Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Rattus norvegicus
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (ortholog); peptidyl-proline 4-dioxygenase activity (ortholog); peptidyl-proline dioxygenase activity (ortholog); INVOLVED IN regulation of cell proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); apoptotic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell cancer pathway; ASSOCIATED WITH acute kidney failure; Acute Kidney Injury; acute myocardial infarction; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
Also known as: egl nine homolog 3; EGL nine homolog 3 (C. elegans); egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD-3; PHD3; prolyl hydroxylase domain-containing protein 3; SM-20
Homo sapiens (human) : EGLN3 (egl-9 family hypoxia inducible factor 3)  HGNC
Mus musculus (house mouse) : Egln3 (egl-9 family hypoxia-inducible factor 3)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Egln3 (egl-9 family hypoxia inducible factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Canis lupus familiaris (dog) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln3 (egl-9 family hypoxia inducible factor 3)
more info ...
Allele / Splice: Egln3m1Mcwi  
Genetic Models: FHH-Egln3m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBI
Cytogenetic Map6q23NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Egln3
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 71019
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2017-08-08
Status: ACTIVE