Gene: Sdhd (succinate dehydrogenase complex, subunit D, integral membrane protein)
Rattus norvegicus
Symbol:
Sdhd
Name:
succinate dehydrogenase complex, subunit D, integral membrane protein
Description:
ENCODES a protein that exhibits heme binding (ortholog); succinate dehydrogenase activity (ortholog); ubiquinone binding (ortholog); INVOLVED IN tricarboxylic acid cycle (ortholog); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; electron transport chain pathway; ASSOCIATED WITH Carcinoid Tumors, Intestinal (ortholog); Carcinoma, Renal Cell (ortholog); Carney-Stratakis Syndrome (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial respiratory chain complex II (ortholog); mitochondrion (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; amiodarone; benzbromarone
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
CII-4; cybS; MGC72971; QPs3; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex subunit D; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; succinate-ubiquinone reductase membrane anchor subunit
Orthologs:
Homo sapiens : SDHD
(succinate dehydrogenase complex, subunit D, integral membrane protein)
HGNC
Mus musculus : Sdhd
(succinate dehydrogenase complex, subunit D, integral membrane protein)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 8 q23 NCBI RGSC Genome Assembly v5.0 8 53,625,447 - 53,634,926 - NCBI RGSC Genome Assembly v3.4 8 53,955,067 - 53,964,547 - NCBI Rat Celera Assembly 8 50,493,184 - 50,502,624 - NCBI Genome Assembly 3.1 8 53,974,120 - 53,983,601 - NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1332252 6480464 Ethinyl Estradiol results in increased expression of SDHD mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1332252 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHD mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1345704 6480464 Tetrachlorodibenzodioxin results in decreased expression of SDHD mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1345704 6480464 Tetrachlorodibenzodioxin results in decreased expression of SDHD mRNA CTD PMID:17101203 PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1332252 6480464 Tetrachlorodibenzodioxin affects the expression of SDHD mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1332252 6480464 Tetrachlorodibenzodioxin results in increased expression of SDHD mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1332252 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHD mRNA CTD PMID:17942748 2-methylcholine affects expression ISO RGD:1345704 6480464 beta-methylcholine affects the expression of SDHD mRNA CTD PMID:21179406 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of SDHD mRNA CTD PMID:19483382 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of SDHD mRNA CTD PMID:19483382 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of SDHD mRNA CTD PMID:19483382 benzo[a]pyrene multiple interactions ISO RGD:1332252 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of SDHD mRNA CTD PMID:21715664 benzo[a]pyrene multiple interactions ISO RGD:1332252 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SDHD mRNA] CTD PMID:22228805 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of SDHD mRNA CTD PMID:19483382 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SDHD mRNA CTD PMID:17602206 cyclosporin A decreases expression ISO RGD:1345704 6480464 Cyclosporine results in decreased expression of SDHD mRNA CTD PMID:20106945 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of SDHD mRNA CTD PMID:19483382 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SDHD mRNA CTD PMID:17602206 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of SDHD mRNA CTD PMID:19483382 paracetamol affects expression ISO RGD:1332252 6480464 Acetaminophen affects the expression of SDHD mRNA CTD PMID:17562736 paraquat increases expression ISO RGD:1332252 6480464 Paraquat results in increased expression of SDHD mRNA CTD PMID:21371552 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of SDHD mRNA CTD PMID:19483382 resveratrol increases expression ISO RGD:1332252 6480464 resveratrol results in increased expression of SDHD mRNA CTD PMID:22610192 rosiglitazone increases expression ISO RGD:1332252 6480464 rosiglitazone results in increased expression of SDHD mRNA CTD PMID:17245590 rosiglitazone affects expression ISO RGD:1332252 6480464 rosiglitazone affects the expression of SDHD mRNA CTD PMID:22013433 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of SDHD mRNA CTD PMID:19483382 toluene affects expression EXP 6480464 Toluene affects the expression of SDHD mRNA CTD PMID:21827849 trans-resveratrol increases expression ISO RGD:1332252 6480464 resveratrol results in increased expression of SDHD mRNA CTD PMID:22610192 tunicamycin decreases expression ISO RGD:1332252 6480464 Tunicamycin results in decreased expression of SDHD mRNA CTD PMID:17127020 zidovudine increases expression ISO RGD:1345704 6480464 Zidovudine results in increased expression of SDHD mRNA CTD PMID:16894629
Biological Process
biological_process ND 1598407 10/2012: no relevant rat data RGD electron transport chain IEA UniProtKB-KW:KW-0249 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 tricarboxylic acid cycle ISO RGD:1345704 1624291 PMID:9533030 RGD PMID:9533030 tricarboxylic acid cycle IEA UniPathway:UPA00223 1600115 GO_REF:0000041 UniPathway GO_REF:0000041
Cellular Component
