 RGD
G Ankrd1 ankyrin repeat domain 1 GBrowse link IEP 1 240,316,123 240,324,804 RGD:5133278 RGD
G Aqp1 aquaporin 1 GBrowse link ISO 4 84,098,346 84,110,524 RGD:1624291 RGD
G Aqp1 aquaporin 1 GBrowse link ISS 4 84,098,346 84,110,524 RGD:1600115 UniProtKB
G Asl argininosuccinate lyase GBrowse link IEP 12 27,702,882 27,720,230 RGD:1599264 RGD
G Bad BCL2-associated agonist of cell death GBrowse link ISO 1 209,617,373 209,626,292 RGD:1624291 RGD
G Bad BCL2-associated agonist of cell death GBrowse link IEA 1 209,617,373 209,626,292 RGD:1600115 ENSEMBL
G Bbc3 Bcl-2 binding component 3 ISO RGD:1624291 RGD
G Bdkrb2 bradykinin receptor B2 GBrowse link IEP 6 129,744,781 129,748,851 RGD:4891057 RGD
G Bnip3 BCL2/adenovirus E1B interacting protein 3 GBrowse link ISO 1 198,683,009 198,700,075 RGD:1624291 RGD
G Bnip3 BCL2/adenovirus E1B interacting protein 3 GBrowse link IEA 1 198,683,009 198,700,075 RGD:1600115 ENSEMBL
G Casr calcium-sensing receptor GBrowse link IEP 11 66,084,169 66,153,292 RGD:7206834 RGD
G Cbs cystathionine beta synthase GBrowse link IDA 20 10,047,478 10,075,520 UniProtKB
G Ccnb1 cyclin B1 GBrowse link IEP 2 31,574,600 31,581,784 RGD:2316579 RGD
G Clca1 chloride channel accessory 1 GBrowse link IEP 2 243,057,135 243,084,146 RGD:4188872 RGD
G E2f1 E2F transcription factor 1 GBrowse link IEP 3 145,032,489 145,043,729 RGD:2316261 RGD
G Egr1 early growth response 1 GBrowse link IEP 18 27,343,919 27,346,117 RGD:5131857 RGD
G Fabp1 fatty acid binding protein 1, liver GBrowse link ISO 4 104,412,200 104,415,981 RGD:1624291 RGD
G Fabp1 fatty acid binding protein 1, liver GBrowse link IEA 4 104,412,200 104,415,981 RGD:1600115 ENSEMBL
G Fam162a family with sequence similarity 162, member A GBrowse link ISO 11 66,518,103 66,546,302 RGD:1624291 RGD
G Fam162a family with sequence similarity 162, member A GBrowse link ISO 11 66,518,103 66,546,302 RGD:1624291 RGD
G Fam162a family with sequence similarity 162, member A GBrowse link IDA 11 66,518,103 66,546,302 UniProtKB
G Fndc1 fibronectin type III domain containing 1 GBrowse link IMP 1 41,522,019 41,583,357 MGI
G Gata6 GATA binding protein 6 GBrowse link ISO 18 2,504,264 2,534,648 RGD:1624291 RGD
G Gnb1 guanine nucleotide binding protein (G protein), beta polypeptide 1 GBrowse link IDA 5 172,341,135 172,386,772 MGI
G Gngt1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 GBrowse link IDA 4 28,831,171 28,834,156 MGI
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISO 6 96,419,024 96,463,891 RGD:1624291 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISO 6 96,419,024 96,463,891 RGD:1624291 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISO 6 96,419,024 96,463,891 RGD:1624291 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISS 6 96,419,024 96,463,891 RGD:1600115 UniProtKB
G Higd1a HIG1 hypoxia inducible domain family, member 1A GBrowse link ISO 8 127,076,654 127,085,885 RGD:1624291 RGD
G Higd1a HIG1 hypoxia inducible domain family, member 1A GBrowse link ISO 8 127,076,654 127,085,885 RGD:1624291 RGD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link ISO 19 13,963,139 13,969,960 RGD:1624291 RGD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link IEA 19 13,963,139 13,969,960 RGD:1600115 ENSEMBL
G Icam1 intercellular adhesion molecule 1 GBrowse link IEP 8 20,040,177 20,051,939 RGD:4145424 RGD
G Irak1 interleukin-1 receptor-associated kinase 1 GBrowse link IEP X 159,960,184 159,969,180 RGD:1579809 RGD
