Gene: Egln1 (egl-9 family hypoxia-inducible factor 1) Rattus norvegicus
Symbol: Egln1
Name: egl-9 family hypoxia-inducible factor 1
Description: ENCODES a protein that exhibits enzyme binding; peptidyl-proline dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (ortholog); INVOLVED IN negative regulation of cAMP catabolic process; negative regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of sequence-specific DNA binding transcription factor activity; PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell cancer pathway; ASSOCIATED WITH Erythrocytosis, Familial, 3 (ortholog); FOUND IN cytosol; cytoplasm (ortholog); INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; astemizole
Type: protein-coding
RefSeq Status: MODEL
Also known as: egl nine homolog 1; EGL nine homolog 1 (C. elegans); HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; hypoxia-inducible factor prolyl hydroxylase 2; PHD-2; PHD2; prolyl hydroxylase domain-containing protein 2
Latest Assembly: RGSC Genome Assembly v5.0
NCBI Annotation Information: Annotation category: suggests misassembly
RGSC Genome Assembly v6.01957,660,194 - 57,701,158-NCBI
Rat Cytogenetic Map19q12 NCBI
RGSC Genome Assembly v5.01968,373,433 - 68,412,983-NCBI
RGSC Genome Assembly v3.41955,080,670 - 55,118,226-NCBI
Rat Celera Assembly1952,235,066 - 52,273,829-NCBI
Genome Assembly 3.11955,086,125 - 55,122,813-NCBI

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Strain Sequence Variants

Additional Information

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Nomenclature History
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RGD Object Information
RGD ID: 631375
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2015-11-09
Status: ACTIVE