Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1D-myo-inositol 1,4,5-trisphosphate | multiple interactions | ISO | RGD:10291 | 6480464 | [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate | CTD | PMID:7874174 | aluminium atom | multiple interactions | EXP | | 6480464 | [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; more ... | CTD | PMID:10231437 | aluminium trichloride | increases activity | ISO | RGD:10291 | 6480464 | aluminum chloride results in increased activity of CASR protein | CTD | PMID:16316325 | aluminium(0) | multiple interactions | EXP | | 6480464 | [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; more ... | CTD | PMID:10231437 | amikacin | increases activity | ISO | RGD:10291 | 6480464 | Amikacin results in increased activity of CASR protein | CTD | PMID:19884751 | amitriptyline | decreases expression | EXP | | 6480464 | Amitriptyline results in decreased expression of CASR mRNA | CTD | PMID:22341215 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CASR mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CASR mRNA | CTD | PMID:21839799 | calcitriol | increases expression | EXP | | 6480464 | Calcitriol results in increased expression of CASR protein; more ... | CTD | PMID:15788476 | calcium atom | multiple interactions | ISO | RGD:10291 | 6480464 | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium]; more ... | CTD | PMID:21562303 | calcium atom | multiple interactions | EXP | | 6480464 | Calcium binds to and results in increased activity of CASR protein | CTD | PMID:10231437 PMID:11071898 | calcium atom | multiple interactions | EXP | | 6480464 | [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; more ... | CTD | PMID:10231437 | calcium atom | increases response to substance | ISO | RGD:10291 | 6480464 | CASR protein mutant form results in increased susceptibility to Calcium | CTD | PMID:11701698 PMID:7874174 | calcium atom | multiple interactions | ISO | RGD:10291 | 6480464 | [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium]; more ... | CTD | PMID:19781536 | calcium atom | multiple interactions | EXP | | 6480464 | Calcium binds to and results in increased activity of CASR protein | CTD | PMID:11071898 | calcium atom | affects expression | EXP | | 6480464 | Calcium affects the expression of CASR mRNA; more ... | CTD | PMID:15788476 | calcium atom | multiple interactions | ISO | RGD:10291 | 6480464 | [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate | CTD | PMID:7874174 | calcium atom | multiple interactions | ISO | RGD:10291 | 6480464 | N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine affects the reaction [CASR gene mutant form results in increased susceptibility to Calcium]; more ... | CTD | PMID:11089548 | calcium atom | increases response to substance | ISO | RGD:10291 | 6480464 | CASR protein mutant form results in increased susceptibility to Calcium | CTD | PMID:7874174 PMID:11701698 | calcium atom | decreases response to substance | ISO | RGD:10291 | 6480464 | CASR protein mutant form results in decreased susceptibility to Calcium | CTD | PMID:9011580 | calcium atom | increases response to substance | ISO | RGD:10291 | 6480464 | CASR gene mutant form results in increased susceptibility to Calcium | CTD | PMID:11089548 | calcium atom | increases phosphorylation | ISO | RGD:10291 | 6480464 | Calcium results in increased phosphorylation of CASR protein | CTD | PMID:17376781 | calcium atom | multiple interactions | ISO | RGD:10291 | 6480464 | bisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]]; more ... | CTD | PMID:17376781 | calcium atom | increases uptake | ISO | RGD:10291 | 6480464 | CASR protein results in increased uptake of Calcium | CTD | PMID:21562303 | calcium atom | multiple interactions | ISO | RGD:10291 | 6480464 | [Calcium binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium; more ... | CTD | PMID:17041782 | calcium atom | increases activity | ISO | RGD:10291 | 6480464 | Calcium results in increased activity of CASR protein | CTD | PMID:17041782 | calcium dichloride | multiple interactions | ISO | RGD:10291 | 6480464 | Calcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein] | CTD | PMID:17376781 | calcium dichloride | increases activity | ISO | RGD:10291 | 6480464 | Calcium Chloride results in increased activity of CASR protein | CTD | PMID:16316325 | calcium(0) | multiple interactions | ISO | RGD:10291 | 6480464 | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium]; more ... | CTD | PMID:21562303 | calcium(0) | multiple interactions | EXP | | 6480464 | Calcium binds to and results in increased activity of CASR protein | CTD | PMID:10231437 PMID:11071898 | calcium(0) | multiple interactions | EXP | | 6480464 | [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; more ... | CTD | PMID:10231437 | calcium(0) | increases response to substance | ISO | RGD:10291 | 6480464 | CASR protein mutant form results in increased susceptibility to Calcium | CTD | PMID:11701698 PMID:7874174 | calcium(0) | multiple interactions | ISO | RGD:10291 | 6480464 | [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium]; more ... | CTD | PMID:19781536 | calcium(0) | multiple interactions | EXP | | 6480464 | Calcium binds to and results in increased activity of CASR protein | CTD | PMID:11071898 | calcium(0) | affects expression | EXP | | 6480464 | Calcium affects the expression of CASR mRNA; more ... | CTD | PMID:15788476 | calcium(0) | multiple interactions | ISO | RGD:10291 | 6480464 | [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate | CTD | PMID:7874174 | calcium(0) | multiple interactions | ISO | RGD:10291 | 6480464 | N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine affects the reaction [CASR gene mutant form results in increased susceptibility to Calcium]; more ... | CTD | PMID:11089548 | calcium(0) | increases response to substance | ISO | RGD:10291 | 6480464 | CASR protein mutant form results in increased susceptibility to Calcium | CTD | PMID:7874174 PMID:11701698 | calcium(0) | decreases response to substance | ISO | RGD:10291 | 6480464 | CASR protein mutant form results in decreased susceptibility to Calcium | CTD | PMID:9011580 | calcium(0) | increases response to substance | ISO | RGD:10291 | 6480464 | CASR gene mutant form results in increased susceptibility to Calcium | CTD | PMID:11089548 | calcium(0) | increases phosphorylation | ISO | RGD:10291 | 6480464 | Calcium results in increased phosphorylation of CASR protein | CTD | PMID:17376781 | calcium(0) | multiple interactions | ISO | RGD:10291 | 6480464 | bisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]]; more ... | CTD | PMID:17376781 | calcium(0) | increases uptake | ISO | RGD:10291 | 6480464 | CASR protein results in increased uptake of Calcium | CTD | PMID:21562303 | calcium(0) | multiple interactions | ISO | RGD:10291 | 6480464 | [Calcium binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium; more ... | CTD | PMID:17041782 | calcium(0) | increases activity | ISO | RGD:10291 | 6480464 | Calcium results in increased activity of CASR protein | CTD | PMID:17041782 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of CASR mRNA | CTD | PMID:15620428 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of CASR mRNA | CTD | PMID:18636392 | flufenamic acid | multiple interactions | ISO | RGD:10291 | 6480464 | Flufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium] | CTD | PMID:21562303 | gadolinium atom | multiple interactions | EXP | | 6480464 | Gadolinium binds to and results in increased activity of CASR protein | CTD | PMID:11071898 | gadolinium atom | multiple interactions | EXP | | 6480464 | Gadolinium binds to and results in increased activity of CASR protein | CTD | PMID:10231437 PMID:11071898 | gadolinium atom | multiple interactions | EXP | | 6480464 | [Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; more ... | CTD | PMID:10231437 | isoniazide | affects expression | EXP | | 6480464 | Isoniazid affects the expression of CASR mRNA | CTD | PMID:20623750 | lanthanum