G Ireb2 iron responsive element binding protein 2 GBrowse link IEP 8 58,433,218 58,477,305 RGD:6893269 RGD
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 GBrowse link IEP 4 143,705,360 144,030,051 RGD:6482794 RGD
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 GBrowse link IEP 4 183,677,606 184,066,130 RGD:6482794 RGD
G Kcnk3 potassium channel, subfamily K, member 3 GBrowse link IMP 6 25,745,923 25,782,144 RGD:2316539 RGD
G Lmna lamin A/C GBrowse link ISO 2 180,595,724 180,616,354 RGD:1624291 RGD
G Lmna lamin A/C GBrowse link IEA 2 180,595,724 180,616,354 RGD:1600115 ENSEMBL
G Mdm2 p53 E3 ubiquitin protein ligase GBrowse link ISO 7 56,996,694 57,020,926 RGD:1624291 RGD
G Mdm2 p53 E3 ubiquitin protein ligase GBrowse link IEA 7 56,996,694 57,020,926 RGD:1600115 ENSEMBL
G Mdm4 Mdm4 p53 binding protein homolog (mouse) GBrowse link ISO 13 45,895,832 45,931,421 RGD:1624291 RGD
G Mdm4 Mdm4 p53 binding protein homolog (mouse) GBrowse link IEA 13 45,895,832 45,931,421 RGD:1600115 ENSEMBL
G Mgarp mitochondria-localized glutamic acid-rich protein GBrowse link ISO 2 140,282,230 140,290,372 RGD:1624291 RGD
G Mgarp mitochondria-localized glutamic acid-rich protein GBrowse link IEA 2 140,282,230 140,290,372 RGD:1600115 ENSEMBL
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) GBrowse link IEP 20 13,191,986 13,192,851 RGD:4890975 RGD
G Mt3 metallothionein 3 GBrowse link ISO 19 11,284,554 11,286,402 RGD:1624291 RGD
G Mt3 metallothionein 3 GBrowse link IEA 19 11,284,554 11,286,402 RGD:1600115 ENSEMBL
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link ISO 5 165,531,402 165,640,899 RGD:1624291 RGD
G Mtor mechanistic target of rapamycin (serine/threonine kinase) GBrowse link ISS 5 165,531,402 165,640,899 RGD:1600115 UniProtKB
G Myocd myocardin GBrowse link IEP 10 51,496,223 51,588,226 RGD:5132874 RGD
G Ndrg1 N-myc downstream regulated 1 GBrowse link ISO 7 104,302,038 104,344,842 RGD:1624291 RGD
G Ndrg1 N-myc downstream regulated 1 GBrowse link IEA 7 104,302,038 104,344,842 RGD:1600115 ENSEMBL
G Nkx3-1 NK3 homeobox 1 GBrowse link ISO 15 49,743,313 49,745,905 RGD:1624291 RGD
G Nkx3-1 NK3 homeobox 1 GBrowse link IEA 15 49,743,313 49,745,905 RGD:1600115 ENSEMBL
G Npepps aminopeptidase puromycin sensitive GBrowse link ISO 10 85,927,819 86,011,826 RGD:1624291 RGD
G Npepps aminopeptidase puromycin sensitive GBrowse link IEA 10 85,927,819 86,011,826 RGD:1600115 ENSEMBL
G Palld palladin, cytoskeletal associated protein GBrowse link IEP 16 31,144,028 31,144,544 RGD:2325785 RGD
G Plau plasminogen activator, urokinase GBrowse link IEP 15 3,680,072 3,686,232 RGD:7241802 RGD
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link ISO 18 62,914,845 62,918,832 RGD:1624291 RGD
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link ISO 18 62,914,845 62,918,832 RGD:1624291 RGD
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link IEA 18 62,914,845 62,918,832 RGD:1600115 ENSEMBL
G Ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha GBrowse link IEP 14 64,278,115 64,370,912 RGD:7242177 RGD
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit GBrowse link IEP 2 54,327,821 54,360,462 RGD:2316813 RGD
G Prkce protein kinase C, epsilon GBrowse link ISO 6 9,631,234 10,097,311 RGD:1624291 RGD
G Prkce protein kinase C, epsilon GBrowse link IEA 6 9,631,234 10,097,311 RGD:1600115 ENSEMBL
G Ptgis prostaglandin I2 (prostacyclin) synthase GBrowse link ISO 3 158,356,878 158,387,984 RGD:1624291 RGD
