Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (ortholog); peptidyl-proline 4-dioxygenase activity (ortholog); peptidyl-proline dioxygenase activity (ortholog); INVOLVED IN regulation of cell proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); apoptotic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell cancer pathway; ASSOCIATED WITH Acute Kidney Injury; Kidney Reperfusion Injury; Myocardial Infarction; FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; SM-20
Orthologs:
Allele / Splice: Egln3m1Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBI
Cytogenetic Map6q23NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Egln3
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 71019
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2016-08-09
Status: ACTIVE