atom | multiple interactions | ISO | RGD:10291 | 6480464 | Lanthanum inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]; more ... | CTD | PMID:17041782 | lanthanum atom | multiple interactions | ISO | RGD:10291 | 6480464 | Lanthanum inhibits the reaction [CASR protein results in increased uptake of Calcium] | CTD | PMID:21562303 | magnesium atom | increases expression | EXP | | 6480464 | Magnesium results in increased expression of CASR protein; more ... | CTD | PMID:11563847 | magnesium atom | multiple interactions | EXP | | 6480464 | [Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; more ... | CTD | PMID:10231437 | magnesium atom | increases response to substance | ISO | RGD:1553551 | 6480464 | CASR protein results in increased susceptibility to Magnesium | CTD | PMID:15068510 | nickel atom | multiple interactions | ISO | RGD:10291 | 6480464 | [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of COL1A1 mRNA]; more ... | CTD | PMID:19781536 | nickel atom | increases activity | ISO | RGD:10291 | 6480464 | Nickel results in increased activity of CASR protein | CTD | PMID:19781536 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of CASR mRNA | CTD | PMID:18636392 | phenylephrine | multiple interactions | EXP | | 6480464 | Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] | CTD | PMID:11071898 | phosphorus atom | affects abundance | ISO | RGD:10291 | 6480464 | CASR protein affects the abundance of Phosphorus | CTD | PMID:11589681 | phosphorus(.) | affects abundance | ISO | RGD:10291 | 6480464 | CASR protein affects the abundance of Phosphorus | CTD | PMID:11589681 | sodium fluoride | decreases expression | ISO | RGD:1553551 | 6480464 | Sodium Fluoride results in decreased expression of CASR mRNA | CTD | PMID:21340527 | spermine | multiple interactions | EXP | | 6480464 | NPS R-467 promotes the reaction [Spermine binds to and results in increased activity of CASR protein]; more ... | CTD | PMID:11071898 | spermine | multiple interactions | ISO | RGD:10291 | 6480464 | 2-aminoethoxydiphenyl borate inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; more ... | CTD | PMID:17041782 | strontium atom | increases response to substance | ISO | RGD:10291 | 6480464 | CASR protein results in increased susceptibility to Strontium | CTD | PMID:15068510 | strontium atom | affects activity | ISO | RGD:10291 | 6480464 | Strontium affects the activity of CASR protein | CTD | PMID:15068510 | testosterone | increases expression | ISO | RGD:1553551 | 6480464 | Testosterone deficiency results in increased expression of CASR mRNA | CTD | PMID:21045173 | testosterone | decreases expression | ISO | RGD:1553551 | 6480464 | Testosterone results in decreased expression of CASR mRNA | CTD | PMID:20403060 | testosterone | multiple interactions | ISO | RGD:1553551 | 6480464 | Testosterone inhibits the reaction [Testosterone deficiency results in increased expression of CASR mRNA] | CTD | PMID:21045173 | thapsigargin | multiple interactions | EXP | | 6480464 | Thapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] | CTD | PMID:11071898 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of CASR mRNA | CTD | PMID:21515302 | vancomycin | increases expression | ISO | RGD:1553551 | 6480464 | Vancomycin results in increased expression of CASR mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | E-cadherin signaling in keratinocytes (PID:200147) |
Disease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| Pathway Interaction Database | E-cadherin signaling in keratinocytes (PID:200147) |
References - curated| 1. |
Aguirre A, etal., Biochem Biophys Res Commun. 2010 Feb 26;393(1):156-61. doi: 10.1016/j.bbrc.2010.01.109. Epub 2010 Feb 1. |
| 2. |
Alam MU, etal., Cardiovasc Res. 2009 Feb 1;81(2):260-8. doi: 10.1093/cvr/cvn279. Epub 2008 Oct 13. |
| 3. |
Bai SZ, etal., Diabetes Res Clin Pract. 2012 Mar;95(3):378-85. doi: 10.1016/j.diabres.2011.11.007. Epub 2011 Dec 3. |
| 4. |
Canaff L, etal., J Biol Chem 2001 Feb 9;276(6):4070-9. Epub 2000 Nov 08.