cellular_component ND 1598407 10/2012: no relevant rat data RGD integral to membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 mitochondrial inner membrane ISO RGD:1345704 1624291 PMID:9533030 RGD PMID:9533030 mitochondrial inner membrane ISS UniProtKB:A5GZW8 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 mitochondrial respiratory chain complex II ISS UniProtKB:A5GZW8 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 mitochondrion ISO RGD:1332252 1624291 MGI:MGI:2682130|PMID:14651853 RGD MGI:MGI:2682130 PMID:14651853 mitochondrion ISO RGD:1332252 1624291 MGI:MGI:3852644|PMID:18614015 RGD MGI:MGI:3852644 PMID:18614015 mitochondrion ISO RGD:1332252 1624291 MGI:MGI:3629441|PMID:16120479 RGD MGI:MGI:3629441 PMID:16120479
Molecular Function
heme binding ISS UniProtKB:A5GZW8 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 molecular_function ND 1598407 10/2012: no relevant rat data RGD succinate dehydrogenase activity ISO RGD:1345704 1624291 PMID:9533030 RGD PMID:9533030 ubiquinone binding ISS UniProtKB:A5GZW8 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024
71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 Glucose level postprandial 8 3039822 61462321 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 Brain/spinal cord inflammation demyelination 8 8294860 115338082 Rat 1354595 Despr4 Despair related QTL 4 .0036 Activity level immobility level 8 9008612 54008612 Rat 1354627 Despr14 Despair related QTL 14 .0056 Activity level swimming level 8 9008612 54008612 Rat 1598824 Memor4 Memory QTL 4 2.5 Memory navigation-spatial 8 9581132 56397678 Rat 61353 Bp35 Blood pressure QTL 35 Blood pressure 8 9581132 103685771 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 .005 White blood cell count 8 10116155 55116155 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 Joint/bone inflammation adjuvant induced 8 10116155 55116155 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 .00036 Spike wave discharge measurement frequency 8 16442230 61442230 Rat 631271 Cati1 Cataract Ihara QTL 1 .001 Cataract susceptibility 8 16468237 61468237 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 Renal function urine albumin level 8 19815642 98451660 Rat 631842 Inf1 Infertility severity QTL 1 4.1 .001 Seminal vesicle mass 8 26358063 71358063 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 .0003 Lipid level triglyceride 8 28414004 58991068 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 Kidney mass 8 28414004 103684785 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 Blood pressure post sympathetic nervous system block 8 28414004 103684785 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 Cardiac mass 8 28414004 103684785 Rat 2303572 Insul13 Insulin level QTL 13 2 Insulin level 8 29077622 74077622 Rat 2303564 Gluco43 Glucose level QTL 43 3 Glucose level fasting 8 29077622 74077622 Rat 1300146 Rf17 Renal function QTL 17 2.9 Renal function salt-loaded renal blood flow 8 29559446 74559446 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 Cardiac mass 8 29559446 103672447 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 Renal function urine albumin level 8 30878636 74178909 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5 0 Neurodegradation motoneuron cell number 8 31508524 98947320 Rat 1331744 Bp217 Blood pressure QTL 217 3.398 Blood pressure systolic 8 32203394 61853629 Rat 1359033 Bp273 Blood pressure QTL 273 Blood pressure response to intrathecal cytisine 8 32203394 64762616 Rat 2313046 Bss78 Bone structure and strength QTL 78 3.5 .0001 Bone strength 8 32203394 86628010 Rat 2313057 Bss76 Bone structure and strength QTL 76 3 .0001 Bone structure 8 32203394 86628010 Rat 2313067 Bss77 Bone structure and strength QTL 77 3.1 .0001 Bone structure 8 32203394 86628010 Rat 2313088 Bss75 Bone structure and strength QTL 75 3.1 .0001 Bone structure 8 32203394 86628010 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 Renal function urine abumin level 8 32203394 98986263 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 .0001 Renal function urine protein level 8 32203394 98986263 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 .0001 Renal histology kidney lesion grade 8 32203499 98986085 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 .001 Renal function urine albumin level 8 32203499 98986085 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 Lipid level serum cholesterol 8 32203499 110106272 Rat 1298065 Scl16 Serum cholesterol level QTL 16 3.8 Lipid level cholesterol 8 33897608 78897608 Rat 1582222 Epfw2 Epididymal fat weight QTL 2 3.2 .0005 Epididymal fat weight 8 34808657 79808657 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 .0004 Insulin level fasting 8 38003289 103665018 Rat 61358 Bp39 Blood pressure QTL 39 2 Blood pressure 8 38902937 83902937 Rat 737824 Hcar10 Hepatocarcinoma resistance QTL 10 2.9 Liver tumor resistance nodule number 8 43313902 87122960 Rat 1358906 Bp253 Blood pressure QTL 253 4 .0004 Blood pressure post sympathetic nervous system block 8 43313902 98451660 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 .0001 Bone mineral density distal femur volumetric BMD by pQCT 8 43561064 129041809 Rat 1331769 Rf39 Renal function QTL 39 3.871 Renal function urine volume 8 44484215 103672447 Rat 1298079 Activ2 Activity QTL 2 9.5 .000001 Activity level novel environment 8 44484215 129041809 Rat 631216 Stl9 Serum triglyceride level QTL 9 4.71 .0001 Lipid level triglyceride 8 44484347 74178405 Rat 70161 Bp62 Blood pressure QTL 62 2.9 .001 Blood pressure salt-loaded systolic 8 45291674 94514282 Rat 2313086 Bss60 Bone structure and strength QTL 60 4.1 .0001 Bone structure 8 53049279 86628010 Rat 4889938 Bss89 Bone structure and strength QTL 89 3.8 Bone structure 8 53049279 86628010 Rat 5684973 Bss100 Bone structure and strength QTL 100 4.7 Bone structure tibial area 8 53049279 86628010 Rat 2303570 Gluco48 Glucose level QTL 48 2 Glucose level post-restraint 8 53621297 98621297 Rat