Kdm6a (lysine demethylase 6A) - Rat Genome Database

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Gene: Kdm6a (lysine demethylase 6A) Rattus norvegicus
Analyze
Symbol: Kdm6a
Name: lysine demethylase 6A
RGD ID: 9275041
Description: Predicted to enable DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and identical protein binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; and positive regulation of cell size. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lysine (K)-specific demethylase 6A; lysine-specific demethylase 6A; NEWGENE_1565481
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,920,374 - 7,060,027 (-)NCBIGRCr8
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X4,805,493 - 4,945,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX4,806,277 - 4,945,944 (-)EnsemblRnor6.0rn6Rnor6.0
CeleraX4,851,606 - 4,991,275 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma. Audenet F, etal., Clin Cancer Res. 2019 Feb 1;25(3):967-976. doi: 10.1158/1078-0432.CCR-18-2039. Epub 2018 Oct 23.
2. Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer. Chen H, etal., Oncoimmunology. 2020 Jun 30;9(1):1788252. doi: 10.1080/2162402X.2020.1788252.
3. Combination of lysine-specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer. Chen X, etal., Cancer Med. 2021 Jan;10(1):317-324. doi: 10.1002/cam4.3602. Epub 2020 Nov 11.
4. Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma. Cregan S, etal., Int J Oncol. 2017 Mar;50(3):1044-1052. doi: 10.3892/ijo.2017.3870. Epub 2017 Feb 9.
5. Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma. Dong Z, etal., Cell Death Dis. 2019 Dec 5;10(12):930. doi: 10.1038/s41419-019-2171-3.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. Ho AS, etal., J Clin Invest. 2019 Oct 1;129(10):4276-4289. doi: 10.1172/JCI128227.
8. The mutational landscape of adenoid cystic carcinoma. Ho AS, etal., Nat Genet. 2013 Jul;45(7):791-8. doi: 10.1038/ng.2643. Epub 2013 May 19.
9. Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential. Hu J, etal., Cancer Med. 2019 Aug;8(9):4338-4347. doi: 10.1002/cam4.2199. Epub 2019 Jun 14.
10. Lung mitochondria adaptation to endurance training in rats. Jarmuszkiewicz W, etal., Free Radic Biol Med. 2020 Dec;161:163-174. doi: 10.1016/j.freeradbiomed.2020.10.011. Epub 2020 Oct 16.
11. Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-β1-induced gene expression in mesangial cells and diabetic kidney. Jia Y, etal., J Biol Chem. 2019 Aug 23;294(34):12695-12707. doi: 10.1074/jbc.RA119.007575. Epub 2019 Jul 2.
12. Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Komers R, etal., Lab Invest. 2013 May;93(5):543-52. doi: 10.1038/labinvest.2013.47. Epub 2013 Mar 18.
13. Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain. Lee YM, etal., Cancers (Basel). 2020 Dec 4;12(12). pii: cancers12123632. doi: 10.3390/cancers12123632.
14. Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3. Leng X, etal., Oncogene. 2020 Oct;39(41):6468-6479. doi: 10.1038/s41388-020-01449-y. Epub 2020 Sep 2.
15. [KDM6A mutation and expression in gastric cancer are associated with prognosis]. Li LL, etal., Zhonghua Zhong Liu Za Zhi. 2020 Aug 23;42(8):648-652. doi: 10.3760/cma.j.cn112152-20190528-00334.
16. The Prognostic Significance of Histone Demethylase UTX in Esophageal Squamous Cell Carcinoma. Li SH, etal., Int J Mol Sci. 2018 Jan 19;19(1). pii: ijms19010297. doi: 10.3390/ijms19010297.
17. KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway. Li Y, etal., Exp Ther Med. 2020 Sep;20(3):2774-2782. doi: 10.3892/etm.2020.9000. Epub 2020 Jul 13.
18. Kdm6A Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis via H3K27me3 Demethylation of Ncx Gene. Li Y, etal., J Cardiovasc Transl Res. 2019 Oct;12(5):488-495. doi: 10.1007/s12265-019-09882-5. Epub 2019 Mar 18.
19. Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells. Moena D, etal., J Cell Physiol. 2020 Jun;235(6):5404-5412. doi: 10.1002/jcp.29428. Epub 2020 Jan 7.
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. Rosales W, etal., Biomed Res Int. 2016;2016:2634976. doi: 10.1155/2016/2634976. Epub 2016 Sep 18.
22. The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation. Tang X, etal., Cancer Cell Int. 2019 May 22;19:144. doi: 10.1186/s12935-019-0841-y. eCollection 2019.
23. In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis. Wu Q, etal., Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3978-E3986. doi: 10.1073/pnas.1716589115. Epub 2018 Apr 9.