|
| 5. |
Canalejo R, etal., J Am Soc Nephrol. 2010 Jul;21(7):1125-35. doi: 10.1681/ASN.2009040427. Epub 2010 Apr 29. |
| 6. |
Cha SK, etal., J Biol Chem. 2011 Jan 21;286(3):1828-35. doi: 10.1074/jbc.M110.160390. Epub 2010 Nov 17. |
| 7. |
Chattopadhyay N, etal., Endocrinology 2004 Jul;145(7):3451-62. Epub 2004 Apr 7. |
| 8. |
Cheng SX Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G60-70. doi: 10.1152/ajpgi.00425.2011. Epub 2012 Apr 19. |
| 9. |
Cheng SX, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G240-50. |
| 10. |
Chi J, etal., Mol Cell Biochem. 2012 Aug;367(1-2):227-36. doi: 10.1007/s11010-012-1336-5. Epub 2012 Jun 8. |
| 11. |
Chou YH, etal., Am J Hum Genet. 1995 May;56(5):1075-9. |
| 12. |
Chou YH, etal., PLoS One. 2011;6(9):e25227. doi: 10.1371/journal.pone.0025227. Epub 2011 Sep 22. |
| 13. |
Dong S, etal., Mol Cell Biochem. 2010 Aug;341(1-2):195-206. doi: 10.1007/s11010-010-0450-5. Epub 2010 Apr 11. |
| 14. |
Elamin WF and de Buyl O, J Med Case Rep. 2010 Oct 29;4:349. doi: 10.1186/1752-1947-4-349. |
| 15. |
Eren PA, etal., Clin Nephrol. 2009 Aug;72(2):114-21. |
| 16. |
Ferreira LG, etal., Nephron Clin Pract. 2010;114(2):c135-44. doi: 10.1159/000254386. Epub 2009 Nov 3. |
| 17. |
GOA data from the GO Consortium |
| 18. |
Guo J, etal., Clin Exp Pharmacol Physiol. 2010 Mar;37(3):e128-35. doi: 10.1111/j.1440-1681.2010.05345.x. |
| 19. |
Guo J, etal., Mol Cell Biochem. 2012 Jul;366(1-2):345-54. doi: 10.1007/s11010-012-1312-0. Epub 2012 Apr 17. |
| 20. |
Haligur M, etal., Exp Diabetes Res. 2012;2012:120645. doi: 10.1155/2012/120645. Epub 2012 Jul 11. |
| 21. |
Hannan FM, etal., Clin Endocrinol (Oxf). 2010 Dec;73(6):715-22. doi: 10.1111/j.1365-2265.2010.03870.x. |
| 22. |
He YH, etal., J Nutr. 2011 Nov;141(11):1938-46. doi: 10.3945/jn.111.141762. Epub 2011 Sep 21. |
| 23. |
Ho C, etal., Nat Genet. 1995 Dec;11(4):389-94. |
| 24. |
Hough TA, etal., Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13566-71. Epub 2004 Sep 3. |
| 25. |
Huang C, etal., Am J Physiol Renal Physiol. 2007 Mar;292(3):F1073-81. Epub 2006 Nov 22. |
| 26. |
Kobayashi M, etal., J Clin Endocrinol Metab. 1997 Aug;82(8):2716-9. |
| 27. |
Koleganova N, etal., Kidney Int. 2009 Jan;75(1):60-71. doi: 10.1038/ki.2008.490. Epub 2008 Oct 1. |
| 28. |
Koleganova N, etal., Lab Invest. 2009 May;89(5):520-30. doi: 10.1038/labinvest.2009.7. Epub 2009 Feb 2. |
| 29. |
Li GW, etal., Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):185-93. doi: 10.1111/j.1742-7843.2010.00639.x. Epub 2010 Nov 12. |
| 30. |
Li HX, etal., Mol Cell Biochem. 2012 Mar;362(1-2):115-22. doi: 10.1007/s11010-011-1133-6. Epub 2011 Nov 15. |
| 31. |
MGD data from the GO Consortium |
| 32. |
Molostvov G, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F946-55. Epub 2007 May 30. |
| 33. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 34. |
O'Seaghdha CM, etal., Hum Mol Genet. 2010 Nov 1;19(21):4296-303. doi: 10.1093/hmg/ddq342. Epub 2010 Aug 12. |
| 35. |
Okamoto K, etal., Diabetes. 2012 Jul;61(7):1734-41. doi: 10.2337/db11-1201. Epub 2012 May 7. |
| 36. |
Parkash J Life Sci. 2011 Jan 31;88(5-6):257-64. doi: 10.1016/j.lfs.2010.12.002. Epub 2010 Dec 10. |
| 37. |
Pearce SH, etal., N Engl J Med. 1996 Oct 10;335(15):1115-22. |
| 38. |
Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8. |
| 39. |
Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6. |
| 40. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 41. |
Pollak MR, etal., Cell. 1993 Dec 31;75(7):1297-303. |
| 42. |
Pollak MR, etal., Nat Genet. 1994 Nov;8(3):303-7. |
| 43. |
RGD automated data pipeline |
| 44. |
RGD automated import pipeline for gene-chemical interactions |
| 45. |
RGD Automated Pipelines |
| 46. |