G Ptgis prostaglandin I2 (prostacyclin) synthase GBrowse link IEA 3 158,356,878 158,387,984 RGD:1600115 ENSEMBL
G Ptgis prostaglandin I2 (prostacyclin) synthase GBrowse link ISS 3 158,356,878 158,387,984 RGD:1600115 UniProtKB
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link ISO 13 64,427,288 64,432,978 RGD:1624291 RGD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link IEA 13 64,427,288 64,432,978 RGD:1600115 ENSEMBL
G Rgcc regulator of cell cycle GBrowse link ISO 15 60,451,831 60,452,229 RGD:1624291 RGD
G Rgcc regulator of cell cycle GBrowse link IEA 15 60,451,831 60,452,229 RGD:1600115 ENSEMBL
G S100b S100 calcium binding protein B GBrowse link IEP 20 12,791,440 12,824,508 RGD:2325647 RGD
G Sfrp1 secreted frizzled-related protein 1 GBrowse link IEA 16 73,030,458 73,067,304 RGD:1600115 ENSEMBL
G Sfrp1 secreted frizzled-related protein 1 GBrowse link ISO 16 73,030,458 73,067,304 RGD:1624291 RGD
G Sirt1 sirtuin 1 GBrowse link IEA 20 25,675,302 25,686,494 RGD:1600115 ENSEMBL
G Sirt1 sirtuin 1 GBrowse link ISO 20 25,675,302 25,686,494 RGD:1624291 RGD
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 GBrowse link IEP 7 139,094,505 139,127,427 RGD:5688411 RGD
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link IEP 9 11,000,054 11,014,914 RGD:1598899 RGD
G Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) GBrowse link IEP 3 148,157,256 148,170,524 RGD:2324980 RGD
G Stc1 stanniocalcin 1 GBrowse link IEP 15 49,566,885 49,577,539 RGD:2324700 RGD
G Stc2 stanniocalcin 2 GBrowse link IEP 10 16,514,603 16,524,369 RGD:2324700 RGD
G Tp53 tumor protein p53 GBrowse link ISO 10 56,399,721 56,411,150 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link ISO 6 52,605,869 52,607,863 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link ISO 6 52,605,869 52,607,863 RGD:1624291 RGD
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link IEA 6 52,605,869 52,607,863 RGD:1600115 ENSEMBL
G Twist1 twist basic helix-loop-helix transcription factor 1 GBrowse link IEA 6 52,605,869 52,607,863 RGD:1600115 ENSEMBL
G Ucn2 urocortin 2 GBrowse link IEP 8 114,003,817 114,005,366 RGD:2306174 RGD
G Ucn3 urocortin 3 GBrowse link IEP 17 77,482,852 77,488,471 RGD:2306174 RGD
G Vasn vasorin GBrowse link ISO 10 11,047,084 11,057,591 RGD:1624291 RGD
G Vegfa vascular endothelial growth factor A GBrowse link ISO 9 10,520,730 10,536,071 RGD:1624291 RGD
G Vldlr very low density lipoprotein receptor GBrowse link IDA 1 230,666,736 230,697,748 RGD:2324641 RGD
hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Pdk1 pyruvate dehydrogenase kinase, isozyme 1 GBrowse link ISO 3 54,292,076 54,319,242 RGD:1624291 RGD
G Pdk1 pyruvate dehydrogenase kinase, isozyme 1 GBrowse link ISS 3 54,292,076 54,319,242 RGD:1600115 UniProtKB
G Pdk3 pyruvate dehydrogenase kinase, isozyme 3 GBrowse link ISO X 81,104,667 81,171,536 RGD:1624291 RGD
G Pdk3 pyruvate dehydrogenase kinase, isozyme 3 GBrowse link IEA X 81,104,667 81,171,536 RGD:1600115 ENSEMBL
negative regulation of cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cd34 CD34 molecule GBrowse link ISO 13 110,877,594 110,896,722 RGD:1624291 RGD
G Cd34 CD34 molecule GBrowse link ISS 13 110,877,594 110,896,722 RGD:1600115 UniProtKB
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link ISO 1 12,721,500 12,723,943 RGD:1624291 RGD
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link IEA 1 12,721,500 12,723,943 RGD:1600115 ENSEMBL