Additional References at PubMed
PMID:17500065   PMID:21095589   PMID:22949634   PMID:23028370   PMID:23658530   PMID:32020624   PMID:34122720  


Genomics

Comparative Map Data
Kdm6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X6,920,374 - 7,060,027 (-)NCBIGRCr8
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X4,805,493 - 4,945,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX4,806,277 - 4,945,944 (-)EnsemblRnor6.0rn6Rnor6.0
CeleraX4,851,606 - 4,991,275 (-)NCBICelera
Cytogenetic MapXq11NCBI
KDM6A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X44,873,188 - 45,112,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX44,873,188 - 45,112,779 (+)EnsemblGRCh38hg38GRCh38
GRCh37X44,732,434 - 44,972,024 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X44,617,725 - 44,856,791 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X44,489,034 - 44,728,097NCBI
CeleraX48,869,187 - 49,108,532 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX42,453,849 - 42,692,064 (+)NCBIHuRef
CHM1_1X44,765,277 - 45,004,740 (+)NCBICHM1_1
T2T-CHM13v2.0X44,280,009 - 44,519,820 (+)NCBIT2T-CHM13v2.0
Kdm6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X18,027,101 - 18,147,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX18,028,814 - 18,146,175 (+)EnsemblGRCm39 Ensembl
GRCm38X18,160,862 - 18,279,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX18,162,575 - 18,279,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X17,739,793 - 17,856,484 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X17,319,626 - 17,436,317 (+)NCBIMGSCv36mm8
CeleraX15,748,215 - 15,864,723 (+)NCBICelera
Cytogenetic MapXA1.2- A1.3NCBI
cM MapX13.45NCBI
Kdm6a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555163,149,948 - 3,346,832 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555163,151,350 - 3,346,832 (-)NCBIChiLan1.0ChiLan1.0
KDM6A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X46,508,863 - 46,743,952 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X46,512,050 - 46,747,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X37,313,000 - 37,548,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X45,127,382 - 45,362,029 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX45,127,382 - 45,362,029 (+)Ensemblpanpan1.1panPan2
KDM6A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X38,745,854 - 38,964,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX38,745,854 - 38,959,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX25,972,576 - 26,186,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X38,834,431 - 39,048,434 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX38,834,431 - 39,048,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X38,867,587 - 39,081,494 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X38,853,967 - 39,068,049 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X38,946,725 - 39,160,664 (+)NCBIUU_Cfam_GSD_1.0
Kdm6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X31,139,574 - 31,354,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650210,980,118 - 11,196,163 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650210,980,303 - 11,196,711 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDM6A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,953,814 - 40,154,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X39,953,764 - 40,154,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X44,504,617 - 44,704,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KDM6A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X42,053,272 - 42,291,013 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX42,053,336 - 42,290,526 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660767,255,731 - 7,491,004 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdm6a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248871,065,883 - 1,279,186 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248871,065,173 - 1,279,660 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kdm6a
248 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 33 52 36 19 36 5 5 72 32 34 11 5
Low 1 10 5 5 5 3 6 2 3 7 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002727525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002727526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002727527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002727528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002727529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003754729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide GAPM01000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000077238   ⟹   ENSRNOP00000073763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,339,404 - 4,477,062 (-)Ensembl
Rnor_6.0 EnsemblX4,806,847 - 4,945,944 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)Ensembl
Rnor_6.0 EnsemblX4,806,277 - 4,945,725 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101565   ⟹   ENSRNOP00000086422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104659   ⟹   ENSRNOP00000090298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109873   ⟹   ENSRNOP00000083804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112344   ⟹   ENSRNOP00000096881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX4,337,750 - 4,477,062 (-)Ensembl
RefSeq Acc Id: NM_001427597   ⟹   NP_001414526
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,960 (-)NCBI
RefSeq Acc Id: XM_039100359   ⟹   XP_038956287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,060,027 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100362   ⟹   XP_038956290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100363   ⟹   XP_038956291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100364   ⟹   XP_038956292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100365   ⟹   XP_038956293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,988 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,099 (-)NCBI