Riccardi D, etal., Proc Natl Acad Sci U S A 1995 Jan 3;92(1):131-5. |
| 47. |
Ritter CS, etal., J Bone Miner Res 2002 Dec;17(12):2206-13. |
| 48. |
Ruat M, etal., Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3161-5. |
| 49. |
Sfar S, etal., Mol Biol Rep. 2012 Mar;39(3):2395-400. doi: 10.1007/s11033-011-0990-0. Epub 2011 Jun 12. |
| 50. |
Shakhssalim N, etal., Scand J Urol Nephrol. 2010 Dec;44(6):406-12. doi: 10.3109/00365599.2010.497770. Epub 2010 Jul 5. |
| 51. |
Sorheim JI, etal., Horm Res Paediatr. 2010;74(6):399-405. doi: 10.1159/000303188. Epub 2010 May 26. |
| 52. |
Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15. |
| 53. |
Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3. |
| 54. |
Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20. |
| 55. |
Tu Q, etal., J Clin Invest 2003 Apr;111(7):1029-37. |
| 56. |
Vezzoli G, etal., Eur J Endocrinol. 2011 Mar;164(3):421-7. doi: 10.1530/EJE-10-0915. Epub 2010 Dec 23. |
| 57. |
Vezzoli G, etal., J Am Soc Nephrol. 2002 Oct;13(10):2517-23. |
| 58. |
Vezzoli G, etal., Nephrol Dial Transplant. 2010 Jul;25(7):2245-52. doi: 10.1093/ndt/gfp760. Epub 2010 Jan 12. |
| 59. |
Wang Y, etal., Am J Physiol Cell Physiol 2003 Jul;285(1):C64-75. Epub 2003 Mar 12. |
| 60. |
Watanabe S, etal., Lancet 2002 Aug 31;360(9334):692-4. |
| 61. |
Xi QL, etal., Urology. 2011 Dec;78(6):1442.e1-7. doi: 10.1016/j.urology.2011.08.051. |
| 62. |
Yamamura A, etal., Circ Res. 2012 Aug 3;111(4):469-81. doi: 10.1161/CIRCRESAHA.112.266361. Epub 2012 Jun 22. |
| 63. |
Yan L, etal., Mol Biol Rep. 2011 Apr;38(4):2695-701. doi: 10.1007/s11033-010-0412-8. Epub 2010 Nov 19. |
| 64. |
Yan L, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Mar;40(2):207-12. |
| 65. |
Yano S, etal., Kidney Int. 2000 Nov;58(5):1980-6. |
| 66. |
Zhang J, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):471-84. doi: 10.1089/ars.2011.4168. Epub 2012 Jan 25. |
| 67. |
Zhao Y, etal., Pharmazie. 2011 Dec;66(12):968-74. |
| 68. |
Zheng H, etal., Mol Cell Biochem. 2011 Dec;358(1-2):335-43. doi: 10.1007/s11010-011-0984-1. Epub 2011 Jul 16. |
References - uncurated| PubMed | 12372772 |
| 12970167 | |
| 14645111 | |
| 15576443 | |
| 15684428 | |
| 15950968 | |
| 16019433 | |
| 16767692 | |
| 16859639 | |
| 17267550 | |
| 18032544 | |
| 18175029 | |
| 18348986 | |
| 18414396 | |
| 18455448 | |
| 18556746 | |
| 18636168 | |
| 18684886 | |
| 19056349 | |
| 19091789 | |
| 19593209 | |
| 19728995 | |
| 19896983 | |
| 20307499 | |
| 21215232 | |
| 21314926 | |
| 21316341 | |
| 21692826 | |
| 22013999 | |
| 22038624 | |
| 22050992 | |
| 22314915 | |
| 22708524 | |
| 23300272 |
RGD Disease Portals| Casr has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Comparative Map Data| Casr (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| CASR (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Casr (Mus musculus) |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_016996 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06068852 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06068853 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06068854 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01069671 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01069672 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01069673 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01069674 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01069675 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY214122 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473967 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U10354 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U20289 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_016996 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058692 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_058692 | (Get FASTA) |