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link IEA 1 249,607,945 249,618,000 RGD:1600115 ENSEMBL
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link ISO 1 249,607,945 249,618,000 RGD:1624291 RGD
G Vhl von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase GBrowse link ISO 4 149,529,396 149,536,289 RGD:1624291 RGD
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Plk3 polo-like kinase 3 GBrowse link ISO 5 137,443,540 137,448,715 RGD:1624291 RGD
G Plk3 polo-like kinase 3 GBrowse link ISS 5 137,443,540 137,448,715 RGD:1600115 UniProtKB
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link IEA 6 96,419,024 96,463,891 RGD:1600115 ENSEMBL
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISO 6 96,419,024 96,463,891 RGD:1624291 RGD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link ISO 6 96,419,024 96,463,891 RGD:1624291 RGD
G Notch1 notch 1 GBrowse link ISO 3 4,631,797 4,677,640 RGD:1624291 RGD
G Notch1 notch 1 GBrowse link IEA 3 4,631,797 4,677,640 RGD:1600115 ENSEMBL
G Notch1 notch 1 GBrowse link ISS 3 4,631,797 4,677,640 RGD:1600115 UniProtKB
G Vegfa vascular endothelial growth factor A GBrowse link IEA 9 10,520,730 10,536,071 RGD:1600115 ENSEMBL
G Vegfa vascular endothelial growth factor A GBrowse link ISO 9 10,520,730 10,536,071 RGD:1624291 RGD
regulation of cellular response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Ajuba ajuba LIM protein GBrowse link ISO 15 32,627,633 32,637,861 RGD:1624291 RGD
G Ajuba ajuba LIM protein GBrowse link IEA 15 32,627,633 32,637,861 RGD:1600115 ENSEMBL
G Usp19 ubiquitin specific peptidase 19 ISO RGD:1624291 RGD
G Usp19 ubiquitin specific peptidase 19 ISS RGD:1600115 UniProtKB
regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 GBrowse link ISO 11 27,467,207 27,500,173 RGD:1624291 RGD
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 GBrowse link IEA 11 27,467,207 27,500,173 RGD:1600115 ENSEMBL
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 135967
    response to stimulus 34057
      response to stress 7464
        response to hypoxia 486
          cellular response to hypoxia 126
            hypoxia-inducible factor-1alpha signaling pathway + 4
            negative regulation of cellular response to hypoxia + 2
            positive regulation of cellular response to hypoxia + 0
            positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia 2
            regulation of cellular response to hypoxia + 6
            regulation of transcription from RNA polymerase II promoter in response to hypoxia + 15
Path 2
Term Annotations click to browse term
  biological_process 135967
    cellular process 85138
      single-organism cellular process 56334
        cellular response to stimulus 19015
          cellular response to chemical stimulus 4549
            cellular response to oxygen levels 136
              cellular response to decreased oxygen levels 126
                cellular response to hypoxia 126
                  hypoxia-inducible factor-1alpha signaling pathway + 4
                  negative regulation of cellular response to hypoxia + 2
                  positive regulation of cellular response to hypoxia + 0
                  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia 2
                  regulation of cellular response to hypoxia + 6
                  regulation of transcription from RNA polymerase II promoter in response to hypoxia + 15
paths to the root

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