RefSeq Acc Id: XM_039100366   ⟹   XP_038956294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100367   ⟹   XP_038956295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,099 (-)NCBI
RefSeq Acc Id: XM_039100368   ⟹   XP_038956296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100369   ⟹   XP_038956297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,100 (-)NCBI
RefSeq Acc Id: XM_039100370   ⟹   XP_038956298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,099 (-)NCBI
RefSeq Acc Id: XM_039100371   ⟹   XP_038956299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,099 (-)NCBI
RefSeq Acc Id: XM_039100372   ⟹   XP_038956300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,099 (-)NCBI
RefSeq Acc Id: XM_039100373   ⟹   XP_038956301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
mRatBN7.2X4,337,466 - 4,477,099 (-)NCBI
RefSeq Acc Id: XM_063279717   ⟹   XP_063135787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
RefSeq Acc Id: XM_063279718   ⟹   XP_063135788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
RefSeq Acc Id: XM_063279719   ⟹   XP_063135789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
RefSeq Acc Id: XM_063279720   ⟹   XP_063135790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
RefSeq Acc Id: XM_063279721   ⟹   XP_063135791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X6,920,374 - 7,059,986 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000073763   ⟸   ENSRNOT00000077238
RefSeq Acc Id: XP_038956297   ⟸   XM_039100369
- Peptide Label: isoform X12
- UniProtKB: A6JZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956294   ⟸   XM_039100366
- Peptide Label: isoform X8
- UniProtKB: A6JZV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956291   ⟸   XM_039100363
- Peptide Label: isoform X4
- UniProtKB: A6JZV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956296   ⟸   XM_039100368
- Peptide Label: isoform X11
- UniProtKB: V9GWQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956292   ⟸   XM_039100364
- Peptide Label: isoform X5
- UniProtKB: A6JZV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956290   ⟸   XM_039100362
- Peptide Label: isoform X3
- UniProtKB: V9GWQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956287   ⟸   XM_039100359
- Peptide Label: isoform X1
- UniProtKB: A6JZV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956301   ⟸   XM_039100373
- Peptide Label: isoform X18
- UniProtKB: A0A8I6ADI5 (UniProtKB/TrEMBL),   V9GWQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956300   ⟸   XM_039100372
- Peptide Label: isoform X17
- UniProtKB: V9GWQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956299   ⟸   XM_039100371
- Peptide Label: isoform X16
- UniProtKB: A6JZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956298   ⟸   XM_039100370
- Peptide Label: isoform X15
- UniProtKB: V9GWQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956295   ⟸   XM_039100367
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZM74 (UniProtKB/TrEMBL),   A6JZV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956293   ⟸   XM_039100365
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZXR3 (UniProtKB/TrEMBL),   V9GWQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086422   ⟸   ENSRNOT00000101565
RefSeq Acc Id: ENSRNOP00000090298   ⟸   ENSRNOT00000104659
RefSeq Acc Id: ENSRNOP00000096881   ⟸   ENSRNOT00000112344
RefSeq Acc Id: ENSRNOP00000083804   ⟸   ENSRNOT00000109873
RefSeq Acc Id: XP_063135791   ⟸   XM_063279721
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063135788   ⟸   XM_063279718
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135787   ⟸   XM_063279717
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135790   ⟸   XM_063279720
- Peptide Label: isoform X13
- UniProtKB: A0A8I6GMA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135789   ⟸   XM_063279719
- Peptide Label: isoform X10
RefSeq Acc Id: NP_001414526   ⟸   NM_001427597
- UniProtKB: A0A8I6A5T3 (UniProtKB/TrEMBL)
Protein Domains
JmjC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6D0-F1-model_v2 AlphaFold A0A0G2K6D0 1-1366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701706
Promoter ID:EPDNEW_R12225
Type:initiation region
Name:Kdm6a_1
Description:lysine demethylase 6A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X4,945,749 - 4,945,809EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9275041 AgrOrtholog
BioCyc Gene G2FUF-3133 BioCyc
Ensembl Genes ENSRNOG00000052721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077238.2 UniProtKB/TrEMBL
  ENSRNOT00000092829.2 UniProtKB/TrEMBL
  ENSRNOT00000101565.1 UniProtKB/TrEMBL
  ENSRNOT00000104659.1 UniProtKB/TrEMBL
  ENSRNOT00000109873 ENTREZGENE
  ENSRNOT00000109873.1 UniProtKB/TrEMBL
  ENSRNOT00000112344.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1370 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
  2.10.110.20 UniProtKB/TrEMBL
  Cupin UniProtKB/TrEMBL
InterPro JmjC_dom UniProtKB/TrEMBL
  KDM6_GATAL_sf UniProtKB/TrEMBL
  KDM6A_B-like_C-hel UniProtKB/TrEMBL
  KDM6A_B-like_GATAL UniProtKB/TrEMBL
  TPR-like_helical_dom UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene Kdm6a ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE UniProtKB/TrEMBL
  LYSINE-SPECIFIC DEMETHYLASE 6A UniProtKB/TrEMBL
Pfam JmjC UniProtKB/TrEMBL
  KDM6_C-hel UniProtKB/TrEMBL
  KDM6_GATAL UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PhenoGen Kdm6a PhenoGen
PROSITE JMJC UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052721 RatGTEx
SMART JmjC UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A0G2K6D0_RAT UniProtKB/TrEMBL
  A0A8I5ZM74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXR3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5T3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMA3 ENTREZGENE, UniProtKB/TrEMBL
  A6JZV2 ENTREZGENE, UniProtKB/TrEMBL
  A6JZV3 ENTREZGENE, UniProtKB/TrEMBL
  V9GWQ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-20 Kdm6a  lysine demethylase 6A  NEWGENE_1565481  lysine (K)-specific demethylase 6A  Name and Symbol changed 629549 APPROVED