| GenBank Protein | AAC52149 | (Get FASTA) |
| AAC52195 | (Get FASTA) | |
| AAO59490 | (Get FASTA) | |
| EDM11279 | (Get FASTA) | |
| EDM11280 | (Get FASTA) | |
| EDM11281 | (Get FASTA) | |
| EDM11282 | (Get FASTA) | |
| P48442 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002265 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000003092 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000003092 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 24247 | ENTREZGENE |
| Germonline | ENSRNOG00000002265 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 332 | ENTREZGENE |
| InterPro | ANF_lig_bd_rcpt | UniProtKB/Swiss-Prot |
| GPCR_3 | UniProtKB/Swiss-Prot | |
| GPCR_3_9-Cys_dom | UniProtKB/Swiss-Prot | |
| GPCR_3_C | UniProtKB/Swiss-Prot | |
| GPCR_3_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00190846 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24247 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | 7tm_3 | UniProtKB/Swiss-Prot |
| ANF_receptor | UniProtKB/Swiss-Prot | |
| NCD3G | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRMGR | UniProtKB/Swiss-Prot |
| PROSITE | G_PROTEIN_RECEP_F3_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F3_2 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F3_3 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F3_4 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.10019 | ENTREZGENE |
| UniProt | CASR_RAT | UniProtKB/Swiss-Prot |
| Q80ZA8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Casr | calcium-sensing receptor | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | present at both the apical and basolateral surfaces of colonic surface and crypt cells | 628315 |
| gene_disease | inactivating mutations have been described in familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), activating mutations have been described in autosomal dominant hypoparathyroidism a | 62420 |
| gene_expression | expressed in gastrointestinal tract, including colon | 628315 |
| gene_function | G protein-coupled receptor, acts as a receptor for Ca2+, Mg 2+, trivalent, and polycations | 62420 |
| gene_function | activatss PKC as well as the ERK1/2, p38 MAPK, and JNK pathways to regulate PTHrP release | 1298591 |
| gene_process | may be a physiological receptor for Mg++ and polycations, such as spermine, at certain sites in the body | 62420 |
| gene_process | mobilizes intracellular Ca2++ from IP3-sensitive stores and stimulates bile flow | 62420 |
| gene_process | modulator of intestinal fluid secretion; mediates various cellualr processes including increases in intracellular Ca2+ and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], reductions in cellular cAMP, activation of mitogen-activated protein kinases, regulatio | 628315 |
| gene_process | responds to extracellular Ca2+, Mg2+, Gd3+, and neomycin producing a characteristic activation of inositol phospholipid-dependent, intracellular Ca(2+)-induced Cl- currents | 1298562 |
| gene_product | member of Family C of the superfamily of GPCRs | 628315 |
| gene_regulation | responsive not only to divalent cations Ca++ and Mg ++ but also trivalent cations such as the transition metal, gadolinium (Gd+++) | 62420 |
| gene_regulation | activation modulated by changes in ionic strength | 62420 |
| gene_regulation | responsiveness to ligands potentiated by certain phenylalkylamine compounds and their deschloro derivatives | 62420 |
| More on Casr | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2277 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.